MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation

Journal of Immunology

Volumn 183, Issue 7, 2009, Pages 4197-4204

  Howie, Duncan ^a   Nolan, Kathleen F ^a   Daley, Stephen ^a   Butterfield, Emma ^a   Adams, Elizabeth ^a   Garcia Rueda, Hugo ^a   Thompson, Claire ^a   Saunders, Nigel J ^a   Cobbold, Stephen P ^a   Tone, Yukiko ^b   Tone, Masahide ^b   Waldmann, Herman ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; COMPLEMENTARY DNA; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 2; MS4A4B PROTEIN; PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; MS4A4B PROTEIN, MOUSE; NERVE GROWTH FACTOR RECEPTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TNFRSF18 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; YEAST; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CBA MOUSE; CELL LINE; CHO CELL; CRICETULUS; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PHYSIOLOGY; TRANSGENIC MOUSE; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; GENE EXPRESSION PROFILING; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, INBRED CBA; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES, REGULATORY; UP-REGULATION;

EID: 70449725288     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901070     Document Type: Article

References (36)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
2. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2: 301-306.
3. + immunoregulatory T cells. J. Exp. Med. 194: 427-438.
4. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
5. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
6. Apostolou, I., and H. von Boehmer. 2004. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199: 1401-1408. (Pubitemid 38685731)
7. Chen, T. C., S. P. Cobbold, P. J. Fairchild, and H. Waldmann. 2004. Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen. J. Immunol. 172: 5900-5907.
8. - precursors. J. Immunol. 169: 4183-4189.
9. - T cells to acquire regulatory cell function. Blood 101: 5076-5083.
10. - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172: 5149-5153.
11. Cobbold, S. P., K. F. Nolan, L. Graca, R. Castejon, A. Le Moine, M. Frewin, S. Humm, E. Adams, S. Thompson, D. Zelenika, et al. 2003. Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms. Immunol. Rev. 196: 109-124.
12. + regulatory T cells in inflamed synovia. J. Exp. Med. 201: 1793-1803.
13. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3: 135-142.
14. Lee, B. P., E. Mansfield, S. C. Hsieh, T. Hernandez-Boussard, W. Chen, C. W. Thomson, M. S. Ford, S. E. Bosinger, S. Der, Z. X. Zhang, et al. 2005. Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival. J. Immunol. 174: 4535-4544.
15. + T cells. Genes Immun. 6: 596-608.
16. Ishibashi, K., M. Suzuki, S. Sasaki, and M. Imai. 2001. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and β subunit of the high-affinity IgE receptor. Gene 264: 87-93.
17. Liang, Y., and T. F. Tedder. 2001. Identification of a CD20-, FcεRIβ-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics 72: 119-127. (Pubitemid 32242951)
18. Johnsson, N., and A. Varshavsky. 1994. Split ubiquitin as a sensor of protein interactions in vivo. Proc. Natl. Acad. Sci. USA 91: 10340-10344. (Pubitemid 24328992)
19. Ronchetti, S., O. Zollo, S. Bruscoli, M. Agostini, R. Bianchini, G. Nocentini, E. Ayroldi, and C. Riccardi. 2004. GITR, a member of the TNF receptor super-family, is costimulatory to mouse T lymphocyte subpopulations. Eur. J. Immunol. 34: 613-622. (Pubitemid 39255908)
20. Chen, T. C., H. Waldmann, and P. J. Fairchild. 2004. Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby. J. Clin. Invest. 113: 1754-1762.
21. Marson, A., K. Kretschmer, G. M. Frampton, E. S. Jacobsen, J. K. Polansky, K. D. MacIsaac, S. S. Levine, E. Fraenkel, H. von Boehmer, and R. A. Young. 2007. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 445: 931-935. (Pubitemid 46309829)
22. Kinet, J. P. 1999. The high-affinity IgE receptor (FcεRI): from physiology to pathology. Annu. Rev. Immunol. 17: 931-972. (Pubitemid 29241144)
23. Adra, C. N., J. M. Lelias, H. Kobayashi, M. Kaghad, P. Morrison, J. D. Rowley, and B. Lim. 1994. Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the β subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions. Proc. Natl. Acad. Sci. USA 91: 10178-10182. (Pubitemid 24985045)
24. Blank, U., C. Ra, L. Miller, K. White, H. Metzger, and J. P. Kinet. 1989. Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 337: 187-189. (Pubitemid 19025382)
25. Kinet, J. P., U. Blank, C. Ra, K. White, H. Metzger, and J. Kochan. 1988. Isolation and characterization of cDNAs coding for the β subunit of the high-affinity receptor for immunoglobulin E. Proc. Natl. Acad. Sci. USA 85: 6483-6487.
26. Kuster, H., L. Zhang, A. T. Brini, D. W. MacGlashan, and J. P. Kinet. 1992. The gene and cDNA for the human high affinity immunoglobulin E receptor β chain and expression of the complete human receptor. J. Biol. Chem. 267: 12782-12787.
27. Deans, J. P., G. L. Schieven, G. L. Shu, M. A. Valentine, L. A. Gilliland, A. Aruffo, E. A. Clark, and J. A. Ledbetter. 1993. Association of tyrosine and serine kinases with the B cell surface antigen CD20: induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-γ 1 and PLC phospholipase C-γ 2. J. Immunol. 151: 4494-4504.
28. Kanzaki, M., M. A. Lindorfer, J. C. Garrison, and I. Kojima. 1997. Activation of the calcium-permeable cation channel CD20 by α subunits of the Gi protein. J. Biol. Chem. 272: 14733-14739. (Pubitemid 27251739)
29. 2+ conductance found constitutively in B lymphocytes. J. Cell Biol. 121: 1121-1132.
30. Dombrowicz, D., S. Lin, V. Flamand, A. T. Brini, B. H. Koller, and J. P. Kinet. 1998. Allergy-associated FcRβ is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity 8: 517-529. (Pubitemid 28196805)
31. Levy, S., and T. Shoham. 2005. The tetraspanin web modulates immune-signalling complexes. Nat. Rev. Immunol. 5: 136-148. (Pubitemid 40208903)
32. Tone, M., Y. Tone, E. Adams, S. F. Yates, M. R. Frewin, S. P. Cobbold, and H. Waldmann. 2003. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc. Natl. Acad. Sci. USA 100: 15059-15064. (Pubitemid 37518016)
33. Cobbold, S. P., E. Adams, L. Graca, and H. Waldmann. 2003. Serial analysis of gene expression provides new insights into regulatory T cells. Semin. Immunol. 15: 209-214.
34. Zelenika, D., E. Adams, S. Humm, L. Graca, S. Thompson, S. P. Cobbold, and H. Waldmann. 2002. Regulatory T cells overexpress a subset of Th2 gene transcripts. J. Immunol. 168: 1069-1079. (Pubitemid 34094470)
35. Gietz, R. D., and R. A. Woods. 2001. Genetic transformation of yeast. Bio- Techniques 30: 816-831.
36. Venkataraman, C., G. Schaefer, and U. Schindler. 2000. Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes. J. Immunol. 165: 632-636. (Pubitemid 30484727)