-
1
-
-
21744443319
-
Neurofibromatosis type 1 - a model for nervous system tumour formation?
-
Rubin JB, Gutmann DH. Neurofibromatosis type 1 - a model for nervous system tumour formation? Nat Rev Cancer 2005; 5: 557-564.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 557-564
-
-
Rubin, J.B.1
Gutmann, D.H.2
-
2
-
-
0025251137
-
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
-
Martin GA, Viskochil D, Bollag G, McCabe PC, Crosier WJ, Haubruck H et al. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 1990; 63: 843-849.
-
(1990)
Cell
, vol.63
, pp. 843-849
-
-
Martin, G.A.1
Viskochil, D.2
Bollag, G.3
McCabe, P.C.4
Crosier, W.J.5
Haubruck, H.6
-
3
-
-
0026521070
-
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
-
Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature 1992; 356: 713-715.
-
(1992)
Nature
, vol.356
, pp. 713-715
-
-
Basu, T.N.1
Gutmann, D.H.2
Fletcher, J.A.3
Glover, T.W.4
Collins, F.S.5
Downward, J.6
-
4
-
-
0026528368
-
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
-
DeClue JE, Papageorge AG, Fletcher JA, Diehl SR, Ratner N, Vass WC et al. Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell 1992; 69: 265-273.
-
(1992)
Cell
, vol.69
, pp. 265-273
-
-
DeClue, J.E.1
Papageorge, A.G.2
Fletcher, J.A.3
Diehl, S.R.4
Ratner, N.5
Vass, W.C.6
-
5
-
-
0030062955
-
Ras-GTP levels are elevated in human NF1 peripheral nerve tumors
-
Guha A, Lau N, Huvar I, Gutmann D, Provias J, Pawson T et al. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors. Oncogene 1996; 12: 507-513.
-
(1996)
Oncogene
, vol.12
, pp. 507-513
-
-
Guha, A.1
Lau, N.2
Huvar, I.3
Gutmann, D.4
Provias, J.5
Pawson, T.6
-
6
-
-
0028307836
-
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
-
Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet 1994; 7: 353-361.
-
(1994)
Nat Genet
, vol.7
, pp. 353-361
-
-
Jacks, T.1
Shih, T.S.2
Schmitt, E.M.3
Bronson, R.T.4
Bernards, A.5
Weinberg, R.A.6
-
7
-
-
0032763861
-
Mouse models of tumor development in neurofibromatosis type 1
-
Cichowski K, Shih TS, Schmitt E, Santiago S, Reilly K, McLaughlin ME et al. Mouse models of tumor development in neurofibromatosis type 1. Science 1999; 286: 2172-2176.
-
(1999)
Science
, vol.286
, pp. 2172-2176
-
-
Cichowski, K.1
Shih, T.S.2
Schmitt, E.3
Santiago, S.4
Reilly, K.5
McLaughlin, M.E.6
-
8
-
-
0036293742
-
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
-
Bajenaru ML, Zhu Y, Hedrick NM, Donahoe J, Parada LF, Gutmann DH. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol 2002; 22 5100-5113.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5100-5113
-
-
Bajenaru, M.L.1
Zhu, Y.2
Hedrick, N.M.3
Donahoe, J.4
Parada, L.F.5
Gutmann, D.H.6
-
9
-
-
0034708076
-
A neurofibromatosis-1-regulated pathway is required for learning in Drosophila
-
Guo HF, Tong J, Hannan F, Luo L, Zhong Y. A neurofibromatosis-1-regulated pathway is required for learning in Drosophila. Nature 2000; 403: 895-898.
-
(2000)
Nature
, vol.403
, pp. 895-898
-
-
Guo, H.F.1
Tong, J.2
Hannan, F.3
Luo, L.4
Zhong, Y.5
-
10
-
-
0030996903
-
-
The I, Hannigan GE, Cowley GS, Reginald S, Zhong Y, Gusella JF et al. Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science 1997; 276: 791-794.
-
The I, Hannigan GE, Cowley GS, Reginald S, Zhong Y, Gusella JF et al. Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science 1997; 276: 791-794.
-
-
-
-
11
-
-
0027979813
-
Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function
-
Johnson MR, DeClue JE, Felzmann S, Vass WC, Xu G, White R et al. Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function. Mol Cell Biol 1994; 14: 641-645.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 641-645
-
-
Johnson, M.R.1
DeClue, J.E.2
Felzmann, S.3
Vass, W.C.4
Xu, G.5
White, R.6
-
12
-
-
0141529951
-
The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes
-
Dasgupta B, Dugan LL, Gutmann DH. The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes. J Neurosci 2003; 23: 8949-8954.
-
(2003)
J Neurosci
, vol.23
, pp. 8949-8954
-
-
Dasgupta, B.1
Dugan, L.L.2
Gutmann, D.H.3
-
13
-
-
33645116938
-
Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras
-
Hannan F, Ho I, Tong JJ, Zhu Y, Nurnberg P, Zhong Y. Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Hum Mol Genet 2006; 15: 1087-1098.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1087-1098
-
-
Hannan, F.1
Ho, I.2
Tong, J.J.3
Zhu, Y.4
Nurnberg, P.5
Zhong, Y.6
-
14
-
-
0025784539
-
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
-
Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 1991; 352: 345-347.
-
(1991)
Nature
, vol.352
, pp. 345-347
-
-
Yonish-Rouach, E.1
Resnitzky, D.2
Lotem, J.3
Sachs, L.4
Kimchi, A.5
Oren, M.6
-
15
-
-
0035835823
-
DAP kinase-a proapoptotic gene that functions as a tumor suppressor
-
Raveh T, Kimchi A. DAP kinase-a proapoptotic gene that functions as a tumor suppressor. Exp Cell Res 2001; 264: 185-192.
-
(2001)
Exp Cell Res
, vol.264
, pp. 185-192
-
-
Raveh, T.1
Kimchi, A.2
-
16
-
-
0036166278
-
Apoptosis coincident with the differentiation of skeletal myoblasts is delayed by caspase 3 inhibition and abrogated by MEK-independent constitutive Ras signaling
-
Dee K, Freer M, Mei Y, Weyman CM. Apoptosis coincident with the differentiation of skeletal myoblasts is delayed by caspase 3 inhibition and abrogated by MEK-independent constitutive Ras signaling. Cell Death Differ 2002; 9: 209-218.
-
(2002)
Cell Death Differ
, vol.9
, pp. 209-218
-
-
Dee, K.1
Freer, M.2
Mei, Y.3
Weyman, C.M.4
-
17
-
-
0034548712
-
K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression
-
Guerrero S, Casanova I, Farre L, Mazo A, Capella G, Mangues R. K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res 2000; 60: 6750-6756.
-
(2000)
Cancer Res
, vol.60
, pp. 6750-6756
-
-
Guerrero, S.1
Casanova, I.2
Farre, L.3
Mazo, A.4
Capella, G.5
Mangues, R.6
-
18
-
-
1642553461
-
The dark side of Ras: Regulation of apoptosis
-
Cox AD, Der CJ. The dark side of Ras: Regulation of apoptosis. Oncogene 2003; 22: 8999-9006.
-
(2003)
Oncogene
, vol.22
, pp. 8999-9006
-
-
Cox, A.D.1
Der, C.J.2
-
19
-
-
0347725620
-
Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells
-
Donovan S, See W, Bonifas J, Stokoe D, Shannon KM. Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells. Cancer Cell 2002; 2: 507-514.
-
(2002)
Cancer Cell
, vol.2
, pp. 507-514
-
-
Donovan, S.1
See, W.2
Bonifas, J.3
Stokoe, D.4
Shannon, K.M.5
-
20
-
-
1642282700
-
Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells
-
Hiatt K, Ingram DA, Huddleston H, Spandau DF, Kapur R, Clapp DW. Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol 2004; 164: 1471-1479.
-
(2004)
Am J Pathol
, vol.164
, pp. 1471-1479
-
-
Hiatt, K.1
Ingram, D.A.2
Huddleston, H.3
Spandau, D.F.4
Kapur, R.5
Clapp, D.W.6
-
21
-
-
0032535276
-
p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons
-
Klesse LJ, Parada LF. p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J Neurosci 1998; 18: 10420-10428.
-
(1998)
J Neurosci
, vol.18
, pp. 10420-10428
-
-
Klesse, L.J.1
Parada, L.F.2
-
22
-
-
0028349997
-
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
-
Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW et al. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev 1994; 8: 1019-1029.
-
(1994)
Genes Dev
, vol.8
, pp. 1019-1029
-
-
Brannan, C.I.1
Perkins, A.S.2
Vogel, K.S.3
Ratner, N.4
Nordlund, M.L.5
Reid, S.W.6
-
23
-
-
0037443055
-
Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor
-
Cichowski K, Santiago S, Jardim M, Johnson BW, Jacks T. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev 2003; 17: 449-454.
-
(2003)
Genes Dev
, vol.17
, pp. 449-454
-
-
Cichowski, K.1
Santiago, S.2
Jardim, M.3
Johnson, B.W.4
Jacks, T.5
-
24
-
-
20844435467
-
The NF1 tumor suppressor critically regulates TSC2 and mTOR
-
Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K. The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci USA 2005; 102: 8573-8578.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8573-8578
-
-
Johannessen, C.M.1
Reczek, E.E.2
James, M.F.3
Brems, H.4
Legius, E.5
Cichowski, K.6
-
25
-
-
3042559944
-
Prenyl-binding domains: Potential targets for Ras inhibitors and anti-cancer drugs
-
Kloog Y, Cox AD. Prenyl-binding domains: Potential targets for Ras inhibitors and anti-cancer drugs. Semin Cancer Biol 2004; 14 253-261.
-
(2004)
Semin Cancer Biol
, vol.14
, pp. 253-261
-
-
Kloog, Y.1
Cox, A.D.2
-
27
-
-
33749354937
-
The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosistype 1
-
Barkan B, Starinsky S, Friedman E, Stein R, Kloog Y. The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosistype 1. Clin Cancer Res 2006; 12: 5533-5542.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5533-5542
-
-
Barkan, B.1
Starinsky, S.2
Friedman, E.3
Stein, R.4
Kloog, Y.5
-
28
-
-
33745472798
-
E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition
-
Blum R, Nakdimon I, Goldberg L, Elkon R, Shamir R, Rechavi G et al. E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition. Int J Cancer 2006; 119: 527-538.
-
(2006)
Int J Cancer
, vol.119
, pp. 527-538
-
-
Blum, R.1
Nakdimon, I.2
Goldberg, L.3
Elkon, R.4
Shamir, R.5
Rechavi, G.6
-
29
-
-
20444363057
-
Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo
-
Dasgupta B, Gutmann DH. Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo. J Neurosci 2005; 25: 5584-5594.
-
(2005)
J Neurosci
, vol.25
, pp. 5584-5594
-
-
Dasgupta, B.1
Gutmann, D.H.2
-
31
-
-
0028807189
-
Neurofibromin-deficient fibroblasts fail to form perineurium in vitro
-
Rosenbaum T, Boissy YL, Kombrinck K, Brannan CI, Jenkins NA, Copeland NG et al. Neurofibromin-deficient fibroblasts fail to form perineurium in vitro. Development 1995; 121: 3583-3592.
-
(1995)
Development
, vol.121
, pp. 3583-3592
-
-
Rosenbaum, T.1
Boissy, Y.L.2
Kombrinck, K.3
Brannan, C.I.4
Jenkins, N.A.5
Copeland, N.G.6
-
32
-
-
0036154164
-
Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis
-
Schulze KM, Hanemann CO, Muller HW, Hanenberg H. Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis. Hum Mol Genet 2002; 11: 69-76.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 69-76
-
-
Schulze, K.M.1
Hanemann, C.O.2
Muller, H.W.3
Hanenberg, H.4
-
33
-
-
30344445706
-
The tumour-suppressor genes NF2/Merlin and expanded act through Hippo signalling to regulate cell proliferation and apoptosis
-
Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C et al. The tumour-suppressor genes NF2/Merlin and expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 2006; 8: 27-36.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 27-36
-
-
Hamaratoglu, F.1
Willecke, M.2
Kango-Singh, M.3
Nolo, R.4
Hyun, E.5
Tao, C.6
-
34
-
-
0028981375
-
Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid
-
Marom M, Haklai R, Ben Baruch G, Marciano D, Egozi Y, Kloog Y. Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. J Biol Chem 1995; 270: 22263-22270.
-
(1995)
J Biol Chem
, vol.270
, pp. 22263-22270
-
-
Marom, M.1
Haklai, R.2
Ben Baruch, G.3
Marciano, D.4
Egozi, Y.5
Kloog, Y.6
-
35
-
-
0034731902
-
Bcl-xS and Bax induce different apoptotic pathways in PC12 cells
-
Lindenboim L, Yuan J, Stein R. Bcl-xS and Bax induce different apoptotic pathways in PC12 cells. Oncogene 2000; 19: 1783-1793.
-
(2000)
Oncogene
, vol.19
, pp. 1783-1793
-
-
Lindenboim, L.1
Yuan, J.2
Stein, R.3
-
36
-
-
0035829731
-
Galectin-1 binds H-Ras to mediate Ras membrane anchorage and cell transformation
-
Paz A, Haklai R, Elad G, Ballan E, Kloog Y. Galectin-1 binds H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene 2001; 20: 7486-7493.
-
(2001)
Oncogene
, vol.20
, pp. 7486-7493
-
-
Paz, A.1
Haklai, R.2
Elad, G.3
Ballan, E.4
Kloog, Y.5
-
37
-
-
0028861711
-
Inhibition of drug-induced apoptosis by survival factors in PC12 cells
-
Lindenboim L, Haviv R, Stein R. Inhibition of drug-induced apoptosis by survival factors in PC12 cells. J Neurochem 1995; 64: 1054-1063
-
(1995)
J Neurochem
, vol.64
, pp. 1054-1063
-
-
Lindenboim, L.1
Haviv, R.2
Stein, R.3
|