메뉴 건너뛰기




Volumn 396, Issue 1, 2010, Pages 118-124

Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis

Author keywords

Cell cycle regulation; E2 25K; E7; Human papillomavirus (HPV); Proteasomal degradation; Rb; Ubiquitination

Indexed keywords

ALANINE; CYSTEINE; LYSINE; PROTEIN E7; PROTEIN MDM2; RETINOBLASTOMA PROTEIN; UBIQUITIN CONJUGATING ENZYME E2;

EID: 70649102943     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.10.018     Document Type: Article
Times cited : (25)

References (43)
  • 1
    • 0031442175 scopus 로고    scopus 로고
    • Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16E7 oncoprotein
    • Berezutskaya E., Morozov A., Raychaudhuri P., and Bagchi S. Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16E7 oncoprotein. Cell Growth Differ. 8 (1997) 1277-1286
    • (1997) Cell Growth Differ. , vol.8 , pp. 1277-1286
    • Berezutskaya, E.1    Morozov, A.2    Raychaudhuri, P.3    Bagchi, S.4
  • 2
    • 33947246502 scopus 로고    scopus 로고
    • Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
    • Binné U.K., Classon M.K., Dick F.A., Wei W., Rape M., Kaelin Jr. W.G., Näär A.M., and Dyson N.J. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat. Cell. Biol. 9 (2007) 225-232
    • (2007) Nat. Cell. Biol. , vol.9 , pp. 225-232
    • Binné, U.K.1    Classon, M.K.2    Dick, F.A.3    Wei, W.4    Rape, M.5    Kaelin Jr., W.G.6    Näär, A.M.7    Dyson, N.J.8
  • 3
    • 0029834371 scopus 로고    scopus 로고
    • E7 protein of human papillomavirus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
    • Boyer S.N., Wazer D.E., and Band V. E7 protein of human papillomavirus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res. 56 (1996) 4620-4624
    • (1996) Cancer Res. , vol.56 , pp. 4620-4624
    • Boyer, S.N.1    Wazer, D.E.2    Band, V.3
  • 4
    • 0028783782 scopus 로고
    • Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes
    • Cheng S., Schmidt-Grimminger D.C., Murant T., Broker T.R., and Chow L.T. Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes. Genes Dev. 9 (1995) 2335-2349
    • (1995) Genes Dev. , vol.9 , pp. 2335-2349
    • Cheng, S.1    Schmidt-Grimminger, D.C.2    Murant, T.3    Broker, T.R.4    Chow, L.T.5
  • 5
    • 18344383345 scopus 로고    scopus 로고
    • Pocket proteins and cell cycle control
    • Cobrinik D. Pocket proteins and cell cycle control. Oncogene 24 (2005) 2796-2809
    • (2005) Oncogene , vol.24 , pp. 2796-2809
    • Cobrinik, D.1
  • 6
    • 0032502709 scopus 로고    scopus 로고
    • Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1
    • Coux O., and Goldberg A.L. Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1. J. Biol. Chem 273 (1998) 8820-8828
    • (1998) J. Biol. Chem , vol.273 , pp. 8820-8828
    • Coux, O.1    Goldberg, A.L.2
  • 7
    • 0036100267 scopus 로고    scopus 로고
    • Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins
    • Dick F.A., and Dyson N. Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins. J. Virol. 76 (2002) 6224-6234
    • (2002) J. Virol. , vol.76 , pp. 6224-6234
    • Dick, F.A.1    Dyson, N.2
  • 8
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRb-family proteins
    • Dyson N. The regulation of E2F by pRb-family proteins. Genes Dev. 12 (1998) 2245-2262
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 9
    • 0001109314 scopus 로고    scopus 로고
    • RB and apoptotic cell death
    • Dou Q.P., and An B. RB and apoptotic cell death. Front Biosci. 3 (1998) d419-30
    • (1998) Front Biosci. , vol.3
    • Dou, Q.P.1    An, B.2
  • 10
    • 0033947269 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle
    • Flores E.R., Allen-Hoffmann B.L., Lee D., and Lambert P.F. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J. Virol. 74 (2000) 6622-6631
    • (2000) J. Virol. , vol.74 , pp. 6622-6631
    • Flores, E.R.1    Allen-Hoffmann, B.L.2    Lee, D.3    Lambert, P.F.4
  • 12
    • 0033591363 scopus 로고    scopus 로고
    • Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaB alpha
    • Gonen H., Bercovich B., Orian A., Carrano A., Takizawa C., Yamanaka K., Pagano M., Iwai M.K., and Ciechanover A. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaB alpha. J. Biol. Chem. 274 (1999) 14823-14830
    • (1999) J. Biol. Chem. , vol.274 , pp. 14823-14830
    • Gonen, H.1    Bercovich, B.2    Orian, A.3    Carrano, A.4    Takizawa, C.5    Yamanaka, K.6    Pagano, M.7    Iwai, M.K.8    Ciechanover, A.9
  • 13
    • 0034899522 scopus 로고    scopus 로고
    • Degradation of the retinoblastoma tumor suppressor by the human papillomavirus Type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7
    • Gonzalez S.L., Stremlau M., He X., Basile J.R., and Munger K. Degradation of the retinoblastoma tumor suppressor by the human papillomavirus Type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7. J. Virol. 75 (2001) 7583-7591
    • (2001) J. Virol. , vol.75 , pp. 7583-7591
    • Gonzalez, S.L.1    Stremlau, M.2    He, X.3    Basile, J.R.4    Munger, K.5
  • 14
    • 0037330709 scopus 로고    scopus 로고
    • Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins
    • Helt A.M., and Galloway D.A. Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis 24 (2003) 159-169
    • (2003) Carcinogenesis , vol.24 , pp. 159-169
    • Helt, A.M.1    Galloway, D.A.2
  • 16
    • 0033978257 scopus 로고    scopus 로고
    • Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
    • Higashitsuji H., Itoh K., Nagao T., Dawson S., Nonoguchi K., Kido T., Mayer R.J., Arii S., and Fujita J. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. Nat. Med. 6 (2000) 96-99
    • (2000) Nat. Med. , vol.6 , pp. 96-99
    • Higashitsuji, H.1    Itoh, K.2    Nagao, T.3    Dawson, S.4    Nonoguchi, K.5    Kido, T.6    Mayer, R.J.7    Arii, S.8    Fujita, J.9
  • 17
    • 34848876774 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor
    • Huh K., Zhou X., Hayakawa H., Cho J.Y., Libermann T.A., Jin J., Harper J.W., and Munger K. Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. J. Virol. 81 (2007) 9737-9747
    • (2007) J. Virol. , vol.81 , pp. 9737-9747
    • Huh, K.1    Zhou, X.2    Hayakawa, H.3    Cho, J.Y.4    Libermann, T.A.5    Jin, J.6    Harper, J.W.7    Munger, K.8
  • 18
    • 0027053491 scopus 로고
    • The ubiquitin-conjugation system
    • Jentsch S. The ubiquitin-conjugation system. Ann. Rev. Genet. 26 (1992) 179-207
    • (1992) Ann. Rev. Genet. , vol.26 , pp. 179-207
    • Jentsch, S.1
  • 19
    • 4944252223 scopus 로고    scopus 로고
    • An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant
    • Ji P., Jiang H., Rekhtman K., Bloom J., Ichetovkin M., Pagano M., and Zhu L. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol. Cell. 16 (2004) 47-58
    • (2004) Mol. Cell. , vol.16 , pp. 47-58
    • Ji, P.1    Jiang, H.2    Rekhtman, K.3    Bloom, J.4    Ichetovkin, M.5    Pagano, M.6    Zhu, L.7
  • 20
    • 0031438309 scopus 로고    scopus 로고
    • Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis
    • Jones D.L., Thompson D.A., and Münger K. Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis. Virology 239 (1997) 97-107
    • (1997) Virology , vol.239 , pp. 97-107
    • Jones, D.L.1    Thompson, D.A.2    Münger, K.3
  • 21
    • 0037373383 scopus 로고    scopus 로고
    • Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors
    • Kalejta R.F., Bechtel J.T., and Shenk T. Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors. Mol. Cell. Biol. 23 (2003) 1885-1895
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1885-1895
    • Kalejta, R.F.1    Bechtel, J.T.2    Shenk, T.3
  • 24
    • 29444438631 scopus 로고    scopus 로고
    • Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase
    • Knight J.S., Sharma N., and Robertson E.S. Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 18562-18566
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 18562-18566
    • Knight, J.S.1    Sharma, N.2    Robertson, E.S.3
  • 25
    • 0032493417 scopus 로고    scopus 로고
    • Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K
    • Mastrandrea L.D., Kasperek E.M., Niles E.G., and Pickart C.M. Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K. Biochemistry 37 (1998) 9784-9792
    • (1998) Biochemistry , vol.37 , pp. 9784-9792
    • Mastrandrea, L.D.1    Kasperek, E.M.2    Niles, E.G.3    Pickart, C.M.4
  • 27
    • 29144483321 scopus 로고    scopus 로고
    • Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase
    • Munakata T., Nakamura M., Liang Y., Li K., and Lemon S.M. Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 18159-18164
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 18159-18164
    • Munakata, T.1    Nakamura, M.2    Liang, Y.3    Li, K.4    Lemon, S.M.5
  • 28
    • 2342591439 scopus 로고    scopus 로고
    • The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin1/Skp2 containing E3 ligase
    • Oh K.J., Kalinina A., Wang J., Nakayama K., Nakayama K.e.i.I., and Bagchi S. The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin1/Skp2 containing E3 ligase. J. Virol. 78 (2004) 5338-5346
    • (2004) J. Virol. , vol.78 , pp. 5338-5346
    • Oh, K.J.1    Kalinina, A.2    Wang, J.3    Nakayama, K.4    Nakayama, K.e.i.I.5    Bagchi, S.6
  • 29
    • 33745813943 scopus 로고    scopus 로고
    • Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein
    • Oh K.J., Kalinina A., Park N.H., and Bagchi S. Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein. J. Virol. 80 (2006) 7079-7088
    • (2006) J. Virol. , vol.80 , pp. 7079-7088
    • Oh, K.J.1    Kalinina, A.2    Park, N.H.3    Bagchi, S.4
  • 30
    • 0034915764 scopus 로고    scopus 로고
    • Mechanisms underlying ubiquitination
    • Pickart C.M. Mechanisms underlying ubiquitination. Ann. Rev. Biochem. 70 (2001) 503-533
    • (2001) Ann. Rev. Biochem. , vol.70 , pp. 503-533
    • Pickart, C.M.1
  • 31
    • 38449113943 scopus 로고    scopus 로고
    • Human papillomavirus in cervical and head-and-neck cancer
    • Psyrri A., and DiMaio D. Human papillomavirus in cervical and head-and-neck cancer. Nat. Clin. Pract. Oncol. 5 (2008) 24-31
    • (2008) Nat. Clin. Pract. Oncol. , vol.5 , pp. 24-31
    • Psyrri, A.1    DiMaio, D.2
  • 32
    • 0034735901 scopus 로고    scopus 로고
    • Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue
    • Reinstein E., Scheffner M., Oren M., Ciechanover A., and Schwartz A. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene 19 (2000) 5944-5950
    • (2000) Oncogene , vol.19 , pp. 5944-5950
    • Reinstein, E.1    Scheffner, M.2    Oren, M.3    Ciechanover, A.4    Schwartz, A.5
  • 33
    • 0031982377 scopus 로고    scopus 로고
    • Activation of papillomavirus late gene transcription and genome amplification upon differentiation in semisolid medium is coincident with expression of involucrin and transglutaminase but not keratin-10
    • Reusch M.N., Stubenrauch F., and Laimins L.A. Activation of papillomavirus late gene transcription and genome amplification upon differentiation in semisolid medium is coincident with expression of involucrin and transglutaminase but not keratin-10. J. Virol. 72 (1998) 5016-5024
    • (1998) J. Virol. , vol.72 , pp. 5016-5024
    • Reusch, M.N.1    Stubenrauch, F.2    Laimins, L.A.3
  • 34
    • 34447097834 scopus 로고    scopus 로고
    • Sequential E2s drive polyubiquitin chain assembly on APC targets
    • Rodrigo-Brenni M.C., and Morgan D.O. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell 130 (2007) 127-139
    • (2007) Cell , vol.130 , pp. 127-139
    • Rodrigo-Brenni, M.C.1    Morgan, D.O.2
  • 36
    • 28444437051 scopus 로고    scopus 로고
    • MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein
    • Sdek P., Ying H., Chang D.L., Qiu W., Zheng H., Touitou R., Allday M.J., and Xiao Z.X. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol. Cell. 20 (2005) 699-708
    • (2005) Mol. Cell. , vol.20 , pp. 699-708
    • Sdek, P.1    Ying, H.2    Chang, D.L.3    Qiu, W.4    Zheng, H.5    Touitou, R.6    Allday, M.J.7    Xiao, Z.X.8
  • 37
    • 7244260495 scopus 로고    scopus 로고
    • Alzheimer's disease meets the ubiquitin-proteasome system
    • Song S., and Jung Y.K. Alzheimer's disease meets the ubiquitin-proteasome system. Trends Mol. Med. 10 (2004) 565-570
    • (2004) Trends Mol. Med. , vol.10 , pp. 565-570
    • Song, S.1    Jung, Y.K.2
  • 39
    • 0033511021 scopus 로고    scopus 로고
    • Human papillomavirus life cycle: active and latent phases
    • Stubenrauch F., and Laimins L.A. Human papillomavirus life cycle: active and latent phases. Semin. Cancer Biol. 9 (1999) 379-386
    • (1999) Semin. Cancer Biol. , vol.9 , pp. 379-386
    • Stubenrauch, F.1    Laimins, L.A.2
  • 41
    • 0035797506 scopus 로고    scopus 로고
    • Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cells
    • Wang J., Sampath A., Raychaudhuri P., and Bagchi S. Both Rb and E7 are regulated by the ubiquitin proteasome pathway in HPV-containing cervical tumor cells. Oncogene 20 (2001) 4740-4749
    • (2001) Oncogene , vol.20 , pp. 4740-4749
    • Wang, J.1    Sampath, A.2    Raychaudhuri, P.3    Bagchi, S.4
  • 42
    • 33644770294 scopus 로고    scopus 로고
    • Targeting retinoblastoma protein for degradation by proteasomes
    • Ying H., and Xiao Z.X. Targeting retinoblastoma protein for degradation by proteasomes. Cell. Cycle. 5 (2006) 506-508
    • (2006) Cell. Cycle. , vol.5 , pp. 506-508
    • Ying, H.1    Xiao, Z.X.2
  • 43
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: from basic studies to clinical application
    • zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. 2 (2002) 342-350
    • (2002) Nat. Rev. , vol.2 , pp. 342-350
    • zur Hausen, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.