Immunomodulatory activity of IL-27 in human periapical lesions

Journal of Dental Research

Volumn 88, Issue 12, 2009, Pages 1142-1147

  Coli M ^a   Gazivoda, D ^a   Majstorovi I ^a   Dragicevi A ^a   Vasiliji S ^a   Rudolf, R ^b   Milosavljevi P ^a   Vucevi D ^a  

^a UNIVERSITY OF DEFENCE   (Serbia)

^b UNIVERSITY OF MARIBOR   (Slovenia)

Author keywords

Cell culture; Confocal microscopy; IL 27; Immunohistochemistry; Periapical lesion; T helper cytokine

Indexed keywords

CD14 ANTIGEN; CD3 ANTIGEN; GAMMA INTERFERON; IL27 PROTEIN, HUMAN; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 5; INTERLEUKIN DERIVATIVE; PROTEIN SUBUNIT;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; BLOOD; CELL CULTURE; COMPARATIVE STUDY; DOWN REGULATION; ENDOTHELIUM CELL; HUMAN; IMMUNOLOGY; IMMUNOMODULATION; MACROPHAGE; MIDDLE AGED; MONOCYTE; MONONUCLEAR CELL; PHAGOCYTE; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TOOTH PERIAPICAL DISEASE;

ADULT; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD14; ANTIGENS, CD3; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMANS; IMMUNOMODULATION; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-5; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MIDDLE AGED; MONOCYTES; PERIAPICAL DISEASES; PHAGOCYTES; PROTEIN SUBUNITS; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS; YOUNG ADULT;

EID: 70450168965     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034509351407     Document Type: Article

References (30)

1. Akamine A., Hashiguchi I., Toriya Y., Maeda K. (1994). Immunohistochemical examination on the localization of macrophages and plasma cells in induced rat periapical lesions. Endod Dent Traumatol 10: 121-128.
2. Amadi-Obi A., Yu CR, Liu X., Mahdi RM, Clarke GL, Nussenblatt RB, et al. (2007). TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 13: 711-718.
3. Batten M., Li J., Yi S., Kljavin NM, Danilenko DM, Lucas S., et al. (2006). Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7: 929-936.
4. Carl JW, Bai XF (2008). IL27: its roles in the induction and inhibition of inflammation. Int J Clin Exp Pathol 1: 117-123.
5. Colí M., Jandrí D., Stojí-Vukaní Z., Antí-Stankoví J., Popoví P., Vasilijí S., et al. (2003). Differentiation of human dendritic cells from monocytes in vitro using granulocyte-macrophage colony stimulating factor and low concentration of interleukin-4. Vojnosanit Pregl 60: 531-538.
6. Colí M., Lukí A., Vuceví D., Milosavljeví P., Majstoroví I., Marjanoví M., et al. (2006). Correlation between the phenotypic characteristics of mononuclear cells isolated from human periapical lesions and their in vitro production of Th1 and Th2 cytokines. Arch Oral Biol 51: 1120-1130.
7. Colí M., Vasilijí S., Gazivoda D., Vuceví D., Marjanoví M., Lukí A. (2007). Interleukin-17 plays a role in the exacerbation of inflammation within chronic periapical lesions. Eur J Oral Sci 115: 315-320.
8. Colí M., Gazivoda D., Vuceví D., Vasilijí S., Rudolf R., Lukí A. (2009). Pro-inflammatory and immunoregulatory mechanisms in periapical lesions. Mol Immunol (in press).
9. Collins DP (2000). Cytokine and cytokine receptor expression as a biological indicator of immune activation: important considerations in the development of in vitro model systems. J Immunol Methods 243: 125-145.
10. De Rossi A., Rocha LB, Rossi MA (2008). Interferon-gamma, interleukin-10, intercellular adhesion molecule-1, and chemokine receptor 5, but not interleukin-4, attenuate the development of periapical lesions. J Endod 34: 31-38.
11. Fitzgerald DC, Zhang GX, El-Behi M., Fonseca-Kelly Z., Li H., Yu S., et al. (2007). Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol 8: 1372-1379 ; erratum in Nat Immunol 9: 105, 2008.
12. Hibbert L., Pflanz S., De Waal Malefyt R., Kastelein RA (2003). IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res 23: 513-522.
13. Kalliolias GD, Ivashkiv LB (2008). IL-27 activates human monocytes via STAT1 and suppresses IL-10 production, but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J Immunol 180: 6325-6333.
14. Kamiya S., Nakamura C., Fukawa T., Ono K., Ohwaki T., Yoshimoto T., et al. (2007). Effects of IL-23 and IL-27 on osteoblasts and osteoclasts: inhibitory effects on osteoclast differentiation. J Bone Miner Metab 25: 277-285.
15. Kastelein RA, Hunter CA, Cua DJ (2007). Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 25: 221-242.
16. Kawashima N., Stashenko P. (1999). Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation. Arch Oral Biol 44: 55-66.
17. Larousserie F., Pflanz S., Coulomb-L-Hermine A., Brousse N., Kastelein R., Devergne O. (2004). Expression of IL-27 in human Th1-associated granulomatous diseases. J Pathol 202: 164-171.
18. Lucas S., Ghilardi N., Li J., de Sauvage FJ (2003). IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci USA 100: 15047-15052.
19. Lukí A., Vasilijí S., Majstoroví I., Vuceví D., Mojsiloví S., Gazivoda D., et al. (2006). Characterization of antigen-presenting cells in human apical periodontitis lesions by flow cytometry and immunocytochemistry. Int Endod J 39: 626-636.
20. Marton IJ, Kiss C. (2000). Protective and destructive immune reactions in apical periodontitis. Oral Microbiol Immunol 15: 139-150.
21. Nair PN (2004). Pathogenesis of apical periodontitis and the causes of endodontic failures. Crit Rev Oral Biol Med 15: 348-381.
22. Owaki T., Asakawa M., Morishima N., Hata K., Fukai F., Matsui M., et al. (2005). A role for IL-27 in early regulation of Th1 differentiation. J Immunol 175: 2191-2200.
23. Pflanz S., Timans JC, Cheung J., Rosales R., Kanzler H., Gilbert J., et al. (2002). IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16: 779-790.
24. Pflanz S., Hibbert L., Mattson J., Rosales R., Vaisberg E., Bazan JF, et al. (2004). WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 172: 2225-2231.
25. Stumhofer JS, Hunter CA (2008). Advances in understanding the antiinflammatory properties of IL-27. Immunol Lett 117: 123-130.
26. Tani N, Osada T, Watanabe Y, Umemoto T (1992). Comparative immunohistochemical identification and relative distribution of immune competent cells in sections of frozen or formalin-fixed tissue from human periapical inflammatory lesions. Endod Dent Traumatol 8:163-169
27. Tani N, Osada T, Watanabe Y, Umemoto T (1992). Comparative immunohistochemical identification and relative distribution of immune competent cells in sections of frozen or formalin-fixed tissue from human periapical inflammatory lesions. Endod Dent Traumatol 8:163-169. Tesmer LA, Lundy SK, Sarkar S, Fox DA (2008). Th17 cells in human disease. Immunol Rev 223:87-113.
28. Wallstrom JB, Torabinejad M., Kettering J., McMillan P. (1993). Role of T cells in the pathogenesis of periapical lesions. A preliminary report. Oral Surg Oral Med Oral Pathol 76: 213-218.
29. Waterman PAJr, Torabinejd M., McMillan PJ, Kettering JD (1998). Development of periradicular lesions in immunosuppressed rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85: 720-725.
30. Yoshimura T., Takeda A., Hamano S., Miyazaki Y., Kinjyo I., Ishibashi T., et al. (2006). Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J Immunol 177: 5377-5385.