Role of prostaglandins, nitric oxide, sulfhydryls and capsaicin-sensitive neurons in gastroprotection of stigmasterol and β-sitosterol

Natural Product Communications

Volumn 3, Issue 4, 2008, Pages 505-510

  Sánchez Mendoza, María Elena ^a   Arrieta, Jesús ^a   Navarrete, Andrés ^a  

^a Universidad Nacional Autonoma de Mexico Facultad de Quimica   (Mexico)

Author keywords

Gastroprotective effect; Peptic ulcer; Phytosterols; Stigmasterol; Vegetarian diet; sitosterol

Indexed keywords

ALCOHOL; CAPSAICIN; CARBENOXOLONE; HYDROXYL GROUP; INDOMETACIN; N ETHYLMALEIMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POLYSORBATE 80; PROSTAGLANDIN; SITOSTEROL; STIGMASTEROL; SULFUR DERIVATIVE; THIOL DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; NONHUMAN; PROTEIN FUNCTION; RAT; SENSORY NERVE CELL; STOMACH MUCOSA INJURY; STOMACH PROTECTION; STOMACH ULCER;

RATTUS;

EID: 70450221990     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0800300406     Document Type: Article

References (26)

1. Tsukimi Y, Okabe S. (2001) Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing. Biological and Pharmaceutical Bulletin, 24, 1-9.
2. Calatayud S, Borrachina MD, Espulgues JV. (2001) Nitric oxide: Relation to integrity, injury, and healing of the gastric mucosa. Microscopy Research and Technique, 53, 325-335.
3. Toma W, Graciosos JS, Pezzuto de Andrade FD, Hiruma-Lima CA, Wagner Vilegaa W, Brito ARMS (2002) Antiulcerogenic activity of four extracts obtained from the bark wood of Quassia amara L. (Simaroubaceae). Biological and Pharmaceutical Bulletin, 25, 1151-1155.
4. Lewis DA, Hanson PJ. (1991) Anti-ulcer drugs of plant origin. Progress in Medicinal Chemistry, 28, 201-231.
5. Borrelli F, Izzo A. (2000) The plant kingdom as a source of anti-ulcer remedies. Phytotherapy Research, 14, 581-591.
6. Oliveira FA, Vieira-Junior GM, Chaves MH, Almeida FRC, Santos KA, Martins FS, Silva RM, Santos FA, Rao VSN. (2004) Gastroprotective effect of the mixture of α- and β-amyrin from Protium heptaphyllum: Role of capsaicin-sensitive primary afferent neurons. Planta Medica, 70, 780-782.
7. Navarrete A, Trejo-Miranda JL, Reyes-Trejo LJ. (2002) Principles of root bark of Hippocratea excelsa (Hippocrataceae) with gastroprotective activity. Journal of Ethnopharmacology, 79, 383-388.
8. Arrieta J, Benitez J, Flores E, Castillo C, Navarrete A. (2003) Purification of gastroprotective triterpenoids from the stem bark of Amphipterygium adstringens; Role of prostaglandins, sulfhydryls, nitric oxide and capsaicin-sensitive neurons. Planta Medica, 69, 905-909.
9. Ling WH, Jones, PJH. (1995) Dietary phytosterols: A review of metabolism, benefits and side effects. Life Sciences, 57, 195-206.
10. Garcia MD, Saenz MT, Gomez MA, Fernandez MA. (1999) Topical antiinflammatory activity of phytosterols isolated from Eryngium foetidum on chronic and acute inflammation models. Phytotherapy Research, 13, 78-80.
11. Villaseñor I, Angelada J, Canlas A, Echegoyen D. (2002) Bioactivity studies on β-sitosterol and its glucoside. Phytotherapy Research, 16, 417-421.
12. Awad AB, Fink CS. (2000) Phytosterols as anticancer dietary components: Evidence and mechanism of action. The Journal of Nutrition, 130, 2127-2130.
13. Navarrete A, Arrieta J, Terrones L, Abou-Gazar H, Calis I. (2005) Gastroprotective effect of astragaloside IV: role of prostaglandins, sulfhydryls and nitric oxide. Journal of Pharmacy and Pharmacology, 57, 1059-1064.
14. Chandranath SI, Bataski SMA, Singh J. (2002) A comparative study on the activity of lansoprazole, omeprazole and PD-13450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat. Clinical and Experimental Pharmacology and Physiology, 29, 173-180.
15. Whittle BJR, Lopez-Belmonte J, Moncada S. (1990) Regulation of gastric mucosal integrity by endogenous nitric oxide: interaction with prostanoids and sensory neuropeptides in the rat. British Journal of Pharmacology, 99, 607-611. (Pubitemid 20069172)
16. Atay S, Tarnawski A, Dubois A. (2000) Eicosanoids and the stomach. Prostaglandins and other lipid mediators, 61, 105-124.
17. Navarrete A, Martínez-Uribe LS, Reyes B. (1998) Gastroprotective activity of the stem bark of Amphipterygium adstringens in rats. Phytotherapy Research, 12, 1-4.
18. Wan B, Gottfried S. (1985) Cytoprotective action of carbenoxolone sodium on ethanol-induced gastric lesions in rats and its inhibition by indomethacin. Journal of Pharmacy and Pharmacology, 37, 739-741. (Pubitemid 15229702)
19. Elliott SN, Wallace JL. (1998) Nitric oxide: A regulator of mucosal defense and injury. Journal of Gastroenterology, 33, 792-803.
20. Denizbasi A, Yagen C, Ozturk M, Yegen B. (2000) Role of nitric oxide in gastric injury induced by hemorrhagic shock in rats. Pharmacology, 61, 106-112. (Pubitemid 30665991)
21. Whittle BJR, Lopez-Belmonte J. (1993) Action and interaction of endothelins, prostacyclin and nitric oxide in the gastric mucosa. Journal of Physiology and Pharmacology, 44, 91-107. (Pubitemid 23235228)
22. G-nitro-L- arginine methyl ester and L-arginine on gastric mucosal tolerant cytoprotection under stress. Chinese Journal of Digestive Diseases, 3, 1-6.
23. Szabo S, Trier JS, Frankel PW. (1981) Sulfhydryls compounds may mediate gastric cytoprotection. Science, 214, 2000-2002.
24. Holzer P, Sametz W. (1986) Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive efferent neurons. Gastroenterology, 91, 975-981. (Pubitemid 16023343)
25. Robert A. (1979) Cytoprotection by prostaglandins. Gastroenterology, 77, 761-767.
26. Matsuda H, Li Y, Yoshikawa M.(1999) Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sciences, 65, PL27-PL32.