Genotoxic damage of human adipose-tissue derived mesenchymal stem cells triggers their terminal differentiation

Neoplasma

Volumn 56, Issue 6, 2009, Pages 542-547

  Altanerova, V ^a   Horvathova, E ^b   Matuskova, M ^a   Kucerova, L ^a   Altaner, C ^a  

^a Laboratory of Molecular Oncology   (Slovakia)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Chemical carcinogen 4nqo; Genotoxic damage; Human adipose tissue derived mesenchymal stem cells; Single cell gel electrohoresis; Terminal differentiation

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; CYTOSINE DEAMINASE; HYDROGEN PEROXIDE; URACIL PHOSPHORIBOSYLTRANSFERASE; GLYCOSYLTRANSFERASE; OXIDIZING AGENT;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; CELL DIFFERENTIATION; COMET ASSAY; DNA DAMAGE; GENETIC STABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; LIPOMA; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; SINGLE STRANDED DNA BREAK; ANIMAL; APOPTOSIS; CELL AGING; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; TRANSGENE;

ADIPOSE TISSUE; ANIMALS; APOPTOSIS; CELL AGING; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOSINE DEAMINASE; DNA DAMAGE; HUMANS; HYDROGEN PEROXIDE; LIPOMA; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; OXIDANTS; PENTOSYLTRANSFERASES; TRANSGENES;

EID: 70449719457     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: 10.4149/neo_2009_06_542     Document Type: Article

References (49)

1. SCHAFFLER A, BUCHLER C. Concise review: adipose tissue-derived stromal cells - basic and clinical implications for novel cell-based therapies. Stem Cells 2007; 25: 818-827. doi:10.1634/stemcells.2006-0589
2. ZUK PA, ZHU M, ASHJIAN P et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002; 13: 4279-4295. doi:10.1091/mbc.E02- 02-0105
3. KUCEROVA L, ALTANEROVA V, MATUSKOVA M et al. Adipose tissue derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res 2007; 67: 6304-6313. doi:10.1158/0008-5472.CAN-06-4024
4. KERN S, EICHLER H, STOEVE J et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood or adipose tissue. Stem Cells 2006; 24: 1294-1301. doi:10.1634/stemcells.2005-0342 (Pubitemid 44464698)
5. ALTANER C. Prodrug cancer gene therapy. Cancer Letters 2008; 270: 191-201. doi:10.1016/j.canlet.2008.04.023
6. ALTANER C. Glioblastoma and stem cells Minireview. NEOPLASMA 2008; 55: 369-374.
7. KUCEROVA L, MATUSKOVA M, PASTORAKOVA A et al. Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice. J Gene Med 2008; 10: 1071-1082. doi:10.1002/jgm.1239
8. CAVARRETTA I, ALTANEROVA V, MATUSKOVA M et al. Adipose tissue-derived mesenchymal stem cells expressing prodrug converting enzyme inhibit human prostate tumor growth. Molecular Therapy (2009, in revision)
9. SINGH, NP, MCCOY MT, TICE RR et al. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res.1988; 175: 184-191. doi:10.1016/0014-4827(88)90265-0
10. SLAMENOVA D, GABELOVA A, RUZEKOVA L et al. Detection of MNNG-induced DNA lesions inmammalian cells: validation of comet assay against DNA unwinding technique,alkaline elution of DNA and chromosomal aberrations. Mutat. Res. 1997; 383: 243-252.
11. SLAMENOVA D, HORVATHOVA E, MARSALKOVA L, et al. Carvacrol given to rats in drinking water reduces the level of DNA lesions induced in freshly isolated hepatocytes and testicular cells by H2O2. Neoplasma. 2008; 55: 394-399.
12. GABELOVA A, SLAMENOVA D, RUZEKOVA L et al. Measurement of DNA strand breakage and DNA repair induced with hydrogen peroxide using single cell gel electrophoresis, alkaline DNA unwinding and alkaline elution of DNA. Neoplasma 1997; 44: 380-388.
13. STREM BM, HICOK KC, ZHU M et al. Multipotential differentiation of adipose tissue-derived stem cells. Keio J.Med. 2005; 54:132-141. doi:10.2302/kjm.54.132 (Pubitemid 41542713)
14. KEATING A. Mesenchymal stromal cells. Curr. Opin. Hematol. 2006; 13: 419-425. doi:10.1097/01.moh.0000245697.54887.6f
15. MCINTOSH K, ZVONIC S, GARRETT S et al. The immunogenicity of human adipose derived cells: Temporal changes in vitro. Stem Cells 2006; 24: 1246-1253. doi:10.1634/stemcells.2005-0235
16. NIEMEYER P, KORNACKER M, MEHLORN A et al. Comparison of immunological properties of bone marrow stromal cells and adipose tissue derived stem cells before and after osteogenic differentiation in vitro. Tissue Eng 2007; 13: 111-121. doi:10.1089/ten.2006.0114
17. CROP MJ, BAAN CC, KOREVAAR SS. et al. Donor-derived mesenchymal stem cells suppress alloreactivity of kidney transplant patients. Transplantation. 2009; 87: 896-906. doi:10.1097/TP.0b013e31819b3d72
18. PUISSANT B., BARREAU C., BOURIN P et al. Immunomodulatory effect of human adipose tissue derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 2005; 129: 118-129. doi:10.1111/j.1365- 2141.2005.05409.x
19. CUI L, YIN S, LIU W et al. Expanded adipose derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E2. Tissue Eng 2007; 13: 1185-1195. doi:10.1089/ten.2006.0315
20. YAÑEZ R, LAMANA ML, GARCÍA-CASTRO J et al. Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus host disease. Stem Cells 2006; 24: 2582-2591. doi:10.1634/stemcells.2006-0228
21. STUDENY FC, MARINI JL, DEMBINSKI C et al. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents, J. Natl. Cancer Inst. 2004; 96: 1593-1603.
22. ABOODY KS, BUSH RA, GARCIA E, et al. Development of a tumor selective approach to treat metastatic cancer. PLoS ONE 2006;1: E23-31. doi:10.1371/journal.pone.0000023
23. LAZENNEC G, JORGENSEN C Concise review: adult multipotent stromal cells and cancer: risk or benefit? Stem Cells. 2008; 26: 1387-1394. doi:10.1634/stemcells.2007-1006
24. HUNG SC, DENG WP, YANG WK et al. Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clin. Cancer Res.2005; 11: 7749-7756. doi:10.1158/1078-0432.CCR-05-0876
25. KARNOUB AE, DASH AB, VO AP et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature, 2007; 449: 557-563. doi:10.1038/nature06188
26. STUDENY M, MARINI FC, CHAMPLIN RE et al. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors, Cancer Res. 2002; 62: 3603-3608.
27. NAKAMIZO A. MARINI F, AMANO T et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res. 2005; 65: 3307-3318.
28. KAPLAN RN, PSAILA B, LYDEN D Bone marrow cells in the'pre-metastatic niche': within bone and beyond, Cancer Metastasis Rev 2006; 25: 521-529. doi:10.1007/s10555-006-9036-9 (Pubitemid 46071861)
29. HAMADA H, KOBUNE M, NAKAMURA K et al. Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy, Cancer Sci. 2005; 96: 149-156. doi:10.1111/j.1349-7006.2005.00032.x (Pubitemid 40575915)
30. RAMASAMY R, LAM EW, SOEIRO I. et al. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 2007; 21: 304-310. doi:10.1038/sj.leu.2404489
31. OHLSSON LB, VARAS L, KJELLMAN C, et al. Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix. Exp Mol Pathol. 2003; 75: 248-255. doi:10.1016/j.yexmp.2003.06.001
32. KHAKOO AY, PATI S, ANDERSON SA et al. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma, J. Exp. Med. 2006; 203: 1235-1247. doi:10.1084/jem.20051921
33. MIURA M, MIURA Y, PADILLA-NASH HM, et al. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells. 2006; 24: 1095-1103. doi:10.1634/stemcells.2005-0403
34. TOLAR J, NAUTA AJ, OSBORN MJ, et al. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells. 2007; 25: 371-379. doi:10.1634/stemcells. 2005-0620
35. ZHOU YF, BOSCH-MARCE M, OKUYAMA H, et al. Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Res. 2006; 66: 10849-10854. doi:10.1158/0008-5472.CAN-06-2146 (Pubitemid 44876981)
36. RUBIO D, GARCIA-CASTRO J, MARTÍN MC, et al. Spontaneous human adult stem cell transformation. Cancer Res. 2005; 65: 3035-3039.
37. RØSLAND GV, SVENDSEN A, TORSVIK A, et al. Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 2009; 69: 5331-5339. doi:10.1158/0008- 5472.CAN-08-4630
38. AGUILAR S, NYE E, CHAN J, et al. Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells. 2007; 25: 1586-1594. doi:10.1634/stemcells.2006-0762
39. TASSO R, AUGELLO A, CARIDA M et al. Development of sarcomas in mice implanted with mesenchymal stem cells seeded onto bioscaffolds. Carcinogenesis 2009; 30: 150-157. doi:10.1093/carcin/bgn234
40. KUCEROVA L, MATUSKOVA, M. HLUBINOVA, K et al. Human adipose tissue-derived mesenchymal stromal cells as modulators of tumor microenvironment. Molecular Cancer (2009, submitted).
41. HILDRESTRAND GA, DUGGAL S, BJØRÅS M, et al. Modulation of DNA glycosylase activities in mesenchymal stem cells. Exp Cell Res. 2009 May 25. [Epub ahead of print]
42. MIAO ZH, RAO VA, AGAMA K et al. 4-Nitroquinoline-1-Oxide induces the formation of cellular topoisomerase I-DNA cleavage complexes. Cancer Res. 2006; 66: 6540-6545. doi:10.1158/0008-5472.CAN-05-4471
43. NAGAO M, SUGIMURA T. Molecular biology of the carcinogen, 4-nitroquinoline 1-oxide. Adv Cancer Res 1976; 23: 131-169. doi:10.1016/S0065- 230X(08)60545-X
44. WAGNER W, HORN P, CASTOLDI M, et al. Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One. 2008; 3: e2213. doi:10.1371/journal.pone.0002213
45. WAGNER W, BORK S, HORN P, et al. Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One. 2009; 4: e5846. doi:10.1371/journal.pone.0005846
46. INOMATA K, AOTO T, BINH NT et al. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell. 2009; 137: 1088-1099. doi:10.1016/j.cell.2009.03.037
47. RUZANKINA Y, PINZON-GUZMAN C, Asare A, et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell. 2007; 1: 113-126. doi:10.1016/j.stem.2007. 03.002
48. INOUE-NARITA T, HAMADA K, SASAKI T, et al. Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res. 2008; 68: 5760-5768. doi:10.1158/0008-5472.CAN-08- 0889
49. NISHIMURA EK, GRANTER SR, FISHER DE Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science. 2005; 307: 720-724. doi:10.1126/science.1099593