Toxicological and pharmacokinetic evaluation of concomitant intake of grapefruit juice and simvastatin in rats after repeated treatment over 28 days

Planta Medica

Volumn 75, Issue 11, 2009, Pages 1196-1202

  Butterweck, Veronika ^a   Zdrojewski, Immo ^a   Galloway, Cheryl ^a   Frye, Reginald ^a   Derendorf, Hartmut ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Cholesterol; Drug interactions; Grapefruit juice; Muscle toxicity; Pharmacokinetics; Simvastatin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; HYDROXYACID; LACTONE DERIVATIVE; SIMVASTATIN; SIMVASTATIN HYDROXY ACID; SIMVASTATIN LACTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GRAPEFRUIT JUICE; LIVER WEIGHT; MALE; NONHUMAN; RAT; STRENGTH;

ANIMALS; BEVERAGES; BODY WEIGHT; CHOLESTEROL; CITRUS PARADISI; DRUG INTERACTIONS; MALE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

CITRUS X PARADISI; RATTUS;

EID: 70350754319     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185534     Document Type: Article

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