New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function

Genesis (United States)

Volumn 39, Issue 4, 2004, Pages 263-272

  Silver, Serena J ^a,b   Chen, Fangli ^a,b   Doyon, Laura ^a   Zink, Andrina Williams ^a   Rebay, Ilaria ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Guanine nucleotide exchange factor; Rac; Ras; Receptor tyrosine kinase; Yan

Indexed keywords

GENOMIC DNA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN TYROSINE KINASE; RAC PROTEIN; RAS PROTEIN; SOS PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; YAN PROTEIN;

ALLELE; ARTICLE; DEVELOPMENTAL GENETICS; EMBRYO DEVELOPMENT; GENE LOCUS; GENE OVEREXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 4444297885     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/gene.20054     Document Type: Article

References (48)

1. Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF. 2001. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res 56:127-155.
2. Bergmann A, Tugentman M, Shilo BZ, Steller H. 2002. Regulation of cell number by MAPK-dependent control of apoptosis. A mechanism for trophic survival signaling. Dev Cell 2:159-170.
3. Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J. 1998. The structural basis of the activation of Ras by Sos. Nature 394:337-343.
4. Brand A, Perrimon N. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401-415.
5. Buday L, Downward J. 1993. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73:611-620.
6. Buday L, Warne PH, Downward J. 1995. Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. Oncogene 11:1327-1331.
7. Byrne JL, Paterson HF, Marshall CJ. 1996. p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus. Oncogene 13:2055-2065.
8. Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. 1993. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260:1338-1343.
9. Chen RH, Corbalan-Garcia S, Bar-Sagi D. 1997. The role of the PH domain in the signal-dependent membrane targeting of Sos. EMBO J 16:1351-1359.
10. Chen RA, Michaeli T, Van Aelst L, Ballester R. 2000. A role for the noncatalytic N terminus in the function of Cdc25, a Saccharomyces cerevisiae Ras-guanine nucleotide exchange factor. Genetics 154:1473-1484.
11. Chou TB, Perrimon N. 1996. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics 144:1673-1679.
12. Corbalan-Garcia S, Margarit SM, Galron D, Yang SS, Bar-Sagi D. 1998. Regulation of Sos activity by intramolecular interactions. Mol Cell Biol 18:880-886.
13. Das B, Shu X, Day GJ, Han J, Krishna UM, Falck JR, Broek D. 2000. Control of intramolecular interactions between the pleckstrin homology and Db1 homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem 275:15074-15081.
14. Diaz-Benjumea FJ, Hafen E. 1994. The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120:569-578.
15. Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA, Artavanis-Tsakonas S. 1990. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61:523-534.
16. Fehon RG, Johansen K, Rebay I, Artavanis-Tsakonas S. 1991. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol 113:657-669.
17. Freeman M. 1997. Cell determination strategies in the Drosophila eye. Development 124:261-270.
18. Gabay L, Scholz H, Golembo M, Klaes A, Shilo BZ, Klambt C. 1996. EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122:3355-3362.
19. Hall A. 1998. Rho GTPases and the actin cytoskeleton. Science 279:509-514.
20. Innocenti M, Tenca P, Frittoli E, Faretta M, Tocchetti A, Di Fiore PP, Scita G. 2002. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J Cell Biol 156:125-136.
21. Karlovich CA, Bonfini L, McCollam L, Rogge RD, Daga A, Czech MP, Banerjee U. 1995. In vivo functional analysis of the Ras exchange factor son of sevenless. Science 268:576-579.
22. Lai CC, Boguski M, Broek D, Powers S. 1993. Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins. Mol Cell Biol 13:1345-1352.
23. Liu BX, Wei W, Broek D. 1993. The catalytic domain of the mouse sos1 gene product activates Ras proteins in vivo and in vitro. Oncogene 8:3081-3084.
24. Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J. 2003. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112:685-695.
25. Nagaraj R, Pickup AT, Howes R, Moses K, Freeman M, Banerjee U. 1999. Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial. Development 126:975-985.
26. Nimnual AS, Yatsula BA, Bar-Sagi D. 1998. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279:560-563.
27. Olivier JP, Raabe T, Henkemeyer M, Dickson B, Mbamalu G, Margolis B, Schlessinger J, Hafen E, Pawson T. 1993. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73:179-191.
28. O'Neill EM, Rebay I, Tjian R, Rubin GM. 1994. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78:137-147.
29. Perkins LA, Larsen I, Perrimon N. 1992. corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 70:225-236.
30. Perkins LA, Johnson MR, Melnick MB, Perrimon N. 1996. The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev Biol 180:63-81.
31. Quilliam LA, Huff SY, Rabun KM, Wei W, Park W, Broek D, Der CJ. 1994. Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity. Proc Natl Acad Sci U S A 91:8512-8516.
32. Rebay I, Fehon RG. 2000. Generating antibodies against Drosophila proteins. In: Sullivan W, Ashburner M, Hawley RS, editors. Drosophila protocols. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. p 389-411.
33. Rebay I, Rubin GM. 1995. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81:857-866.
34. Rebay I, Fehon RG, Artavanis-Tsakonas S. 1993. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74:319-329.
35. Rebay I, Chen F, Hsiao F, Kolodziej PA, Kuang BH, Laverty T, Suh C, Voas M, Williams A, Rubin GM. 2000. A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics 154:695-712.
36. Schweitzer R, Shilo BZ. 1997. A thousand and one roles for the Drosophila EGF receptor. Trends Genet 13:191-196.
37. Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegard M, Betsholtz C, Di Fiore PP. 1999. EPS8 and E3B1 transduce signals from Ras to Rac. Nature 401:290-293.
38. Scita G, Tenca P, Frittoli E, Tocchetti A, Innocenti M, Giardina G, Di Fiore PP. 2000. Signaling from Ras to Rac and beyond: not just a matter of GEFs. EMBO J 19:2393-2398.
39. Scita G, Tenca P, Areces LB, Tocchetti A, Frittoli E, Giardina G, Ponzanelli I, Sini P, Innocenti M, Di Fiore PP. 2001. An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine. J Cell Biol 154:1031-1044.
40. Simon MA, Bowtell DD, Dodson GS, Laverty TR, Rubin GM. 1991. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67:701-716.
41. Sini P, Cannas A, Koleske AJ, Fiore PPD, Scita G. 2004. Ab1-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation. Nat Cell Biol 6:268-275.
42. Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J. 1998. Crystal structure of the Db1 and pleckstrin homology domains from the human Son of sevenless protein. Cell 95:259-268.
43. Sondermann H, Soisson SM, Bar-Sagi D, Kuriyan J. 2003. Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. Structure (Camb) 11:1583-1593.
44. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. 1997. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25:4876-4882.
45. Tomlinson A, Bowtell DD, Hafen E, Rubin GM. 1987. Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell 51:143-150.
46. Tootle TL, Lee PS, Rebay I. 2003. CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Development 130:845-857.
47. Wolff T. 2000. Histological techniques for the Drosophila eye part I: larva and pupa. In: Sullivan W, Ashburner M, Hawley RS, editors. Drosophila protocols. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. p 201-227.
48. Xu T, Rubin GM. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117:1223-1237.