Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin

Biochemical Pharmacology

Volumn 64, Issue 3, 2002, Pages 497-505

  Xu, Cang Bao ^a   Stenman, Emelie ^a   Edvinsson, Lars ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Atherosclerosis; Basic fibroblast growth factor; Endothelin receptors; Proliferation; Smooth muscle cells; Statins

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; ATORVASTATIN; BASIC FIBROBLAST GROWTH FACTOR; COMPACTIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; MESSENGER RNA; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL WALL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; INCUBATION TIME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTICHOLESTEREMIC AGENTS; AORTA; CELL DIVISION; CEREBRAL ARTERIES; DRUG INTERACTIONS; FIBROBLAST GROWTH FACTOR 2; HEPTANOIC ACIDS; LOVASTATIN; MALE; MUSCLE, SMOOTH; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 0036685160     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01189-9     Document Type: Article

References (39)

1. The pathogenesis of atherosclerosis: A perspective for the 1990s
2. Factors controlling smooth-muscle cell proliferation
3. Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop
4. Statins: Effective antiatherosclerotic therapy
5. Randomized trial of cholesterol lowering in 4444 participants with coronary heart disease: The Scandinavian Simvastatin Survival Study
6. Effects of statins on vascular wall: Vasomotor function inflammation and plaque stability
7. Neuroprotective properties of statins in cerebral ischemia and stroke
8. Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs
9. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages
10. Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase
11. Inhibition of endothelial cell migration by cerivastatin an HMG-CoA reductase inhibitor: Contribution to its anti-angiogenic effect
12. Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors comparison with other human cell types
13. Pharmacological control of the mevalonate pathway: Effect on arterial smooth muscle cell proliferation
14. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia
15. Reduced susceptibility of low density lipoprotein (LDL) to lipid peroxidation after fluvastatin therapy is associated with the hypocholesterolemic effect of the drug and its binding to the LDL
16. Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E lovastatin and amlodipine
17. Structural mechanism for statin inhibition of HMG-CoA reductase
18. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
19. Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts
20. PLA2 phosphorylation and cyclooxygenase-2 induction through p38 MAP kinase pathway is involved in the IL-1beta-induced bradykinin B2 receptor gene transcription
21. Rat cerebral microvascular smooth muscle cells in culture
22. Tyrphostin inhibition of ATP-stimulated DNA synthesis cell proliferation and fos-protein expression in vascular smooth muscle cells
23. Comparison of in vitro anticancer drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines
24. Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells
25. Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins)
26. Cytokine profiles in paraffin-embedded biopsy samples of lepromatous leprosy patients: Semi-quantitative measure of cytokine mRNA using RT-PCR
27. Transcriptional regulated plasticity of vascular contractile endothelin ET(B) receptors after organ culture
28. MRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung
29. Plasticity of contractile endothelin-B receptors in human arteries after organ culture
30. Coronary and aortic vasoreactivity protection with endothelin receptor antagonist, bosentan, after ischemia and hypoxia in aged rats
31. Cell replication in the arterial wall: Activation of signaling pathway following in vivo injury
32. Basic fibroblast growth factor: Its role in the control of smooth muscle cell migration
33. Effect of statin therapy on restenosis after coronary stent implantation
34. Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: A novel autocrine function
35. Growth factor-induced modulation of endothelin-1 binding to human smooth-muscle cells
36. B receptor blockade
37. Vascular smooth muscle cell effect on endothelial cell endothelin-1 production
38. Increased immunoreactivity of endothelin-1 and endothelin B receptor in human atherosclerotic lesions. A possible role in atherogenesis
39. B receptor contractile activity in rat cerebral artery