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Volumn 411, Issue 1-2, 2010, Pages 99-105

Identification of genetic polymorphisms of human OAT1 and OAT2 genes and their relationship to hOAT2 expression in human liver

Author keywords

Expression level; Genetic polymorphism; Interindividual variations; Organic anion transporter (OAT); SLC22A6; SLC22A7

Indexed keywords

ANION; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2;

EID: 70449535432     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.10.015     Document Type: Article
Times cited : (23)

References (37)
  • 1
    • 3042630508 scopus 로고    scopus 로고
    • Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters
    • Eraly S.A., Monte J.C., and Nigam S.K. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics 18 (2004) 12-24
    • (2004) Physiol Genomics , vol.18 , pp. 12-24
    • Eraly, S.A.1    Monte, J.C.2    Nigam, S.K.3
  • 2
    • 0033938669 scopus 로고    scopus 로고
    • The multispecific organic anion transporter (OAT) family
    • Sekine T., Cha S.H., and Endou H. The multispecific organic anion transporter (OAT) family. Pflugers Arch 440 (2000) 337-350
    • (2000) Pflugers Arch , vol.440 , pp. 337-350
    • Sekine, T.1    Cha, S.H.2    Endou, H.3
  • 3
    • 33644781452 scopus 로고    scopus 로고
    • Implications of genetic polymorphisms in drug transporters for pharmacotherapy
    • Kerb R. Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett 234 (2006) 4-33
    • (2006) Cancer Lett , vol.234 , pp. 4-33
    • Kerb, R.1
  • 4
    • 33745901941 scopus 로고    scopus 로고
    • Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
    • Meier Y., Pauli-Magnus C., Zanger U.M., et al. Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Hepatology 44 (2006) 62-74
    • (2006) Hepatology , vol.44 , pp. 62-74
    • Meier, Y.1    Pauli-Magnus, C.2    Zanger, U.M.3
  • 5
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: translating functional genomics into rational therapeutics
    • Evans W.E., and Relling M.V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286 (1999) 487-491
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 6
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum R. Inheritance and drug response. N Engl J Med 348 (2003) 529-537
    • (2003) N Engl J Med , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 7
    • 0141649391 scopus 로고    scopus 로고
    • Estimating the contribution of genes and environment to variation in renal drug clearance
    • Leabman M.K., and Giacomini K.M. Estimating the contribution of genes and environment to variation in renal drug clearance. Pharmacogenetics 13 (2003) 581-584
    • (2003) Pharmacogenetics , vol.13 , pp. 581-584
    • Leabman, M.K.1    Giacomini, K.M.2
  • 8
    • 31344468048 scopus 로고    scopus 로고
    • Variability in renal clearance of substrates for renal transporters in chinese subjects
    • Yin O.Q., Tomlinson B., and Chow M.S. Variability in renal clearance of substrates for renal transporters in chinese subjects. J Clin Pharmacol 46 (2006) 157-163
    • (2006) J Clin Pharmacol , vol.46 , pp. 157-163
    • Yin, O.Q.1    Tomlinson, B.2    Chow, M.S.3
  • 9
    • 0347859200 scopus 로고    scopus 로고
    • Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions
    • Sakata T., Anzai N., Shin H.J., et al. Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions. Biochem Biophys Res Commun 313 (2004) 789-793
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 789-793
    • Sakata, T.1    Anzai, N.2    Shin, H.J.3
  • 10
    • 0036865724 scopus 로고    scopus 로고
    • Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences
    • Kerb R., Brinkmann U., Chatskaia N., et al. Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics 12 (2002) 591-595
    • (2002) Pharmacogenetics , vol.12 , pp. 591-595
    • Kerb, R.1    Brinkmann, U.2    Chatskaia, N.3
  • 11
    • 0038184179 scopus 로고    scopus 로고
    • Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1
    • Shu Y., Leabman M.K., Feng B., et al. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A 100 (2003) 5902-5907
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5902-5907
    • Shu, Y.1    Leabman, M.K.2    Feng, B.3
  • 12
    • 34047123147 scopus 로고    scopus 로고
    • Identification and functional characterization of genetic variants of human organic cation transporters in a korean population
    • Kang H.J., Song I.S., Shin H.J., et al. Identification and functional characterization of genetic variants of human organic cation transporters in a korean population. Drug Metab Dispos 35 (2007) 667-675
    • (2007) Drug Metab Dispos , vol.35 , pp. 667-675
    • Kang, H.J.1    Song, I.S.2    Shin, H.J.3
  • 13
    • 38349085099 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics
    • Shu Y., Brown C., Castro R.A., et al. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther 83 (2008) 273-280
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 273-280
    • Shu, Y.1    Brown, C.2    Castro, R.A.3
  • 14
    • 34248156160 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
    • Shu Y., Sheardown S.A., Brown C., et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 117 (2007) 1422-1431
    • (2007) J Clin Invest , vol.117 , pp. 1422-1431
    • Shu, Y.1    Sheardown, S.A.2    Brown, C.3
  • 15
    • 54249106729 scopus 로고    scopus 로고
    • Genetic variants of the organic cation transporter 2 influence the disposition of metformin
    • Song I.S., Shin H.J., Shim E.J., et al. Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin Pharmacol Ther 84 (2008) 559-562
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 559-562
    • Song, I.S.1    Shin, H.J.2    Shim, E.J.3
  • 16
    • 50249136652 scopus 로고    scopus 로고
    • Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes
    • Song I.S., Shin H.J., and Shin J.G. Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes. Xenobiotica 38 (2008) 1252-1262
    • (2008) Xenobiotica , vol.38 , pp. 1252-1262
    • Song, I.S.1    Shin, H.J.2    Shin, J.G.3
  • 17
    • 0036842911 scopus 로고    scopus 로고
    • Structure, function, and regulation of renal organic anion transporters
    • You G. Structure, function, and regulation of renal organic anion transporters. Med Res Rev 22 (2002) 602-616
    • (2002) Med Res Rev , vol.22 , pp. 602-616
    • You, G.1
  • 18
    • 0038728565 scopus 로고    scopus 로고
    • Transport of organic anions across the basolateral membrane of proximal tubule cells
    • Burckhardt B.C., and Burckhardt G. Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol 146 (2003) 95-158
    • (2003) Rev Physiol Biochem Pharmacol , vol.146 , pp. 95-158
    • Burckhardt, B.C.1    Burckhardt, G.2
  • 19
    • 33644848884 scopus 로고    scopus 로고
    • Molecular physiology of renal organic anion transporters
    • Sekine T., Miyazaki H., and Endou H. Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol 290 (2006) F251-F261
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Sekine, T.1    Miyazaki, H.2    Endou, H.3
  • 20
    • 20244389716 scopus 로고    scopus 로고
    • Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)
    • Fujita T., Brown C., Carlson E.J., et al. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics 15 (2005) 201-209
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 201-209
    • Fujita, T.1    Brown, C.2    Carlson, E.J.3
  • 21
    • 22944433202 scopus 로고    scopus 로고
    • Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)
    • Bleasby K., Hall L.A., Perry J.L., Mohrenweiser H.W., and Pritchard J.B. Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther 314 (2005) 923-931
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 923-931
    • Bleasby, K.1    Hall, L.A.2    Perry, J.L.3    Mohrenweiser, H.W.4    Pritchard, J.B.5
  • 22
    • 70350075408 scopus 로고    scopus 로고
    • Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
    • Nies A.T., Koepsell H., Winter S., et al. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology (2009)
    • (2009) Hepatology
    • Nies, A.T.1    Koepsell, H.2    Winter, S.3
  • 23
    • 18444369013 scopus 로고    scopus 로고
    • The structure of haplotype blocks in the human genome
    • Gabriel S.B., Schaffner S.F., Nguyen H., et al. The structure of haplotype blocks in the human genome. Science 296 (2002) 2225-2229
    • (2002) Science , vol.296 , pp. 2225-2229
    • Gabriel, S.B.1    Schaffner, S.F.2    Nguyen, H.3
  • 24
    • 0036260663 scopus 로고    scopus 로고
    • Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
    • Enomoto A., Takeda M., Shimoda M., et al. Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther 301 (2002) 797-802
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 797-802
    • Enomoto, A.1    Takeda, M.2    Shimoda, M.3
  • 25
    • 31644434086 scopus 로고    scopus 로고
    • Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]
    • Xu G., Bhatnagar V., Wen G., Hamilton B.A., Eraly S.A., and Nigam S.K. Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int 68 (2005) 1491-1499
    • (2005) Kidney Int , vol.68 , pp. 1491-1499
    • Xu, G.1    Bhatnagar, V.2    Wen, G.3    Hamilton, B.A.4    Eraly, S.A.5    Nigam, S.K.6
  • 26
    • 0035211396 scopus 로고    scopus 로고
    • Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins
    • Iida A., Saito S., Sekine A., et al. Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins. J Hum Genet 46 (2001) 668-683
    • (2001) J Hum Genet , vol.46 , pp. 668-683
    • Iida, A.1    Saito, S.2    Sekine, A.3
  • 27
    • 33747068033 scopus 로고    scopus 로고
    • Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters
    • Vormfelde S.V., Schirmer M., Hagos Y., et al. Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters. Br J Clin Pharmacol 62 (2006) 323-335
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 323-335
    • Vormfelde, S.V.1    Schirmer, M.2    Hagos, Y.3
  • 28
    • 33748042671 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions
    • Shitara Y., and Sugiyama Y. Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions. Pharmacol Ther 112 (2006) 71-105
    • (2006) Pharmacol Ther , vol.112 , pp. 71-105
    • Shitara, Y.1    Sugiyama, Y.2
  • 29
    • 22544454498 scopus 로고    scopus 로고
    • Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells
    • Kameyama Y., Yamashita K., Kobayashi K., Hosokawa M., and Chiba K. Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics 15 (2005) 513-522
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 513-522
    • Kameyama, Y.1    Yamashita, K.2    Kobayashi, K.3    Hosokawa, M.4    Chiba, K.5
  • 30
    • 16644386102 scopus 로고    scopus 로고
    • Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors
    • Tachibana-Iimori R., Tabara Y., Kusuhara H., et al. Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors. Drug Metab Pharmacokinet 19 (2004) 375-380
    • (2004) Drug Metab Pharmacokinet , vol.19 , pp. 375-380
    • Tachibana-Iimori, R.1    Tabara, Y.2    Kusuhara, H.3
  • 31
    • 18244401389 scopus 로고    scopus 로고
    • A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy
    • Morimoto K., Oishi T., Ueda S., Ueda M., Hosokawa M., and Chiba K. A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy. Drug Metab Pharmacokinet 19 (2004) 453-455
    • (2004) Drug Metab Pharmacokinet , vol.19 , pp. 453-455
    • Morimoto, K.1    Oishi, T.2    Ueda, S.3    Ueda, M.4    Hosokawa, M.5    Chiba, K.6
  • 32
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy - a genomewide study
    • Link E., Parish S., Armitage J., et al. SLCO1B1 variants and statin-induced myopathy - a genomewide study. N Engl J Med 359 (2008) 789-799
    • (2008) N Engl J Med , vol.359 , pp. 789-799
    • Link, E.1    Parish, S.2    Armitage, J.3
  • 33
    • 33646198187 scopus 로고    scopus 로고
    • Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin
    • Igel M., Arnold K.A., Niemi M., et al. Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin. Clin Pharmacol Ther 79 (2006) 419-426
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 419-426
    • Igel, M.1    Arnold, K.A.2    Niemi, M.3
  • 34
    • 33646911616 scopus 로고    scopus 로고
    • Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes
    • Hedman M., Antikainen M., Holmberg C., et al. Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes. Br J Clin Pharmacol 61 (2006) 706-715
    • (2006) Br J Clin Pharmacol , vol.61 , pp. 706-715
    • Hedman, M.1    Antikainen, M.2    Holmberg, C.3
  • 35
    • 34548009561 scopus 로고    scopus 로고
    • SLCO1B1 521T→C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients
    • Zhang W., Chen B.L., Ozdemir V., et al. SLCO1B1 521T→C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients. Br J Clin Pharmacol 64 (2007) 346-352
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 346-352
    • Zhang, W.1    Chen, B.L.2    Ozdemir, V.3
  • 36
    • 3242808852 scopus 로고    scopus 로고
    • High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)
    • Niemi M., Schaeffeler E., Lang T., et al. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics 14 (2004) 429-440
    • (2004) Pharmacogenetics , vol.14 , pp. 429-440
    • Niemi, M.1    Schaeffeler, E.2    Lang, T.3
  • 37
    • 20444466590 scopus 로고    scopus 로고
    • Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics
    • Niemi M., Backman J.T., Kajosaari L.I., et al. Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics. Clin Pharmacol Ther 77 (2005) 468-478
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 468-478
    • Niemi, M.1    Backman, J.T.2    Kajosaari, L.I.3


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