Endogenous type i interferon inducers in autoimmune diseases

Autoimmunity

Volumn 42, Issue 4, 2009, Pages 349-352

  Finke, Doreen ^a   Eloranta, Maija Leena ^a   Rönnblom, Lars ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Immune complex; POC; Type I interferon inducers

Indexed keywords

ALPHA INTERFERON; AUTOANTIBODY; AUTOANTIGEN; DNA; FC RECEPTOR IIA; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN G; INTERFERON; INTERFERON ANTIBODY; MYELOID DIFFERENTIATION FACTOR 88; NUCLEIC ACID; RNA; SMALL NUCLEAR RIBONUCLEOPROTEIN; STAT4 PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR;

ANTIGEN ANTIBODY COMPLEX; AUTOIMMUNE DISEASE; CELL ACTIVATION; CPG ISLAND; CYTOSOL; DENDRITIC CELL; DISEASE PREDISPOSITION; DNA METHYLATION; ENDOCYTOSIS; ENDOSOME; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; INNATE IMMUNITY; INTERFERON PRODUCTION; PLASMACYTOID DENDRITIC CELL; POLYMYOSITIS; PSORIASIS; SHORT SURVEY; SINGLE DRUG DOSE; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; DENDRITIC CELLS; HUMANS; INTERFERON INDUCERS; INTERFERON TYPE I; SIGNAL TRANSDUCTION;

EID: 70749157321     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930902831829     Document Type: Short Survey

References (20)

1. Rönnblom L, Eloranta ML, Alm GV. The type I IFN system in systemic lupus erythematosus. Arthritis Rheum 2006;54:408-420.
2. Martin DA, Elkon KB. Autoantibodies make a U-turn: The toll hypothesis for Autoantibody specificity. J Exp Med 2005;202: 1465-1469.
3. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801.
4. Finke D, Randers K, Hoerster R, Hennig H, Zawatzky R, Marion T, Brockmann C, Klempt-Giessing K, Jacobsen K, Kirchner H, et al. Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: Implications for induction of SLE. Eur J Immunol 2007;37: 1702-1709.
5. Munoz LE, van Bavel C, Franz S, Berden J, Herrmann M, van der Vlag J. Apoptosis in the pathogenesis of SLE. Lupus 2008; 17:371-375.
6. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S. Species-specific recognition of single-stranded RNA via TLR 7 and 8. Science 2004;303:1526-1529.
7. Scofield RH, Farris AD, Horsfall AC, Harley JB. Fine specificity of the autoimmune response to the Ro/SSA and La/SSB RNP. Arthritis Rheum 1999;42:199-209.
8. HofD, Raats JM, Pruijn GJ. Apoptotic modifications affect the autoreactivity of the U1 snRNP autoantigen. Autoimmun Rev 2005;4:380-388.
9. Eloranta ML, Barbasso Helmers S, Ulfgren AK, Rönnblom L, Alm GV, Lundberg IE. A possible mechanism for endogenous activation of the type IE IFN system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies. Arthritis Rheum 2007;56:3112-3124.
10. Vallin H, Perers A, Alm GV, Rönnblom L. Anti-dsDNA Ab and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus. J Immunol 1999;163:6306-6313.
11. Kim D, Peck A, Santer D, Patole P, Schwartz SM, Molitor JA, Arnett FC, Elkon KB. Induction of IFN-alpha by scleroderma sera containing autoantibodies to topoisomerase I: Association of higher IFN-alpha activity with lung fibrosis. Arthritis Rheum 2008;58:2163-2173.
12. Lövgren T, Eloranta ML, Kastner B, Wahren-Herlenius M, Alm GV, Rönnblom L. Induction of IFN-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigens and Sjogren's syndrome autoantigenassociated RNA. Arthritis Rheum 2006;54:1917-1927.
13. Bave U, Nordmark G, Lövgren T, Rönnelid J, Cajander S, ElorantaML,AlmGV,RönnblomL.Activation of the type I IFN systemin primary Sjogren's syndrome:Apossible etiopathogenic mechanism. Arthritis Rheum 2005;52:1185-1195.
14. Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, et al. TLR-9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007;8:487-496.
15. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Su B, Nestle FO, Zal T, et al. plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007;449:564-569.
16. Chi H, Flavell RA. Innate recognition of non-self nucleic acid. Genome Biol 2008;9:211.
17. GillietM, CaoW, Liu YJ. plasmacytoid dendritic cells: Sensing nucleic acid in viral infection and autoimmune diseases.Nat Rev Immunol 2008;8:594-606.
18. Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, Jonsen A, Rantapaa-Dahlqvist S, Mö ller B, Kere J, et al. Polymorphisms in the tyrosine kinase 2 and IRF-5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 2005;76:528-537.
19. Niewold TB, Kelly JA, Flesch MH, Espinoza LR, Harley JB, Crow MK. Association of the IRF5 risk haplotype with high serum IFN-alpha activity in systemic lupus erythematosus patients. Arthritis Rheum 2008;58:2481-2487.
20. Sigurdsson S, Nordmark G, Garnier S, Grundberg E, Kwan T, Nilsson O, Eloranta ML, Gunnarsson I, Svenungsson E, Sturfelt G, et al. A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet 2008;17:2868-2876.