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Volumn 62, Issue 7, 2006, Pages 1378-1389

Total synthesis of FR901464: Second generation

Author keywords

Asymmetric synthesis; Cell cycle inhibitor; Coupling reactions; FR901464

Indexed keywords

DEOXYGLUCOSE; FR 901464; LACTIC ACID; TETRAHYDROPYRAN DERIVATIVE; THREONINE;

EID: 30744455263     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2005.11.031     Document Type: Article
Times cited : (39)

References (37)
  • 6
    • 0003141477 scopus 로고    scopus 로고
    • (c) Chem. Abstr. 2000, 132, 676.
    • (2000) Chem. Abstr. , vol.132 , pp. 676
  • 16
    • 33748777194 scopus 로고
    • For examples of Wittig reactions on thioamides and O,O-dimethyl ethanebis(thiolate), see: (a) K. Hartke, A. Kumar, and J. Koester Liebigs Ann. Chem. 1983 267 273
    • (1983) Liebigs Ann. Chem. , pp. 267-273
    • Hartke, K.1    Kumar, A.2    Koester, J.3
  • 27
    • 30744432967 scopus 로고    scopus 로고
    • note
    • 3 However, we found out known compound 24 from Ref. 16, therefore we decided to start synthesis of segment C from triol 24.
  • 36
    • 0021159751 scopus 로고
    • HBTU stands for O-benzotriazol-1-yl-N,N,N′,N′- tetramethyluronium hexafluorophosphate. V. Dourtoglou, and B. Gross Synthesis 1984 572 574
    • (1984) Synthesis , pp. 572-574
    • Dourtoglou, V.1    Gross, B.2
  • 37
    • 30744442851 scopus 로고    scopus 로고
    • note
    • In this reaction, a small amount (5-10%) of by-product, in which side reaction was thought to have occurred at nitrogen of the amide moiety, was obtained. This compound was readily separated by preparative HPLC.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.