Bone morphogenetic protein 7 induces mesenchymal-to-epithelial transition in melanoma cells, leading to inhibition of metastasis

Cancer Science

Volumn 100, Issue 11, 2009, Pages 2218-2225

  Na, Yi Rang ^a   Seok, Seung Hyeok ^a   Kim, Dong Jae ^a   Han, Ju Hee ^a   Kim, Tae Hyoun ^a   Jung, Hyun ^a   Lee, Byoung Hee ^b   Park, Jae Hak ^a  

^a Seoul National University   (South Korea)

^b National Institute of Biological Resources   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CISPLATIN; OSTEOGENIC PROTEIN 1; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR TWIST;

ARTICLE; CANCER GROWTH; CELL ASSAY; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL STRAIN HEK293; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; MESENCHYME CELL; METASTASIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BONE MORPHOGENETIC PROTEIN 7; BONE MORPHOGENETIC PROTEIN RECEPTORS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; CISPLATIN; EPITHELIAL CELLS; HUMANS; MELANOMA; MESODERM; NEOPLASM METASTASIS; NUCLEAR PROTEINS; TWIST TRANSCRIPTION FACTOR;

EID: 71049150077     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01301.x     Document Type: Article

References (45)

1. Cheng GZ, Chan J, Wang Q, Zhang W, Sun CD, Wang LH. Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res 2007, 67:1979-87.
2. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002, 2:563-72.
3. Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat Rev Cancer 2004, 4:448-56.
4. Wu Y, Zhou BP. New insights of epithelial-mesenchymal transition in cancer metastasis. Acta Biochim Biophys Sin (Shanghai) 2008, 40:643-50.
5. MacDonald IC, Groom AC, Chambers AF. Cancer spread and micrometastasis development: quantitative approaches for in vivo models. BioEssays 2002, 24:885-93.
6. Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005, 17:548-58.
7. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002, 2:442-54.
8. Dudley AT, Lyons KM, Robertson EJ. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 1995, 9:2795-807.
9. Vukicevic S, Kopp JB, Luyten FP, Sampath TK. Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc Natl Acad Sci USA 1996, 93:9021-6.
10. Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Res 2006, 66:4549-52.
11. Cheung M, Chaboissier MC, Mynett A, Hirst E, Schedl A, Briscoe J. The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell 2005, 8:179-92.
12. Martin SS, Ridgeway AG, Pinkas J. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene 2004, 23:4641-5.
13. Wang X, Belguise K, Kersual N. Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol 2007, 9:470-8.
14. Ozkaynak E, Rueger DC, Drier EA. OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. EMBO J 1990, 9:2085-93.
15. Ducy P, Karsenty G. The family of bone morphogenetic proteins. Kidney Int 2000, 57:2207-14.
16. Itoh S, Itoh F, Goumans MJ, Ten Dijke P. Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 2000, 267:6954-67.
17. Simic P, Vukicevic S. Bone morphogenetic proteins in development and homeostasis of kidney. Cytokine Growth Factor Rev 2005, 16:299-308.
18. Zeisberg M, Hanai J, Sugimoto H. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003, 9:964-8.
19. Howe JR, Sayed MG, Ahmed AF. The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet 2004, 41:484-91.
20. Waite KA, Eng C. From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family. Nat Rev Genet 2003, 4:763-73.
21. Hsu MY, Rovinsky SA, Lai CY. Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation. Lab Invest 2008, 88:842-55.
22. Buijs JT, Henriquez NV, van Overveld PG. Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res 2007, 67:8742-51.
23. Buijs JT, Rentsch CA, van der Horst G. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am J Pathol 2007, 171:1047-57.
24. Notting I, Buijs J, Mintardjo R. Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo. Invest Ophthalmol Vis Sci 2007, 48:4882-9.
25. Alonso SR, Tracey L, Ortiz P. A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. Cancer Res 2007, 67:3450-60.
26. Kulesa PM, Kasemeier-Kulesa JC, Teddy JM. Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment. Proc Natl Acad Sci USA 2006, 103:3752-7.
27. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
28. Yang S, Zhong C, Frenkel B, Reddi AH, Roy-Burman P. Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells. Cancer Res 2005, 65:5769-77.
29. Hsu MY, Rovinsky S, Penmatcha S, Herlyn M, Muirhead D. Bone morphogenetic proteins in melanoma: angel or devil?. Cancer Metastasis Rev 2005, 24:251-63.
30. Yang MH, Wu KJ. TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle 2008, 7:2090-6.
31. Yang MH, Wu MZ, Chiou SH. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008, 10:295-305.
32. Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM, Postovit LM. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer 2007, 7:246-55.
33. Kuphal S, Palm HG, Poser I, Bosserhoff AK. Snail-regulated genes in malignant melanoma. Melanoma Res 2005, 15:305-13.
34. Poser I, Dominguez D, de Herreros AG, Varnai A, Buettner R, Bosserhoff AK. Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail. J Biol Chem 2001, 276:24661-6.
35. Tsutsumida A, Hamada J, Tada M. Epigenetic silencing of E- and P-cadherin gene expression in human melanoma cell lines. Int J Oncol 2004, 25:1415-21.
36. Na YR, Seok SH, Kim DJ. Zebrafish embryo extracts promote sphene-forming abilities of human melanoma cell line. Cancer Sci. 2009, 100:1429-33.
37. Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, ten Dijke P, van der Pluijm G. TGF-beta and BMP7 interactions in tumour progression and bone metastasis. Clin Exp Metastasis 2007, 24:609-17.
38. Grijelmo C, Rodrigue C, Svrcek M. Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. Cell Signal 2007, 19:1722-32.
39. Ro TB, Holt RU, Brenne AT. Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells. Oncogene 2004, 23:3024-32.
40. Tu WH, Thomas TZ, Masumori N. The loss of TGF-beta signaling promotes prostate cancer metastasis. Neoplasia 2003, 5:267-77.
41. Piek E, Moustakas A, Kurisaki A, Heldin CH, ten Dijke P. TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 1999, 112(Pt 24):4557-68.
42. Prindull G. Hypothesis: cell plasticity, linking embryonal stem cells to adult stem cell reservoirs and metastatic cancer cells?. Exp Hematol 2005, 33:738-46.
43. Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A. TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 2005, 16:1987-2002.
44. Ingber DE. Can cancer be reversed by engineering the tumor microenvironment?. Semin Cancer Biol 2008, 18:356-64.
45. Sonnenschein C, Soto AM. Theories of carcinogenesis: an emerging perspective. Semin Cancer Biol 2008, 18:372-7.