Protein kinase inhibition differentially regulates organic cation transport

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 10, 2009, Pages 821-830

  Gerlyand, Alexander M ^a   Sitar, Daniel S ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Amantadine; HEK293 cells; Kidney; Organic cation transport; rOCT1; rOCT2; Tetraethylammonium

Indexed keywords

ADENYLATE CYCLASE; AMANTADINE; BICARBONATE; CYCLIC AMP; FORSKOLIN; GLUCOSE; INSULIN; LACTIC ACID; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; PROTEIN KINASE INHIBITOR; TETRYLAMMONIUM;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENYLATE CYCLASE; AMANTADINE; BICARBONATES; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD GLUCOSE; CELL LINE; CYCLIC AMP; FORSKOLIN; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECOMBINANT PROTEINS; TETRAETHYLAMMONIUM COMPOUNDS;

EID: 70449117878     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-072     Document Type: Article

References (52)

1. Berkhin, E.B., and Humphreys, M.H. 2001. Regulation of renal tubular secretion of organic compounds. Kidney Int. 59(1): 17-30. doi:10.1046/j.1523- 1755.2001.00461.x. PMID:11135053.
2. Blecher, M., Merlino, N.S., and Ro'Ane, J.T. 1968. Controle of the metabolism and lipolytic effects of cyclic 3′,5′-adenosine monophosphate in adipose tissue by insulin, methyl xanthines, and nicotinic acid. J. Biol. Chem. 243(14): 3973-3977. PMID:4298515.
3. Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature, 414(6865): 813-820. doi:10.1038414813a. PMID:11742414. (Pubitemid 34000785)
4. Burckhardt, C., and Wolff, N.A. 2000. Structure of renal organic anion and cation transporters. Am. J. Physiol. Renal Physiol. 278(6): F853-F866. PMID:10836973.
5. Butcher, R.W., and Sutherland, E.W. 1967. The effects of the catecholamines, adrenergic blocking agents, prostaglandin E1, and insulin on cyclie AMP levels in the rat epididymal fat pad in vitro. Ann. N. Y. Acad. Sci. 139(3): 849-859. doi:10.1111/j.1749-6632.1967.tb41255.x. PMID:4382732.
6. Butcher, R.W., Sneyd, J.G., Park, C.R., and Sutherland, E.W., Jr. 1966. Effect of insulin on adenosine 3′,5′-monophosphate in the rat epididymal fat pad. J. Biol. Chem. 241(7): 1651-1653. PMID:5946622.
7. Butler, A.A., and LeRoith, D. 2001. Minireview: tissue-specific versus generalized gene targeting of the igfl and igflr genes and their roles in insulin-like growth factor physiology. Endocrinology, 142(5): 1685-1688. doi:10.1210/en.142.5.1685. PMID:11316729. (Pubitemid 32405920)
8. Cetinkaya, I., Ciarimboli, G., Yalçinkaya, G., Mehrens, T., Velic, A., Hirsch, J.R., et al. 2003. Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. Am. J. Physiol. Renal Physiol. 284(2): F293-F302. PMID:12388397.
9. Chen, Y., Cann, M.J., Litvin, T.N., Iourgenko, V., Sinclair, M.L., Levin, L.R., and Buck, J. 2000. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science, 289(5479): 625-628. doi:10.1126/science. 289.5479.625. PMID:10915626. (Pubitemid 30622067)
10. Ciarimboli, G., and Schlatter, E. 2005. Regulation of organic cation transport. Pflugers Arch. 449(5): 423-441. doi:10.1007/s00424-004-1355-5.
11. Ciarimboli, G., Koepsell, H., Iordanova, M., Gorboulev, V., Dürner, B., Lang, D., et al. 2005. Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation. J. Am. Soc. Nephrol. 16(6): 1562-1570. doi:10.1681/ASN.2004040256. PMID:15829703.
12. Dremier, S., Coulonval, K., Perpete, S., Vandeput, F., Fortemaison, N., Van Keymeulen, A., et al. 2002. The role of cyclic AMP and its effect on protein kinase A in the mitogenic action of thyrotropin on the thyroid cell. Ann. N. Y. Acad. Sci. 968(1): 106-121. doi:10.1111/j.1749-6632.2002.tb04330.x. PMID:12119271.
13. Dumortier, F., Vanhalewyn, M., Debast, C., Colombo, S., Ma, P., Winderickx, J., et al. 2000. A specific mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K176M, eliminates glucose-and acidification-induced cAMP signalling and delays glucose-induced loss of stress resistance. Int. J. Food Microbiol. 55(1-3): 103-107. doi:10.1016/S0168-1605(00)00184-7. PMID:10791726.
14. 2+ release kinetics of the type I and III InsP3 receptors. Biochem. Biophys. Res. Commun. 302(1): 121-126. doi:10.1016/S0006-291X(03)00120-7. PMID:12593857.
15. Escobar, M.R., and Sitar, D.S. 1995. Site-selective effect of bicarbonate on amantadine renal transport: quinine-sensitive in proximal vs quinidine-sensitive sites in distal tubules. J. Pharmacol. Exp. Ther. 273(1): 72-79. PMID:7714816.
16. Escobar, M.R., Goralski, K., and Sitar, D.S. 1995. L(+)- and D(-)-lactate modulate rat renal tubular accumulation of amantadine in the presence and absence of bicarbonate. J. Pharmacol. Exp. Ther. 275(3): 1317-1323. PMID:8531098.
17. Escorbar, M.R., Wong, L.T., and Sitar, D.S. 1994. Bicarbonate-dependent amantadine transport by rat renal cortical proximal and distal tubules. J. Pharmacol. Exp. Ther. 270(3): 979-986. PMID:7932210.
18. Goralski, K.B., and Sitar, D.S. 1999. Tetraethylammonium and amantadine identify distinct organic cation transporters in rat renal cortical proximal and distal tubules. J. Pharmacol. Exp. Ther. 290(1): 295-302. PMID:10381790.
19. Goralski, K.B., Stupack, D.G., Hatch, G.M., and Sitar, D.S. 2001. Perturbation of rat renal tubule transport of the organic cation amantadine in recent onset streptozotocin-induced diabetes and in uninephrectomy. Can. J. Physiol. Pharmacol. 79(1): 18-24. doi:10.1139/cjpp-79-1-18. PMID:11201497.
20. Goralski, K.B., Lou, G., Prowse, M.T., Gorboulev, V., Volk, C., Koepsell, H., and Sitar, D.S. 2002. The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J. Pharmacol. Exp. Ther. 303(3): 959-968. doi:10.1124/jpet. 102.038885. PMID:12438515.
21. Gomall, A.G., Bardawill, C.J., and David, M.M. 1949. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177(2): 751-766. PMID:18110453.
22. Grellier, P., Sabbah, M., Fouqueray, B., Woodruff, K., Yee, D., Abboud, H.E., and Abboud, S.L. 1996. Characterization of insulin-like growth factor binding proteins and regulation of IGFBP3 in human mesangial cells. Kidney Int. 49(4): 1071-1078. doi:10.1038/ki.1996.156. PMID:8691727. (Pubitemid 26124366)
23. Grover, B., Auberger, C., Sarangarajan, R., and Cacini, W. 2002. Functional impairment of renal organic cation transport in experimental diabetes. Pharmacol. Toxicol. 90(4): 181-186. doi:10.1034/j.1600-0773.2002. 900402.x. PMID:12076311.
24. Grover, B., Buckley, D., Buckley, A.R., and Cacini, W. 2004. Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes. J. Pharmacol. Exp. Ther. 308(3): 949-956. doi:10.1124/jpet.103.058388. PMID:14718608.
25. Gründemann, D., Gorboulev, V., Gambaryan, S., Veyhl, M., and Koepsell, H. 1994. Drug excretion mediated by a new prototype of polyspecific transporter. Nature, 372(6506): 549-552. doi:10.1038/372549a0. PMID:7990927. (Pubitemid 24368536)
26. Inui, K.I., Masuda, S., and Saito, H. 2000. Cellular and molecular aspects of drug transport in the kidney. Kidney Int. 58(3): 944-958. doi:10.1046/j.1523-1755.2000.00251.x. PMID:10972658. (Pubitemid 30678018)
27. Jonker, J.W., and Schinkel, A.H. 2004. Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3). J. Pharmacol. Exp. Ther. 308(1): 2-9. doi:10.1124/jpet.103.053298. PMID:14576340.
28. Koepsell, H., Gorboulev, V., and Arndt, P. 1999. Molecular pharmacology of organic cation transporters in kidney. J. Membr. Biol. 167(2): 103-117. doi:10.1007/s002329900475. PMID:9916142.
29. Mehrens, T., Lelleck, S., Cetinkaya, I., Knollmann, M., Hohage, H., Gorboulev, V., et al. 2000. The affinity of the organic cation transporter rOCT1 is increased by protein kinase C-dependent phosphorylation. J. Am. Soc. Nephrol. 11(7): 1216-1224. PMID:10864577.
30. Miele, C., Rochford, J.J., Filippa, N., Giorgetti-Peraldi, S., and Van Obberghen, E. 2000. Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J. Biol. Chem. 275(28): 21695-21702. doi:10.1074/jbc.M000805200. PMID:10777488.
31. Nilius, B., and Droogmans, G. 2001. Ion channels and their functional role in vascular endothelium. Physiol. Rev. 81(4): 1415-1459. PMID:11581493.
32. Patti, M.E., and Kahn, C.R. 1998. The insulin receptor-a critical link in glucose homeostasis and insulin action. J. Basic Clin. Physiol. Pharmacol. 9(2-4): 89-109. PMID:10212828.
33. Pietig, G., Mehrens, T., Hirsch, J.R., Cetinkaya, I., Piechota, H., and Schlatter, E. 2001. Properties and regulation of organic cation transport in freshly isolated human proximal tubules. J. Biol. Chem. 276(36): 33741-33746. doi:10.1074/jbc.M104617200. PMID:11447227.
34. Popp, C., Gorboulev, V., Müller, T.D., Gorbunov, D., Shatskaya, N., and Koepsell, H. 2005. Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Mol. Pharmacol. 67(5): 1600-1611. doi:10.1124/mol.104.008839. PMID:15662044.
35. Ramsammy, L.S., Josepovitz, C., Jones, D., Ling, K.Y., Lane, B.P., and Kaloyanides, G.J. 1987. Induction of nephrotoxicity by high doses of gentamicin in diabetic rats. Proc. Soc. Exp. Biol. Med. 186(3): 306-312. PMID:3423018.
36. Rich, T.C., Fagan, K.A., Nakata, H., Schaack, J., Cooper, D.M., and Karpen, J.W. 2000. Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion. J. Gen. Physiol. 116(2): 147-161. doi:10.1085/jgp.116.2.147. PMID:10919863.
37. Rolland, F., De Winde, J.H., Lemaire, K., Boles, E., Thevelein, J.M., and Winderickx, J. 2000. Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process. Mol. Microbiol. 38(2): 348-358. doi:10.1046/j.1365-2958.2000.02125.x. PMID:11069660.
38. Schmitt, B.M., and Koepsell, H. 2005. Alkali cation binding and permeation in the rat organic cation transporter rOCT2. J. Biol. Chem. 280(26): 24481-24490. doi:10.1074/jbc.M414550200. PMID:15878879.
39. Scott, L.A., Madan, E., and Valentovic, M.A. 1990. Influence of streptozotocin (STZ)-induced diabetes, dextrose diuresis and acetone on cisplatin nephrotoxicity in Fischer 344 (F344) rats. Toxicology, 60(1-2): 109-125. doi:10.1016/0300483X(90)90166-E. PMID:2107603.
40. Steen, H., Oosting, R., and Meijer, D.K. 1991. Mechanisms for the uptake of cationic drugs by the liver: a study with tributylmethylammonium (TBuMA). J. Pharmacol. Exp. Ther. 258(2): 537-543. PMID:1865356.
41. Sweet, D.H., Miller, D.S., and Pritchard, J.B. 2000. Basolateral localization of organic cation transporter 2 in intact renal proximal tubules. Am. J. Physiol. Renal Physiol. 279(5): F826-F834. PMID:11053042.
42. Takahashi, N., Ito, O., and Abe, K. 1996. Tubular effects of insulin. Hypertens. Res. 19(Suppl 1): S41-S45. doi:10.1291/hypres.19.SupplementI-S41. PMID:9240763.
43. Teixeira, R.B., Kelley, J., Alpert, H., Pardo, V., and Vaamonde, C.A. 1982. Complete protection from gentamicin-induced acute renal failure in the diabetes mellitus rat. Kidney Int. 21(4): 600-612. doi:10.1038/ki.1982.67. PMID:7098275.
44. The Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329(14): 977-986. doi:10.1056/NEJM199309303291401. PMID:8366922.
45. Thevelein, J.M., and de Winde, J.H. 1999. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 33(5): 904-918. doi:10.1046/j.1365-2958.1999.01538. x. PMID:10476026.
46. UK Prospective Diabetes Study (UKPDS) Group. 1998. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet, 352(9131): 837-853. doi:10.1016/S0140-6736(98)07019-6. PMID:9742976.
47. -, pH; inhibition by aliphatic primary, secondary and tertiary amines and mono- and bisquaternary compounds. Pflugers Arch. 419(1): 84-92. doi:10.1007/BF00373751. PMID:1834988.
48. Urakami, Y., Okuda, M., Masuda, S., Saito, H., and Inui, K.I. 1998. Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J. Pharmacol. Exp. Ther. 287(2): 800-805. PMID:9808712.
49. Valentovic, M.A., Ball, J.G., Elliott, C., and Madan, E. 1989. Cephaloridine nephrotoxicity in streptozotocin induced diabetic Fischer 344 (F344) rats. Toxicology, 57(2): 193-207. doi:10.1016/0300483X(89)90165-90170 PMID:2749746.
50. Volk, C., Gorboulev, V., Budiman, T., Nagel, C., and Koepsell, H. 2003. Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2. Mol. Pharmacol. 64(5): 1037-1047. doi:10.1124/mol.64.5.1037. PMID:14573752.
51. Wright, S.H., Evans, K.K., Zhang, X., Cherrington, N.J., Sitar, D.S., and Dantzler, W.H. 2004. Functional map of TEA transport activity in isolated rabbit renal proximal tubules. Am. J. Physiol. Renal Physiol. 287(3): F442-F451. doi:10.1152/ajprenal.00115.2004. PMID:15126247.
52. Zippin, J.H., Levin, L.R., and Buck, J. 2001. CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor. Trends Endocrinol. Metab. 12(8): 366-370. doi:10.1016/S1043-2760(01)004544. PMID:11551811.