Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects

British Journal of Clinical Pharmacology

Volumn 61, Issue 5, 2006, Pages 533-537

  Uno, Tsukasa ^a,b   Ohkubo, Tadashi ^a   Motomura, Shigeru ^b   Sugawara, Kazunobu ^a  

^a HIROSAKI UNIVERSITY HOSPITAL   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

Author keywords

CYP3A4; Enantiomer; Grapefruit juice; Manidipine

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYTOCHROME P450 3A4; MANIDIPINE; WATER;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ENANTIOMER; ENZYME INHIBITION; FOOD DRUG INTERACTION; GRAPEFRUIT JUICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; BEVERAGES; CALCIUM CHANNEL BLOCKERS; CITRUS PARADISI; CROSS-OVER STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; DIHYDROPYRIDINES; FOOD-DRUG INTERACTIONS; HUMANS; MALE; STEREOISOMERISM; TIME FACTORS;

EID: 33646263125     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2006.02583.x     Document Type: Article

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