DMBT1 polymorphisms: Relationship to malignant glioma tumorigenesis

Cancer Research

Volumn 62, Issue 6, 2002, Pages 1790-1796

  Sasaki, Hikaru ^a   Betensky, Rebecca A ^b   Cairncross, J Gregory ^c   Louis, D N ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN DMBT1; UNCLASSIFIED DRUG;

AGE; ALLELE; ARTICLE; BRAIN TUMOR; CARCINOGENESIS; CHROMOSOME 10Q; CHROMOSOME LOSS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE DELETION; GENE LOCUS; GENE LOSS; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GLIOMA; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RISK FACTOR; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

AGGLUTININS; ALLELES; BLOTTING, SOUTHERN; BRAIN NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 10; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; GLIOMA; HUMANS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE;

EID: 0037086096     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Identification of a candidate tumour suppressor gene, MMACI, at chromosome 10q23.3 that is mutated in multiple advanced cancers
2. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
3. Chromosome 10 deletion mapping in human gliomas: A common deletion region in 10q25
4. Deletion mapping of gliomas suggests the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q
5. New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26
6. Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades
7. Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter
8. Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors
9. Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer
10. Deletion mapping on chromosome 10q25-q 26 in human endometrial cancer
11. Identification of two distinct tumor-suppressor loci on the long arm of chromosome 10 in small cell lung cancer
12. Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer
13. Expression of the DMBT1 gene is frequently suppressed in human lung cancer
14. Analysis of the DMBT1 gene in carcinomas of the respiratory tract
15. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours
16. Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression
17. Lack of DMBT1 expression in oesophageal, gastric and colon cancers
18. The genomic structure of the DMBT1 gene: Evidence for a region with susceptibility to genomic instability
19. DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer
20. PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis
21. Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner
22. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D
23. Suppression of tumor growth in vivo by local and systemic 90K level increase
24. Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system, mannan-binding proteindependent cell-mediated cytotoxicity
25. Centre d’etude du polymorphisme humain (CEPH): Collaborative genetic mapping of the human genome
26. A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC)
27. A (CA)n dinucleotide repeat assay for evaluating loss of allelic heterozygosity in small and archival human brain tumor specimens
28. Genomic sequencing
29. Comparative study of p53 gene and protein alterations in human astrocytic tumors
30. Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors
31. Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA
32. The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight women
33. Polymorphic repeats in the androgen receptor gene: Molecular markers of prostate cancer risk
34. A candidate prostate cancer susceptibility gene at chromosome 17p
35. Identification of regulatory regions of the putative tumor suppressor gene DMBT1
36. Promoter haplotype combinations of the platelet-derived growth factor a-receptor gene predispose to human neural tube defects