Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 32, 2009, Pages 4090-4096

  Sparidans, Rolf W ^a   Iusuf, Dilek ^b   Schinkel, Alfred H ^b   Schellens, Jan H M ^a,b   Beijnen, Jos H ^a,b,c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

Axitinib; Erlotinib; Human plasma; LC MS MS; Trans to cis isomerization; Tyrosine kinase inhibitor

Indexed keywords

ERLOTINIB; HUMAN PLASMA; HUMAN PLASMAS; LC/MS/MS; TYROSINE KINASE INHIBITOR;

ACETONITRILE; AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; ELECTRON TRANSITIONS; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ISOMERIZATION; ISOMERS; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; ORGANIC ACIDS; PLASMA (HUMAN); SILICA; SOLVENT EXTRACTION;

PLASMAS;

ACETONITRILE; AXITINIB; ERLOTINIB; FORMIC ACID; METHANOL; WATER;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SELECTIVITY; DRUG TISSUE LEVEL; ELECTROSPRAY; ISOMERIZATION; LIGHT EXPOSURE; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ANIMALS; CHROMATOGRAPHY, LIQUID; HUMANS; IMIDAZOLES; INDAZOLES; LIMIT OF DETECTION; MICE; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 70849085455     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.10.024     Document Type: Article

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