Aberrant expression of synaptic plasticity-related genes in the NF1 +/- mouse hippocampus

Journal of Neuroscience Research

Volumn 87, Issue 14, 2009, Pages 3107-3119

  Chang, Sin Park ^a   Zhong, Ling ^b   Tang, Shao Jun ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Hippocampus; Learning disabilities; Memory; Neurofibromatosis 1; Synapse

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MEVINOLIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; NEUROFIBROMIN; RAB PROTEIN; SYNAPTOTAGMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DYSFUNCTION; CELL COMMUNICATION; CELL TRANSPORT; CONTROLLED STUDY; CYTOSKELETON; DISEASE ASSOCIATION; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; GENE MUTATION; HAPPY PUPPET SYNDROME; HIPPOCAMPUS; LEARNING DISORDER; LONG TERM MEMORY; LONG TERM POTENTIATION; MEMORY CONSOLIDATION; MEMORY DISORDER; MICROARRAY ANALYSIS; MOUSE; NERVE CELL PLASTICITY; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEARNING DISORDERS; LOVASTATIN; MEMORY; MICE; MICE, MUTANT STRAINS; NEUROFIBROMIN 1; NEURONAL PLASTICITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNAPSES;

EID: 70449470630     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22134     Document Type: Article

References (53)

1. Angelo M, Plattner F, Giese KP. 2006. Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. J Neurochem 99:353-370. (Pubitemid 44477194)
2. Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt JD. 2000. The MAPK cascade is required for mammalian associative learning. Nat Neurosci 1:602-609.
3. Bukalo O, Fentrop N, Lee AYW, Salmen B, Law JWS, Wotjak CT, Schweizer M, Dityatev A, Schachner M. 2004. Conditional ablation of the neural cell adhesion molecule reduces precision of spatial learning, long-term potentiation, and depression in the CA1 subfield of mouse hippocampus. J Neurosci 24:1565-1577. (Pubitemid 38240951)
4. Cavallaro S, D'Agata V, Manickam P, Dufour F, Alkon DL. 2002. Memory-specific temporal profiles of gene expression in the hippocampus. Proc Natl Acad Sci U S A 99:16279-16284. (Pubitemid 35462786)
5. Chan C-S, Weeber EJ, Kurup S, Sweatt JD, Davis RL. 2003. Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci 23:7107-7116. (Pubitemid 36975875)
6. Cichowski K, Jacks T. 2001. NF1 tumor suppressor gene function: narrowing the GAP. Cell 104:593-604. (Pubitemid 32201953)
7. Costa RM, Silva AJ. 2003. Mouse models of neurofibromatosis type I: bridging the GAP. Trends Mol Med 9:19-23. (Pubitemid 36139251)
8. Costa RM, Yang T, Duong PH, Pulst SM, Viskochi HD, Silva JA, Brannan IC. 2001. Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1. Nat Genet 27:399-405. (Pubitemid 32268420)
9. Costa RM, Fedrov NB, Kogan HJ, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva JA. 2002. Mechanism for the learning deficits in a mouse model of neurofirbromatosis type 1. Nature 415:526-530. (Pubitemid 34130607)
10. Davis S, Vanhoutte P, Pages C, Caboche J, Laroche S. 2000. The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J Neurosci 20:4563-4572. (Pubitemid 30396622)
11. Eliason MJ. 1988. Neurofibromatiosis: implications for learning and behavior. Dev Behav Pediatr 7:175-179.
12. Engert F, Bonhoeffer T. 1999. Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 399:66-70. (Pubitemid 129524287)
13. English JD, Sweatt JD. 1997. A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation. J Biol Chem 272:19103-19106.
14. Ferner RE, Hughes RA, Weinman J. 1996. Intellectual impairment in neurofibromatosis 1. J Neurol Sci 138:125-133.
15. Frankland PW, Cestari V, Filipkowski RK, McDonald RJ, Silva AJ. 1998. The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behav Neurosci 112:863-874. (Pubitemid 28397368)
16. Grimwood PD, Martin SJ, Morris RGM. 2001. Synaptic plasticity and memory. In: Cowan WM, Sudhof TC, Stevens CF, editors. Synapses. Baltimore: The Johns Hopkins University Press. p 519-570.
17. Guo HF, The I, Hannan F, Bernards A, Zhong Y. 1997. Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science 276:795-798.
18. Guo HF, Tong J, Hannan F, Luo L, Zhong Y. 2000. A nuerofibromatosis-1- regulated pathway is required for learning in Drosophila. Nature 403:895-898. (Pubitemid 30130991)
19. Hofman KJ, Harris EL, Bryan RN, Denckla MB. 1994. Neurofibromatosis type 1: the cognitive phenotype. J Pediatr 124:s1-8.
20. Hung S-P, Baldi P, Hatfield GW. 2002. Global gene expression profiling in Escherichia coli K12. The effects of leucine-responsive regulatory protein. J Biol Chem 277:40309-40323. (Pubitemid 35215604)
21. Kayl EA, Moore DB. 2000. Behavioral phenotype of neurofibromatosis, type 1. Mental Retardation Dev Disabil Res Rev 6:117-124.
22. Kessels HW, Malinow R. 2009. Synaptic AMPA receptor plasticity and behavior. Neuron 61:340.
23. Levenson JM, Choi S, Lee S-Y, Cao YA, Ahn HJ, Worley KC, Pizzi M, Liou H-C, Sweatt JD. 2004. A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-Rel. J Neurosci 24:3933-3943. (Pubitemid 38544220)
24. Li L, Cao D, Kim H, Lester R, Fukuchi K. 2006. Simvastatin enhances learning and memory independent of amyloid load in mice. Ann Neurol 60:729-739. (Pubitemid 46061359)
25. Li W, Cui Y, Kushner SA, Brown RA, Jentsch JD, Frankland PW, Cannon TD, Silva AJ. 2005. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol 15:1961-1967. (Pubitemid 41566145)
26. Ling Li DCHKRLK-iF. 2006. Simvastatin enhances learning and memory independent of amyloid load in mice. Ann Neurol 60:729-739.
27. Lisman J, Schulman H, Cline H. 2002. The molecular basis of CaMKII function in synaptic and behavioral memory. Nat Rev Neurosci 3:175-190. (Pubitemid 135706588)
28. Liu Y-F, Chen H-I, Yu L, Kuo Y-M, Wu F-S, Chuang J-I, Liao P-C, Jen CJ. 2008. Up-regulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice. Neurobiol Learn Mem 90:81.
29. Lu D, Qu C, Goussev A, Jiang H, Lu C, Schallert T, Mahmood A, Chen J, Li Y, Chopp M. 2007. Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrama 24:1132-1146.
30. Malenka RC, Bear MF. 2004. LTP and LTD: an embarrassment of riches. Neuron 44:5.
31. Matsuzaki M, Honkura N, Ellis-Davies GC, Kasai H. 2004. Structural basis of long-term potentiation in single dendritic spines. Nature 429:761-766. (Pubitemid 38833127)
32. 2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J Neurosci 25:9883-9892.
33. Nordlund ML, Rizvi TA, Brannan CI, Ratner N. 1995. Neurofibromin expression and astrogilosis in neurofibromatosis (type 1) brains. J Neuropathol Exp Neurol 54:588-600.
34. North K. 1993. Neurofibromatosis type 1: review of the first 200 patients in an Australian clinic. J Child Neurol 8:395-402. (Pubitemid 23292477)
35. North K. 2000. Neurofibromatosis type 1. Am J Med Genet 97:119-127.
36. North K, Joy P, Yuille D, Cocks N, Hutchins P. 1995. Cognitive function and academic performance in children with neurofibromatosis type 1. Dev Med Child Neurol 37:427-436.
37. Orban PC, Chapman PF, Brambilla R. 1999. Is the Ras-MAPK signalling pathway necessary for long-term memory formation? Trends Neurosci 22:38-44.
38. Park CS, Gong R, Stuart J, Tang S-J. 2006. Molecular network and chromosomal clustering of genes involved in synaptic plasticity in the hippocampus. J Biol Chem 281:30195-30211. (Pubitemid 44537027)
39. Sanes JR, Lichtman JW. 1999. Can molecules explain long-term potentiation? Nat Neurosci 2:597-604.
40. Silva AJ, Frankland PW, Marowitz Z, Friedman E, Lazlo G, Ciofii D, Jacks T, Bourtchuladze R. 1997. A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat Genet 15:281-284. (Pubitemid 27098723)
41. Silva AJ, Kogan JH, Frankland PW, Kida S. 1998. CREB and memory. Annu Rev Neurosci 21:127-148.
42. Suto F, Tsuboi M, Kamiya H, Mizuno H, Kiyama Y, Komai S, Shimizu M, Sanbo M, Yagi T, Hiromi Y, Chédotal A, Mitchell KJ, Manabe T, Fujisawa H. 2007. Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers. Neuron 53:535. (Pubitemid 46216759)
43. The I, Hannigan GE, Cowley GS, Reginald S, Zhong Y, Gusella JF, Hariharan IK, Bernards A. 1997. Rescuse of Drosophila NF1 mutant phenotype by proten kinase A. Science 276:791-794.
44. Thomas GM, Huganir RL. 2004. MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci 5:173-183.
45. Tong J, Hannan F, Zhu Y, Bernards A, Zhong Y. 2002. Neurofibromin regulates G protein-stimulated adenlyl cyclase activity. Nat Neurosci 5:95-96. (Pubitemid 34121572)
46. Toni N, Buchs PA, Nikonenko I, Bron CR, Muller D. 1999. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature 402:421-425. (Pubitemid 129544831)
47. Weeber EJ, Sweatt JD. 2002. Molecular neurobiology of human cognition. Neuron 33:845-848.
48. Williams JA, Su HS, Berbards A, Field J, Sehgal A. 2001. A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK. Science 293:2251-2256. (Pubitemid 32900234)
49. Yang S, Farias M, Kapfhamer D, Tobias J, Grant G, Abel T, Bucan M. 2007. Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse. Genes Brain Behav 6:77-96. (Pubitemid 46090335)
50. Yuste R, Bonhoeffer T. 2001. Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci 24:1071-1089. (Pubitemid 32695254)
51. Zeng X, Sun M, Liu L, Chen F, Wei L, Xie W. 2007. Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila. FEBS Lett 581:2509. (Pubitemid 46779043)
52. Zhu Y, Parada LF. 2001a. Neurofibromin, a tumor suppressor in the nervous system. Exp Cell Res 264:19-28. (Pubitemid 32989078)
53. Zhu Y, Parada LF. 2001b. A particular GAP in mind. Nat Genet 27:354-355.