Expression of RhoA mRNA and activated RhoA in urothelium and smooth muscle, and effects of a Rho-kinase inhibitor on contraction of the porcine urinary bladder

Neurourology and Urodynamics

Volumn 28, Issue 6, 2009, Pages 521-528

  Nakanishi, Kimihiro ^a   Kamai, Tako ^a   Mizuno, Tomoya ^a   Arai, Kyoko ^a   Yamanishi, Tomonori ^a,b  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b NONE   (Japan)

Author keywords

Bladder; Rho; Rho kinase; Urothelium; Y 27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CARBACHOL; MESSENGER RNA; POTASSIUM CHLORIDE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; DETRUSOR MUSCLE; ELECTROSTIMULATION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; UROTHELIUM; WESTERN BLOTTING;

AMIDES; ANIMALS; BLOTTING, WESTERN; CARBACHOL; CHOLINERGIC AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FEMALE; IMMUNOHISTOCHEMISTRY; MUSCLE CONTRACTION; MUSCLE, SMOOTH; POTASSIUM CHLORIDE; PROTEIN KINASE INHIBITORS; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; SWINE; URINARY BLADDER; UROTHELIUM;

EID: 70049090561     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.20694     Document Type: Article

References (29)

1. Andersson K-E. LUTS treatment: Future treatment options. Neurourol Urodynam 2007;26:934-47.
2. Yamanishi T, Chapple CR, Chess-Williams R. Which muscarinic receptor is important in the bladder? World J Urol 2001;19:299-306.
3. Christ GJ, Andersson K-E. Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract. Neurourol Urodynam 2007;26:948-54.
4. Peters SLM, Schmidt M, Michel MC. Rho kinase: A target for treating urinary bladder dysfunction? Trends Pharmacol Sci 2006;27:492-7.
5. Kamai T, Arai K, Sumi T, et al. The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumor. BJU Int 2002;89:449-53.
6. Kamai T, Tsujii T, Arai K, et al. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 2003;9: 2632-41.
7. Somlyo AV, Phelips C, Dipierro C, et al. Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants. FASEB J 2003;17:223-34.
8. Shibata R, Kai H, Seki Y, et al. Role of Rho-associated kinase in neointina formation after vascular injury. Circulation 2001;103:284-9.
9. Ratz PH, Meehl JT, Eddinger TJ. RhoA kinase and protein kinase C participate in regulation of rabbit stomach funds smooth muscle contraction. Br J Pharmacol 2002;137:983-92.
10. Somlyo AP, Wu X, Walker LA, et al. Pharmaco-mechanical coupling: The role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol 1999;134:201-34.
11. Frazier EP, Peters SLM, Braverman AS, et al. Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and β-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 2008;377: 449-62.
12. Braverman AS, Doumanian LR, Ruggieri MR. M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder. J Pharmacol Ext Ter 2006;316:875-80.
13. Bing W, Chang S, Hypolite JA, et al. Obstruction-induced changes in urinary bladder smooth muscle contractility: A role for Rho kinase. Am J Physiol Renal Physiol 2003;285:F990-F997.
14. Jeizer JR, Brady JD, Rosenstein DI, et al. Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels. Br J Pharmacol 2001;134:78-87.
15. Wibberley A, Chen Z, Hu E, et al. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle. Br J Pharmacol 2003;138:757-66.
16. Rajasekaran M, Wilkens N, Kuntz S, et al. Rho-kinase inhibition suppresses bladder hyperactivity in spontaneously hypertensive rats. Neurourol Urodynam 2005;24:295-300.
17. Schneider T, Hein P, Bai J, et al. A role for muscarinic receptors or rho-kinase in hypertension associated rat bladder dysfunction. J Urol 2005;173:2178-81.
18. 2+ sensitization in contraction of human bladder smooth muscle. J Urol 2004;172:748-52.
19. Yamanishi T, Chapple CR, Yasuda K, et al. The functional role of badrenoceptor subtypes in mediating relaxation of the pig urethral smooth muscle. J Urol 2003;170:2508-11.
20. Kamai T, Yanai Y, Arai K, et al. Increased interferon alpha receptor 2 mRNA levels is associatedwith renal cell carcinoma metastasis. BMC Cancer 2007;7: published online: DOI: 10.1186/1471-2407-7-159.
21. Kamai T, Arai K, Tsujii T, et al. Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour. BJU Int 2001;87:227-31.
22. Suwa H, Ohshio G, Imamura T, et al. Overexpression of the rho C gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer 1998;77:147-52.
23. Habes R, Dawid I, He X. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev 2003;17:295-307.
24. Alstergren P, Zhu B, Glougauer M, et al. Polarization and diredted migration of murine neutrophils is dependent on cell surface expression of CD44. Cell Immunol 2004;231:146-57.
25. Rees RW, Foxowell NA, Ralph DJ, et al. Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J Urol 2003;170:2517-22.
26. Hawthorn MH, Chapple CR, Cock M, et al. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol 2000;129:416-9.
27. Takemoto M, Sun J, Hiroki J, et al. Rho-kinase mediates hypoxia - Induced downregulation of endothelial nitric oxide synthase. Circulation 2002;106: 57-62.
28. Krepinsky JC, Ingram AJ, Tang D, et al. Nitric oxide inhibits stretch-induced MARK activation in mesangial cells through RhoA inactivation. J Am Soc Nephrol 2003;14:2790-800.
29. Ikegaki I, Hattori T, Yamaguchi T, et al. Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats. Eur J Pharmacol 2001;427:69-75.