Methylation profiling of tumor suppressor genes and oncogenes in hepatitis virus-related hepatocellular carcinoma in northern India

Cancer Genetics and Cytogenetics

Volumn 195, Issue 2, 2009, Pages 112-119

  Kiran, Manjula ^a   Chawla, Yogesh K ^a   Kaur, Jyotdeep ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GLUTATHIONE TRANSFERASE P1; SUPPRESSOR OF CYTOKINE SIGNALING 1; UVOMORULIN;

ADULT; ARTICLE; CANCER RISK; CHRONICITY; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENE SILENCING; GENETIC ASSOCIATION; GENETIC EPIGENESIS; GENETIC RISK; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; INDIA; LIVER CELL CARCINOMA; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE MYC; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE; VIRUS CARCINOGENESIS; VIRUS HEPATITIS;

BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CPG ISLANDS; DNA METHYLATION; DNA PRIMERS; GENES, TUMOR SUPPRESSOR; HEPATITIS, VIRAL, HUMAN; HUMANS; INDIA; LIVER NEOPLASMS; MIDDLE AGED; ONCOGENES; POLYMERASE CHAIN REACTION;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

EID: 70949107362     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2009.06.021     Document Type: Article

References (37)

1. But D.Y.K., Lai C.L., and Yuen M.F. Natural history of hepatitis-related hepatocellular carcinoma. World J Gastroenterol 14 (2008) 1652-1656
2. Murakami S. Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol 36 (2001) 651-660
3. Dunn B.K. Hypomethylation: one side of a larger picture. Ann N Y Acad Sci 983 (2003) 28-42
4. Esteller M. Dormant hypermethylated tumor suppressor genes: questions and answers. J Pathol 205 (2005) 172-180
5. Iwata N., Yamamoto H., Sasaki S., Itoh F., Suzuki H., Kikuchi T., Kaneto H., Iku S., Ozeki I., Karino Y., Satoh T., Toyota J., Satoh M., Endo T., and Imai K. Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3σ gene in human hepatocellular carcinoma. Oncogene 19 (2000) 5298-5302
6. INK4A gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut 48 (2001) 372-377
7. Tischoff I., and Tannapfel A. DNA methylation in hepatocellular carcinoma. World J Gastroenterol 14 (2008) 1741-1748
8. Frigola J., Solé X., Paz M.F., Moreno V., Esteller M., Capellà G., and Peinado M.A. Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum Mol Genet 14 (2005) 319-326
9. Sato N., Maitra A., Fukushima N., van Heek N.T., and Matsubayashi H. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res 63 (2003) 4158-4166
10. Sato N., Fukushima N., Matsubayashi H., and Goggins M. Identification of maspin and S100p as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. Oncogene 23 (2004) 1531-1538
11. Piotrowski A., Benetkiewicz M., Menzel U., de Ståhl T.D., Mantripragada K., Grigelionis G., Buckley P.G., Jankowski M., Hoffman J., Bała D., Srutek E., Laskowski R., Zegarski W., and Dumanski J.P. Microarray-based survey of CpG islands identifies concurrent hyper- and hypomethylation patterns in tissues derived from patients with breast cancer. Genes Chromosomes Cancer 45 (2006) 656-667
12. INK4 is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology 116 (1999) 394-400
13. Wong I.H., Lo Y.M., Yeo W., Lau W.Y., and Johnson P.J. Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients. Clin Cancer Res 6 (2000) 3516-3521
14. Yoshikawa H., Matsubara K., Qian G.S., Jackson P., Groopman J.D., Manning J.E., Harris C.C., and Herman J.G. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 28 (2001) 29-35
15. Herman JG, Baylin SB. Methylation specific PCR. Curr Protoc Hum Genet 1998 Feb.;Chapter 10:Unit 10.6.
16. Granau C., Clark S.J., and Rosenthal A. Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res 29 (2001) 65-71
17. Maruyama R., Toyooka S., Toyooka K.O., Virmani A.K., Zöchbauer-Müller S., Farinas A.J., Minna J.D., McConnell J., Frenkel E.P., and Gazdar A.F. Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features. Clin Cancer Res 8 (2002) 514-519
18. INK4A methylation in sera of patients with liver cirrhosis and hepatocellular carcinoma. J Korean Med Sci 19 (2004) 83-86
19. Jin M., Piao Z., Kim N.G., Park C., Shin E.C., Park J.H., Jung H.J., Kim C.G., and Kim H. p16 is a major inactivation target in hepatocellular carcinoma. Cancer 89 (2000) 60-68
20. Yu J., Ni M., Xu J., Zhang H., Gao B., Gu J., Chen J., Zhang L., Wu M., Zhen S., and Zhu J. Methylation profiling of twenty promoter CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer 2 (2002) 29
21. Qin Y., Liu J.Y., Li B., Sun Z.L., and Sun Z.F. Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis. World J Gastroenterol 10 (2004) 1276-1280
22. Roncalli M., Bianchi P., Bruni B., Laghi L., Destro A., Di Gioia S., Gennari L., Tommasini M., Malesci A., and Coggi G. Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. Hepatology 36 (2002) 427-432
23. WAF1/CIP1) affects thymidine incorporation in human liver cancer cells. Br J Cancer 86 (2002) 625-629
24. Merlo A., Herman J.G., Mao L., Lee D.J., Gabrielson E., Burger P.C., Baylin S.B., and Sidransky D. 5′CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1 (1995) 686-692
25. Yang B., Guo M., Herman J.G., and Clark D.P. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 163 (2003) 1101-1107
26. Di Ilio C., Aceto A., Bucciarelli T., Angelucci S., Felaco M., Grilli A., Zezza A., Tenaglia R., and Federici G. Glutathione transferase isoenzymes in normal and neoplastic human kidney tissue. Carcinogenesis 12 (1991) 1471-1475
27. Silvestrini R., Veneroni S., Benini E., Daidone M.G., Luisi A., Leutner M., Maucione A., Kenda R., Zucali R., and Veronesi U. Expression of p53, glutathione S-transferase-pi, and Bcl-2 proteins and benefit from adjuvant radiotherapy in breast cancer. J Natl Cancer Inst 89 (1997) 639-645
28. Esteller M., Corn P.G., Urena J.M., Gabrielson E., Baylin S.B., and Herman J.G. Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia. Cancer Res 58 (1998) 4515-4518
29. Tchou J.C., Lin X., Freije D., Isaacs W.B., Brooks J.D., Rashid A., De Marzo A.M., Kanai Y., Hirohashi S., and Nelson W.G. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. Int J Oncol 16 (2000) 663-676
30. Anzola M., Cuevas N., López-Martínez M., Saiz A., Burgos J.J., and de Pancorbo M.M. No association between GSTP1 gene aberrant promoter methylation and prognosis in surgically resected hepatocellular carcinoma patients from the Basque Country (Northern Spain). Liver Int 23 (2003) 249-254
31. Zhong S., Tang M.W., Yeo W., Liu C., Lo Y.M., and Johnson P.J. Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas. Clin Cancer Res 8 (2002) 1087-1092
32. Lee W.H., Isaacs W.B., Bova G.S., and Nelson W.G. CG island methylation changes near the GSTP1 gene in prostatic carcinoma cells detected using the polymerase chain reaction: a new prostate cancer biomarker. Cancer Epidemiol Biomarkers Prev 6 (1997) 443-450
33. Tang Z., Qin L., Wang X., Zhou G., and Liao Y. Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness. Chin Med J (Engl) 111 (1998) 313-318
34. Himeno Y., Fukuda Y., Hatanaka M., and Imura H. Expression of oncogenes in human liver disease. Liver 8 (1988) 208-212
35. Nambu S., Inoue K., and Saski H. Site-specific hypomethylation of the c-myc oncogene in human hepatocellular carcinoma. Jpn J Cancer Res 78 (1987) 695-704
36. Aiba N., Nambu S., Inoue K., and Sasaki H. Hypomethylation of the c-myc oncogene in liver cirrhosis and chronic hepatitis. Gastroenterol Jpn 24 (1989) 270-276
37. Kaneko Y., Shibuya M., Nakayama T., Hayashida N., Toda G., Endo Y., Oka H., and Oda T. Hypomethylation of c-myc and epidermal growth factor receptor genes in human hepatocellular carcinoma and fetal liver. Jpn J Cancer Res 76 (1985) 1136-1140