Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium

International Journal of Urology

Volumn 16, Issue 12, 2009, Pages 959-966

  Tatsumiya, Katsuhisa ^a   Yamanishi, Tomonori ^a   Watanabe, Miho ^a   Masuda, Akinori ^a   Mizuno, Tomoya ^a   Kamai, Takao ^a   Yoshida, Ken Ichiro ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Bladder; Fasudil; Rho; Rho kinase; Urothelium

Indexed keywords

CARBACHOL; FASUDIL; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; BLADDER MUSCLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG EFFECT; DRUG MECHANISM; DRUG TISSUE LEVEL; ELECTROSTIMULATION; FEMALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; SWINE; UROTHELIUM;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; CARBACHOL; CHOLINERGIC AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FEMALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; POTASSIUM CHLORIDE; PROTEIN KINASE INHIBITORS; RHO-ASSOCIATED KINASES; SWINE; URINARY BLADDER; UROTHELIUM;

EID: 70450239510     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2009.02397.x     Document Type: Article

References (39)

1. Andersson K-E. LUTS treatment: future treatment options. Neurourol. Urodyn. 2007 26 : 934 947.
2. Yamanishi T, Chapple CR, Chess-Williams R. Which muscarinic receptor is important in the bladder? World J. Urol. 2001 19 : 299 306.
3. Christ GJ, Andersson K-E. Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract. Neurourol. Urodyn. 2007 26 : 948 954.
4. Peters SLM, Schmidt M, Michel MC. Rho kinase: a target for treating urinary bladder dysfunction? Trends Pharmacol. Sci. 2006 27 : 492 497.
5. Kamai T, Arai K, Sumi T, Honda T, Yamanishi T, Yoshida K-I. The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumor. BJU Int. 2002 89 : 449 453.
6. Kamai T, Tsujii T, Arai K et al. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin. Cancer Res. 2003 9 : 2632 2641.
7. Somlyo AV, Phelips C, Dipierro C et al. Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants. FASEB J. 2003 17 : 223 234.
8. Shibata R, Kai H, Seki Y et al. Role of Rho-associated kinase in neointima formation after vascular injury. Circulation 2001 103 : 284 289.
9. Ratz PH, Meehl JT, Eddinger TJ. RhoA kinase and protein kinase C participate in regulation of rabbit stomach funds smooth muscle contraction. Br. J. Pharmacol. 2002 137 : 983 992.
10. Somlyo AP, Wu X, Walker LA, Somlyo AV. Pharmaco-mechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev. Physiol. Biochem. Pharmacol. 1999 134 : 201 234.
11. Frazier EP, Peters SLM, Braverman AS, Ruggieri MR, Michel MC. Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and β-adrenoceptors. Naunyn. Schmiedebergs Arch. Pharmacol. 2008 377 : 449 462.
12. Braverman AS, Doumanian LR, Ruggieri MR. M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder. J. Pharmacol. Exp. Ter. 2006 316 : 875 880.
13. Bing W, Chang S, Hypolite JA et al. Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase. Am. J. Physiol. Renal Physiol. 2003 285 : F990 7.
14. Jeizer JR, Brady JD, Rosenstein DI, Mc-Cammon KA, Miner AS, Ratz PH. Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels. Br. J. Pharmacol. 2001 134 : 78 87.
15. Wibberley A, Chen Z, Hu E, Hiebe JP, Westafall TD. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle. Br. J. Pharmacol. 2003 138 : 757 766.
16. Rajasekaran M, Wilkens N, Kuntz S, Albo M. Rho-kinase inhibition suppresses bladder hyperactivity in spontaneously hypertensive rats. Neurourol. Urodyn. 2005 24 : 295 300.
17. Schneider T, Hein P, Bai J, Michel MC. A role for muscarinic receptors or rho-kinase in hypertension associated rat bladder dysfunction. J. Urol. 2005 173 : 2178 2181.
18. 2+ sensitization in contraction of human bladder smooth muscle. J. Urol. 2004 172 : 748 752.
19. Nakanishi K, Kamai T, Mizuno T, Arai K, Yamanishi T. Expression of RhoA mRNA and activated RhoA in urothelium and smooth muscle, and effects of a Rho-kinase inhibitor on contraction of the porcine urinary bladder. Neurourol. Urodyn. 2009 28 : 521 528.
20. Asano T, Suzuki T, Tsuchiya M et al. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br. J. Pharmacol. 1989 98 : 1091 1100.
21. Asano T, Ikegaki I, Satoh S et al. Mechanism of action of a novel antivasospasm drug, HA1077. J. Pharmacol. Exp. Ther. 1987 241 : 1033 1140.
22. Asano T, Hidaka H. New pharmacological strategies in vascular diseases: a novel intracellular calcium antagonist, HA1077 (AT-877) and cerebral vasospasm. Methods Find. Exp. Clin. Pharmacol. 1990 12 : 443 448.
23. Shimokawa H, Takeshita A. Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler. Thromb. Vasc. Biol. 2005 25 : 1767 1775.
24. Shimokawa H, Seto M, Katsumata N et al. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc. Res. 1999 43 : 1029 1039.
25. Takemoto M, Sun J, Hiroki J, Shimokawa H, Liao JK. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 2002 106 : 57 62.
26. 3-Adrenoceptors in mediating relaxation of porcine detrusor muscle. Br. J. Pharmacol. 2002 135 : 129 134.
27. Yamanishi T, Chapple CR, Yasuda K, Yoshida K, Chess-Williams R. The functional role of β-adrenoceptor subtypes in mediating relaxation of the pig urethral smooth muscle. J. Urol. 2003 170 : 2508 2511. (Pubitemid 37414045)
28. Hawthorn MH, Chapple CR, Cock M, Chess-Williams R. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br. J. Pharmacol. 2000 129 : 416 419.
29. Rees RW, Foxwell NA, Ralph DJ, Kell PD, Moncada S, Selim C. Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J. Urol. 2003 170 : 2517 2522.
30. Togashi H, Emala CW, Hall IP, Hirshman CA. Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells. Am. J. Physiol. 1998 274 : L803 9.
31. Braverman AS, Tibb AS, Ruggieri MR Sr. M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder. J. Pharmacol. Exp. Ther. 2006 316 : 869 874.
32. Nagumo H, Sasaki Y, Ono Y, Okamoto H, Seto M, Takuma Y. Rho kinase inhibitor HA1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. Am. J. Physiol. Cell Physiol. 2000 278 : C57 65.
33. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 2000 351 : 95 105.
34. Tamura M, Nakao H, Yoshizaki H et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochimica et Biophysica Acta 2005 1754 : 245 252.
35. Krepinsky JC, Ingram AJ, Tang D, Dongcheng WU, Liu L, Scholey JW. Nitric oxide inhibits stretch-induced MARK activation in mesangial cells through RhoA inactivation. J. Am. Soc. Nephrol. 2003 14 : 2790 2800.
36. Ikegaki I, Hattori T, Yamaguchi T et al. Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats. Eur. J. Pharmacol. 2001 427 : 69 75.
37. Wolfrum S, Dendorfer A, Rikitake Y et al. Inhibition of Rho-kinase leads to rapid activation of phosphatidyl inisitol 3-kinase/perotein kinase Akt and cardiovascular protection. Arterioscler. Thromb. Vasc. Biol. 2004 24 : 1842 1847.
38. Shibuya M, Suzuki Y, Sugita K et al. Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J. Neurosurg. 1992 76 : 571 577.
39. Shimokawa H, Hiramori K, Iinuma H et al. Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study. Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study. J. Cardiovasc. Pharmacol. 2002 40 : 751 761.