Oncogenes do not fully override cell-intrinsic traits: Pronounced impact of the cellular programme

Cancer Microenvironment

Volumn 2, Issue SUPPL. 1, 2009, Pages

  Wȩsierska Ga̧dek, Józefa ^a   Walzi, Eva ^a   Dolečkova, Iva ^a   Schmid, Gerald ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

C Ha Ras; Cell cycle arrest; Cell synchronization; FPTase; FTI; P53 tumor suppressor; Signal transduction

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; CYCLIN DEPENDENT KINASE; OLOMOUCINE; PROTEIN P53; ROSCOVITINE;

ANIMAL CELL; CARCINOGENESIS; CELL CLONE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL IMMORTALIZATION; CELL ISOLATION; CELL PROLIFERATION; CELL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MALIGNANT TRANSFORMATION; NONHUMAN; ONCOGENE C H RAS; PRIORITY JOURNAL; RAT; TEMPERATURE SENSITIVITY;

EID: 70350624696     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-009-0024-9     Document Type: Conference Paper

References (48)

1. DM Berman SS Karhadkar A Maitra R Montes De Oca MR Gerstenblith K Briggs AR Parker Y Shimada JR Eshleman DN Watkins PA Beachy 2003 Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours Nature. 425 6960 846 851
2. C Bernstein H Bernstein CM Payne H Garewal 2002 DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis Mutat. Res. 511 2 145 178
3. MV Blagosklonny 2002 P53: an ubiquitous target of anticancer drugs Int. J. Cancer 98 2 161 166
4. V De Laurenzi A Costanzo D Barcaroli A Terrinoni M Falco M Annicchiarico-Petruzzelli M Levrero G Melino 1998 Two new p73 splice variants, gamma and delta, with different transcriptional activity J Exp Med 188 9 1763 1768
5. R Dhavan LH Tsai 2001 A decade of CDK5 Nat. Rev. 2 10 749 759
6. D Eliyahu D Michalovitz M Oren 1985 Overproduction of p53 antigen makes established cells highly tumorigenic Nature. 316 6024 158 160
7. SC Evans G Lozano 1997 The Li-Fraumeni syndrome: an inherited susceptibility to cancer Mol Med Today 3 9 390 395
8. G Feldmann S Dhara V Fendrich D Bedja R Beaty M Mullendore C Karikari H Alvarez C Iacobuzio-Donahue A Jimeno KL Gabrielson W Matsui A Maitra 2007 Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers Cancer Res. 67 5 2187 2196
9. G Feldmann N Habbe S Dhara S Bisht H Alvarez V Fendrich R Beaty M Mullendore C Karikari N Bardeesy MM Ouellette W Yu A Maitra 2008 Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer Gut 57 10 1420 1430
10. E Gottlieb R Haffner A King G Asher P Gruss P Lonai M Oren 1997 Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis Embo J 16 6 1381 1390
11. MS Greenblatt WP Bennett M Hollstein CC Harris 1994 Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis Cancer Res. 54 18 4855 4878
12. O Halevy D Michalovitz M Oren 1990 Different tumor-derived p53 mutants exhibit distinct biological activities Science. 250 4977 113 116
13. CC Harris 1996 p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment Environ. Health Perspect. 104 Suppl 3 435 439
14. L Havlicek J Hanus J Vesely S Leclerc L Meijer G Shaw M Strnad 1997 Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds J. of Med. Chem. 40 4 408 412
15. F Ide M Kitada H Sakashita K Kusama K Tanaka T Ishikawa 2003 p53 haploinsufficiency profoundly accelerates the onset of tongue tumors in mice lacking the xeroderma pigmentosum group A gene Am. J. Pathol. 163 5 1729 1733
16. A Inga F Storici TA Darden MA Resnick 2002 Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence Mol. Cell. Biol. 22 24 8612 8625
17. RU Janicke D Sohn K Schulze-Osthoff 2008 The dark side of a tumor suppressor: anti-apoptotic p53 Cell Death Differ. 15 6 959 976
18. Z Ji FC Mei J Xie X Cheng 2007 Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells J Biol Chem 282 19 14048 14055
19. M Kanai K Hanashiro SH Kim S Hanai AH Boulares M Miwa K Fukasawa 2007 Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation Nat. Cell Biol. 9 10 1175 1183
20. MB Kastan O Onyekwere D Sidransky B Vogelstein RW Craig 1991 Participation of p53 protein in the cellular response to DNA damage Cancer Res. 51 23 Pt 1 6304 6311
21. W Kolch 2000 Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions Biochem. J. 351 Pt 2 289 305
22. J Lau H Kawahira M Hebrok 2006 Hedgehog signaling in pancreas development and disease Cell. Mol. Life Sci. 63 6 642 652
23. FP Li JF Fraumeni Jr 1969 Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann. Intern. Med. 71 4 747 752
24. L Liu J Guo L Yuan M Cheng L Cao H Shi H Tong N Wang W De 2007 Alpha-fetoprotein is dynamically expressed in rat pancreas during development Dev. Growth Differ. 49 8 669 681
25. D Michalovitz O Halevy M Oren 1990 Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53 Cell 62 4 671 680
26. H Offer R Wolkowicz D Matas S Blumenstein Z Livneh V Rotter 1999 Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery FEBS Lett. 450 3 197 204
27. G Paglini A Caceres 2001 The role of the Cdk5-p35 kinase in neuronal development European journal of biochemistry / FEBS 268 6 1528 1533
28. M Pasca di Magliano S Sekine A Ermilov J Ferris AA Dlugosz M Hebrok 2006 Hedgehog/Ras interactions regulate early stages of pancreatic cancer Genes Dev. 20 22 3161 3173
29. G Schmid MP Kramer M Maurer S Wandl J Wesierska-Gadek 2007 Cellular and organismal ageing: Role of the p53 tumor suppressor protein in the induction of transient and terminal senescence J. Cell. Biochem. 101 6 1355 1369
30. G Schmid MP Kramer J Wesierska-Gadek 2009 p53-mediated regulation of cell cycle progression: pronounced impact of cellular microenvironment J. Cell. Physiol. 219 2 459 469
31. S Taurin V Seyrantepe SN Orlov TL Tremblay P Thibault MR Bennett P Hamet AV Pshezhetsky 2002 Proteome analysis and functional expression identify mortalin as an antiapoptotic gene induced by elevation of [Na+]i/[K+]i ratio in cultured vascular smooth muscle cells Circ. Res. 91 10 915 922
32. WR Taylor SE Egan M Mowat AH Greenberg JA Wright 1992 Evidence for synergistic interactions between ras, myc and a mutant form of p53 in cellular transformation and tumor dissemination Oncogene 7 7 1383 1390
33. SP Thayer MP di Magliano PW Heiser CM Nielsen DJ Roberts GY Lauwers YP Qi S Gysin C Fernandez-del Castillo V Yajnik B Antoniu M McMahon AL Warshaw M Hebrok 2003 Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature. 425 6960 851 856
34. F Toledo GM Wahl 2006 Regulating the p53 pathway: in vitro hypotheses, in vivo veritas Nat Rev Cancer 6 12 909 923
35. K Viktorsson L De Petris R Lewensohn 2005 The role of p53 in treatment responses of lung cancer Biochem. Biophys. Res. Commun. 331 3 868 880
36. LL Vindelov IJ Christensen NI Nissen 1983 A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis Cytometry 3 5 323 327
37. R Wadhwa S Takano K Kaur CC Deocaris OM Pereira-Smith RR Reddel SC Kaul 2006 Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis Int. J. Cancer 118 12 2973 2980
38. J Wesierska-Gadek G Schmid 2000 Overexpressed poly(ADP-ribose) polymerase delays the release of rat cells from p53-mediated G(1) checkpoint J. Cell. Biochem. 80 1 85 103
39. J Wesierska-Gadek G Schmid 2001 Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein Cell. Mol. Biol. Lett. 6 2 117 140
40. J Wesierska-Gadek A Bugajska-Schretter C Cerni 1996a ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild- type p53 is modified J Cell Biochem 62 1 90 101
41. J Wesierska-Gadek G Schmid C Cerni 1996 ADP-ribosylation of wild-type p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification Biochemical and biophysical research communications 224 1 96 102
42. J Wesierska-Gadek J Wojciechowski G Schmid 2003 Central and carboxy-terminal regions of human p53 protein are essential for interaction and complex formation with PARP-1 J. Cell. Biochem. 89 2 220 232
43. J Wesierska-Gadek J Wojciechowski G Schmid 2003 Phosphorylation regulates the interaction and complex formation between wt p53 protein and PARP-1 J. Cell. Biochem. 89 6 1260 1284 (Pubitemid 36969787)
44. J Wesierska-Gadek M Gueorguieva C Ranftler G Zerza-Schnitzhofer 2005 A new multiplex assay allowing simultaneous detection of the inhibition of cell proliferation and induction of cell death J. Cell. Biochem. 96 1 1 7
45. J Wesierska-Gadek M Kramer G Schmid 2006 Prevention of farnesylation of c-Ha-Ras protein enhances synergistically the cytotoxic action of doxorubicin in cycling but not in quiescent cells J. Cell. Biochem. 99 6 1664 1676
46. A Yang M Kaghad Y Wang E Gillett MD Fleming V Dotsch NC Andrews D Caput F McKeon 1998 p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities Mol Cell 2 3 305 316
47. Z Zhang R Yao J Li Y Wang CW Boone RA Lubet M You 2005 Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53 Mol Cancer Res 3 10 563 574
48. Z Zhang Y Wang R Yao J Li RA Lubet M You 2006 p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer Mol Cancer Res 4 6 401 410