IL-18 in induced sputum and airway hyperresponsiveness in mild asthmatics: Effect of smoking

Respiratory Medicine

Volumn 103, Issue 12, 2009, Pages 1919-1925

  Rovina, Nikoletta ^a,c   Dima, Efrossini ^a,c   Gerassimou, Christina ^c   Kollintza, Androniki ^c   Gratziou, Christina ^b,c   Roussos, Charis ^a,b,c  

^a UNIVERSITY OF ATHENS   (Greece)

^b Evgenidion Hospital   (Greece)

^c M Simos Laboratories   (Greece)

Author keywords

Airway hyperresponsiveness; Bronchial asthma; Cigarette smoking; IL 18; Induced sputum

Indexed keywords

INTERLEUKIN 18; METHACHOLINE;

ADULT; ARTICLE; ASTHMA; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; FORCED EXPIRATORY VOLUME; HUMAN; PRICK TEST; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY TRACT INFLAMMATION; SPIROMETRY; SPUTUM EXAMINATION;

ADULT; ASTHMA; BIOLOGICAL MARKERS; BRONCHIAL HYPERREACTIVITY; BRONCHOCONSTRICTOR AGENTS; CELL COUNT; HUMANS; INTERLEUKIN-18; METHACHOLINE CHLORIDE; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; SMOKING; SPUTUM;

EID: 70449527802     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2009.05.023     Document Type: Article

References (41)

1. Busse W.W., and Lemanske R.J. Asthma. N Engl J Med 344 (2001) 350-362
2. Cohn L., Elias J.A., and Chupp G.L. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 22 (2004) 789-815
3. Davies D.E., Wicks J., Powell R.M., et al. Airway remodeling in asthma: new insights. J Allergy Clin Immunol 111 (2003) 215-225
4. Elias J.A., Lee C.G., Zheng T., et al. New insights into the pathogenesis of asthma. J Clin Invest 111 (2003) 291-297
5. Umetsu D.T., McIntire J.J., Akbari O., et al. Asthma: an epidemic of dysregulated immunity. Nat Immunol 3 (2002) 715-720
6. Althuis M., Sexton M., and Prybylski D. Cigarette smoking and asthma symptom severity among adult asthmatics. J Asthma 36 (1999) 257-264
7. Apostol G., Jacobs D., Tsai A., et al. Early life factors contribute to the decrease in lung function between ages 18 and 40. Am J Respir Crit Care Med 166 (2002) 166-172
8. Lange P., Parner J., Vestbo J., et al. A 15 year follow-up study of ventilatory function in adults with asthma. N Engl J Med 339 (1998) 1194-1200
9. Chalmers G.W., Macleod K.J., Little S.A., et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 57 (2002) 226-230
10. Tomlinson J.E.M., McMahon A.D., Chaudhuri R., et al. Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax 60 (2005) 282-287
11. Chaudhuri R., Livingston E., McMahon A.D., et al. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 168 (2003) 1308-1311
12. Nakanishi K., Yoshimoto T., Tsutsui H., et al. Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 19 (2001) 423-474
13. Lee K.S., Kim S.R., Park S.J., et al. Antioxidant down-regulates interleukin-18 expression in asthma. Mol Pharmacol 70 (2006) 1184-1193
14. + T cells. Eur J Immunol 30 (2000) 1998-2006
15. Campbell E., Kunkel S.L., Strieter R.M., et al. Differential roles of IL-18 in allergic airway disease: induction of eotaxin by resident cell populations exacerbates eosinophil accumulation. J Immunol 164 (2000) 1096-1102
16. Chalmers G.W., MacLeod K.J., Thomson L., et al. Smoking and airway inflammation in patients with mild asthma. Chest 120 (2001) 1917-1922
17. Takanashi S., Hasegawa Y., and Kanehira Y. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers. Eur Respir J 14 (1999) 309-314
18. Robinson D.S., Hamid Q., Ying S., et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 326 (1992) 298-304
19. Hashimoto S., Amemiya E., Tomita Y., et al. Elevation of soluble IL-2 receptor and IL-4, and non-elevation of IFN-gamma in sera from patients with allergic asthma. Ann Allergy 71 (1993) 455-458
20. Ford J.G., Rennick D., Donaldson D.D., et al. Il-13 and IFN-gamma: interactions in lung inflammation. J Immunol 167 (2001) 1769-1777
21. Rovina N., Dima E., Gerassimou C., et al. Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease. Respir Med 103 (2009) 1056-1062
22. McKay A., Komai-Koma M., MacLeod K.J., et al. Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers. Clin Exp Allergy 34 (2004) 904-910
23. Tanaka H., Miyazaki N., Oashi K., et al. IL-18 might reflect disease activity in mild and moderate asthma exacerbation. J Allergy Clin Immunol 107 2 (2001) 331-336
24. Kumano K., Nakao A., Nakajima H., et al. Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways. Am J Respir Crit Care Med 160 3 (1999) 873-878
25. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 136 (1987) 226-234
26. National Institute of Health. Global Initiative for asthma-global strategy for asthma management and prevention (GINA) (2007).
27. Quanjer P.H., Tammeling G.J., Cotes J.E., et al. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 16 (1993) 5-40
28. Rutgers S.R., Timens W., Kaufmann H.F., et al. Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD. Eur Respir J 15 (2000) 109-115
29. Vignola A.M., Bonanno A., Mirabella A., et al. Increased levels of elastase and alpha 1-antitrypsin in sputum of asthmatic patients. Am J Respir Crit Care Med 157 2 (1998) 505-511
30. McCrea K.A., Ensor J.E., Nall K., et al. Altered cytokine regulation in the lungs of cigarette smokers. Am J Respir Crit Care Med 150 3 (1994) 696-703
31. Hagiwara E., Takahashi K., Okubo T., et al. Cigarette smoking depletes cells spontaneously secreting Th(1) cytokines in the human airway. Cytokine 14 2 (2001) 121-126
32. Sur S., Crotty T.B., Kephart G.M., et al. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?. J Immunol 167 4 (2001) 2349-2353
33. Wenzel S.E., Szefler S.J., Leung D.Y., et al. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 156 3 Pt 1 (1997) 737-743
34. Hayashi N., Yoshimoto T., Izuhara K., et al. T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production. Proc Natl Acad Sci U S A 104 37 (2007) 14765-14770
35. Sugawara S., Uehara A., Nochi T., et al. Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J Immunol 167 11 (2001) 6568-6575
36. Sugimoto T., Ishikawa Y., Yoshimoto T., et al. Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse. J Exp Med 199 4 (2004) 535-545
37. Yamagata S., Tomita K., Sato R., et al. Interleukin-18-deficient mice exhibit diminished chronic inflammation and airway remodelling in ovalbumin-induced asthma model. Clin Exp Immunol 154 3 (2008) 295-304
38. D'Hulst A.I., Maes T., Bracke K.R., et al. Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?. Respir Res 6 (2005) 147
39. Gebel S., Gebel S., Gerstmayer B., et al. The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression. Toxicol Sci 93 (2006) 422-431
40. Ghayur T., Banerjee S., Hugunin M., et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 386 6625 (1997) 619-623
41. Akita K., Ohtsuki T., Nukada Y., et al. Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP-1 cells. J Biol Chem 272 42 (1997) 26595-26603