The global cysteine peptidase landscape in parasites

Trends in Parasitology

Volumn 25, Issue 12, 2009, Pages 573-581

  Atkinson, Holly J ^a   Babbitt, Patricia C ^b   Sajid, Mohammed ^c,d  

^a UCSF Graduate Program in Biological and Medical Informatics

^b UCSF Department of Bioengineering and Therapeutic Sciences

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5 OXOPROLYL PEPTIDASE; CATHEPSIN; CYSTEINE PROTEINASE; GLYCOSYLPHOSPHATIDYLINOSITOL; NUCLEOPHILE; SENTRIN SPECIFIC PROTEASE; SONIC HEDGEHOG PROTEIN; SUMO 1 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

BABESIA BOVIS; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME DEGRADATION; GENE DUPLICATION; GENE SEQUENCE; HELMINTH; HOST PARASITE INTERACTION; IMMUNE SYSTEM; LEISHMANIA BRAZILIENSIS; LEISHMANIA INFANTUM; LIFE CYCLE; NONHUMAN; PARASITE SURVIVAL; PARASITE TRANSMISSION; PARASITOLOGY; PATHOGENESIS; PHYLOGENY; PLASMODIUM VIVAX; PROTOZOON; REVIEW; SUMOYLATION; UBIQUITINATION;

ANIMALS; APICOMPLEXA; CYSTEINE PROTEASES; EUGLENOZOA; GENETIC VARIATION; GENOME, HELMINTH; GENOME, PROTOZOAN; HELMINTHS; HOST-PATHOGEN INTERACTIONS; HUMANS; PARASITES;

EID: 70449084597     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2009.09.006     Document Type: Review

References (67)

1. McKerrow J.H., et al. Proteases in parasitic diseases. Annu. Rev. Pathol. 1 (2006) 497-536
2. Sajid M., et al. Proteases of parasitic protozoa - current status and validation. In: Selzer P. (Ed). Drug Discovery in Infectious Diseases: From Drug Targets to Drug Candidates (2009), Wiley-VCH Verlag 177-208
3. Dixit A.K., et al. Immunodiagnostic/protective role of cathepsin L cysteine proteinases secreted by Fasciola species. Vet. Parasitol. 154 (2008) 177-184
4. Goldberg D.E. Hemoglobin degradation. Curr. Top. Microbiol. Immunol. 295 (2005) 275-291
5. Ponder E.L., and Bogyo M. Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa. Eukaryot. Cell 6 (2007) 1943-1952
6. Zacks M.A., and Garg N. Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism. Mol. Membr. Biol. 23 (2006) 209-225
7. Sajid M., and McKerrow J.H. Cysteine proteases of parasitic organisms. Mol. Biochem. Parasitol. 120 (2002) 1-21
8. Atkinson H.J., et al. Using sequence similarity networks for visualization of relationships across diverse protein superfamilies. PLoS ONE 4 (2009) e4345
9. Rawlings N.D., et al. MEROPS: the peptidase database. Nucl. Acids Res. 36 (2008) D320-325
10. Nijman S.M., et al. A genomic and functional inventory of deubiquitinating enzymes. Cell 123 (2005) 773-786
11. Paugam A., et al. Characterization and role of protozoan parasite proteasomes. Trends Parasitol. 19 (2003) 55-59
12. Russo I., et al. A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 1554-1559
13. Rosenthal P.J. Cysteine proteases of malaria parasites. Int. J. Parasitol. 34 (2004) 1489-1499
14. Karrer K.M., et al. Two distinct gene subfamilies within the family of cysteine protease genes. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 3063-3067
15. Renslo A.R., and McKerrow J.H. Drug discovery and development for neglected parasitic diseases. Nat. Chem. Biol. 2 (2006) 701-710
16. Stoch S.A., and Wagner J.A. Cathepsin K inhibitors: a novel target for osteoporosis therapy. Clin. Pharmacol. Ther. 83 (2008) 172-176
17. Hohman M., et al. Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery. Drug Discov. Today 14 (2009) 261-270
18. Buxbaum L.U., et al. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. J. Immunol. 171 (2003) 3711-3717
19. Doyle P.S., et al. A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob. Agents Chemother. 51 (2007) 3932-3939
20. El-Sayed N.M., et al. Comparative genomics of trypanosomatid parasitic protozoa. Science 309 (2005) 404-409
21. Mottram J.C., et al. The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences. J. Biol. Chem. 272 (1997) 14285-14293
22. Miller S.K., et al. A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J. Biol. Chem. 277 (2002) 47524-47532
23. Caffrey C.R., and Steverding D. Kinetoplastid papain-like cysteine peptidases. Mol. Biochem. Parasitol. 167 (2009) 12-19
24. Nikolskaia O.V., et al. Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease. J. Clin. Invest. 116 (2006) 2739-2747
25. Mendoza-Palomares C., et al. Molecular and biochemical characterization of a cathepsin B-like protease family unique to Trypanosoma congolense. Eukaryot. Cell 7 (2008) 684-697
26. Besteiro S., et al. Protein turnover and differentiation in Leishmania. Int. J. Parasitol. 37 (2007) 1063-1075
27. Chung Y.B., et al. A 27 kDa cysteine protease secreted by newly excysted Paragonimus westermani metacercariae induces superoxide anion production and degranulation of human eosinophils. Korean J. Parasitol. 46 (2008) 95-99
28. Craig H., et al. Unravelling the moulting degradome: new opportunities for chemotherapy?. Trends Parasitol. 23 (2007) 248-253
29. Ford L., et al. Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interference. PLoS Negl. Trop. Dis. 3 (2009) e377
30. Mottram J.C., et al. Clan CD cysteine peptidases of parasitic protozoa. Trends Parasitol. 19 (2003) 182-187
31. Uren A.G., et al. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol. Cell 6 (2000) 961-967
32. Caffrey C.R., et al. Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 20 (2004) 241-248
33. Götz M.G., et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J. Med. Chem. 51 (2008) 2816-2832
34. Lillico S., et al. Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8. Mol. Biol. Cell 14 (2003) 1182-1194
35. Ambit A., et al. An essential role for the Leishmania major metacaspase in cell cycle progression. Cell Death Differ. 15 (2008) 113-122
36. Tuon F.F., et al. Toll-like receptors and leishmaniasis. Infect. Immun. 76 (2008) 866-872
37. Plattner F., and Soldati-Favre D. Hijacking of host cellular functions by the Apicomplexa. Annu. Rev. Microbiol. 62 (2008) 471-487
38. Sajid M., et al. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol. Biochem. Parasitol. 131 (2003) 65-75
39. Watanabe N., and Lam E. Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. J. Biol. Chem. 280 (2005) 14691-14699
40. González I.J., et al. Leishmania major metacaspase can replace yeast metacaspase in programmed cell death and has arginine-specific cysteine peptidase activity. Int. J. Parasitol. 37 (2007) 161-172
41. Salvesen G.S., and Riedl S.J. Caspase mechanisms. Adv. Exp. Med. Biol. 615 (2008) 13-23
42. Bruchhaus I., et al. Protozoan parasites: programmed cell death as a mechanism of parasitism. Trends Parasitol. 23 (2007) 376-383
43. Vercammen D., et al. Are metacaspases caspases?. J. Cell Biol. 179 (2007) 375-380
44. Mazzoni C., and Falcone C. Caspase-dependent apoptosis in yeast. Biochim. Biophys. Acta 1783 (2008) 1320-1327
45. Helms M.J., et al. Bloodstream form Trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes. J. Cell Sci. 119 (2006) 1105-1117
46. Moss C.X., et al. Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing. FEBS Lett. 581 (2007) 5635-5639
47. Le Chat L., et al. The role of metacaspase 1 in Plasmodium berghei development and apoptosis. Mol. Biochem. Parasitol. 153 (2007) 41-47
48. Berriman M., et al. The genome of the blood fluke Schistosoma mansoni. Nature 460 (2009) 352-358
49. Gregan J., et al. Solving the shugoshin puzzle. Trends Genet. 24 (2008) 205-207
50. Anantharaman V., and Aravind L. Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biol. 4 (2003) R11
51. Drag M., and Salvesen G.S. DeSUMOylating enzymes - SENPs. IUBMB Life 60 (2008) 734-742
52. Braun L., et al. The small ubiquitin-like modifier (SUMO)-conjugating system of Toxoplasma gondii. Int. J. Parasitol. 39 (2009) 81-90
53. Issar N., et al. Identification of a novel post-translational modification in Plasmodium falciparum: protein sumoylation in different cellular compartments. Cell Microbiol. 10 (2008) 1999-2011
54. Shang Q., et al. Solution structure of SUMO from Trypanosoma brucei and its interaction with Ubc9. Proteins 76 (2009) 266-269
55. Schaeffer M., et al. Differentiation of Leishmania major is impaired by over-expression of pyroglutamyl peptidase I. Mol. Biochem. Parasitol. 150 (2006) 318-329
56. Morty R.E., et al. Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts. Biochem. J. 394 (2006) 635-645
57. Varjosalo M., and Taipale J. Hedgehog: functions and mechanisms. Genes Dev. 22 (2008) 2454-2472
58. Charonis A., et al. Basement membrane peptides: functional considerations and biomedical applications in autoimmunity. Curr. Med. Chem. 12 (2005) 1495-1502
59. Blackman M.J. Malarial proteases and host cell egress: an 'emerging' cascade. Cell Microbiol. 10 (2008) 1925-1934
60. Yu J.W., and Shi Y. FLIP and the death effector domain family. Oncogene 27 (2008) 6216-6227
61. Holt D.C., et al. A multigene family of inactivated cysteine proteases in Sarcoptes scabiei. J. Invest. Dermatol. 123 (2004) 240-241
62. Sanders I.R. Rapid disease emergence through horizontal gene transfer between eukaryotes. Trends. Ecol. Evol. (Amst.) 21 (2006) 656-658
63. von Pawel-Rammingen U., et al. IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. EMBO J. 21 (2002) 1607-1615
64. Altschul S.F., et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucl. Acids Res. 25 (1997) 3389-3402
65. Shannon P., et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13 (2003) 2498-2504
66. Bateman A., et al. The Pfam protein families database. Nucl. Acids Res. 32 (2004) D138-141
67. Schechter I., and Berger A. On the size of the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27 (1967) 157-162