Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways

Cellular Microbiology

Volumn 10, Issue 9, 2008, Pages 1775-1786

  Wolfson, Jennifer J ^a   May, Kerrie L ^b   Thorpe, Cheleste M ^a   Jandhyala, Dakshina M ^a   Paton, James C ^b   Paton, Adrienne W ^b  

^a TUFTS MEDICAL CENTER   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; BACTERIAL TOXIN; CELL PROTEIN; CYTOTOXIN; GLUCOSE REGULATED PROTEIN 78; INOSITOL REQUIRING ENZYME 1; MESSENGER RNA; PHOSPHOTRANSFERASE; PKR LIKE ENDOPLASMIC RETICULUM KINASE; PROTEIN IRE1; SUBTILASE CYTOTOXIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 6; TRANSCRIPTION FACTOR ELF 2ALPHA; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; VERO CELL;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; CERCOPITHECUS AETHIOPS; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SHIGA-TOXIGENIC ESCHERICHIA COLI; SIGNAL TRANSDUCTION; SUBTILISINS; VERO CELLS;

ESCHERICHIA COLI;

EID: 48749112866     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2008.01164.x     Document Type: Article

References (27)

1. Boyce, M., and Yuan, J. (2006) Cellular response to endoplasmic reticulum stress: A matter of life or death. Cell Death Differ 13: 363-373.
2. Chan, S.W., and Egan, P.A. (2005) Hepatitis C virus envelope proteins regulate CHOP via induction of the unfolded protein response. FASEB J 19: 1510-1512.
3. Chong, D.C., Paton, J.C., Thorpe, C.M., and Paton, A.W. (2007) Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB 5 toxin that targets the ER chaperone BiP. Cell Microbiol 10: 795-806.
4. DuRose, J.B., Tam, A.B., and Niwa, M. (2006) Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress. Mol Biol Cell 17: 3095-3107.
5. Eriksson, K.K., Vago, R., Calanca, V., Galli, C., Paganetti, P., and Molinari, M. (2004) EDEM contributes to maintenance of protein folding efficiency and secretory capacity. J Biol Chem 279: 44600-44 605.
6. Gething, M.J. (1999) Role and regulation of the ER chaperone BiP. Semin Cell Dev Biol 10: 465-472.
7. Hendershot, L.M. (2004) The ER function BiP is a master regulator of ER function. Mt Sinai J Med 71: 289-297.
8. Hu, P., Han, Z., Couvillon, A.D., Kaufman, R.J., and Exton, J.H. (2006) Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol 26: 3071-3084.
9. Kim, P.S., and Arvan, P. (1998) Endocrinopathies in the family of endoplasmic reticulum (ER) storage diseases: Disorders of protein trafficking and the role of ER molecular chaperones. Endocr Rev 19: 173-202.
10. Leung, Y.F., Tam, P.O., Lee, W.S., Lam, D.S., Yam, H.F., Fan, B.J., et al. (2003) The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells. Mol Vis 9: 425-439.
11. Medigeshi, G.R., Lancaster, A.M., Hirsch, A.J., Briese, T., Lipkin, W.I., DeFilippis, V., et al. (2007) West Nile virus infection activates the unfolded protein 1 response leading to CHOP induction and apoptosis. J Virol 81: 10849-10860.
12. Park, H.R., Tomida, A., Sato, S., Tsukumo, Y., Yun, J., Yamori, T., et al. (2004) Effect on tumor cells of blocking survival response to glucose deprivation. J Natl Cancer Inst 96: 1300-1310.
13. 5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature 443: 548-552.
14. Paton, J.C., and Paton, A.W. (1998) Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections. Clin Microbiol Rev 11: 450-479.
15. 5 cytotoxins produced by Shiga toxigenic Escherichia coli. J Exp Med 200: 35-46.
16. Rao, R.V., Ellerby, H.M., and Bredesen, D.E. (2004) Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11: 372-380.
17. Rogers, T.J., Paton, A.W., McColl, S.R., and Paton, J.C. (2003) Enhanced CXC chemokine responses of human colonic epithelial cells to locus of enterocyte effacement-negative Shiga toxigenic Escherichia coli. Infect Immun 71: 5623-5632.
18. Shang, J. (2005) Quantitative measurement of events in the mammalian unfolded protein response. Methods 35: 390-394.
19. Shen, J., and Prywes, R. (2004) Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6. J Biol Chem 279: 43046-43051.
20. Shen, J., Snapp, E.L., Lippincott-Schwartz, J., and Prywes, R. (2005) Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response. Mol Cell Biol 25: 921-932.
21. Siezen, R.J., and Leunissen, J.A. (1997) Subtilases: The superfamily of subtilisin-like serine proteases. Protein Sci 6: 501-523.
22. Szegezdi, E., Logue, S.E., Gorman, A.M., and Samali, A. (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7: 880-885.
23. Talbot, U.M., Paton, J.C., and Paton, A.W. (2005) Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli. Infect Immun 73: 4432-4436.
24. Thorpe, C.M., Hurley, B.P., Lincicome, L.L., Jacewicz, M.S., Keusch, G.T., and Acheson, D.W. (1999) Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells. Infect Immun 67: 5985-5993.
25. Wang, Q., He, Z., Zhang, J., Wang, Y., Wang, T., Tong, S., et al. (2005) Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance. Cancer Detection Prevention 29: 544-551.
26. Wang, H., Paton, J.C., and Paton, A.W. (2007) Pathological changes in mice induced by subtilase cytotoxin, an emerging Escherichia coli AB 5 toxin that targets the endoplasmic reticulum. J Infect Dis 196: 1093-1101.
27. Yu, M., and Haslam, D.B. (2005) Shiga toxin is transported from the endoplasmic reticulum following interaction with the luminal chaperone HEDJ/ERdj3. Infect Immun 73: 2524-2532.