Studies on the anti-inflammatory activity of phytopharmaceuticals prepared from Arnica flowers

Planta Medica

Volumn 68, Issue 5, 2002, Pages 385-391

  Klaas, Christoph A ^a   Wagner, Gerd ^b   Laufer, Stefan ^b   Sosa, Silvio ^c   Della Loggia, Roberto ^c   Bomme, Ulrich ^d   Pahl, Heike L ^e   Merfort, Irmgard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF TRIESTE   (Italy)

^d Bayerische Landesanstalt für Bodenkultur und Pflanzenbau   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anti inflammatory activity; Arnica montana; Asteraceae; IL 1 ; Mouse ear edema; NF AT; NF B; Sesquiterpene lactones; TNF

Indexed keywords

11ALPHA,13 DIHYDROHELENALIN DERIVATIVE; ANTIINFLAMMATORY AGENT; ARNICA MONTANA EXTRACT; CROTON OIL; CYTOKINE; HELENALIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; METHACRYLIC ACID; SESQUITERPENE LACTONE DERIVATIVE; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EAR DISEASE; EDEMA; ELECTROPHORETIC MOBILITY; FLOWER; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL LINE; MEDIATOR; PHYTOCHEMISTRY; SPAIN;

ARNICA; ARNICA MONTANA; ASTERACEAE; CROTON;

EID: 0036273516     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-32067     Document Type: Article

References (22)

1. Arnica flowers; pharmacology, toxicology and analysis of the sesquiterpene lactones - Their main active substances
2. Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB
3. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65
4. Anti-inflammatory activity of Arnica tincture (DAB 1998) using the transcription factor NF-κB as molecular target
5. NF-κB a key role in inflammatory diseases
6. The role of NF-AT transcription factors in T cell activation and differentiation
7. Arnika - Arzneipflanze mit Tradition und Zukunft
8. Helenalin- und 11α,13-Dihydrohelenalinester aus Blüten von Arnica montana
9. Zur qualitativen und quantitativen analyse der sesquiterpenlactone von Arnikablüten DAB 9
10. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
11. The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer
12. The croton oil ear test revisited
13. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
14. Inhibition of transcription factor NF-κB by sesquiterpene lactones - A proposed molecular mechanism of action and structure activity relationships
15. Molecular insights into rheumatoid arthritis
16. Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-κB
17. Time-dependent cytokine production in the croton oil-induced mouse ear oedema and inhibition by prednisolone
18. The mechanism of action of cyclosporin A and FK506
19. Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter
20. Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell