Phytomedicines prepared from Arnica flowers inhibit the transcription factors AP-1 and NF-B and modulate the activity of MMP1 and MMP13 in human and bovine chondrocytes

Planta Medica

Volumn 75, Issue 12, 2009, Pages 1319-1325

  Jäger, Christoph ^a   Hrenn, Andrea ^a   Zwingmann, Jörn ^b   Suter, Andreas ^c   Merfort, Irmgard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Bioforce AG   (Switzerland)

Author keywords

AP 1; Arnica montana; Asteraceae; MMP1 and MMP13; NF B; Osteoarthritis; Sesquiterpene lactones

Indexed keywords

ARNICA MONTANA EXTRACT; COLLAGENASE 3; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MESSENGER RNA; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DNA BINDING; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; OSTEOARTHRITIS; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ARNICA; CATTLE; CELLS, CULTURED; CHONDROCYTES; GENE EXPRESSION; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; NF-KAPPA B; PLANT PREPARATIONS; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1;

ARNICA; ARNICA MONTANA; ASTERACEAE; BOVINAE;

EID: 70449337920     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185668     Document Type: Article

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