Key gene and protein changes in the beta-amyloid pathway following Longyanshen polysaccharides treatment in a mouse model of Alzheimer's disease

Neural Regeneration Research

Volumn 4, Issue 10, 2009, Pages 756-762

  Huang, Zhongshi ^a,b   Zhang, Shijun ^a   Xie, Haiyuan ^a   Lin, Xing ^a   Jiang, Weizhe ^a   Huang, Renbin ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

^b YOUJIANG MEDICAL COLLEGE FOR NATIONALITIES   (China)

Author keywords

Longyanshen polysaccharides; amyloid; amyloid precursor protein; site amyloid precursor protein cleaving enzyme

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; HUPERZINE A; LONGYANSHEN POLYSACCHARIDE; MESSENGER RNA; POLYSACCHARIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN TISSUE; CONTROLLED STUDY; DRUG MEGADOSE; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LONGYANSHEN; LOW DRUG DOSE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE;

EID: 70449813315     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2009.10.006     Document Type: Article

References (43)

1. Kong XL, Jiang WZ, Lin ZZ. Effect of extract of Longyanshen on immunodepression induced by cyclophosphamide in mice. Zhongguo Yaofang. 2004;15(6):335-336.
2. Jiang WZ, Kong XL, Huang RB, et al. Protective effects and mechanisms of longyanshen on acute chemical liver injury in mice. Zhongguo Yaofang. 2004;15(7):398-400.
3. Huang ZS, Lin X, Zhang SJ, et al. Effects of LYS polysaccharides on learning and memory as well as monoamine neurotransmitter in SAMP8 mice's brain. Zhongguo Yaofang. 2008;19(9):647-649.
4. Huang ZS, Xie HY, Zhang SJ, et al. Effects of Longyanshen polysaccharides on free radical metabolism in senescence accelerated-prone mice. Neural Regen Res. 2008;3(10):1099-1102.
5. Wilcock DM, Lewis MR, Van Nostrand WE, et al. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci. 2008;28(7):1537-1545.
6. Eckert A, Cotman CW, Zerfass R, et al. Lymphocytesas cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered. J Neural Transm Suppl. 1998;54:259-267. (Pubitemid 28539362)
7. Oakley H, Cole SL, Logan S, et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006;26(40): 10129-10140. (Pubitemid 44527407)
8. Religa D, Laudon H, Styczynska M, et al. Amyloid beta pathology in Alzheimer's disease and schizophrenia. Am J Psychiatry. 2003;160(5):867-872. (Pubitemid 41079570)
9. Petratos S, Li QX, George AJ, et al. The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism. Brain. 2008;131(Pt 1):90-108.
10. Ertekin-Taner N, Younkin LH, Yager DM, et al. Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families. Neurology. 2008;70(8):596-606. (Pubitemid 351294637)
11. Buttini M, Masliah E, Barbour R, et al. Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. J Neurosci. 2005;25(40):9096-9101. (Pubitemid 41500817)
12. Pike KE, Savage G, Villemagne VL, et al. Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain. 2007;130(Pt 11):2837-2844. (Pubitemid 350033975)
13. Sambamurti K, Greig NH, Lahiri DK. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med. 2002;1(1):1-31. (Pubitemid 37021521)
14. Fukui H, Diaz F, Garcia S, et al. Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2007;104(35):14163-14168. (Pubitemid 350003352)
15. Hickman SE, Allison EK, El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci. 2008;28(33):8354-8360.
16. Roberson ED, Scearce-Levie K, Palop JJ, et al. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007;316(5825):750-754. (Pubitemid 46717684)
17. Barnham KJ, Haeffner F, Ciccotosto GD, et al. Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid. FASEB J. 2004;18(12):1427-1429. (Pubitemid 39561603)
18. Gevorkian G, Petrushina I, Manoutcharian K, et al. Mimotopes of conformational epitopes in fibrillar beta-amyloid. J Neuroimmunol. 2004;156(1-2):10-20. (Pubitemid 39304182)
19. Oshima N, Morishima-Kawashima M, Yamaguchi H, et al. Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain. Am J Pathol. 2001;158(6):2209-2218. (Pubitemid 32545207)
20. Huttunen HJ, Guénette SY, Peach C, et al. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem. 2007;282(38):28285-28295. (Pubitemid 47529538)
21. Anandatheerthavarada HK, Devi L. Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease. Neuroscientist. 2007;13(6):626-638. (Pubitemid 350077307)
22. Berezovska O, Lleo A, Herl LD, et al. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci. 2005;25(11):3009-3017. (Pubitemid 40389259)
23. Kumar P, Ambasta RK, Veereshwarayya V, et al. CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. Hum Mol Genet. 2007;16(7):848-864. (Pubitemid 47061630)
24. Mudher A, Chapman S, Richardson J, et al. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. J Neurosci. 2001;21(14):4987-4995. (Pubitemid 32622924)
25. Hinerfeld DA, Moonis M, Swearer JM, et al. Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects. Arch Neurol. 2007;64(11):1672-1673. (Pubitemid 350106773)
26. Chen Q, Kimura H, Schubert D. A novel mechanism for the regulation of amyloid precursor protein metabolism. J Cell Biol. 2002;158(1):79-89. (Pubitemid 34886723)
27. Maloney MT, Minamide LS, Kinley AW, et al. Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease. J Neurosci. 2005;25(49):11313-11321.
28. Cataldo AM, Petanceska S, Terio NB, et al. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging. 2004;25(10):1263-1272. (Pubitemid 39299162)
29. Yankner BA, Lu T. Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem. 2009;284(8):4755-4759.
30. Sadowski M, Pankiewicz J, Scholtzova H, et al. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Am J Pathol. 2004;165(3):937-948. (Pubitemid 39129300)
31. Dong J, Canfield JM, Mehta AK, et al. Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity. Proc Natl Acad Sci U S A. 2007;104(33):13313-13318. (Pubitemid 47293942)
32. Cecchi C, Baglioni S, Fiorillo C, et al. Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates. J Cell Sci. 2005;118(Pt 15):3459-3470. (Pubitemid 41246100)
33. Ciccotosto GD, Tew D, Curtain CC, et al. Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution. J Biol Chem. 2004;279(41):42528-42534. (Pubitemid 39372136)
34. White AR, Multhaup G, Maher F, et al. The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures. J Neurosci. 1999;19(21):9170-9179. (Pubitemid 30228069)
35. Bhatia R, Lin H, Lal R. Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity. FASEB J. 2000;14(9):1233-1243.
36. The Ministry of Science and Technology of the People's Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30.
37. Zhang YL, Zhang WJ, He QH. Removal of protein from the crude persimmon polysaccharides by proteases-Sevag's method. Shipin Gongye Keji. 2005;26(5):107.
38. Zhong ZG, Wu DP, Wang JS, et al. Inhibitive effects of Panax Notoginseng on expression of APP protein in SAMP8 mouse brain. Shizhen Guoyi Guoyao Zazhi. 2008;19(11):2628-2630.
39. Xiao F, Luo HM, Li XG, et al. The therapy effect of Kadsura heteroclita on the AD model mice. Zhongguo Yaolixue Tongbao. 2004;20(9):1001-1004.
40. Miyamoto M. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10. Exp Gerontol. 1997;32(1-2):139-148. (Pubitemid 27131713)
41. Nomura Y, Okuma Y. Age-related defects in lifespan and learning ability in SAMP8 mice. Neurobiol Aging. 1999;20(2):111-115. (Pubitemid 29488721)
42. Pepping J. Huperzine A. Am J Health Syst Pharm. 2000;57(6):530, 533-534.
43. Desilets AR, Gickas JJ, Dunican KC. Role of huperzine a in the treatment of Alzheimer's disease. Ann Pharmacother. 2009;43(3):514-518.