메뉴 건너뛰기




Volumn 35, Issue 5, 2009, Pages 411-426

Simvastatin restores down-regulated gata-6 expression in pulmonary hypertensive Rats

Author keywords

Pulmonary hypertension; Statins; Transcription factor; Vascular remodeling

Indexed keywords

MESSENGER RNA; SIMVASTATIN; TRANSCRIPTION FACTOR GATA 6;

EID: 70849120960     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.1080/01902140902736819     Document Type: Article
Times cited : (12)

References (56)
  • 1
    • 1642453778 scopus 로고    scopus 로고
    • Endothelial dysfunction in pulmonary hypertension
    • Budhiraja R, Tuder RM, Hassoun PM: Endothelial dysfunction in pulmonary hypertension. Circulation. 2004;109:159-165.
    • (2004) Circulation , vol.109 , pp. 159-165
    • Budhiraja, R.1    Tuder, R.M.2    Hassoun, P.M.3
  • 2
    • 0033047617 scopus 로고    scopus 로고
    • Role of hemodynamics in pulmonary vascular remodeling: Implications for primary pulmonary hypertension
    • Botney MD: Role of hemodynamics in pulmonary vascular remodeling: implications for primary pulmonary hypertension. Am J Respir Crit Care Med. 1999;159:361-364.
    • (1999) Am J Respir Crit Care Med. , vol.159 , pp. 361-364
    • Botney, M.D.1
  • 3
    • 24644492790 scopus 로고    scopus 로고
    • The role of increased pulmonary blood flow in pulmonary arterial hypertension
    • van Albada ME, Schoemaker RG, Kemna MS, et al: The role of increased pulmonary blood flow in pulmonary arterial hypertension. Eur Respir J. 2005;26:487-493.
    • (2005) Eur Respir J. , vol.26 , pp. 487-493
    • Van Albada, M.E.1    Schoemaker, R.G.2    Kemna, M.S.3
  • 4
    • 0030934358 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of pulmonary vascular remodeling
    • Stenmark KR, Mecham RP: Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol. 1997;59:89-144.
    • (1997) Annu Rev Physiol. , vol.59 , pp. 89-144
    • Stenmark, K.R.1    Mecham, R.P.2
  • 5
    • 7244224656 scopus 로고    scopus 로고
    • Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells
    • Sokabe T, Yamamoto K, Ohura N, et al: Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2004;287:H2027-H2034.
    • (2004) Am J Physiol Heart Circ Physiol. , vol.287
    • Sokabe, T.1    Yamamoto, K.2    Ohura, N.3
  • 6
    • 0029072762 scopus 로고
    • Flow-mediated endothelial mechanotransduction
    • Davies PF: Flow-mediated endothelial mechanotransduction. Physiol Rev. 1995;75:519-560.
    • (1995) Physiol Rev. , vol.75 , pp. 519-560
    • Davies, P.F.1
  • 7
    • 0026691333 scopus 로고
    • GATA-binding transcription factors in hematopoietic cells
    • Orkin SH: GATA-binding transcription factors in hematopoietic cells. Blood. 1992;80:575-581.
    • (1992) Blood. , vol.80 , pp. 575-581
    • Orkin, S.H.1
  • 8
    • 0034671733 scopus 로고    scopus 로고
    • The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression
    • Molkentin JD: The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. J Biol Chem. 2000;275:38949-38952.
    • (2000) J Biol Chem. , vol.275 , pp. 38949-38952
    • Molkentin, J.D.1
  • 9
    • 0029828994 scopus 로고    scopus 로고
    • Transcription factor GATA-3 is required for development of the T-cell lineage
    • Ting CN, Olson MC, Barton KP, et al: Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 1996;384:474-478.
    • (1996) Nature , vol.384 , pp. 474-478
    • Ting, C.N.1    Olson, M.C.2    Barton, K.P.3
  • 10
    • 0028022916 scopus 로고
    • An early haematopoietic defect in mice lacking the transcription factor GATA-2
    • Tsai FY, Keller G, Kuo FC, et al: An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 1994;371:221-226.
    • (1994) Nature , vol.371 , pp. 221-226
    • Tsai, F.Y.1    Keller, G.2    Kuo, F.C.3
  • 11
    • 0033619265 scopus 로고    scopus 로고
    • Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1
    • De Maria R, Zeuner A, Eramo A, et al: Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature 1999;401:489-493.
    • (1999) Nature , vol.401 , pp. 489-493
    • De Maria, R.1    Zeuner, A.2    Eramo, A.3
  • 12
    • 0032227812 scopus 로고    scopus 로고
    • Transcription factor GATA-1 in megakaryocyte development
    • Orkin SH, Shivdasani RA, Fujiwara Y, et al: Transcription factor GATA-1 in megakaryocyte development. Stem Cells. 1998;16(Suppl 2):79-83.
    • (1998) Stem Cells , vol.16 , Issue.SUPPL. 2 , pp. 79-83
    • Orkin, S.H.1    Shivdasani, R.A.2    Fujiwara, Y.3
  • 13
    • 0036668278 scopus 로고    scopus 로고
    • The GATA family (vertebrates and invertebrates)
    • Patient RK, McGhee JD: The GATA family (vertebrates and invertebrates). Curr Opin Genet Dev. 2002;12:416-422.
    • (2002) Curr Opin Genet Dev. , vol.12 , pp. 416-422
    • Patient, R.K.1    McGhee, J.D.2
  • 14
    • 0036337973 scopus 로고    scopus 로고
    • GATA6 regulates differentiation of distal lung epithelium
    • Yang H, Lu MM, Zhang L, et al: GATA6 regulates differentiation of distal lung epithelium. Development 2002;129:2233-2246.
    • (2002) Development , vol.129 , pp. 2233-2246
    • Yang, H.1    Lu, M.M.2    Zhang, L.3
  • 15
    • 0030578421 scopus 로고    scopus 로고
    • GATA-6: A zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm
    • Morrisey EE, Ip HS, Lu MM, et al: GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev Biol. 1996;177:309-322.
    • (1996) Dev Biol. , vol.177 , pp. 309-322
    • Morrisey, E.E.1    Ip, H.S.2    Lu, M.M.3
  • 16
    • 26444558081 scopus 로고    scopus 로고
    • Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts
    • Fischer A, Klattig J, Kneitz B, et al: Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol. 2005;25:8960-8970.
    • (2005) Mol Cell Biol. , vol.25 , pp. 8960-8970
    • Fischer, A.1    Klattig, J.2    Kneitz, B.3
  • 17
    • 15044362819 scopus 로고    scopus 로고
    • GATA6 is essential for embryonic development of the liver but dispensable for early heart formation
    • Zhao R, Watt AJ, Li J, et al: GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2005;25:2622-2631.
    • (2005) Mol Cell Biol. , vol.25 , pp. 2622-2631
    • Zhao, R.1    Watt, A.J.2    Li, J.3
  • 18
    • 0030589639 scopus 로고    scopus 로고
    • The human GATA-6 gene: Structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals
    • Suzuki E, Evans T, Lowry J, et al: The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals. Genomics 1996;38:283-290.
    • (1996) Genomics , vol.38 , pp. 283-290
    • Suzuki, E.1    Evans, T.2    Lowry, J.3
  • 19
    • 0032577675 scopus 로고    scopus 로고
    • GATA-6 induces p21(Cip1) expression and G1 cell cycle arrest
    • Perlman H, Suzuki E, Simonson M, et al: GATA-6 induces p21(Cip1) expression and G1 cell cycle arrest. J Biol Chem. 1998;273:13713-13718.
    • (1998) J Biol Chem. , vol.273 , pp. 13713-13718
    • Perlman, H.1    Suzuki, E.2    Simonson, M.3
  • 20
    • 0033515612 scopus 로고    scopus 로고
    • Reversal of GATA-6 downregulation promotes smooth muscle differentiation and inhibits intimal hyperplasia in balloon-injured rat carotid artery
    • Mano T, Luo Z, Malendowicz SL, et al: Reversal of GATA-6 downregulation promotes smooth muscle differentiation and inhibits intimal hyperplasia in balloon-injured rat carotid artery. Circ Res. 1999;84:647-654.
    • (1999) Circ Res. , vol.84 , pp. 647-654
    • Mano, T.1    Luo, Z.2    Malendowicz, S.L.3
  • 21
    • 0034644579 scopus 로고    scopus 로고
    • GATA-6: The proliferation stops here: Cell proliferation in glomerular mesangial and vascular smooth muscle cells
    • Morrisey EE: GATA-6: the proliferation stops here: cell proliferation in glomerular mesangial and vascular smooth muscle cells. Circ Res. 2000;87:638-640.
    • (2000) Circ Res. , vol.87 , pp. 638-640
    • Morrisey, E.E.1
  • 22
    • 7244224656 scopus 로고    scopus 로고
    • Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells
    • Sokabe T, Yamamoto K, Ohura N, et al: Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2004;287:H2027-H2034.
    • (2004) Am J Physiol Heart Circ Physiol. , vol.287
    • Sokabe, T.1    Yamamoto, K.2    Ohura, N.3
  • 23
    • 13244297005 scopus 로고    scopus 로고
    • GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells
    • Lepore JJ, Cappola TP, Mericko PA, et al: GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2005;25:309-314.
    • (2005) Arterioscler Thromb Vasc Biol. , vol.25 , pp. 309-314
    • Lepore, J.J.1    Cappola, T.P.2    Mericko, P.A.3
  • 25
    • 0034533147 scopus 로고    scopus 로고
    • Statins as a newly recognized type of immunomodulator
    • Kwak B, Mulhaupt F, Myit S, et al: Statins as a newly recognized type of immunomodulator. Nat Med. 2000;6:1399-1402.
    • (2000) Nat Med. , vol.6 , pp. 1399-1402
    • Kwak, B.1    Mulhaupt, F.2    Myit, S.3
  • 26
    • 0032406276 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis
    • Bustos C, Hernandez-Presa MA, Ortego M, et al: HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis. J Am Coll Cardiol. 1998;32:2057-2064.
    • (1998) J Am Coll Cardiol. , vol.32 , pp. 2057-2064
    • Bustos, C.1    Hernandez-Presa, M.A.2    Ortego, M.3
  • 27
    • 0033972268 scopus 로고    scopus 로고
    • Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury
    • Indolfi C, Cioppa A, Stabile E, et al: Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury. J Am Coll Cardiol. 2000;35:214-221.
    • (2000) J Am Coll Cardiol. , vol.35 , pp. 214-221
    • Indolfi, C.1    Cioppa, A.2    Stabile, E.3
  • 28
    • 0033618378 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)
    • Laufs U, Marra D, Node K, et al: 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). J Biol Chem. 1999;274:21926-21931.
    • (1999) J Biol Chem. , vol.274 , pp. 21926-21931
    • Laufs, U.1    Marra, D.2    Node, K.3
  • 29
    • 0031451344 scopus 로고    scopus 로고
    • Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
    • Laufs U, Fata VL, Liao JK: Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J Biol Chem. 1997;272:31725-31729.
    • (1997) J Biol Chem. , vol.272 , pp. 31725-31729
    • Laufs, U.1    Fata, V.L.2    Liao, J.K.3
  • 30
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I, et al: The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med. 2000;6:1004-1010.
    • (2000) Nat Med. , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3
  • 31
    • 0141730236 scopus 로고    scopus 로고
    • Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells
    • Nishimura T, Vaszar LT, Faul JL, et al: Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation JT - Circulation. 2003;108:1640-1645.
    • (2003) Circulation JT - Circulation. , vol.108 , pp. 1640-1645
    • Nishimura, T.1    Vaszar, L.T.2    Faul, J.L.3
  • 32
    • 0037111215 scopus 로고    scopus 로고
    • Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats
    • Nishimura T, Faul JL, Berry GJ, et al: Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats. Am J Respir Crit Care Med. 2002;166:1403-1408.
    • (2002) Am J Respir Crit Care Med. , vol.166 , pp. 1403-1408
    • Nishimura, T.1    Faul, J.L.2    Berry, G.J.3
  • 33
    • 0041859249 scopus 로고    scopus 로고
    • Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
    • Girgis RE, Li D, Zhan X, et al: Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Heart Circ Physiol. 2003;285:H938-H945.
    • (2003) Am J Physiol Heart Circ Physiol. , vol.285
    • Girgis, R.E.1    Li, D.2    Zhan, X.3
  • 34
    • 49449102924 scopus 로고    scopus 로고
    • Statins activate GATA-6 and induce differentiated vascular smooth muscle cells
    • Wada H, Abe M, Ono K, et al: Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. Biochem Biophys Res Commun. 2008;374:731-736.
    • (2008) Biochem Biophys Res Commun. , vol.374 , pp. 731-736
    • Wada, H.1    Abe, M.2    Ono, K.3
  • 35
    • 0030828893 scopus 로고    scopus 로고
    • Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension
    • Okada K, Tanaka Y, Bernstein M, et al: Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension. Am J Pathol. 1997;151:1019-1025.
    • (1997) Am J Pathol. , vol.151 , pp. 1019-1025
    • Okada, K.1    Tanaka, Y.2    Bernstein, M.3
  • 36
    • 0034526932 scopus 로고    scopus 로고
    • Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats
    • Faul JL, Nishimura T, Berry GJ, et al: Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med. 2000;162:2252-2258.
    • (2000) Am J Respir Crit Care Med. , vol.162 , pp. 2252-2258
    • Faul, J.L.1    Nishimura, T.2    Berry, G.J.3
  • 37
    • 0035131411 scopus 로고    scopus 로고
    • 40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats
    • Nishimura T, Faul JL, Berry GJ, et al: 40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med. 2001;163:498-502.
    • (2001) Am J Respir Crit Care Med. , vol.163 , pp. 498-502
    • Nishimura, T.1    Faul, J.L.2    Berry, G.J.3
  • 38
    • 0035100461 scopus 로고    scopus 로고
    • Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia
    • Hoshikawa Y, Ono S, Suzuki S, et al: Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J Appl Physiol. 2001;90:1299-1306.
    • (2001) J Appl Physiol. , vol.90 , pp. 1299-1306
    • Hoshikawa, Y.1    Ono, S.2    Suzuki, S.3
  • 39
    • 0031821684 scopus 로고    scopus 로고
    • Mechanisms of proliferative and obliterative vascular diseases. Insights from the pulmonary and systemic circulations. NHLBI Workshop summary
    • Fishman AP, FishmanMC, Freeman BA, et al: Mechanisms of proliferative and obliterative vascular diseases. Insights from the pulmonary and systemic circulations. NHLBI Workshop summary. Am J Respir Crit Care Med. 1998;158:670-674.
    • (1998) Am J Respir Crit Care Med. , vol.158 , pp. 670-674
    • Fishman, A.P.1    Fishman, M.C.2    Freeman, B.A.3
  • 40
    • 0034521647 scopus 로고    scopus 로고
    • Hypertensive pulmonary vascular disease: Dawn of the age of prevention?
    • Newman JH, Lane KB: Hypertensive pulmonary vascular disease: dawn of the age of prevention?. Am J Respir Crit Care Med. 2000;162:2020-2021.
    • (2000) Am J Respir Crit Care Med. , vol.162 , pp. 2020-2021
    • Newman, J.H.1    Lane, K.B.2
  • 41
    • 0037972141 scopus 로고    scopus 로고
    • Emerging therapies for pulmonary hypertension: Striving for efficacy and safety
    • Kao PN, Faul JL: Emerging therapies for pulmonary hypertension: striving for efficacy and safety. J Am Coll Cardiol. 2003;41:2126-2129.
    • (2003) J Am Coll Cardiol. , vol.41 , pp. 2126-2129
    • Kao, P.N.1    Faul, J.L.2
  • 42
    • 0037111455 scopus 로고    scopus 로고
    • Therapy of pulmonary hypertension: The evolution from vasodilators to antiproliferative agents
    • Rubin LJ: Therapy of pulmonary hypertension: the evolution from vasodilators to antiproliferative agents. Am J Respir Crit Care Med. 2002;166:1308-1309.
    • (2002) Am J Respir Crit Care Med. , vol.166 , pp. 1308-1309
    • Rubin, L.J.1
  • 43
    • 3042511852 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: Future directions: Report of a national heart lung and blood institute/office of rare diseases workshop
    • Newman JH, Fanburg BL, Archer SL, et al: Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation. 2004;109:2947-2952.
    • (2004) Circulation , vol.109 , pp. 2947-2952
    • Newman, J.H.1    Fanburg, B.L.2    Archer, S.L.3
  • 44
    • 0037065895 scopus 로고    scopus 로고
    • Early and sustained survival benefit associated with statin therapy at the time of percutaneous coronary intervention
    • Chan AW, Bhatt DL, Chew DP, et al: Early and sustained survival benefit associated with statin therapy at the time of percutaneous coronary intervention. Circulation. 2002;105:691-696.
    • (2002) Circulation , vol.105 , pp. 691-696
    • Chan, A.W.1    Bhatt, D.L.2    Chew, D.P.3
  • 45
    • 0037177167 scopus 로고    scopus 로고
    • Withdrawal of statins increases event rates in patients with acute coronary syndromes
    • Heeschen C, Hamm CW, Laufs U, et al: Withdrawal of statins increases event rates in patients with acute coronary syndromes. Circulation. 2002;105:1446-1452.
    • (2002) Circulation , vol.105 , pp. 1446-1452
    • Heeschen, C.1    Hamm, C.W.2    Laufs, U.3
  • 46
    • 11144322775 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function
    • Epstein M, Campese VM: Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function. Am J Kidney Dis. 2005;45:2-14.
    • (2005) Am J Kidney Dis. , vol.45 , pp. 2-14
    • Epstein, M.1    Campese, V.M.2
  • 48
    • 33644694919 scopus 로고    scopus 로고
    • Rho GTPases, statins, and nitric oxide
    • Rikitake Y, Liao JK: Rho GTPases, statins, and nitric oxide. Circ Res. 2005;97:1232-1235.
    • (2005) Circ Res. , vol.97 , pp. 1232-1235
    • Rikitake, Y.1    Liao, J.K.2
  • 49
    • 0031814992 scopus 로고    scopus 로고
    • Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells
    • Stark WW Jr, Blaskovich MA, Johnson BA, et al: Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells. Am J Physiol. 1998;275(1 Pt 1):L55-L63.
    • (1998) Am J Physiol. , vol.275 , Issue.1 PART 1
    • Stark Jr., W.W.1    Blaskovich, M.A.2    Johnson, B.A.3
  • 50
    • 0034730781 scopus 로고    scopus 로고
    • Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells
    • Hernandez-Perera O, Perez-Sala D, Soria E, et al: Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. Circ Res. 2000;87:616-622.
    • (2000) Circ Res. , vol.87 , pp. 616-622
    • Hernandez-Perera, O.1    Perez-Sala, D.2    Soria, E.3
  • 51
    • 0036685160 scopus 로고    scopus 로고
    • Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin
    • Xu CB, Stenman E, Edvinsson L: Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin. Biochem Pharmacol. 2002;64:497-505.
    • (2002) Biochem Pharmacol. , vol.64 , pp. 497-505
    • Xu, C.B.1    Stenman, E.2    Edvinsson, L.3
  • 52
    • 0037176980 scopus 로고    scopus 로고
    • Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin
    • Kalinowski L, Dobrucki LW, Brovkovych V, et al: Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. Circulation. 2002;105:933-938.
    • (2002) Circulation. , vol.105 , pp. 933-938
    • Kalinowski, L.1    Dobrucki, L.W.2    Brovkovych, V.3
  • 53
    • 0035001399 scopus 로고    scopus 로고
    • NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs
    • Weissmann N, Winterhalder S, Nollen M, et al: NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs. Am J Physiol Lung Cell Mol Physiol. 2001;280:L638-L645.
    • (2001) Am J Physiol Lung Cell Mol Physiol. , vol.280
    • Weissmann, N.1    Winterhalder, S.2    Nollen, M.3
  • 54
    • 1842734874 scopus 로고    scopus 로고
    • Regulatory elements directing gut expression of the GATA6 gene during mouse early development
    • Sun-Wada GH, Kamei Y, Wada Y, et al: Regulatory elements directing gut expression of the GATA6 gene during mouse early development. J Biochem (Tokyo) 2004;135:165-169.
    • (2004) J Biochem (Tokyo) , vol.135 , pp. 165-169
    • Sun-Wada, G.H.1    Kamei, Y.2    Wada, Y.3
  • 55
    • 0030250068 scopus 로고    scopus 로고
    • The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle
    • Narita N, Heikinheimo M, Bielinska M, et al: The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle. Genomics 1998;36:345-348.
    • (1998) Genomics , vol.36 , pp. 345-348
    • Narita, N.1    Heikinheimo, M.2    Bielinska, M.3
  • 56
    • 33646753396 scopus 로고    scopus 로고
    • Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells
    • Arora M, Chen L, Paglia M, et al: Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Proc Natl Acad Sci U S A, 2006;103:7777-7782.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7777-7782
    • Arora, M.1    Chen, L.2    Paglia, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.