Structure of an integrin αIIbβ3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 42, 2009, Pages 17729-17734

  Yang, Jun ^a   Ma, Yan Qing ^a   Page, Richard C ^a   Misra, Saurav ^a   Plow, Edward F ^a   Qin, Jun ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

NMR; Protein structure; Transmembrane domain

Indexed keywords

INTEGRIN; INTEGRIN ALPHAIIBETA3 TRANSMEMBRANE TRANSMEMBRANE CYTOPLASMIC HETEROCOMPLEX; MEMBRANE RECEPTOR; UNCLASSIFIED DRUG; FIBRINOGEN RECEPTOR; MULTIPROTEIN COMPLEX; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; DIMERIZATION; GENETIC TRANSFECTION; GENETICS; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; CYTOPLASM; DIMERIZATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; POINT MUTATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 70449566822     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909589106     Document Type: Article

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