Toxicodynamics of subacute co-exposure to groundwater contaminant arsenic and analgesic-antipyretic drug acetaminophen in rats

Ecotoxicology and Environmental Safety

Volumn 73, Issue 1, 2010, Pages 94-100

  Manimaran, Ayyasamy ^a   Nath Sarkar, Souvendra ^a   Sankar, Palanisamy ^a  

^a INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

Acetaminophen; Arsenic; Co exposure; Liver; Oxidative stress; Rats

Indexed keywords

ANALGESIC AGENT; ANTIOXIDANT; ANTIPYRETIC AGENT; ARSENIC; CATALASE; DRUG METABOLIZING ENZYME; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GROUND WATER; LIPID; PARACETAMOL; SUPEROXIDE DISMUTASE; XENOBIOTIC AGENT;

ARSENIC; BODY MASS; DRUG; ENZYME ACTIVITY; GROUNDWATER POLLUTION; PHYSIOLOGICAL RESPONSE; POLLUTION EXPOSURE; RODENT; TOXICITY TEST; TOXICOLOGY; XENOBIOTICS;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME ACTIVITY; FOOD INTAKE; LIPID PEROXIDATION; LIVER MICROSOME; LIVER WEIGHT; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TOXICITY; WATER POLLUTANT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ARSENIC; BODY WEIGHT; CYTOCHROME P-450 ENZYME SYSTEM; EATING; GLUTATHIONE; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; WATER POLLUTANTS, CHEMICAL;

RATTUS;

EID: 70449526818     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2009.09.005     Document Type: Article

References (47)

1. Adeneye A.A., and Benebo A.S. Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats. J. Ethnopharmacol. 118 (2008) 318-323
2. Aebi H.E. Catalase. In: Bergmeyer H.U., Bergmeyer J., and Grabi M. (Eds). Methods of Enzymatic Analysis. third ed. vol. III (1983), Verlag Chemie, Weinheim 273-286
3. Albores A., Cebrian M.E., Connelly J.C., Bach P.H., and Bridges J.W. Effects of arsenite on hepatic mixed-function oxidase activity in rats. Xenobiotica 22 (1992) 591-597
4. Amar P.J., and Schiff E.R. Acetaminophen safety and hepatotoxicity-where do we go from here?. Expert Opin. Drug Saf. 6 (2007) 341-355
5. Bertolini A., Ferrari A., Ottani A., Guerzoni S., Tacchi R., and Leone S. Paracetamol: new vistas of an old drug. CNS Drug Rev. 12 (2006) 250-275
6. De M. Arsenic-India's health crisis attracting global attention. Curr. Sci. 88 (2005) 683-684
7. Fairhurst S., Barber D.J., Clark B., and Horton A.A. Studies on paracetamol-induced lipid peroxidation. Toxicology 23 (1982) 249-259
8. Falkner K.C., McCallum G.P., Cherian M.G., and Bend J.R. Effects of acute sodium arsenite administration on the pulmonary chemical metabolizing enzymes, cytochrome P-450 monooxygenase, NAD(P)H:quinone acceptor oxidoreductase and glutathione S-transferase in guinea pig: comparison with effects in liver and kidney. Chem. Biol. Interact. 86 (1993) 51-68
9. Feierman D.E., Melnikov Z., and Zhang J. The paradoxical effect of acetaminophen on CYP3A4 activity and content in transfected HepG2 cells. Arch. Biochem. Biophys. 398 (2002) 109-117
10. Gibson J.D., Pumford N.R., Samokyszyn V.M., and Hinson J.A. Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress. Chem. Res. Toxicol. 9 (1996) 580-585
11. Goldberg D.M., and Spooner R.J. Glutathione reductase. In: Bergmeyer H.U., Bergmeyer J., and Grabi M. (Eds). Methods of Enzymatic Analysis. third ed. vol. III (1983), Verlag Chemie, Weinheim 258-265
12. Guha Mazumder D.N. Effect of chronic intake of arsenic-contaminated water on liver. Toxicol. Appl. Pharmacol. 206 (2005) 169-175
13. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
14. He X., Chen M.G., Lin G.X., and Ma Q. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer. J. Biol. Chem. 281 (2006) 23620-23631
15. Islam N., Siddique M.A., and Misbahuddin M. Absorption and metabolism of paracetamol in rats drinking high concentration of arsenic. Mymensingh Med. J. 14 (2005) 145-151
16. James L.P., Mayeux P.R., and Hinson J.A.. Acetaminophen-induced hepatotoxicity. Drug Metab. Dispos. 31 (2003) 1499-1506
17. Kim S.N., Seo J.Y., Jung D.W., Lee M.Y., Jung Y.S., and Kim Y.C. Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichlorometahne metabolism and carboxyhemoglobin elevation. Drug Metab. Dispos. 35 (2007) 1754-1758
18. Laine J., Auriola S., Pasanen M., and Juvonen R. Acetaminophen bioactivation by CYP enzymes. Toxicol. Lett. 172 (2007) S85
19. Lee S.M., Cho T.S., Kim D.J., and Cha Y.N. Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice: role of NADH:quinone reductase. Biochem. Pharmacol. 58 (1999) 1547-1555
20. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
21. Madesh M., and Balasubramanian K.A. Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Indian J. Biochem. Biophys. 35 (1998) 184-188
22. Mandal B.K., and Suzuki K.T. Arsenic round the world: a review. Talanta 58 (2002) 201-235
23. Mandal B.K., Chowdhury T.R., Samanta G., Basu G.K., Chowdhury P.P., Chanda C.R., Lodh D., Karan N.K., Dhar R.K., Tamili D.K., Das D., Saha K.C., and Chakraborti D. Arsenic in groundwater in seven districts of West Bengal, India-the biggest arsenic calamity in the world. Curr. Sci. 70 (1996) 976-986
24. Mazel P. Experiments illustrating drug metabolism in vitro. In: La Du B.N., Mandel H.G., and Way E.L. (Eds). Fundamentals of Drug Metabolism and Drug Disposition (1971), Williams and Wilkins, Baltimore 546-582
25. Mitchell J.R., Jollow D.J., Potter W.Z., Gillette J.R., and Brodie B.B. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 187 (1973) 211-217
26. Moffit J.S., Aleksunes L.M., Kardas M.J., Slitt A.L., Klaassen C.D., and Manautou J.E. Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology 230 (2007) 197-206
27. Moling O., Cairon E., Rimenti G., Rizza F., Pristera R., and Mian P. Hepatotoxicity after therapeutic doses of acetaminophen. Clin. Ther. 28 (2006) 755-760
28. Naraharisetti S.B., Aggarwal M., Sarkar S.N., and Malik J.K. Concurrent subacute exposure to arsenic through drinking water and malathion via diet in male rats: effects on hepatic drug-metabolizing enzymes. Arch. Toxicol. 82 (2008) 543-551
29. Nicholls-Grzemski F.A., Calder C.I., Priestly B.G., and Burcham P.C. Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis. Toxicol. Sci. 56 (2000) 220-228
30. Noreault T.L., Kostrubsky V.E., Wood S.G., Nichols R.C., Strom S.C., Trask H.W., Wrighton S.A., Evans R.M., Jacobs J.M., Sinclair P.R., and Sinclair J.F. Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. Drug Metab. Dispos. 33 (2005) 993-1003
31. O'Brien P.J., Slaughter M.R., Swain A., Birmingham J.M., Greenhill R.W., Elcock F., and Bugelski P.J. Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system. Hum. Exp. Toxicol. 19 (2000) 277-283
32. Omura T., and Sato R. The carbon monoxide-binding pigment of liver microsomes. Evidence for its hemoprotein nature. J. Biol. Chem. 239 (1964) 2370-2378
33. Ozdemirler G., Aykac G., Uysal M., and Oz H. Liver lipid peroxidation and glutathione-related defence enzyme systems in mice treated with paracetamol. J. Appl. Toxicol. 14 (1994) 297-299
34. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70 (1967) 158-169
35. Pi J., Yamauchi H., Kumagai Y., Sun G., Yoshida T., Aikawa H., Rich C.H., and Shimojo N. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ. Health Perspect. 110 (2002) 331-336
36. Ramos O., Carrizales L., Yanez L., Meija J., Batres L., Ortiz D., and Diaz-Barrgia F. Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels. Environ. Health Perspect. 103 (1995) 85-88
37. Reicks M.M., Fullerton F.R., Poirier L.A., Whittaker P., and Hathcock J.N. Prolonged acetaminophen ingestion by mice fed a methionine-limited diet does not affect iron-induced liver lipid peroxidation or S-adenosylmethionine. J. Nutr. 122 (1992) 1738-1743
38. Sarkar S., Hazra J., Upadhyay S.N., Singh R.K., and Roy Chowdhury A. Arsenic induced toxicity on testicular tissue of mice. Indian J. Physiol. Pharmacol. 52 (2008) 84-90
39. Sedlak J., and Lindsay R.H. Estimation of total, protein-bound and nonprotein bound sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25 (1968) 192-205
40. Shafiq-Ur-Rehman. Lead-induced regional lipid peroxidation in brain. Toxicol. Lett. 21 (1984) 333-337
41. Shayiq R.M., Roberts D.W., Rothstein K., Snawder J.E., Benson W., Ma X., and Black M. Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury. Hepatology 29 (1999) 451-463
42. Siller F.R., Quintanilla-Vega B., Cebrian M.E., and Albores A. Effects of arsenite pretreatment on the acute toxicity of parathion. Toxicology 116 (1997) 9-65
43. Sivilotti M.L., Good A.M., Yarema M.C., Juurlink D.N., and Johnson D.W. A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure. Clin. Toxicol. 43 (2005) 229-234
44. Slikker Jr. W., Andersen M.E., Bogdanffy M.S., Bus J.S., Cohen S.D., Conolly R.B., David R.M., Doerrer N.G., Dorman D.C., Gaylor D.W., Hattis D., Rogers J.M., Setzer R.W., Swenberg J.A., and Wallace K. Dose-dependent transitions in mechanisms of toxicity: case studies. Toxicol. Appl. Pharmacol. 201 (2004) 226-294
45. Valko M., Morris H., and Cronin M.T.D. Metals, toxicity and oxidative stress. Curr. Med. Chem. 12 (2005) 1161-1208
46. Van Miert A.S.J.P.A.M. The use in animals of drugs licensed for human use only. In: Van Miert A.S.J.P.A.M., Bogaert M.G., and Debackere M. (Eds). Comparative Veterinary Pharmacology, Toxicology and Therapy (1986), MTP Press, Boston 489-500
47. Wrighton S.A., Maurel P., Schuetz E.G., Watkins P.B., Young B., and Guzelian P.S. Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p. Biochemistry 24 (1985) 2171-2178