메뉴 건너뛰기




Volumn 5, Issue 4, 2009, Pages 344-350

Lipid nanoparticles for drug delivery to the brain: In vivo veritas

Author keywords

Blood brain barrier (BBB); Brain drug delivery; Colloids; Lipid colloidal dispersions; Neurovascular unit (NVU); Solid lipid nanoparticles (SLN)

Indexed keywords

BLOOD-BRAIN BARRIER; BLOOD-BRAIN BARRIER (BBB); COLLOIDAL DISPERSION; IN-VIVO; LIPID NANOPARTICLES; POLYMER CARRIER; SOLID LIPID NANOPARTICLES; VERITAS;

EID: 70450160818     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2009.1043     Document Type: Review
Times cited : (26)

References (85)
  • 1
    • 33646825160 scopus 로고    scopus 로고
    • Drug delivery across the blood-brain barrier why is it difficult? How to measure and improve it?
    • Y. Su and P. J. Sinko, Drug delivery across the blood-brain barrier why is it difficult? How to measure and improve it?. Expert Opin. Drug Deliv. 3, 419 (2006).
    • (2006) Expert Opin. Drug Deliv. , vol.3 , pp. 419
    • Su, Y.1    Sinko, P.J.2
  • 2
    • 0042899083 scopus 로고    scopus 로고
    • Blood-brain barrier drug targeting: The future of brain drug development
    • W. M. Pardridge, Blood-brain barrier drug targeting: The future of brain drug development. Mol. Interv. 3, 90 (2003).
    • (2003) Mol. Interv. , vol.3 , pp. 90
    • Pardridge, W.M.1
  • 3
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier An overview structure, regulation, and clinical implications
    • P. Ballabh, A. Braun, and M. Nedergaard, The blood-brain barrier An overview structure, regulation, and clinical implications. Neurobiol. Dis. 16, 1 (2004).
    • (2004) Neurobiol. Dis. , vol.16 , pp. 1
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 4
    • 0033526185 scopus 로고    scopus 로고
    • Blood-brain barrier permeability to small and large molecules
    • E. M. Cornford and S. Hyman, Blood-brain barrier permeability to small and large molecules. Adv. Drug Deliv. Rev. 36, 145 (1999).
    • (1999) Adv. Drug Deliv. Rev. , vol.36 , pp. 145
    • Cornford, E.M.1    Hyman, S.2
  • 5
    • 2942623871 scopus 로고    scopus 로고
    • Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology
    • N. J. Abbott, Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology. Neumchem. Int. 45, 545 (2004).
    • (2004) Neumchem. Int. , vol.45 , pp. 545
    • Abbott, N.J.1
  • 6
    • 33646191912 scopus 로고    scopus 로고
    • Local controller drug delivery to the brain: Mathematical modeling of the underlying mass transport mechanisms
    • J. Siepmann, F. Siepmann, and A. T. Florence, Local controller drug delivery to the brain: Mathematical modeling of the underlying mass transport mechanisms. Int. J. Pharm. 314, 101 (2006).
    • (2006) Int. J. Pharm. , vol.314 , pp. 101
    • Siepmann, J.1    Siepmann, F.2    Florence, A.T.3
  • 7
    • 33745905488 scopus 로고    scopus 로고
    • last accessed 1 April 2009
    • World Health Organization, The Global Burden of Disease Project, http://www.who.int (last accessed 1 April 2009).
    • The Global Burden of Disease Project
  • 8
    • 70450176747 scopus 로고    scopus 로고
    • (last accessed 1 April 2009)
    • Intercontinental Market Services (IMS), World Review (2004). http://imshealth.com (last accessed 1 April 2009)
    • (2004) World Review
  • 9
    • 0037098632 scopus 로고    scopus 로고
    • Sir richard sykes contemplates the future of the pharma industry
    • R. N. Lawrence, Sir richard sykes contemplates the future of the pharma industry. Drug Discov. Today 7, 645 (2002).
    • (2002) Drug Discov. Today , vol.7 , pp. 645
    • Lawrence, R.N.1
  • 11
    • 33745032028 scopus 로고    scopus 로고
    • Delivering drugs to the central nervous system: A medicinal chemistry or a pharmaceutical technology issue?
    • M. Ricci, P. Blasi, S. Giovagnoli, and C. Rossi, Delivering drugs to the central nervous system: A medicinal chemistry or a pharmaceutical technology issue? Curr. Med. Chem. 13, 1757 (2006).
    • (2006) Curr. Med. Chem. , vol.13 , pp. 1757
    • Ricci, M.1    Blasi, P.2    Giovagnoli, S.3    Rossi, C.4
  • 12
    • 0036007257 scopus 로고    scopus 로고
    • Why is the global CNS pharmaceutical market so under-penetrated?
    • W. M. Pardridge, Why is the global CNS pharmaceutical market so under-penetrated? Drug Discov. Today 7, 5 (2002).
    • (2002) Drug Discov. Today , vol.7 , pp. 5
    • Pardridge, W.M.1
  • 13
    • 0037083385 scopus 로고    scopus 로고
    • William Pardridge discusses the lack of BBB research
    • R. N. Lawrence, William Pardridge discusses the lack of BBB research. Drug Discov. Today 7, 223 (2002).
    • (2002) Drug Discov. Today , vol.7 , pp. 223
    • Lawrence, R.N.1
  • 14
    • 0141958109 scopus 로고    scopus 로고
    • In silico prediction of blood-brain barrier permeation
    • D. E. Clark, In silico prediction of blood-brain barrier permeation. Drug Discov. Today 8, 927 (2003).
    • (2003) Drug Discov. Today , vol.8 , pp. 927
    • Clark, D.E.1
  • 15
    • 13844254976 scopus 로고    scopus 로고
    • Predictive in silico modeling for hERG channel blockers
    • A. M. Aronov, Predictive in silico modeling for hERG channel blockers. Drug Discov. Today: Biosilico 10, 149 (2005).
    • (2005) Drug Discov. Today: Biosilico , vol.10 , pp. 149
    • Aronov, A.M.1
  • 17
    • 18444414592 scopus 로고    scopus 로고
    • Small molecule and monoclonal antibody therapies in neurooncology
    • N. Butowski and S. M. Chang, Small molecule and monoclonal antibody therapies in neurooncology. Cancer Control 12, 116 (2005).
    • (2005) Cancer Control , vol.12 , pp. 116
    • Butowski, N.1    Chang, S.M.2
  • 19
    • 33646673555 scopus 로고    scopus 로고
    • A review of nanocarrier-based CNS delivery systems
    • S. B. Tiwari and M. M. Amiji, A review of nanocarrier-based CNS delivery systems. Curr. Drug Deliv. 3, 219 (2006).
    • (2006) Curr. Drug Deliv. , vol.3 , pp. 219
    • Tiwari, S.B.1    Amiji, M.M.2
  • 20
    • 21344451667 scopus 로고    scopus 로고
    • Colloidal carriers and blood-brain barrier (BBB) translocation: A way to deliver drugs to the brain?
    • E. Garcia-Garcia, K. Andrieux, S. Gil, and P. Couvreur, Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain? Int. J. Pharm. 298, 274 (2005).
    • (2005) Int. J. Pharm. , vol.298 , pp. 274
    • Garcia-Garcia, E.1    Andrieux, K.2    Gil, S.3    Couvreur, P.4
  • 24
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery - A review of the state of the art
    • R. H. Müller, K. Mäder, and S. Gohla, Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur. J. Pharm. Biopharm. 50, 161 (2000).
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , pp. 161
    • Müller, R.H.1    Mäder, K.2    Gohla, S.3
  • 25
    • 1942453805 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for parenteral drug delivery
    • S. A. Wissing, O. Kayser, and R. H. Müller, Solid lipid nanoparticles for parenteral drug delivery. Adv. Drug Deliv. Rev. 56, 1257 (2004).
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 1257
    • Wissing, S.A.1    Kayser, O.2    Müller, R.H.3
  • 26
    • 18744409650 scopus 로고    scopus 로고
    • Pathfinder technology for the delivery of drugs to the brain
    • R. H. Müller and S. Schmidt, Pathfinder technology for the delivery of drugs to the brain. New Drugs 2, 38 (2002).
    • (2002) New Drugs , vol.2 , pp. 38
    • Müller, R.H.1    Schmidt, S.2
  • 27
    • 6344258939 scopus 로고    scopus 로고
    • Drug delivery to the brain-realization by novel drug carriers
    • R. H. Müller and C. M. Keck, Drug delivery to the brain-realization by novel drug carriers. J. Nanosci. Nanotechnol. 4, 471 (2004).
    • (2004) J. Nanosci. Nanotechnol. , vol.4 , pp. 471
    • Müller, R.H.1    Keck, C.M.2
  • 28
    • 0001469131 scopus 로고
    • Sub-micron sized parenteral carrier systems based on solid lipids
    • B. Siekmann and K. Westesen, Sub-micron sized parenteral carrier systems based on solid lipids. Pharm. Pharmacol. Lett. 1, 123 (1992).
    • (1992) Pharm. Pharmacol. Lett. , vol.1 , pp. 123
    • Siekmann, B.1    Westesen, K.2
  • 30
    • 0342782004 scopus 로고
    • Method for producing solid lipid microspheres having a narrow size distribution
    • U. S. Patent 5,250,236
    • M. R. Gasco, Method for producing solid lipid microspheres having a narrow size distribution, U. S. Patent 5,250,236 (1993).
    • (1993)
    • Gasco, M.R.1
  • 31
    • 34547883880 scopus 로고    scopus 로고
    • Lipid nanoparticles: Recent advances
    • R. H. Müller, Lipid nanoparticles: Recent advances. Adv. Drug Deliv. Rev. 59, 375 (2007).
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 375
    • Müller, R.H.1
  • 33
    • 42749086446 scopus 로고    scopus 로고
    • Lipid nanoparticles for prolonged topical delivery: An in vitro and in vivo investigation
    • C. Puglia, P. Blasi, L. Rizza, A. Schoubben, F. Bonina, C. Rossi, and M. Ricci, Lipid nanoparticles for prolonged topical delivery: An in vitro and in vivo investigation. Int. J. Pharm. 357, 295 (2008).
    • (2008) Int. J. Pharm. , vol.357 , pp. 295
    • Puglia, C.1    Blasi, P.2    Rizza, L.3    Schoubben, A.4    Bonina, F.5    Rossi, C.6    Ricci, M.7
  • 34
    • 33749985938 scopus 로고    scopus 로고
    • Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations
    • M. A. Casadei, F. Cerreto, S. Cesa, M. Giannuzzo, M. Feeney, C. Marianecci, and P. Paolicelli, Solid lipid nanoparticles incorporated in dextran hydrogels: a new drug delivery system for oral formulations. Int. J. Pharm. 325, 140 (2006).
    • (2006) Int. J. Pharm. , vol.325 , pp. 140
    • Casadei, M.A.1    Cerreto, F.2    Cesa, S.3    Giannuzzo, M.4    Feeney, M.5    Marianecci, C.6    Paolicelli, P.7
  • 36
    • 66949117923 scopus 로고    scopus 로고
    • Nanostructured lipid carrier-based hydrogel formulations for drug delivery: A comprehensive review
    • S. Doktorovova and E. B. Souto, Nanostructured lipid carrier-based hydrogel formulations for drug delivery: A comprehensive review. Expert Opin. Drug Deliv. 6, 165 (2009).
    • (2009) Expert Opin. Drug Deliv. , vol.6 , pp. 165
    • Doktorovova, S.1    Souto, E.B.2
  • 37
    • 0032909537 scopus 로고    scopus 로고
    • Body distribution of camptothecin solid lipid nanoparticles after oral administration
    • S. C. Yang, J. B. Zhu, Y. Lu, B. W. Liang, and C. Z. Yang, Body distribution of camptothecin solid lipid nanoparticles after oral administration. Pharm. Res. 16, 751 (1999).
    • (1999) Pharm. Res. , vol.16 , pp. 751
    • Yang, S.C.1    Zhu, J.B.2    Lu, Y.3    Liang, B.W.4    Yang, C.Z.5
  • 39
    • 0029844618 scopus 로고    scopus 로고
    • Blood-brain-barrier transport of lipid microspheres containing linprost, a prostaglandin 12 analogue
    • T. Minagawa, K. Sakanaka, S. I. Inaba, Y. Sai, I. Tamai, T. Suwa, and A. Suji, Blood-brain-barrier transport of lipid microspheres containing linprost, a prostaglandin 12 analogue. J. Pharm. Pharmacol. 48, 1016 (1996).
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 1016
    • Minagawa, T.1    Sakanaka, K.2    Inaba, S.I.3    Sai, Y.4    Tamai, I.5    Suwa, T.6    Suji, A.7
  • 40
    • 0033797992 scopus 로고    scopus 로고
    • Biodistribution of stealth and non-stealth solid lipid nanospheres after intravenous administration to rats
    • V. Podio, G. P. Zara, M. Carazzone, R. Cavalli, and M. R. Gasco, Biodistribution of stealth and non-stealth solid lipid nanospheres after intravenous administration to rats. J. Pharm. Pharmacol. 52, 1057 (2000).
    • (2000) J. Pharm. Pharmacol. , vol.52 , pp. 1057
    • Podio, V.1    Zara, G.P.2    Carazzone, M.3    Cavalli, R.4    Gasco, M.R.5
  • 41
    • 0033800767 scopus 로고    scopus 로고
    • Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tissue distribution after i.v. administration to rats
    • A. Fundarò, R. Cavalli, A. Bargoni, D. Vighetto, G. P. Zara, and M. R. Gasco, Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tissue distribution after i.v. administration to rats. Pharmacol. Res. 42, 337 (2000).
    • (2000) Pharmacol. Res. , vol.42 , pp. 337
    • Fundarò, A.1    Cavalli, R.2    Bargoni, A.3    Vighetto, D.4    Zara, G.P.5    Gasco, M.R.6
  • 42
    • 0032950389 scopus 로고    scopus 로고
    • Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain
    • S. C. Yang, L. F. Lu, Y. Cai, J. B. Zhu, B. W. Liang, and C. Z. Yang, Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J. Control. Release 59, 299 (1999).
    • (1999) J. Control. Release , vol.59 , pp. 299
    • Yang, S.C.1    Lu, L.F.2    Cai, Y.3    Zhu, J.B.4    Liang, B.W.5    Yang, C.Z.6
  • 43
    • 0344185347 scopus 로고    scopus 로고
    • In situ blood-brain barrier transport of nanoparticles
    • J. M. Koziara, P. R. Lockman, D. D. Allen, and R. J. Mumper, In situ blood-brain barrier transport of nanoparticles. Pharm. Res. 20, 1772 (2003).
    • (2003) Pharm. Res. , vol.20 , pp. 1772
    • Koziara, J.M.1    Lockman, P.R.2    Allen, D.D.3    Mumper, R.J.4
  • 44
    • 4544240398 scopus 로고    scopus 로고
    • Paclitaxel nanoparticles for the potential treatment of brain tumors
    • J. M. Koziara, P. R. Lockman, D. D. Allen, and R. J. Mumper, Paclitaxel nanoparticles for the potential treatment of brain tumors. J. Control. Release 99, 259 (2004).
    • (2004) J. Control. Release , vol.99 , pp. 259
    • Koziara, J.M.1    Lockman, P.R.2    Allen, D.D.3    Mumper, R.J.4
  • 45
    • 33646648428 scopus 로고    scopus 로고
    • Etoposide-incorporated tripalmitin nanoparticles with different surface charge: Formulation, characterization, radiolabeling, and biodistribution studies
    • Article 23
    • L. H. Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. R. Murthy, Etoposide-incorporated tripalmitin nanoparticles with different surface charge: Formulation, characterization, radiolabeling, and biodistribution studies. AAPS J. 6, Article 23 (2004).
    • (2004) AAPS J. , vol.6
    • Reddy, L.H.1    Sharma, R.K.2    Chuttani, K.3    Mishra, A.K.4    Murthy, R.R.5
  • 46
    • 24944496710 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration
    • K. Manjunath and V. Venkateswarlu, Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. J. Control. Release 107, 215 (2005).
    • (2005) J. Control. Release , vol.107 , pp. 215
    • Manjunath, K.1    Venkateswarlu, V.2
  • 47
    • 21744460519 scopus 로고    scopus 로고
    • Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice
    • L. H. Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. S. R. Murthy, Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice. J. Control. Release 105, 185 (2005).
    • (2005) J. Control. Release , vol.105 , pp. 185
    • Reddy, L.H.1    Sharma, R.K.2    Chuttani, K.3    Mishra, A.K.4    Murthy, R.S.R.5
  • 48
    • 0034960971 scopus 로고    scopus 로고
    • Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - Tissue distribution
    • A. Bargoni, R. Cavalli, G. P. Zara, A. Fundarò, O. Caputo, and M. R. Gasco, Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - tissue distribution. Pharmacol. Res. 43, 497 (2001).
    • (2001) Pharmacol. Res. , vol.43 , pp. 497
    • Bargoni, A.1    Cavalli, R.2    Zara, G.P.3    Fundarò, A.4    Caputo, O.5    Gasco, M.R.6
  • 49
    • 0036073236 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats
    • G. P. Zara, A. Bargoni, R. Cavalli, A. Fundarò, D. Vighetto, and M. R. Gasco, Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats. J. Pharm. Sci. 91 1324 (2002).
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1324
    • Zara, G.P.1    Bargoni, A.2    Cavalli, R.3    Fundarò, A.4    Vighetto, D.5    Gasco, M.R.6
  • 50
    • 0036848464 scopus 로고    scopus 로고
    • Enhanced brain targeting by synthesis of 3′,5′-dioctanoyl-5- fluoro-2′-deoxyuridine and incorporation into solid lipid nanoparticles
    • J. X. Wang, X. Sun, and Z. R. Zhang, Enhanced brain targeting by synthesis of 3′,5′-dioctanoyl-5-fluoro-2′-deoxyuridine and incorporation into solid lipid nanoparticles. Eur. J. Pharm. Biopharm. 54, 285 (2002).
    • (2002) Eur. J. Pharm. Biopharm. , vol.54 , pp. 285
    • Wang, J.X.1    Sun, X.2    Zhang, Z.R.3
  • 51
    • 4544275025 scopus 로고    scopus 로고
    • Challenges and solutions for the delivery of biotech drugs - A review of drug nanocrystal technology and lipid nanoparticles
    • R. H. Müller and C. M. Keck, Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles. J. Biotechnol. 113, 151 (2004).
    • (2004) J. Biotechnol. , vol.113 , pp. 151
    • Müller, R.H.1    Keck, C.M.2
  • 52
    • 0035994314 scopus 로고    scopus 로고
    • Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate
    • C. Olbrich, A. Gessner, O. Kayser, and R. H. Müller, Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate. J. Drug Target. 10, 387 (2002).
    • (2002) J. Drug Target. , vol.10 , pp. 387
    • Olbrich, C.1    Gessner, A.2    Kayser, O.3    Müller, R.H.4
  • 53
    • 0035910874 scopus 로고    scopus 로고
    • The role of plasma proteins in brain targeting: Species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles
    • A. Gessner, C. Olbrich, W. Schröder, O. Kayser, and R. H. Müller, The role of plasma proteins in brain targeting: Species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles. Int. J. Pharm. 214, 87 (2001).
    • (2001) Int. J. Pharm. , vol.214 , pp. 87
    • Gessner, A.1    Olbrich, C.2    Schröder, W.3    Kayser, O.4    Müller, R.H.5
  • 54
    • 0030853702 scopus 로고    scopus 로고
    • Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant coated nanoparticles
    • J. Kreuter, V. E. Petrov, D. A. Kharkevich, R. N. Alyautdin, Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant coated nanoparticles. J. Control. Release 49, 81 (1997).
    • (1997) J. Control. Release , vol.49 , pp. 81
    • Kreuter, J.1    Petrov, V.E.2    Kharkevich, D.A.3    Alyautdin, R.N.4
  • 55
    • 33846499122 scopus 로고    scopus 로고
    • Chemotherapy of brain tumor using doxorubicin bound to surfactant-coated polybutyl cyanoacrylate nanoparticles: Revisiting the role of surfactants
    • B. Petri, A. Bootz, A. Khalansky, T. Hekmatara, R. Müller, R. Uhl, J. Kreuter, and S. Gelperina, Chemotherapy of brain tumor using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate nanoparticles: Revisiting the role of surfactants. J. Control. Release 117, 51 (2007).
    • (2007) J. Control. Release , vol.117 , pp. 51
    • Petri, B.1    Bootz, A.2    Khalansky, A.3    Hekmatara, T.4    Müller, R.5    Uhl, R.6    Kreuter, J.7    Gelperina, S.8
  • 56
    • 0038407930 scopus 로고    scopus 로고
    • In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide
    • E. Peira, P. Marzola, V. Podio, S. Aime, A. Sbarbati, and M. R. Gasco, In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide. J. Drug Target. 11, 19 (2003).
    • (2003) J. Drug Target. , vol.11 , pp. 19
    • Peira, E.1    Marzola, P.2    Podio, V.3    Aime, S.4    Sbarbati, A.5    Gasco, M.R.6
  • 59
    • 0001820844 scopus 로고
    • edited by R. Gurny and H. E. Junginger, Wissenschaftliche Verlagsgesellschaft, Stuttgart
    • R. H. Müller, S. Heinemann, Bioadhesion - Possibilities and Future Trends, edited by R. Gurny and H. E. Junginger, Wissenschaftliche Verlagsgesellschaft, Stuttgart (1989), pp. 202-214.
    • (1989) Bioadhesion - Possibilities and Future Trends , pp. 202-214
    • Müller, R.H.1    Heinemann, S.2
  • 60
    • 10744230753 scopus 로고    scopus 로고
    • Plasma protein adsorption of Tween® 80- And poloxamer 188-stabilized solid lipid nanoparticles
    • T. M. Göppert and R. H. Müller, Plasma protein adsorption of Tween® 80- and poloxamer 188-stabilized solid lipid nanoparticles. J. Drug Target. 11, 225 (2003).
    • (2003) J. Drug Target. , vol.11 , pp. 225
    • Göppert, T.M.1    Müller, R.H.2
  • 61
    • 24144452456 scopus 로고    scopus 로고
    • Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting
    • T. M. Göppert and R. H. Müller, Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting. Int. J. Pharm. 302, 172 (2005).
    • (2005) Int. J. Pharm. , vol.302 , pp. 172
    • Göppert, T.M.1    Müller, R.H.2
  • 62
    • 34547923611 scopus 로고    scopus 로고
    • Surface modified solid lipid nanoparticles (SLN) analysis of plasma protein adsorption patterns by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE)
    • H. Weyhers, M. Lück, W. Mehnert, E. B. Souto, and R. H. Müller, Surface modified solid lipid nanoparticles (SLN) analysis of plasma protein adsorption patterns by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). Int. J. Mol. Med. Adv. Sci. 1, 196 (2005).
    • (2005) Int. J. Mol. Med. Adv. Sci. , vol.1 , pp. 196
    • Weyhers, H.1    Lück, M.2    Mehnert, W.3    Souto, E.B.4    Müller, R.H.5
  • 64
    • 1942453793 scopus 로고    scopus 로고
    • Potential role of the low density lipoprotein receptor family as mediators of cellular drug uptake
    • N. S. Chung and K. M. Wasan, Potential role of the low density lipoprotein receptor family as mediators of cellular drug uptake. Adv. Drug Deliv. Rev. 56, 1315 (2004).
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 1315
    • Chung, N.S.1    Wasan, K.M.2
  • 65
    • 0030755944 scopus 로고    scopus 로고
    • A new function for the LDL receptor transcytosis of LDL across the blood-brain barrier
    • B. Dehouck, L. Fenart, M. P. Dehouck, A. Pierce, G. Torpier, and R. Cecchelli, A new function for the LDL receptor transcytosis of LDL across the blood-brain barrier. J. Cell Biol. 138, 877 (1997).
    • (1997) J. Cell Biol. , vol.138 , pp. 877
    • Dehouck, B.1    Fenart, L.2    Dehouck, M.P.3    Pierce, A.4    Torpier, G.5    Cecchelli, R.6
  • 66
    • 33745263735 scopus 로고    scopus 로고
    • Endocytosis at the blood-brain barrier from basic understanding to drug delivery strategies
    • M. W. Smith and M. Gumbleton, Endocytosis at the blood-brain barrier From basic understanding to drug delivery strategies. J. Drug Target. 14, 191 (2006).
    • (2006) J. Drug Target. , vol.14 , pp. 191
    • Smith, M.W.1    Gumbleton, M.2
  • 68
    • 0028928571 scopus 로고
    • Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butylcyanoacrylate) nanoparticles
    • R. N. Alyautdin, D. Gothier, V. Petrov, D. Kharkevich, and J. Kreuter, Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butylcyanoacrylate) nanoparticles. Eur. J. Pharm. Biopharm. 41, 44 (1995).
    • (1995) Eur. J. Pharm. Biopharm. , vol.41 , pp. 44
    • Alyautdin, R.N.1    Gothier, D.2    Petrov, V.3    Kharkevich, D.4    Kreuter, J.5
  • 69
    • 6344294066 scopus 로고    scopus 로고
    • Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain
    • J. Kreuter, Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain. J. Nanosci. Nanotechnol. 4, 484 (2004).
    • (2004) J. Nanosci. Nanotechnol. , vol.4 , pp. 484
    • Kreuter, J.1
  • 70
    • 33847116764 scopus 로고    scopus 로고
    • Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain
    • J. Kreuter, T. Hekmatara, S. Dreis, T. Vogel, S. Gelperina, and K. Langer, Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain. J. Control. Release 118, 54 (2007).
    • (2007) J. Control. Release , vol.118 , pp. 54
    • Kreuter, J.1    Hekmatara, T.2    Dreis, S.3    Vogel, T.4    Gelperina, S.5    Langer, K.6
  • 71
    • 0037335187 scopus 로고    scopus 로고
    • Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
    • J. Kreuter, P. Ramge, V. Petrov, S. Hamm, S. E. Gelperina, B. Engelhardt, R. Alyautdin, H. von Briesen, and D. J. Begley, Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm. Res. 20, 409 (2003).
    • (2003) Pharm. Res. , vol.20 , pp. 409
    • Kreuter, J.1    Ramge, P.2    Petrov, V.3    Hamm, S.4    Gelperina, S.E.5    Engelhardt, B.6    Alyautdin, R.7    Von Briesen, H.8    Begley, D.J.9
  • 72
    • 33646460828 scopus 로고    scopus 로고
    • Application of nanoparticles for the delivery of drugs to the brain
    • J. Kreuter, Application of nanoparticles for the delivery of drugs to the brain. Int. Congr. Ser. 1277, 85 (2005).
    • (2005) Int. Congr. Ser. , vol.1277 , pp. 85
    • Kreuter, J.1
  • 73
    • 0033427851 scopus 로고    scopus 로고
    • Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity
    • J. C. Olivier, L. Fenart, R. Chauvet, C. Pariat, R. Cecchelli, and W. Couet, Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity. Pharm. Res. 16, 1836 (1999).
    • (1999) Pharm. Res. , vol.16 , pp. 1836
    • Olivier, J.C.1    Fenart, L.2    Chauvet, R.3    Pariat, C.4    Cecchelli, R.5    Couet, W.6
  • 74
    • 0242500461 scopus 로고    scopus 로고
    • In vivo and in vitro assessment of baseline bloodbrain barrier parameters in the presence of novel nanoparticles
    • P. R. Lockman, J. Koziara, K. E. Roder, J. Paulson, T. J. Abbruscato, R. J. Mumper, and D. D. Allen, In vivo and in vitro assessment of baseline bloodbrain barrier parameters in the presence of novel nanoparticles. Pharm. Res. 20, 705 (2003).
    • (2003) Pharm. Res. , vol.20 , pp. 705
    • Lockman, P.R.1    Koziara, J.2    Roder, K.E.3    Paulson, J.4    Abbruscato, T.J.5    Mumper, R.J.6    Allen, D.D.7
  • 75
    • 0037457792 scopus 로고    scopus 로고
    • Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier
    • A. V. Kabanov, E. V. Batrakova, and D. W. Miller, Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv. Drug Deliv. Rev. 55, 151 (2003).
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 151
    • Kabanov, A.V.1    Batrakova, E.V.2    Miller, D.W.3
  • 76
    • 11944265265 scopus 로고    scopus 로고
    • Nanoparticle surface charges alter blood-brain barrier integrity and permeability
    • P. R. Lockman, J. M. Koziara, R. J. Mumper, and D. D. Allen, Nanoparticle surface charges alter blood-brain barrier integrity and permeability. J. Drug Target. 12, 635 (2004).
    • (2004) J. Drug Target. , vol.12 , pp. 635
    • Lockman, P.R.1    Koziara, J.M.2    Mumper, R.J.3    Allen, D.D.4
  • 78
    • 34248582291 scopus 로고    scopus 로고
    • Towards controlled release of BDNF-Manufacturing strategies for protein-loaded lipid implants and biocompatibility evaluation in the brain
    • S. Koennings, A. Sapin, T. Blunk, P. Menei, and A. Goepferich, Towards controlled release of BDNF-Manufacturing strategies for protein-loaded lipid implants and biocompatibility evaluation in the brain. J. Contol. Release 119, 163 (2007).
    • (2007) J. Contol. Release , vol.119 , pp. 163
    • Koennings, S.1    Sapin, A.2    Blunk, T.3    Menei, P.4    Goepferich, A.5
  • 82
    • 0031105909 scopus 로고    scopus 로고
    • Evaluation of hepatic antioxidant systems after intravenous administration of polymeric nanoparticles
    • R. Femandez-Urrusuno, E. Fattal, J. Feger, P. Couvreur, and P. Thérond, Evaluation of hepatic antioxidant systems after intravenous administration of polymeric nanoparticles. Biomaterials 18, 511 (1997).
    • (1997) Biomaterials , vol.18 , pp. 511
    • Femandez-Urrusuno, R.1    Fattal, E.2    Feger, J.3    Couvreur, P.4    Thérond, P.5
  • 83
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    • R. H. Müller, M. Radtke, and S. A. Wissing, Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 54, S131 (2002).
    • (2002) Adv. Drug Deliv. Rev. , vol.54
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 84
    • 55749084890 scopus 로고    scopus 로고
    • The targeted delivery of cancer drugs across the blood-brain barrier chemical modifications of drugs or drug-nanoparticles?
    • L. Luillerat-Jeanneret, The targeted delivery of cancer drugs across the blood-brain barrier chemical modifications of drugs or drug-nanoparticles? Drug Discov. Today 13, 1099 (2008).
    • (2008) Drug Discov. Today , vol.13 , pp. 1099
    • Luillerat-Jeanneret, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.