Bovine colostrum supplementation and exercise performance: Potential mechanisms

Sports Medicine

Volumn 39, Issue 12, 2009, Pages 1033-1054

  Shing, Cecilia M ^a   Hunter, Denise C ^b,c   Stevenson, Lesley M ^b,c  

^a UNIVERSITY OF TASMANIA   (Australia)

^b SOUTHERN CROSS UNIVERSITY   (Australia)

^c THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLUCOCORTICOID; GONADORELIN; GROWTH HORMONE; IMMUNOGLOBULIN; LACTOFERRIN; LYSOZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR;

ANAEROBIC EXERCISE; ATHLETE; ATHLETIC PERFORMANCE; BODY MASS; COLOSTRUM; DIGESTIVE SYSTEM INJURY; ENDURANCE; EXERCISE; GASTROINTESTINAL DISEASE; HUMAN; IMMUNE FUNCTION TEST; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; KINETICS; LACTATION; MAMMARY GLAND; MILK; MUSCLE CELL; MUSCLE GROWTH; NEUROENDOCRINE SYSTEM; NONHUMAN; REVIEW; SKELETAL MUSCLE; SPORT; SUPPLEMENTATION; TISSUE GROWTH;

ANIMALS; ATHLETIC PERFORMANCE; CATTLE; COLOSTRUM; DIETARY SUPPLEMENTS; FEMALE; IMMUNE SYSTEM; PREGNANCY;

EID: 70449441165     PISSN: 01121642     EISSN: 11792035     Source Type: Journal    
DOI: 10.2165/11317860-000000000-00000     Document Type: Review

References (115)

1. Uruakpa FO, Ismond MAH, Akobundu ENT. Colostrum and its benefits: a review. Nutr Res 2002; 22: 755-767
2. Korhonen H, Marnila P, Gill HS. Milk immunoglobulins and complement factors. Br J Nutr 2000; 84 Suppl. 1: S75-80
3. Hagiwara K, Kataoka S, Yamanaka H, et al. Detection of cytokines in bovine colostrum. Vet Immunol Immuno-pathol 2000; 76: 183-190
4. Mandalapu P, Pabst HF, Paetkau V. A novel immuno-suppressive factor in human colostrum. Cell Immunol 1995; 162: 178-184
5. Ginjala V, Pakkanen R. Determination of transform-ing growth factor-beta 1 (TGF-beta 1) and insulin-like growth factor (IGF-1) in bovine colostrum samples. J Immunoassay 1998; 19: 195-207
6. Blattler U, Hammon HM, Morel C, et al. Feeding colos-trum, its composition and feeding duration variably modify proliferation and morphology of the intestine and digestive enzyme activities of neonatal calves. J Nutr 2001; 131: 1256-1263
7. Mach JP, Pahud JJ. Secretory IgA: a major immuno-globulin in most bovine external secretions. J Immunol 1971; 106: 552-563
8. Suga M, Ando M, Tanaka F, et al. Triggering effects of opsonized-IgG antibody on the superoxide release in the phagosome and phagosome-lysosome fusion by pulmonary alveolar macrophages in rabbits. J Clin Lab Immunol 1990; 33: 55-59
9. Togo S, Shimokawa T, Fukuchi Y, et al. Alternative spli-cing of myeloid IgA Fc receptor (Fc alpha R, CD89) transcripts in inflammatory responses. FEBS Lett 2003; 535: 205-209
10. Pakkanen R, Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J 1997; 7: 285-297
11. Francis GL, Upton FM, Ballard FJ, et al. Insulin-like growth factors 1 and 2 in bovine colostrums: sequences and biological activities compared with those of a potent truncated form. Biochem J 1988; 251: 95-103
12. Fryburg DA, Jahn LA, Hill SA, et al. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 1995; 96: 1722-1729
13. Froesch ER, Hussain MA, Schmid C, et al. Insulin-like growth factor I: physiology, metabolic effects and clinical uses. Diabetes Metab Rev 1996; 12: 195-215
14. Wong WM, Wright NA. Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation. J Parenter Enteral Nutr 1999; 23 (5 Suppl.): S83-8
15. Amarant T, Fridkin M, Koch Y. Luteinizing hormone-releasing hormone and thyrotropin-releasing hormone in human and bovine milk. Eur J Biochem 1982; 127: 647-650
16. Gopal PK, Gill HS. Oligosaccharides and glycoconjugates in bovine milk and colostrum. Br J Nutr 2000; 84 Suppl. 1: S69-74
17. Ceciliani F, Pocacqua V, Provasi E, et al. Identification of the bovine alpha1-acid glycoprotein in colostrum and milk. Vet Res 2005; 36: 735-746
18. van Hooijdonk AC, Kussendrager KD, Steijns JM. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. Br J Nutr 2000; 84 Suppl. 1: S127-34
19. Floren CH, Chinenye S, Elfstrand L, et al. ColoPlus, a new product based on bovine colostrum, alleviates HIV-associated diarrhoea. Scand J Gastroenterol 2006; 41: 682-686
20. Kim JW, Jeon WK, Yun JW, et al. Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pac J Clin Nutr 2005; 14: 103-107
21. Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999; 44: 653-658
22. Playford RJ, MacDonald CE, Calnan DP, et al. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond) 2001; 100: 627-633
23. Patel K, Rana R. Pedimune in recurrent respiratory infec-tion and diarrhea: the Indian experience. The PRIDE study. Indian J Pediatr 2006; 73: 585-591
24. Brinkworth GD, Buckley JD. Concentrated bovine colos-trum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. Eur J Nutr 2003; 42: 228-232
25. McGuire TC, Pfeiffer NE, Weikel JM, et al. Failure of colostral immunoglobulin transfer in calves dying from infectious disease. J Am Vet Med Assoc 1976; 169: 713-718
26. Rea DE, Tyler JW, Hancock DD, et al. Prediction of calf mortality by use of tests for passive transfer of colostral immunoglobulin. J Am Vet Med Assoc 1996; 208: 2047-2049
27. Brignole TJ, Stott GH. Effect of suckling followed by bottle feeding colostrum on immunoglobulin absorption and calf survival. J Dairy Sci 1980; 63: 451-456
28. Walker-Smith JA, Phillips AD, Walford N, et al. Intra-venous epidermal growth factor/urogastrone increases small-intestinal cell proliferation in congenital micro-villous atrophy. Lancet 1985; 2: 1239-1240
29. Steeb CB, Shoubridge CA, Tivey DR, et al. Systemic in-fusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats. Am J Physiol 1997; 272: G522-33
30. Khan Z, Macdonald C, Wicks AC, et al. Use of the 'nutri-ceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study. Aliment Pharmacol Ther 2002; 16: 1917-1922
31. Playford RJ, Woodman AC, Clark P, et al. Effect of luminal growth factor preservation on intestinal growth. Lancet 1993; 341: 843-848
32. Kim JW, Jeon WK, Kim EJ. Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat. Clin Nutr 2005; 24: 785-793
33. Brinkworth GD, Buckley JD. Bovine colostrum supple-mentation does not affect nutrient absorptive capacity in healthy young men. Nutr Res 2003; 23: 1619-1629
34. Salmon H. The mammary gland and neonate mucosal im-munity. Vet Immunol Immunopathol 1999; 72: 143-155
35. Quigley JD, Strohbehn RE, Kost CJ, et al. Formulation of colostrum supplements, colostrum replacers and acquisition of passive immunity in neonatal calves. J Dairy Sci 2001; 84: 2059-2065
36. Stott GH, Marx DB, Menefee BE, et al. Colostral immuno-globulin transfer in calves: I. Period of absorption. J Dairy Sci 1979; 62: 1632-1638
37. Ontsouka CE, Sauter SN, Blum JW, et al. Effects of colostrum feeding and dexamethasone treatment on mRNA levels of insulin-like growth factors (IGF)-I and-II, IGF binding proteins-2 and-3, and on receptors for growth hormone, IGF-I, IGF-II, and insulin in the gastrointestinal tract of neonatal calves. Domest Anim Endocrinol 2004; 26: 155-175
38. Yamanaka H, Hagiwara K, Kirisawa R, et al. Proinflam-matory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Microbiol Immunol 2003; 47: 461-468
39. Elfstrand L, Lindmark-Mansson H, Oaulsson M, et al. Im-munoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing. Int Dairy J 2002; 12: 879-887
40. Boudry C, Buldgena A, Portetelleb D, et al. Effect of bo-vine colostrum supplementation on cytokine mRNA expression in weaned piglets. Livestock Sci 2007; 108: 295-298
41. Shing CM, Peake J, Suzuki K, et al. Bovine colostrum modulates cytokine production in human peripheral blood mononuclear cells stimulated with lipopolysaccharide and phytohemagglutinin. J Int Cyt Res 2007; 27: 835-839
42. Jeukendrup AE, Vet-Joop K, Sturk A, et al. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci (Lond) 2000; 98: 47-55
43. Gleeson M. Mucosal immune responses and risk of re-spiratory illness in elite athletes. Exerc Immunol Rev 2000; 6: 5-42 (Pubitemid 30445600)
44. Shing CM, Peake J, Suzuki K, et al. Effects of bovine co-lostrum supplementation on immune variables in highly trained cyclists. J Appl Physiol 2007; 102: 1113-1122
45. Talukder MJ, Takeuchi T, Harada E. Receptor-mediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves. J Vet Med Sci 2003; 65: 957-964
46. Talukder MJ, Takeuchi T, Harada E. Transport of colos-tral macromolecules into the cerebrospinal fluid via plasma in newborn calves. J Dairy Sci 2002; 85: 514-524
47. Watkins LR, Maier SF. The pain of being sick: implica-tions of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000; 51: 29-57
48. Maso F, Lac G, Filaire E, et al. Salivary testosterone and cortisol in rugby players: correlation with psychological overtraining items. Br J Sports Med 2004; 38: 260-263
49. Marshall-Gradisnik SM, Sample R, O'Leary L, et al. Im-provements in health and psychological indicators in healthy males after eight-week bovine colostrum powder supplementation [abstract]. Aust J Dairy Technol 2003; 58: 197
50. Filaire E, Legrand B, Lac G, et al. Training of elite cyclists: effects on mood state and selected hormonal responses. J Sports Sci 2004; 22: 1025-1033
51. Odland L, Wallin S, Walum E. Lipid peroxidation and activities of tyrosine aminotransferase and glutamine synthetase in hepatoma and glioma cells grown in bovine colostrum-supplemented medium. In Vitro Cell Dev Biol 1986; 22: 259-262
52. Przybylska J, Albera E, Kankofer M. Antioxidants in bovine colostrum. Reprod Domest Anim 2007; 42: 402-409
53. Korhonen BH. Antimicrobial factors in bovine colsotrum. J Sci Agric Soc Finland 1977; 49: 434-447
54. Torre C, Jeusette I, Serra M, et al. Bovine colostrum increases proliferation of canine skin fibroblasts. J Nutr 2006; 136: 2058S-60
55. Sporn MB, Roberts AB, Shull JH, et al. Polypeptide trans-forming growth factors isolated from bovine sources and used for wound healing in vivo. Science 1983; 219: 1329-1331
56. Mero A, Miikkulainen H, Riski J, et al. Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. J Appl Physiol 1997; 83: 1144-1151
57. Hofman Z, Smeets R, Verlaan G, et al. The effect of bovine colostrum supplementation on exercise performance in elite field hockey players. Int J Sport Nutr Exerc Metab 2002; 12: 461-469
58. Buckley JD, Brinkworth GD, Abbott MJ. Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I. J Sports Sci 2003; 21: 577-588
59. Leppaluoto J, Rasi S, Martikkala V, et al. Bovine colos-trum supplementation enhances physical performance on maximal exercise tests. 2000 Pre-Olympic Congress Sports Medicine and Physical Education International Congress on Sport Science; 2000 Sep 7-13: Brisbane (QLD)
60. Coombes JS, Conacher M, Austen SK, et al. Dose effects of oral bovine colostrum on physical work capacity in cyclists. Med Sci Sports Exerc 2002; 34: 1184-1188
61. Buckley JD, Abbott MJ, Brinkworth GD, et al. Bovine colostrum supplementation during endurance running training improves recovery, but not performance. J Sci Med Sport 2002; 5: 65-79
62. Kerksick C, Kreider R, Rasmussen C, et al. Effects of bovine colostrum supplementation on training adaptations II: performance [abstract]. FASEB J 2001; 15: LB315
63. Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition 2001; 17: 243-247
64. Fry A, Schilling B, Chiu L, et al. Muscle fibre and perfor-mance adaptations to resistance exercise with MyoVive, colostrum or casein and whey supplementation. Res Sports Med 2003; 11: 109-127
65. Kreider R, Rasmussen C, Kerksick C, et al. Effects of bo-vine colostrum supplementation on training adaptations: I. Body composition [abstract]. FASEB J 2001; 15: LB316
66. Hoffman JR, Kang J, Ratamess NA, et al. Biochemical and hormonal responses during an intercollegiate football season. Med Sci Sports Exerc 2005; 37: 1237-1241
67. Brinkworth GD, Buckley JD, Bourdon PC, et al. Oral bovine colostrum supplementation enhances buffer capacity but not rowing performance in elite female rowers. Int J Sport Nutr Exerc Metab 2002; 12: 349-365
68. Mero A, Nykanen T, Rasi S, et al. IGF-1, IGFBP-3, growth hormone and testosterone in male and female athletes during bovine colostrum supplementation [abstract]. Med Sci Sports Exerc 2002; 35: s299
69. O'Leary L. Assessment of anaerobic performance in heal-thy males after an eight week concentrated bovine colostrum supplementation. Australian Conference of Science and Medicine in Sport; 2003 Oct 25-28: Canberra (ACT)
70. Brinkworth GD, Buckley JD, Slavotinek JP, et al. Effect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young men. Eur J Appl Physiol 2004; 91 (1): 53-60
71. Brinkworth GD, Buckley JD. Bovine colostrum supple-mentation does not affect plasma buffer capacity or haemoglobin content in elite female rowers. Eur J Appl Physiol 2004; 91: 353-356
72. Sample R, O'Leary L, Myers S, et al. Bovine colostrum supplementation and its effect on muscle histology, strength, performance and body composition in the elderly [abstract]. J Sci Med Sport 2004; 7: S16
73. Mero A, Nykanen T, Keinanen O, et al. Protein metabo-lism and strength performance after bovine colostrum supplementation. Amino Acids 2005; 28: 327-335
74. Crooks C, Wall C, Cross M, et al. The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab 2006; 16: 47-64
75. Shing CM, Jenkins DG, Stevenson L, et al. The influence of bovine colostrum supplementation on exercise performance in highly-trained cyclists. Br J Sports Med 2006; 40: 797-801
76. Kuhne S, Hammon HM, Bruckmaier RM, et al. Growth per-formance, metabolic and endocrine traits, and absorptive capacity in neonatal calves fed either colostrum or milk replacer at two levels. J Anim Sci 2000; 78: 609-620
77. Hammon H, Blum JW. The somatotropic axis in neonatal calves can be modulated by nutrition, growth hormone, and Long-R3-IGF-I. Am J Physiol 1997; 273: E130-8
78. Sacheck JM, Ohtsuka A, McLary SC, et al. IGF-I stimu-lates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 2004; 287: E591-601
79. Malisoux L, Francaux M, Nielens H, et al. Calcium sensi-tivity of human single muscle fibers following plyometric training. Med Sci Sports Exerc 2006; 38: 1901-1908
80. Mero A, Kahkonen J, Nykanen T, et al. IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training. J Appl Physiol 2002; 93: 732-739
81. Kimura T, Murakawa Y, Ohno M, et al. Gastrointestinal absorption of recombinant human insulin-like growth factor-1 in rats. J Pharmacol Exp Ther 1997; 283: 611-618 (Pubitemid 27514617)
82. Kuipers H, van Breda E, Verlaan G, et al. Effects of oral bovine colostrum supplementation on serum insulin-like growth factor-I levels. Nutrition 2002; 18: 566-567
83. Nemet D, Pontello AM, Rose-Gottron C, et al. Cytokines and growth factors during and after a wrestling season in adolescent boys. Med Sci Sports Exerc 2004; 36: 794-800
84. Steimer KS, Packard R, Holden D, et al. The serum-free growth of cultured cells in bovine colostrum and in milk obtained later in the lactation period. J Cell Physiol 1981; 109: 223-234
85. Donath MY, Jenni R, Brunner HP, et al. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans. J Clin Endocrinol Metab 1996; 81: 4089-4094
86. Hussain MA, Schmitz O, Mengel A, et al. Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans. J Clin Invest 1994; 94: 1126-1133
87. Buckley J, Abbott M, Martin S, et al. Effects of an oral bovine colostrum supplement (intact TM) on running performance. Australian Conference of Science and Medicine in Sport; 1998 Oct 13-16; Adelaide (SA)
88. Hammon HM, Sauter SN, Reist M, et al. Dexamethasone and colostrum feeding affect hepatic gluconeogenic enzymes differently in neonatal calves. J Anim Sci 2003; 81: 3095-3106
89. Hawley JA, Palmer GS, Noakes TD. Effects of 3 days of carbohydrate supplementation on muscle glycogen content and utilisation during a 1-h cycling performance. Eur J Appl Physiol Occup Physiol 1997; 75: 407-412
90. Kavouras SA, Troup JP, Berning JR. The influence of low versus high carbohydrate diet on a 45-min strenuous cycling exercise. Int J Sport Nutr Exerc Metab 2004; 14: 62-72
91. McInerney P, Lessard SJ, Burke LM, et al. Failure to re-peatedly supercompensate muscle glycogen stores in highly trained men. Med Sci Sports Exerc 2005; 37: 404-411
92. Karlsson J, Saltin B. Diet, muscle glycogen, and endurance performance. J Appl Physiol 1971; 31: 203-206
93. Rauprich AB, Hammon HM, Blum JW. Influence of feeding different amounts of first colostrum on metabolic, endocrine, and health status and on growth performance in neonatal calves. J Anim Sci 2000; 78: 896-908
94. Nieman DC. Is infection risk linked to exercise workload? Med Sci Sports Exerc 2000; 32: S406-11
95. Atlaoui D, Duclos M, Gouarne C, et al. The 24-h urinary cortisol/cortisone ratio for monitoring training in elite swimmers. Med Sci Sports Exerc 2004; 36: 218-224
96. Halson SL, Bridge MW, Meeusen R, et al. Time course of performance changes and fatigue markers during intensified training in trained cyclists. J Appl Physiol 2002; 93: 947-956
97. Halson SL, Lancaster GI, Jeukendrup AE, et al. Immuno-logical responses to overreaching in cyclists. Med Sci Sports Exerc 2003; 35: 854-861
98. Fitzgerald L. Overtraining increases the susceptibility to infection. Int J Sports Med 1991; 12 Suppl. 1: S5-8
99. Gleeson M. Assessing immune function changes in exercise and diet intervention studies. Curr Opin Clin Nutr Metab Care 2005; 8: 511-515
100. McKune AJ, Smith LL, Semple SJ, et al. Immunoglobulin responses to a repeated bout of downhill running. Br J Sports Med 2006 Oct; 40: 844-849
101. McKune AJ, Smith LL, Semple SJ, et al. Influence of ultra-endurance exercise on immunoglobulin isotypes and subclasses. Br J Sports Med 2005; 39: 665-670
102. McKune AJ, Smith LL, Semple SJ, et al. Changes in mu-cosal and humoral atopic-related markers and immuno-globulins in elite cyclists participating in the Vuelta a Espana. Int J Sports Med 2006; 27: 560-566
103. Biron CA. Cytokines in the generation of immune re-sponses to, and resolution of, virus infection. Curr Opin Immunol 1994; 6: 530-538
104. Sethi SK, Bianco A, Allen JT, et al. Interferon-gamma (IFN-gamma) down-regulates the rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) on human airway epithelial cells. Clin Exp Immunol 1997; 110: 362-369
105. Bachert C, van Kempen MJ, Hopken K, et al. Elevated levels of myeloperoxidase, pro-inflammatory cytokines and chemo-kines in naturally acquired upper respiratory tract infections. Eur Arch Otorhinolaryngol 2001; 258: 406-412
106. Carmichael MD, Davis JM, Murphy EA, et al. Role of brain IL-beta on fatigue following exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol 2006; 291 (5): R1344-8
107. Lakier Smith L. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med 2003; 33: 347-364
108. Lambert GP, Broussard LJ, Mason BL, et al. Gastro-intestinal permeability during exercise: effects of aspirin and energy-containing beverages. J Appl Physiol 2001; 90: 2075-2080
109. Prosser C, Stelwagen K, Cummins R, et al. Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders. J Appl Physiol 2004; 96: 650-654
110. Lim CL, Wilson G, Brown L, et al. Pre-existing inflam-matory state compromises heat tolerance in rats exposed to heat stress. Am J Physiol Regul Integr Comp Physiol 2007; 292: R186-94
111. Buckley JD, Brinkworth GD, Southcott E, et al. Bovine colostrum and whey protein supplementation during running training increase intestinal permeability [abstract]. Asia Pac J Clin Nutr 2004; 13: S81
112. Caradonna L, Amati L, Magrone T, et al. Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance. J Endotoxin Res 2000; 6: 205-214
113. Spiekermann GM, Finn PW, Ward ES, et al. Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med 2002; 196: 303-310
114. Roos N, Mahe S, Benamouzig R, et al. 15N-labeled im-munoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J Nutr 1995; 125: 1238-1244
115. Davis PF, Greenhill NS, Rowan AM, et al. The safety of New Zealand bovine colostrum: nutritional and physiological evaluation in rats. Food Chem Toxicol 2007; 45: 229-36