Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

Journal of Experimental Medicine

Volumn 206, Issue 11, 2009, Pages 2429-2440

  Hu, Chih Chi Andrew ^a   Dougan, Stephanie K ^a   Winter, Sebastian Virreira ^a   Paton, Adrienne W ^b   Paton, James C ^b   Ploegh, Hidde L ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CYTOTOXIN; GLUCOSE REGULATED PROTEIN 78; GLYCOPROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; INTERLEUKIN 6; PROTEIN P97; SUBTILASE CYTOTOXIN; UNCLASSIFIED DRUG; ANTIBODY; ESCHERICHIA COLI PROTEIN; HEAT SHOCK PROTEIN; HLA ANTIGEN CLASS 1; MOLECULAR CHAPERONE GRP78; PEPTIDE FRAGMENT; SUBTILASE CYTOTOXIN, E COLI; SUBTILISIN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CELL STRAIN HEPG2; CYTOKINE RELEASE; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN SECRETION; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL MEMBRANE; CHEMISTRY; DRUG EFFECT; IMMUNOLOGY; INTRACELLULAR SPACE; METABOLISM; PROTEIN FOLDING; PROTEIN TRANSPORT; SECRETION;

ANIMALS; ANTIBODIES; B-LYMPHOCYTES; CELL MEMBRANE; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI PROTEINS; HEAT-SHOCK PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN M; INTERLEUKIN-6; INTRACELLULAR SPACE; MICE; MODELS, IMMUNOLOGICAL; PEPTIDE FRAGMENTS; PROTEIN FOLDING; PROTEIN TRANSPORT; SUBTILISINS;

EID: 70449704526     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20090782     Document Type: Article

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