The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer

Breast Cancer Research

Volumn 3, Issue 2, 2001, Pages 91-94

  Chiarle, Roberto ^a,b   Pagano, Michele ^a   Inghirami, Giorgio ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Breast cancer; Cell cycle; P27; Survival; Ubiquitination

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; ESTROGEN RECEPTOR; KI 67 ANTIGEN; ONCOPROTEIN; PROTEIN P21; PROTEIN P27; PROTEIN P53; UBIQUITIN;

APOCRINE CARCINOMA; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER INFILTRATION; CANCER INHIBITION; CANCER INVASION; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE S PHASE; CONTROLLED STUDY; FEMALE; HUMAN; LYMPH NODE; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TUMOR VOLUME;

BREAST NEOPLASMS; CELL CYCLE PROTEINS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENZYME INHIBITORS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPH NODES; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 0035057846     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr277     Document Type: Article

References (30)

1. CDK inhibitors: Positive and negative regulators of G1-phase progression
2. Kip1 is haplo-insufficient for tumour suppression
3. kip1 gene to 12p13 and its analysis in leukemias
4. Kip1: Chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors
5. ip1 in human malignancies
6. ip1 accumulation during the cell cycle
7. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
8. The F-box protein family
9. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
10. ip1 ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
11. ip1 degradation and induces S phase in quiescent cells
12. P27/Kip1 mutation found in breast cancer
13. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
14. Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma
15. Proteasome-dependent degradation of p27/kip1 in gliomas
16. ip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
17. kip1 protein: Prognostic implications in primary breast cancer
18. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas
19. kip1 in node-positive breast cancer
20. kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma
21. kip1 and degree of malignancy in human breast and colorectal cancers
22. kip1 expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up
23. Cell cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breast
24. Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation
25. ip1-Cdk2 complex formation: Receptor overexpression does not determine growth dependency
26. ip1 and apoptosis in human breast cancer
27. ip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells
28. ip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells
29. A comparison of cell cycle markers in well-differentiated lobular and ductal carcinomas
30. Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: Its correlation to histologic findings in 43 cases