The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies

Journal of Biological Chemistry

Volumn 275, Issue 22, 2000, Pages 17122-17129

  Brahms, Hero ^a,b   Raymackers, Jos ^c   Union, Ann ^c   De Keyser, Filip ^d   Meheus, Lydie ^c   Lührmann, Reinhard ^a,b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c INNOGENETICS   (Belgium)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; AUTOANTIBODY; AUTOANTIGEN; DIPEPTIDE; EPITOPE; GLYCINE; SMALL NUCLEAR RIBONUCLEOPROTEIN;

AMINO ACID SEQUENCE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; METHYLATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROCESSING; SEROLOGY; SPLICEOSOME; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; ARGININE; AUTOANTIBODIES; AUTOANTIGENS; B-LYMPHOCYTES; DIPEPTIDES; EPITOPES; HELA CELLS; HUMANS; IMMUNE SERA; MOLECULAR SEQUENCE DATA; REPETITIVE SEQUENCES, AMINO ACID; RIBONUCLEOPROTEINS, SMALL NUCLEAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EUKARYOTA; INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 0034595798     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M000300200     Document Type: Article

References (60)

1. Burge, C. B., Tuschl, T., and Sharp, P. A. (1999) in The RNA World, 2nd Ed. (Gesteland, R. F., Chech, T. R., and Atkins, J. E., eds) pp. 525-560, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
2. Will, C. L., and Lührmann, R. (1997) Curr. Opin. Cell Biol. 9, 320-328
3. Hermann, H., Fabrizio, P., Raker, V. A., Foulaki, K., Hornig, H., Brahms, H., and Lührmann, R. (1995) EMBO J. 9, 2076-2088
4. Lehmeier, T., Raker, V. A., Hermann, H., and Lührmann, R. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12317-12321
5. Raker, V. A., Plessel, G., and Lührmann, R. (1996) EMBO J. 15, 2256-2269
6. Fury, M., Andersen, J., Ponda, P., Aimes, R., and Zieve, G. W. (1999) J. Autoimmunity 12, 91-100
7. Branlant, C., Krol, A., Ebel, J. P., Lazar, E., Haendler, B., and Jacob, M. (1982) EMBO J. 1, 1259-1265
8. Mattaj, I. (1986) Cell 46, 905-911
9. Plessel, G., Fischer, U., and Lührmann, R. (1994) Mol. Cell. Biol. 14, 4160-4172
10. Hamm, J., Darzynkiewicz, E., Tahara, S. M., and Mattaj, I. W. (1990) Cell 62, 569-577
11. Fischer, U., and Lührmann, R. (1990) Science 249, 786-790
12. Nelissen, R. L., Will, C. L., van Venrooij, W. J., and Lührmann, R. (1994) EMBO J. 13, 4113-4125
13. Van Mühlen, C. A., and Tan, E. M. (1995) Semin. Arthritis Rheum. 24, 323-358
14. Van Venrooij, W. J., and Pruijn, G. J. M. (1995) Curr. Opin. Immunol. 7, 819-824
15. Tan, E. M. (1989) Adv. Immunol. 44, 93-151
16. Lehmeier, T., Foulaki, K., and Lührmann, R. (1990) Nucleic Acids Res. 18, 6475-6484
17. Hoch, S. O. (1994) in Manual of Biological Markers of Disease (van Venrooij, W. J., and Maini, R. N., eds.) pp. 1-29, Kluwer, Dordrecht, The Netherlands
18. Brahms, H., Raker, V. A., van Venrooij, W. J., and Lührmann, R. (1997) Arthritis Rheum. 40, 672-682
19. Rokeach, L. A., Jannatipour, M., and Hoch, S. O. (1990) J. Immunol. 144, 1015-1022
20. Cooper, M., Johnston, L. H., and Beggs, J. D. (1995) EMBO J. 14, 2066-2075
21. Séraphin, B. (1995) EMBO J. 9, 2089-2098
22. Kambach, C., Walke, S., Young, R., Avis, J. M., de la Fortelle, E., Raker, V. A., Lührmann, R., Li, J., and Nagai, K. (1999) Cell 96, 375-387
23. Rokeach, L. A., Jannatipour, M., Haselby, J. A., and Hoch, S. O. (1992) Clin. Immunol. Immunopathol. 65, 315-324
24. Hirakata, M., Craft, J., and Hardin, J. (1993) J. Immunol. 150, 3592-3601
25. Rokeach, L. A., and Hoch, S. O. (1992) Mol. Biol. Rep. 16, 165-174
26. Rokeach, L. A., Haselby, J. A., and Hoch, S. O. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 4832-4836
27. Barakat, S., Briand, J.-P., and Weber, J.-C. (1990) Clin. Exp. Immunol. 81, 256-262
28. Sabbatini, A., Dolcher, M. P., Marchini, B., Bombardieri, S., and Migliorini, P. (1993) J. Rheumatol. 20, 1679-1683
29. James, J. A., Mamula, M. J., and Harley, J. B (1994) Clin. Exp. Immunol. 98, 419-426
30. Rivkin, E., Vella, M. J., and Lahita, R. G. (1994) J. Autoimmun. 7, 119-132
31. Gary, J. D., and Clarke, S. (1998) Prog. Nucleic Acids Res. Mol. Biol. 61, 65-131
32. Ou, Y., Sun, D., Sharp, G. C., Hoch, S. O. (1997) Clin. Immunol. Immunopathol. 83, 310-317
33. Rokeach, L. A., Haselby, J. A., and Hoch, S. O. (1992) Gene (Amst.) 118, 247-253
34. Wagatsuma, M., Asami, N., Miyachi, J., Uchida, S., Watanabe, H., and Amann, E. (1993) Mol. Immunol. 30, 1491-1498
35. Rosenfeld, J., Capdevielle, J., Guillemot, J. C., and Ferrara, P. (1992) Anal. Biochem. 203, 173-179
36. Shevchenko, A., Wilm, M., Vorm, O., and Mann, M. (1996) Anal. Chem. 68, 850-858
37. Pollet, D. E., Saman, E. L., Peeters, D. C., Warmenbol, H. M., Heyndrickx, L. M., Wouters, C. J., Beelaert, G., van der Groen, G., and Van Heuverawijn, H. (1991) Clin. Chem. 73, 1700-1707
38. Bach, M., Bringmann, P., and Lührmann, R. (1990) Methods Enzymol. 181, 232-257
39. Lerner, E. A., Lerner, M. E., Janeway, C. A., Steitz, J. A. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 2737-2741
40. Riemekasten, G., Marell, J., Trebeljahr, G., Klein, R., Hausdorf, G., Häupl, T., Schneider-Mergener, J., Burmester, G. R., and Hiepe, F. (1998) J. Clin. Invest. 102, 754-763
41. Pruijn, G. J. M., Schoute, F., Thijssen, J. P. H., Smeenk, R. J. T., and van Venrooij, W. J. (1997) J. Autoimmun. 10, 127-136
42. Hasegawa, H., Uchiumi, T., Sato, T., Arakawa, M., and Kominami, R. (1998) Arthritis Rheum. 41, 1040-1046
43. Schellekens, G. A., de Jong, B. A. W., van den Hoogen, F. H. J., van de Putte, L. B. A., and van Venrooij, W. J. (1998) J. Clin. Invest. 101, 273-281
44. Union, A., Amerijckx, L., Raymackers, J., Dauwe, M., De Keyser, F., Veya, E., and Meheus, L. (1998) Arthritis Rheum. 41, Suppl. 9, S84 (Abstr. 311)
45. Ochs, R. L., Lischwe, M. A., Spohn, W. H., and Busch, H. (1985) Biol. Cell 54, 123-133
46. Jensen, L., Kuff, E. L., Wilson, S. H., Steinberg, A. D., and Klinman, D. M. (1988) J. Autoimmun, 1, 73-83
47. Minota, S., Jarjour, W. N., Suzuki, N., Nojima, Y., Roubey, R. A., Mimura, T., Yamada, A., Hosoya, T., Takaku, F., and Winfield, J. B. (1991) J. Immunol. 146, 2249-2252
48. Utz, P. J., and Anderson, P. (1998) Arthritis Rheum. 41, 1152-1160
49. Tax, W. J. M., Kramiers, C., van Bruggen, M. C. J., and Berden, J. H. M. (1995) Kidney Int. 48, 666-673
50. Casciola-Rosen, L. A., Anhalt, G., and Rosen, A. (1994) J. Exp. Med. 179, 1317-1330
51. Baldwin, G. S., and Carnegie, P. R. (1971) Science 171, 579-581
52. Gary, J. D., Lin, W.-J., Yang, M. C., Hershman, H. R., and Clarke, S. (1996) J. Biol. Chem. 271, 12585-12594
53. Lin, W.-J., Gary, J. D., Yang, M. C., Clarke, S., and Hershman, H. R. (1996) J. Biol. Chem. 271, 15034-15044
54. Abramovich, C., Yakobson, B., Chebath, J., and Revel, M. (1997) EMBO J. 16, 260-266
55. Rawal, N., Rajpurohit, R., Lischwe, M. A., Williams, K. R., Paik, W. K., and Kim, S. (1995) Biochim. Biophys. Acta 1248, 11-18
56. Kim, S., Lim, I. K., Park, G.-H., and Paik, W. K. (1997) Int. J. Biochem. Cell Biol. 29, 743-751
57. Roy, J., Zheng, B., Rymond, B. C., and Woolford, J. L. (1995) Mol. Cell. Biol. 1, 445-455
58. Rymond, B. C. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 848-852
59. Calnan, B. J., Tidor, B., Biancalana, S., Hudson, D., and Frankel, A. D. (1991) Science 252, 1167-1171
60. Shen, E. C., Henry, M. F., Weiss, V. H., Valentini, S. R., Silver, P. A., and Lee, M. S. (1998) Genes Dev. 12, 679-691