Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: Increase in dichloromethane metabolism and carboxyhemoglobin elevation

Drug Metabolism and Disposition

Volumn 35, Issue 10, 2007, Pages 1754-1758

  Kim, Su N ^a   Seo, Ji Y ^a   Jung, Da W ^a   Lee, Min Y ^a   Jung, Young S ^a   Kim, Young C ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROANISOLE; 4 NITROPHENOL; ALANINE AMINOTRANSFERASE; AMINOPYRINE N DEMETHYLASE; ASPARTATE AMINOTRANSFERASE; CARBOXYHEMOGLOBIN; CHLORZOXAZONE; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DICHLOROMETHANE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; IDITOL DEHYDROGENASE; MICROSOME ENZYME; PARACETAMOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; LIVER METABOLISM; LIVER MICROSOME; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICOKINETICS; WESTERN BLOTTING;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARBOXYHEMOGLOBIN; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; FEMALE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; L-IDITOL 2-DEHYDROGENASE; LIVER; METHYLENE CHLORIDE; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 34748903745     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.015545     Document Type: Article

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