-
1
-
-
33646825160
-
Drug delivery across the blood-brain barrier why is it difficult? How to measure and improve it?
-
Y. Su and P. J. Sinko, Drug delivery across the blood-brain barrier why is it difficult? How to measure and improve it?. Expert Opin. Drug Deliv. 3, 419 (2006).
-
(2006)
Expert Opin. Drug Deliv.
, vol.3
, pp. 419
-
-
Su, Y.1
Sinko, P.J.2
-
2
-
-
0042899083
-
Blood-brain barrier drug targeting: The future of brain drug development
-
W. M. Pardridge, Blood-brain barrier drug targeting: The future of brain drug development. Mol. Interv. 3, 90 (2003).
-
(2003)
Mol. Interv.
, vol.3
, pp. 90
-
-
Pardridge, W.M.1
-
3
-
-
2342471420
-
The blood-brain barrier An overview structure, regulation, and clinical implications
-
P. Ballabh, A. Braun, and M. Nedergaard, The blood-brain barrier An overview structure, regulation, and clinical implications. Neurobiol. Dis. 16, 1 (2004).
-
(2004)
Neurobiol. Dis.
, vol.16
, pp. 1
-
-
Ballabh, P.1
Braun, A.2
Nedergaard, M.3
-
4
-
-
0033526185
-
Blood-brain barrier permeability to small and large molecules
-
E. M. Cornford and S. Hyman, Blood-brain barrier permeability to small and large molecules. Adv. Drug Deliv. Rev. 36, 145 (1999).
-
(1999)
Adv. Drug Deliv. Rev.
, vol.36
, pp. 145
-
-
Cornford, E.M.1
Hyman, S.2
-
5
-
-
2942623871
-
Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology
-
N. J. Abbott, Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology. Neumchem. Int. 45, 545 (2004).
-
(2004)
Neumchem. Int.
, vol.45
, pp. 545
-
-
Abbott, N.J.1
-
6
-
-
33646191912
-
Local controller drug delivery to the brain: Mathematical modeling of the underlying mass transport mechanisms
-
J. Siepmann, F. Siepmann, and A. T. Florence, Local controller drug delivery to the brain: Mathematical modeling of the underlying mass transport mechanisms. Int. J. Pharm. 314, 101 (2006).
-
(2006)
Int. J. Pharm.
, vol.314
, pp. 101
-
-
Siepmann, J.1
Siepmann, F.2
Florence, A.T.3
-
7
-
-
33745905488
-
-
last accessed 1 April 2009
-
World Health Organization, The Global Burden of Disease Project, http://www.who.int (last accessed 1 April 2009).
-
The Global Burden of Disease Project
-
-
-
8
-
-
70450176747
-
-
(last accessed 1 April 2009)
-
Intercontinental Market Services (IMS), World Review (2004). http://imshealth.com (last accessed 1 April 2009)
-
(2004)
World Review
-
-
-
9
-
-
0037098632
-
Sir richard sykes contemplates the future of the pharma industry
-
R. N. Lawrence, Sir richard sykes contemplates the future of the pharma industry. Drug Discov. Today 7, 645 (2002).
-
(2002)
Drug Discov. Today
, vol.7
, pp. 645
-
-
Lawrence, R.N.1
-
11
-
-
33745032028
-
Delivering drugs to the central nervous system: A medicinal chemistry or a pharmaceutical technology issue?
-
M. Ricci, P. Blasi, S. Giovagnoli, and C. Rossi, Delivering drugs to the central nervous system: A medicinal chemistry or a pharmaceutical technology issue? Curr. Med. Chem. 13, 1757 (2006).
-
(2006)
Curr. Med. Chem.
, vol.13
, pp. 1757
-
-
Ricci, M.1
Blasi, P.2
Giovagnoli, S.3
Rossi, C.4
-
12
-
-
0036007257
-
Why is the global CNS pharmaceutical market so under-penetrated?
-
W. M. Pardridge, Why is the global CNS pharmaceutical market so under-penetrated? Drug Discov. Today 7, 5 (2002).
-
(2002)
Drug Discov. Today
, vol.7
, pp. 5
-
-
Pardridge, W.M.1
-
13
-
-
0037083385
-
William Pardridge discusses the lack of BBB research
-
R. N. Lawrence, William Pardridge discusses the lack of BBB research. Drug Discov. Today 7, 223 (2002).
-
(2002)
Drug Discov. Today
, vol.7
, pp. 223
-
-
Lawrence, R.N.1
-
14
-
-
0141958109
-
In silico prediction of blood-brain barrier permeation
-
D. E. Clark, In silico prediction of blood-brain barrier permeation. Drug Discov. Today 8, 927 (2003).
-
(2003)
Drug Discov. Today
, vol.8
, pp. 927
-
-
Clark, D.E.1
-
15
-
-
13844254976
-
Predictive in silico modeling for hERG channel blockers
-
A. M. Aronov, Predictive in silico modeling for hERG channel blockers. Drug Discov. Today: Biosilico 10, 149 (2005).
-
(2005)
Drug Discov. Today: Biosilico
, vol.10
, pp. 149
-
-
Aronov, A.M.1
-
17
-
-
18444414592
-
Small molecule and monoclonal antibody therapies in neurooncology
-
N. Butowski and S. M. Chang, Small molecule and monoclonal antibody therapies in neurooncology. Cancer Control 12, 116 (2005).
-
(2005)
Cancer Control
, vol.12
, pp. 116
-
-
Butowski, N.1
Chang, S.M.2
-
18
-
-
20444377785
-
Polyethyleniminebased non-viral gene delivery systems
-
U. Lungwitz, M. Breunig, T. Blunk, and A. Gopferich, Polyethyleniminebased non-viral gene delivery systems. Eur. J. Pharm. Biopharm. 60, 247 (2005).
-
(2005)
Eur. J. Pharm. Biopharm.
, vol.60
, pp. 247
-
-
Lungwitz, U.1
Breunig, M.2
Blunk, T.3
Gopferich, A.4
-
19
-
-
33646673555
-
A review of nanocarrier-based CNS delivery systems
-
S. B. Tiwari and M. M. Amiji, A review of nanocarrier-based CNS delivery systems. Curr. Drug Deliv. 3, 219 (2006).
-
(2006)
Curr. Drug Deliv.
, vol.3
, pp. 219
-
-
Tiwari, S.B.1
Amiji, M.M.2
-
20
-
-
21344451667
-
Colloidal carriers and blood-brain barrier (BBB) translocation: A way to deliver drugs to the brain?
-
E. Garcia-Garcia, K. Andrieux, S. Gil, and P. Couvreur, Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain? Int. J. Pharm. 298, 274 (2005).
-
(2005)
Int. J. Pharm.
, vol.298
, pp. 274
-
-
Garcia-Garcia, E.1
Andrieux, K.2
Gil, S.3
Couvreur, P.4
-
21
-
-
61349091651
-
Fenofibrate-loaded PLGA microparticles: Effects on ischemic stroke
-
D. Klose, M. Laprais, V. Leroux, F. Siepmann, B. Deprez, R. Bordet, and J. Siepmann, Fenofibrate-loaded PLGA microparticles: Effects on ischemic stroke. Eur. J. Pharm. Sci. 37, 43 (2009).
-
(2009)
Eur. J. Pharm. Sci.
, vol.37
, pp. 43
-
-
Klose, D.1
Laprais, M.2
Leroux, V.3
Siepmann, F.4
Deprez, B.5
Bordet, R.6
Siepmann, J.7
-
22
-
-
34547871312
-
Solid lipid nanoparticles for targeted brain drug delivery
-
P. Blasi, S. Giovagnoli, A. Schoubben, M. Ricci, and C. Rossi, Solid lipid nanoparticles for targeted brain drug delivery. Adv. Drug Deliv. Rev. 59, 454 (2007).
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 454
-
-
Blasi, P.1
Giovagnoli, S.2
Schoubben, A.3
Ricci, M.4
Rossi, C.5
-
23
-
-
41449091856
-
Potential of solid lipid nanoparticles in brain targeting
-
I. P. Kaur, R. Bhandari, S. Bhandari, and V. Kakkar, Potential of solid lipid nanoparticles in brain targeting. J. Control. Release 127, 97 (2008).
-
(2008)
J. Control. Release
, vol.127
, pp. 97
-
-
Kaur, I.P.1
Bhandari, R.2
Bhandari, S.3
Kakkar, V.4
-
24
-
-
0038032150
-
Solid lipid nanoparticles (SLN) for controlled drug delivery - A review of the state of the art
-
R. H. Müller, K. Mäder, and S. Gohla, Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur. J. Pharm. Biopharm. 50, 161 (2000).
-
(2000)
Eur. J. Pharm. Biopharm.
, vol.50
, pp. 161
-
-
Müller, R.H.1
Mäder, K.2
Gohla, S.3
-
26
-
-
18744409650
-
Pathfinder technology for the delivery of drugs to the brain
-
R. H. Müller and S. Schmidt, Pathfinder technology for the delivery of drugs to the brain. New Drugs 2, 38 (2002).
-
(2002)
New Drugs
, vol.2
, pp. 38
-
-
Müller, R.H.1
Schmidt, S.2
-
27
-
-
6344258939
-
Drug delivery to the brain-realization by novel drug carriers
-
R. H. Müller and C. M. Keck, Drug delivery to the brain-realization by novel drug carriers. J. Nanosci. Nanotechnol. 4, 471 (2004).
-
(2004)
J. Nanosci. Nanotechnol.
, vol.4
, pp. 471
-
-
Müller, R.H.1
Keck, C.M.2
-
28
-
-
0001469131
-
Sub-micron sized parenteral carrier systems based on solid lipids
-
B. Siekmann and K. Westesen, Sub-micron sized parenteral carrier systems based on solid lipids. Pharm. Pharmacol. Lett. 1, 123 (1992).
-
(1992)
Pharm. Pharmacol. Lett.
, vol.1
, pp. 123
-
-
Siekmann, B.1
Westesen, K.2
-
30
-
-
0342782004
-
Method for producing solid lipid microspheres having a narrow size distribution
-
U. S. Patent 5,250,236
-
M. R. Gasco, Method for producing solid lipid microspheres having a narrow size distribution, U. S. Patent 5,250,236 (1993).
-
(1993)
-
-
Gasco, M.R.1
-
31
-
-
34547883880
-
Lipid nanoparticles: Recent advances
-
R. H. Müller, Lipid nanoparticles: Recent advances. Adv. Drug Deliv. Rev. 59, 375 (2007).
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 375
-
-
Müller, R.H.1
-
32
-
-
38049027492
-
-
edited by H. S. Nalwa, American Scientific Publishers, Los Angeles
-
R. H. Müller, M. Radtke, and S. A. Wissing, Encyclopedia of Nanoscience and Nanotechnology, edited by H. S. Nalwa, American Scientific Publishers, Los Angeles (2004), Vol.10, pp. 43-56.
-
(2004)
Encyclopedia of Nanoscience and Nanotechnology
, vol.10
, pp. 43-56
-
-
Müller, R.H.1
Radtke, M.2
Wissing, S.A.3
-
33
-
-
42749086446
-
Lipid nanoparticles for prolonged topical delivery: An in vitro and in vivo investigation
-
C. Puglia, P. Blasi, L. Rizza, A. Schoubben, F. Bonina, C. Rossi, and M. Ricci, Lipid nanoparticles for prolonged topical delivery: An in vitro and in vivo investigation. Int. J. Pharm. 357, 295 (2008).
-
(2008)
Int. J. Pharm.
, vol.357
, pp. 295
-
-
Puglia, C.1
Blasi, P.2
Rizza, L.3
Schoubben, A.4
Bonina, F.5
Rossi, C.6
Ricci, M.7
-
34
-
-
33749985938
-
Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations
-
M. A. Casadei, F. Cerreto, S. Cesa, M. Giannuzzo, M. Feeney, C. Marianecci, and P. Paolicelli, Solid lipid nanoparticles incorporated in dextran hydrogels: a new drug delivery system for oral formulations. Int. J. Pharm. 325, 140 (2006).
-
(2006)
Int. J. Pharm.
, vol.325
, pp. 140
-
-
Casadei, M.A.1
Cerreto, F.2
Cesa, S.3
Giannuzzo, M.4
Feeney, M.5
Marianecci, C.6
Paolicelli, P.7
-
35
-
-
0037093721
-
Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin
-
R. Cavalli, M. R. Gasco, P. Chetoni, S. Burgalassi, and M. F. Saettone, Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin. Int. J. Pharm. 238, 241 (2002).
-
(2002)
Int. J. Pharm.
, vol.238
, pp. 241
-
-
Cavalli, R.1
Gasco, M.R.2
Chetoni, P.3
Burgalassi, S.4
Saettone, M.F.5
-
36
-
-
66949117923
-
Nanostructured lipid carrier-based hydrogel formulations for drug delivery: A comprehensive review
-
S. Doktorovova and E. B. Souto, Nanostructured lipid carrier-based hydrogel formulations for drug delivery: A comprehensive review. Expert Opin. Drug Deliv. 6, 165 (2009).
-
(2009)
Expert Opin. Drug Deliv.
, vol.6
, pp. 165
-
-
Doktorovova, S.1
Souto, E.B.2
-
37
-
-
0032909537
-
Body distribution of camptothecin solid lipid nanoparticles after oral administration
-
S. C. Yang, J. B. Zhu, Y. Lu, B. W. Liang, and C. Z. Yang, Body distribution of camptothecin solid lipid nanoparticles after oral administration. Pharm. Res. 16, 751 (1999).
-
(1999)
Pharm. Res.
, vol.16
, pp. 751
-
-
Yang, S.C.1
Zhu, J.B.2
Lu, Y.3
Liang, B.W.4
Yang, C.Z.5
-
38
-
-
0032852207
-
Pharmacokinetics of doxorubicin incorporated in solid lipid nanospheres (SLN)
-
G. P. Zara, R. Cavalli, A. Fundarò, A. Bargoni, O. Caputo, and M. R. Gasco, Pharmacokinetics of doxorubicin incorporated in solid lipid nanospheres (SLN). Pharmacol. Res. 40, 281 (1999).
-
(1999)
Pharmacol. Res.
, vol.40
, pp. 281
-
-
Zara, G.P.1
Cavalli, R.2
Fundarò, A.3
Bargoni, A.4
Caputo, O.5
Gasco, M.R.6
-
39
-
-
0029844618
-
Blood-brain-barrier transport of lipid microspheres containing linprost, a prostaglandin 12 analogue
-
T. Minagawa, K. Sakanaka, S. I. Inaba, Y. Sai, I. Tamai, T. Suwa, and A. Suji, Blood-brain-barrier transport of lipid microspheres containing linprost, a prostaglandin 12 analogue. J. Pharm. Pharmacol. 48, 1016 (1996).
-
(1996)
J. Pharm. Pharmacol.
, vol.48
, pp. 1016
-
-
Minagawa, T.1
Sakanaka, K.2
Inaba, S.I.3
Sai, Y.4
Tamai, I.5
Suwa, T.6
Suji, A.7
-
40
-
-
0033797992
-
Biodistribution of stealth and non-stealth solid lipid nanospheres after intravenous administration to rats
-
V. Podio, G. P. Zara, M. Carazzone, R. Cavalli, and M. R. Gasco, Biodistribution of stealth and non-stealth solid lipid nanospheres after intravenous administration to rats. J. Pharm. Pharmacol. 52, 1057 (2000).
-
(2000)
J. Pharm. Pharmacol.
, vol.52
, pp. 1057
-
-
Podio, V.1
Zara, G.P.2
Carazzone, M.3
Cavalli, R.4
Gasco, M.R.5
-
41
-
-
0033800767
-
Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tissue distribution after i.v. administration to rats
-
A. Fundarò, R. Cavalli, A. Bargoni, D. Vighetto, G. P. Zara, and M. R. Gasco, Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tissue distribution after i.v. administration to rats. Pharmacol. Res. 42, 337 (2000).
-
(2000)
Pharmacol. Res.
, vol.42
, pp. 337
-
-
Fundarò, A.1
Cavalli, R.2
Bargoni, A.3
Vighetto, D.4
Zara, G.P.5
Gasco, M.R.6
-
42
-
-
0032950389
-
Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain
-
S. C. Yang, L. F. Lu, Y. Cai, J. B. Zhu, B. W. Liang, and C. Z. Yang, Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J. Control. Release 59, 299 (1999).
-
(1999)
J. Control. Release
, vol.59
, pp. 299
-
-
Yang, S.C.1
Lu, L.F.2
Cai, Y.3
Zhu, J.B.4
Liang, B.W.5
Yang, C.Z.6
-
43
-
-
0344185347
-
In situ blood-brain barrier transport of nanoparticles
-
J. M. Koziara, P. R. Lockman, D. D. Allen, and R. J. Mumper, In situ blood-brain barrier transport of nanoparticles. Pharm. Res. 20, 1772 (2003).
-
(2003)
Pharm. Res.
, vol.20
, pp. 1772
-
-
Koziara, J.M.1
Lockman, P.R.2
Allen, D.D.3
Mumper, R.J.4
-
44
-
-
4544240398
-
Paclitaxel nanoparticles for the potential treatment of brain tumors
-
J. M. Koziara, P. R. Lockman, D. D. Allen, and R. J. Mumper, Paclitaxel nanoparticles for the potential treatment of brain tumors. J. Control. Release 99, 259 (2004).
-
(2004)
J. Control. Release
, vol.99
, pp. 259
-
-
Koziara, J.M.1
Lockman, P.R.2
Allen, D.D.3
Mumper, R.J.4
-
45
-
-
33646648428
-
Etoposide-incorporated tripalmitin nanoparticles with different surface charge: Formulation, characterization, radiolabeling, and biodistribution studies
-
Article 23
-
L. H. Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. R. Murthy, Etoposide-incorporated tripalmitin nanoparticles with different surface charge: Formulation, characterization, radiolabeling, and biodistribution studies. AAPS J. 6, Article 23 (2004).
-
(2004)
AAPS J.
, vol.6
-
-
Reddy, L.H.1
Sharma, R.K.2
Chuttani, K.3
Mishra, A.K.4
Murthy, R.R.5
-
46
-
-
24944496710
-
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration
-
K. Manjunath and V. Venkateswarlu, Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. J. Control. Release 107, 215 (2005).
-
(2005)
J. Control. Release
, vol.107
, pp. 215
-
-
Manjunath, K.1
Venkateswarlu, V.2
-
47
-
-
21744460519
-
Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice
-
L. H. Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. S. R. Murthy, Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice. J. Control. Release 105, 185 (2005).
-
(2005)
J. Control. Release
, vol.105
, pp. 185
-
-
Reddy, L.H.1
Sharma, R.K.2
Chuttani, K.3
Mishra, A.K.4
Murthy, R.S.R.5
-
48
-
-
0034960971
-
Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - Tissue distribution
-
A. Bargoni, R. Cavalli, G. P. Zara, A. Fundarò, O. Caputo, and M. R. Gasco, Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - tissue distribution. Pharmacol. Res. 43, 497 (2001).
-
(2001)
Pharmacol. Res.
, vol.43
, pp. 497
-
-
Bargoni, A.1
Cavalli, R.2
Zara, G.P.3
Fundarò, A.4
Caputo, O.5
Gasco, M.R.6
-
49
-
-
0036073236
-
Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats
-
G. P. Zara, A. Bargoni, R. Cavalli, A. Fundarò, D. Vighetto, and M. R. Gasco, Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats. J. Pharm. Sci. 91 1324 (2002).
-
(2002)
J. Pharm. Sci.
, vol.91
, pp. 1324
-
-
Zara, G.P.1
Bargoni, A.2
Cavalli, R.3
Fundarò, A.4
Vighetto, D.5
Gasco, M.R.6
-
50
-
-
0036848464
-
Enhanced brain targeting by synthesis of 3′,5′-dioctanoyl-5- fluoro-2′-deoxyuridine and incorporation into solid lipid nanoparticles
-
J. X. Wang, X. Sun, and Z. R. Zhang, Enhanced brain targeting by synthesis of 3′,5′-dioctanoyl-5-fluoro-2′-deoxyuridine and incorporation into solid lipid nanoparticles. Eur. J. Pharm. Biopharm. 54, 285 (2002).
-
(2002)
Eur. J. Pharm. Biopharm.
, vol.54
, pp. 285
-
-
Wang, J.X.1
Sun, X.2
Zhang, Z.R.3
-
51
-
-
4544275025
-
Challenges and solutions for the delivery of biotech drugs - A review of drug nanocrystal technology and lipid nanoparticles
-
R. H. Müller and C. M. Keck, Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles. J. Biotechnol. 113, 151 (2004).
-
(2004)
J. Biotechnol.
, vol.113
, pp. 151
-
-
Müller, R.H.1
Keck, C.M.2
-
52
-
-
0035994314
-
Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate
-
C. Olbrich, A. Gessner, O. Kayser, and R. H. Müller, Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate. J. Drug Target. 10, 387 (2002).
-
(2002)
J. Drug Target.
, vol.10
, pp. 387
-
-
Olbrich, C.1
Gessner, A.2
Kayser, O.3
Müller, R.H.4
-
53
-
-
0035910874
-
The role of plasma proteins in brain targeting: Species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles
-
A. Gessner, C. Olbrich, W. Schröder, O. Kayser, and R. H. Müller, The role of plasma proteins in brain targeting: Species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles. Int. J. Pharm. 214, 87 (2001).
-
(2001)
Int. J. Pharm.
, vol.214
, pp. 87
-
-
Gessner, A.1
Olbrich, C.2
Schröder, W.3
Kayser, O.4
Müller, R.H.5
-
54
-
-
0030853702
-
Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant coated nanoparticles
-
J. Kreuter, V. E. Petrov, D. A. Kharkevich, R. N. Alyautdin, Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant coated nanoparticles. J. Control. Release 49, 81 (1997).
-
(1997)
J. Control. Release
, vol.49
, pp. 81
-
-
Kreuter, J.1
Petrov, V.E.2
Kharkevich, D.A.3
Alyautdin, R.N.4
-
55
-
-
33846499122
-
Chemotherapy of brain tumor using doxorubicin bound to surfactant-coated polybutyl cyanoacrylate nanoparticles: Revisiting the role of surfactants
-
B. Petri, A. Bootz, A. Khalansky, T. Hekmatara, R. Müller, R. Uhl, J. Kreuter, and S. Gelperina, Chemotherapy of brain tumor using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate nanoparticles: Revisiting the role of surfactants. J. Control. Release 117, 51 (2007).
-
(2007)
J. Control. Release
, vol.117
, pp. 51
-
-
Petri, B.1
Bootz, A.2
Khalansky, A.3
Hekmatara, T.4
Müller, R.5
Uhl, R.6
Kreuter, J.7
Gelperina, S.8
-
56
-
-
0038407930
-
In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide
-
E. Peira, P. Marzola, V. Podio, S. Aime, A. Sbarbati, and M. R. Gasco, In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide. J. Drug Target. 11, 19 (2003).
-
(2003)
J. Drug Target.
, vol.11
, pp. 19
-
-
Peira, E.1
Marzola, P.2
Podio, V.3
Aime, S.4
Sbarbati, A.5
Gasco, M.R.6
-
57
-
-
70450178767
-
The role of apolipoprotein on brain uptake of nanoparticles-bound drugs
-
J. Kreuter, K. Michaelis, S. Dreis, K. Langer, eds.
-
J. Kreuter, K. Michaelis, S. Dreis, K. Langer, eds. The role of apolipoprotein on brain uptake of nanoparticles-bound drugs. Proceedings of the 15th International Symposium on Microencapsulation, September 18-21, Parma, Italy (2005).
-
Proceedings of the 15th International Symposium on Microencapsulation, September 18-21, Parma, Italy (2005)
-
-
-
58
-
-
33646796753
-
Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain
-
K. Michaelis, M. M. Hoffmann, S. Dreis, E. Herbert, R. N. Alyautdin, M. Michaelis, J. Kreuter, and K. Langer, Covalent linkage of apolipoprotein E to albumin nanoparticles strongly enhances drug transport into the brain. J. Pharmacol. Exp. Ther. 317, 1246 (2006).
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.317
, pp. 1246
-
-
Michaelis, K.1
Hoffmann, M.M.2
Dreis, S.3
Herbert, E.4
Alyautdin, R.N.5
Michaelis, M.6
Kreuter, J.7
Langer, K.8
-
59
-
-
0001820844
-
-
edited by R. Gurny and H. E. Junginger, Wissenschaftliche Verlagsgesellschaft, Stuttgart
-
R. H. Müller, S. Heinemann, Bioadhesion - Possibilities and Future Trends, edited by R. Gurny and H. E. Junginger, Wissenschaftliche Verlagsgesellschaft, Stuttgart (1989), pp. 202-214.
-
(1989)
Bioadhesion - Possibilities and Future Trends
, pp. 202-214
-
-
Müller, R.H.1
Heinemann, S.2
-
60
-
-
10744230753
-
Plasma protein adsorption of Tween® 80- And poloxamer 188-stabilized solid lipid nanoparticles
-
T. M. Göppert and R. H. Müller, Plasma protein adsorption of Tween® 80- and poloxamer 188-stabilized solid lipid nanoparticles. J. Drug Target. 11, 225 (2003).
-
(2003)
J. Drug Target.
, vol.11
, pp. 225
-
-
Göppert, T.M.1
Müller, R.H.2
-
61
-
-
24144452456
-
Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting
-
T. M. Göppert and R. H. Müller, Adsorption kinetics of plasma proteins on solid lipid nanoparticles for drug targeting. Int. J. Pharm. 302, 172 (2005).
-
(2005)
Int. J. Pharm.
, vol.302
, pp. 172
-
-
Göppert, T.M.1
Müller, R.H.2
-
62
-
-
34547923611
-
Surface modified solid lipid nanoparticles (SLN) analysis of plasma protein adsorption patterns by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE)
-
H. Weyhers, M. Lück, W. Mehnert, E. B. Souto, and R. H. Müller, Surface modified solid lipid nanoparticles (SLN) analysis of plasma protein adsorption patterns by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). Int. J. Mol. Med. Adv. Sci. 1, 196 (2005).
-
(2005)
Int. J. Mol. Med. Adv. Sci.
, vol.1
, pp. 196
-
-
Weyhers, H.1
Lück, M.2
Mehnert, W.3
Souto, E.B.4
Müller, R.H.5
-
63
-
-
0035984812
-
Apolipoprotein-mediated transport of nanoparticlebound drugs across the blood-brain barrier
-
J. Kreuter, D. Shamenkov, V. Petrov, P. Ramge, K. Cychutek, C. Koch-Brandt, and R. Alyautdin, Apolipoprotein-mediated transport of nanoparticlebound drugs across the blood-brain barrier. J. Drug Target. 10, 317 (2002).
-
(2002)
J. Drug Target.
, vol.10
, pp. 317
-
-
Kreuter, J.1
Shamenkov, D.2
Petrov, V.3
Ramge, P.4
Cychutek, K.5
Koch-Brandt, C.6
Alyautdin, R.7
-
64
-
-
1942453793
-
Potential role of the low density lipoprotein receptor family as mediators of cellular drug uptake
-
N. S. Chung and K. M. Wasan, Potential role of the low density lipoprotein receptor family as mediators of cellular drug uptake. Adv. Drug Deliv. Rev. 56, 1315 (2004).
-
(2004)
Adv. Drug Deliv. Rev.
, vol.56
, pp. 1315
-
-
Chung, N.S.1
Wasan, K.M.2
-
65
-
-
0030755944
-
A new function for the LDL receptor transcytosis of LDL across the blood-brain barrier
-
B. Dehouck, L. Fenart, M. P. Dehouck, A. Pierce, G. Torpier, and R. Cecchelli, A new function for the LDL receptor transcytosis of LDL across the blood-brain barrier. J. Cell Biol. 138, 877 (1997).
-
(1997)
J. Cell Biol.
, vol.138
, pp. 877
-
-
Dehouck, B.1
Fenart, L.2
Dehouck, M.P.3
Pierce, A.4
Torpier, G.5
Cecchelli, R.6
-
66
-
-
33745263735
-
Endocytosis at the blood-brain barrier from basic understanding to drug delivery strategies
-
M. W. Smith and M. Gumbleton, Endocytosis at the blood-brain barrier From basic understanding to drug delivery strategies. J. Drug Target. 14, 191 (2006).
-
(2006)
J. Drug Target.
, vol.14
, pp. 191
-
-
Smith, M.W.1
Gumbleton, M.2
-
67
-
-
67349121612
-
Albumin nanoparticles targeted with ApoE enter the CNS by transcytosis and are delivered to neurones
-
A. Zensi, D. Begley, C. Pontikis, C. Legros, L. Mihoreanu, S. Wagner, C. Büchel, H. von Briesen, and J. Kreuter, Albumin nanoparticles targeted with ApoE enter the CNS by transcytosis and are delivered to neurones. J. Control. Release 137, 78 (2009).
-
(2009)
J. Control. Release
, vol.137
, pp. 78
-
-
Zensi, A.1
Begley, D.2
Pontikis, C.3
Legros, C.4
Mihoreanu, L.5
Wagner, S.6
Büchel, C.7
Von Briesen, H.8
Kreuter, J.9
-
68
-
-
0028928571
-
Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butylcyanoacrylate) nanoparticles
-
R. N. Alyautdin, D. Gothier, V. Petrov, D. Kharkevich, and J. Kreuter, Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butylcyanoacrylate) nanoparticles. Eur. J. Pharm. Biopharm. 41, 44 (1995).
-
(1995)
Eur. J. Pharm. Biopharm.
, vol.41
, pp. 44
-
-
Alyautdin, R.N.1
Gothier, D.2
Petrov, V.3
Kharkevich, D.4
Kreuter, J.5
-
69
-
-
6344294066
-
Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain
-
J. Kreuter, Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain. J. Nanosci. Nanotechnol. 4, 484 (2004).
-
(2004)
J. Nanosci. Nanotechnol.
, vol.4
, pp. 484
-
-
Kreuter, J.1
-
70
-
-
33847116764
-
Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain
-
J. Kreuter, T. Hekmatara, S. Dreis, T. Vogel, S. Gelperina, and K. Langer, Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain. J. Control. Release 118, 54 (2007).
-
(2007)
J. Control. Release
, vol.118
, pp. 54
-
-
Kreuter, J.1
Hekmatara, T.2
Dreis, S.3
Vogel, T.4
Gelperina, S.5
Langer, K.6
-
71
-
-
0037335187
-
Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
-
J. Kreuter, P. Ramge, V. Petrov, S. Hamm, S. E. Gelperina, B. Engelhardt, R. Alyautdin, H. von Briesen, and D. J. Begley, Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm. Res. 20, 409 (2003).
-
(2003)
Pharm. Res.
, vol.20
, pp. 409
-
-
Kreuter, J.1
Ramge, P.2
Petrov, V.3
Hamm, S.4
Gelperina, S.E.5
Engelhardt, B.6
Alyautdin, R.7
Von Briesen, H.8
Begley, D.J.9
-
72
-
-
33646460828
-
Application of nanoparticles for the delivery of drugs to the brain
-
J. Kreuter, Application of nanoparticles for the delivery of drugs to the brain. Int. Congr. Ser. 1277, 85 (2005).
-
(2005)
Int. Congr. Ser.
, vol.1277
, pp. 85
-
-
Kreuter, J.1
-
73
-
-
0033427851
-
Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity
-
J. C. Olivier, L. Fenart, R. Chauvet, C. Pariat, R. Cecchelli, and W. Couet, Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity. Pharm. Res. 16, 1836 (1999).
-
(1999)
Pharm. Res.
, vol.16
, pp. 1836
-
-
Olivier, J.C.1
Fenart, L.2
Chauvet, R.3
Pariat, C.4
Cecchelli, R.5
Couet, W.6
-
74
-
-
0242500461
-
In vivo and in vitro assessment of baseline bloodbrain barrier parameters in the presence of novel nanoparticles
-
P. R. Lockman, J. Koziara, K. E. Roder, J. Paulson, T. J. Abbruscato, R. J. Mumper, and D. D. Allen, In vivo and in vitro assessment of baseline bloodbrain barrier parameters in the presence of novel nanoparticles. Pharm. Res. 20, 705 (2003).
-
(2003)
Pharm. Res.
, vol.20
, pp. 705
-
-
Lockman, P.R.1
Koziara, J.2
Roder, K.E.3
Paulson, J.4
Abbruscato, T.J.5
Mumper, R.J.6
Allen, D.D.7
-
75
-
-
0037457792
-
Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier
-
A. V. Kabanov, E. V. Batrakova, and D. W. Miller, Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv. Drug Deliv. Rev. 55, 151 (2003).
-
(2003)
Adv. Drug Deliv. Rev.
, vol.55
, pp. 151
-
-
Kabanov, A.V.1
Batrakova, E.V.2
Miller, D.W.3
-
76
-
-
11944265265
-
Nanoparticle surface charges alter blood-brain barrier integrity and permeability
-
P. R. Lockman, J. M. Koziara, R. J. Mumper, and D. D. Allen, Nanoparticle surface charges alter blood-brain barrier integrity and permeability. J. Drug Target. 12, 635 (2004).
-
(2004)
J. Drug Target.
, vol.12
, pp. 635
-
-
Lockman, P.R.1
Koziara, J.M.2
Mumper, R.J.3
Allen, D.D.4
-
77
-
-
70450160253
-
Solid lipid nanoparticles-determination of in vivo toxicity
-
H. Weyhers, W. Mehnert, H. Hahn, R. H. Müller, (eds.)
-
H. Weyhers, W. Mehnert, H. Hahn, R. H. Müller, (eds.), Solid lipid nanoparticles-determination of in vivo toxicity, Proceedings of the first World Meeting APGI/APV, May 9-11, Budapest, Hungary (1995).
-
Proceedings of the First World Meeting APGI/APV, May 9-11, Budapest, Hungary (1995)
-
-
-
78
-
-
34248582291
-
Towards controlled release of BDNF-Manufacturing strategies for protein-loaded lipid implants and biocompatibility evaluation in the brain
-
S. Koennings, A. Sapin, T. Blunk, P. Menei, and A. Goepferich, Towards controlled release of BDNF-Manufacturing strategies for protein-loaded lipid implants and biocompatibility evaluation in the brain. J. Contol. Release 119, 163 (2007).
-
(2007)
J. Contol. Release
, vol.119
, pp. 163
-
-
Koennings, S.1
Sapin, A.2
Blunk, T.3
Menei, P.4
Goepferich, A.5
-
80
-
-
0037466349
-
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications
-
C. Vauthier, C. Dubernet, E. Fattal, H. Pinto-Alphandary, and P. Couvreur, Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications. Adv. Drug Deliv. Rev. 55, 519 (2003).
-
(2003)
Adv. Drug Deliv. Rev.
, vol.55
, pp. 519
-
-
Vauthier, C.1
Dubernet, C.2
Fattal, E.3
Pinto-Alphandary, H.4
Couvreur, P.5
-
81
-
-
0028949141
-
Evaluation of liver toxicological effects induced by polyalkylcyanoacrylate nanoparticles
-
R. Fernandez-Urrusuno, E. Fattal, D. Porquet, J. Feger, and P. Couvreur, Evaluation of liver toxicological effects induced by polyalkylcyanoacrylate nanoparticles. Toxicol. Appl. Pharmacol. 130, 272 (1995).
-
(1995)
Toxicol. Appl. Pharmacol.
, vol.130
, pp. 272
-
-
Fernandez-Urrusuno, R.1
Fattal, E.2
Porquet, D.3
Feger, J.4
Couvreur, P.5
-
82
-
-
0031105909
-
Evaluation of hepatic antioxidant systems after intravenous administration of polymeric nanoparticles
-
R. Femandez-Urrusuno, E. Fattal, J. Feger, P. Couvreur, and P. Thérond, Evaluation of hepatic antioxidant systems after intravenous administration of polymeric nanoparticles. Biomaterials 18, 511 (1997).
-
(1997)
Biomaterials
, vol.18
, pp. 511
-
-
Femandez-Urrusuno, R.1
Fattal, E.2
Feger, J.3
Couvreur, P.4
Thérond, P.5
-
83
-
-
2242472082
-
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
-
R. H. Müller, M. Radtke, and S. A. Wissing, Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 54, S131 (2002).
-
(2002)
Adv. Drug Deliv. Rev.
, vol.54
-
-
Müller, R.H.1
Radtke, M.2
Wissing, S.A.3
-
84
-
-
55749084890
-
The targeted delivery of cancer drugs across the blood-brain barrier chemical modifications of drugs or drug-nanoparticles?
-
L. Luillerat-Jeanneret, The targeted delivery of cancer drugs across the blood-brain barrier chemical modifications of drugs or drug-nanoparticles? Drug Discov. Today 13, 1099 (2008).
-
(2008)
Drug Discov. Today
, vol.13
, pp. 1099
-
-
Luillerat-Jeanneret, L.1
-
85
-
-
39749086433
-
Polymeric nanoparticles for the drug delivery to the central nervous system
-
G. Tosi, L. Costantino, B. Ruozi, F. Forni, and M. A. Vandelli, Polymeric nanoparticles for the drug delivery to the central nervous system. Expert Opin. Drug Deliv. 5, 155 (2008).
-
(2008)
Expert Opin. Drug Deliv.
, vol.5
, pp. 155
-
-
Tosi, G.1
Costantino, L.2
Ruozi, B.3
Forni, F.4
Vandelli, M.A.5
|