Statins activate GATA-6 and induce differentiated vascular smooth muscle cells

Biochemical and Biophysical Research Communications

Volumn 374, Issue 4, 2008, Pages 731-736

  Wada, Hiromichi ^a   Abe, Mitsuru ^b   Ono, Koh ^b   Morimoto, Tatsuya ^a   Kawamura, Teruhisa ^a   Takaya, Tomohide ^a   Satoh, Noriko ^a   Fujita, Masatoshi ^b   Kita, Toru ^b   Shimatsu, Akira ^a   Hasegawa, Koji ^a  

^a NATIONAL HOSPITAL ORGANIZATION KYOTO MEDICAL CENTER   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

GATA 6; Phenotypic modulation; Statin; Vascular smooth muscle cells

Indexed keywords

ALPHA ACTIN; ATORVASTATIN; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MYOSIN HEAVY CHAIN; RHO FACTOR; SIMVASTATIN; TRANSCRIPTION FACTOR GATA 6;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR HISTOCOMPATIBILITY COMPLEX; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ACTINS; AMINO ACID MOTIFS; CELL DIFFERENTIATION; CELL PROLIFERATION; DITERPENES; DNA REPLICATION; GATA6 TRANSCRIPTION FACTOR; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NUCLEIC ACID SYNTHESIS INHIBITORS; POLYISOPRENYL PHOSPHATES; PYRROLES; SESQUITERPENES; SIMVASTATIN; TRANSCRIPTION, GENETIC;

EID: 49449102924     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.07.098     Document Type: Article

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