A high-performance liquid chromatography-mass spectrometry assay for quantitation of the tyrosine kinase inhibitor nilotinib in human plasma and serum

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 20-21, 2009, Pages 1894-1900

  Parise, Robert A ^a,b   Egorin, Merrill J ^b,c   Christner, Susan M ^b   Shah, Dhvani D ^b   Zhou, Wei ^d   Beumer, Jan H ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

AMN 107; Chronic myeloid leukemia; LC MS; Mass spectrometry; Nilotinib

Indexed keywords

AMN-107; CHRONIC MYELOGENOUS LEUKEMIA; CHRONIC MYELOID LEUKEMIA; ELECTROSPRAY; HUMAN PLASMAS; INTER-ASSAY PRECISION; INTRA-ASSAY PRECISION; IONIZATION MASS SPECTROMETRY; LC-MS; NILOTINIB; ORAL ADMINISTRATION; PLASMA CONCENTRATION; PROTEIN PRECIPITATION; SMALL-MOLECULE INHIBITORS; TYROSINE KINASE INHIBITOR;

ACETONITRILE; AMINO ACIDS; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; ORGANIC ACIDS; PLASMA (HUMAN); PLASMAS; PRECIPITATION (CHEMICAL);

SPECTRUM ANALYSIS;

METHANOL; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR; WATER;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY; FOOD AND DRUG ADMINISTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IONIZATION; MASS SPECTROMETER; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; SERUM; VALIDATION PROCESS; VOLUNTEER;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; MALE; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRIMIDINES; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 67049172866     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.05.034     Document Type: Article

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