Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study

Rheumatology International

Volumn 27, Issue 6, 2007, Pages 585-591

  Widrig, Reto ^a   Suter, Andy ^b   Saller, Reinhard ^c   Melzer, Jörg ^c  

^a Rheumatology Clinic   (Switzerland)

^b Bioforce AG   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Arnica gel; Gel treatment; Ibuprofen gel; Osteoarthritis; Randomised trial

Indexed keywords

A VOGEL ARNICA GEL; ACETYLSALICYLIC ACID; ARNICA MONTANA EXTRACT; IBUPROFEN; UNCLASSIFIED DRUG;

ADNEXITIS; ADULT; ADVERSE OUTCOME; AGED; ANALGESIA; ARTICLE; BACKACHE; BRONCHITIS; CHILL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTITIS; DOUBLE BLIND PROCEDURE; ECZEMA; ERYTHEMA; FEMALE; GEL; HAND; HAND FUNCTION; HUMAN; INTERPHALANGEAL JOINT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OSTEOARTHRITIS; PAIN; PAIN ASSESSMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; RADIODIAGNOSIS; RANDOMIZED CONTROLLED TRIAL; RHINITIS; SKIN IRRITATION; SKIN PRURITUS; STATISTICAL ANALYSIS; SYMPTOMATOLOGY; THORAX PAIN; TREATMENT DURATION; VERTIGO; XERODERMA;

ADMINISTRATION, TOPICAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARNICA; DOUBLE-BLIND METHOD; FINGER JOINT; GELS; HAND; HUMANS; IBUPROFEN; OSTEOARTHRITIS; PHYTOTHERAPY; PLANT PREPARATIONS; TREATMENT OUTCOME;

EID: 33947165396     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-007-0304-y     Document Type: Article

References (29)

1. Zhang Y, Niu J, Kelly-Hayes M et al (2002) Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: the Framingham Study. Am J Epidemiol 156:1021-1027
2. Hochberg MC, Vignon E, Maheu E (2000) Clinical assessment of hand OA. Osteoarthr Cartil 8(Suppl A):S38-S40
3. Stamm TA, Machold KP, Smolen JS et al (2002) Joint protection and home hand exercises improve hand function in patients with hand osteoarthritis: a randomized controlled trial. Arthritis Rheum 47:44-49
4. Moore N (2003) Forty years of ibuprofen use. Int J Clin Pract 135(Suppl Apr):28-31
5. Heyneman CA, Lawless-Liday C, Wall GC (2000) Oral versus topical NSAIDs in rheumatic diseases. Drugs 60:555-574
6. Moore RA, Tramèr MR, Carroll D et al (1998) Quantitative systematic review of topically applied non-steroidal antiinflammatory drugs. BMJ 316:333-338
7. Ramesh N, Steuber U (1983) Dolgit® cream in accident- and sports-related injuries in medical practice. Results of a double blind study. Therapiewoche 33:4563-4570
8. Machen J, Whitefield M (2002) Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomised, double-blind, placebo-controlled study. Int J Clin Pract 56:102-106
9. Dreiser RL (1988) Clinical trial of efficacy and tolerability of topical ibuprofen in the treatment of tendonitis. Le J Int Méd 119:15-31
10. Nasonova VA Muravyev IuV, Nasonov EL et al (1995) Local application of dolgit cream in patients with osteoarthritis: multicentre study of efficacy and tolerance. Ter Arkh 67:48-50
11. Guillaume M (1988) Clinical study on the efficacy and tolerability of percutaneous ibuprofen for the symptomatic treatment of arthrosis of small joints. Etude clinique de l'efficacité et de la tolérance de l'ibuprofène percutané dans le traitement symptomatique de l'arthrose des petites articulations. J Intern Med 2:1-4
12. Trnavsky K, Fischer M, Voegtle-Junkert U, Schreyger F (2004) Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study. J Rheumatol 31:565-572
13. Dominkus M, Nicolakis M, Kotz R et al (1996) Comparison of tissue and plasma levels of ibuprofen after oral and topical administration. Arzneimittelforschung 46:1138-1143
14. Steen AE, Reeh PW, Geisslinger G et al (2004) Plasma levels after peroral and topical ibuprofen and effects upon low pH induced cutaneous and muscle pain. Eur J Pain 4:195-209
15. Ernst E (2004) Musculoskeletal conditions and complementary/alternative medicine. Best Pract Res Clin Rheumatol 18:539-556
16. Mayer JG et al (2000) Arnica montana or Mountain Arnica - a cultural-historical essay and on the problems of writing such an essay. Arnica montana L., oder Bergwohlverleih - Ein kulturhistorischer Essay - und über die Schwierigkeiten einen solchen zu verfassen. Zeitschrift für Phytotherapie 21:30-36
17. Knuesel O, Weber M, Suter A (2002) Arnica montana gel in osteoarthritis of the knee: an open, multicentre clinical trial. Adv Ther 19:209-218
18. Lyss G, Schmidt TJ, Merfort I et al (1997) Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-KappaB. Biol Chem 378:951-961
19. De Bosscher K, Vanden Berghe W, Vermeulen L et al (2000) Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc Nat Acad Sci 97:3919-3924
20. Wagner S, Suter A, Merfort I (2004) Skin penetration studies of Arnica preparations and of their sesquiterpene lactones. Planta Med 70:897-903
21. Altman R, Alarcon G, Appelrouth D et al (1990) The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum 33:1601-1610
22. Lequesne MG, Maheu E (2000) Methodology of clinical trials in hand osteoarthritis: conventional and proposed tools. Osteoarthr Cartil 8(Suppl A):S64-S69
23. European Medicines Agency (EMEA) Guideline on the choice of non-inferiority margin. [Document locator: CPMP/ EWP/2158/99]. Available from: http://www.emea.eu.int/pdfs/human/ewp/215899en.pdf (Accessed: 25.04.06)
24. European Medicines Agency (EMEA) Note for Guidance on Choice of Control Groups in Clinical Trials. (Document locator: CPMP/ICH/364/96). Available from: http://www.emea.eu.int/pdfs/human/ich/036496en.pdf (Accessed: 25.04.06)
25. Dreiser RL, Maheu E, Guillou GB et al (1995) Validation of an algofunctional index for osteoarthritis of the hand. Rev Rhum Engl Ed 62(6 Suppl 1):S43-S53
26. Vaile J, Davis P (1998) Topical NSAIDs for musculoskeletal conditions. A review of the literature. Drugs 56:783-799
27. Lin J, Zhand W, Jones A, Doherty M (2004) Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials. BMJ 329(7461):324
28. Cooper C (2004) Topical NSAIDs in osteoarthritis. BMJ 329:304-305
29. Whitefield M, O'Kane CJA (2002) Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study. J Clin Pharm Ther 27:409-417