Occurrence of β-casomorphins 5 and 7 in commercial dairy products and in their digests following in vitro simulated gastro-intestinal digestion

Food Chemistry

Volumn 119, Issue 2, 2010, Pages 560-566

  De Noni, Ivano ^a   Cattaneo, Stefano ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Casomorphins; Dairy products; HPLC MS MS; In vitro gastro intestinal digestion

Indexed keywords

BETA CASOMORPHINE 5; BETA CASOMORPHINE 7; BETA CASOMORPHINE DERIVATIVE; MILK PROTEIN; PEPTIDE; PROBIOTIC AGENT; UNCLASSIFIED DRUG; YOGHURT;

ARTICLE; ARTIFICIAL MILK; CHEESE; CONTROLLED STUDY; DAIRY PRODUCT; DIGESTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MILK; SIMULATION;

EID: 70350573378     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2009.06.058     Document Type: Article

References (44)

1. Addeo F., Chianese L., Salzano A., Sacchi R., Cappuccio U., Ferranti P., and Malorni A. Characterization of the 12% trichloroacetic acid-insoluble oligopeptides of Parmigiano-Reggiano cheese. Journal of Dairy Research 59 (1992) 401-411
2. Brantl V., Teschemacher H., Henschen A., and Lottspeich F. Novel opioid peptides derived from casein (β-casomorphins). I. Isolation from bovine casein peptone. Hoppe-Seyler's Z Physiological Chemistry 360 (1979) 1211-1216
3. Cieslinska A., Kaminski S., Kostyra E., and Sienkiewicz-Szlapka E. Beta-casomorphin 7 in raw and hydrolyzed milk derived from cows of alternative beta-casein genotypes. Milchwissenschaft 62 (2007) 125-127
4. Considine T., Healy A., Kelly A.L., and McSweeney P.L.H. Hydrolysis of bovine caseins by cathepsin B, a cysteine proteinase indigenous to milk. International Dairy Journal 14 (2004) 117-124
5. De Noni I. Release of beta-casomorphins 5 and 7 during simulated gastro-intestinal digestion of bovine beta-casein variants and milk-based infant formulas. Food Chemistry 110 (2008) 897-903
6. Donkor O.N., Henriksson A., Singh T.K., Vasiljevic T., and Shah N.P. ACE-inhibitory activity of probiotic yoghurt. International Dairy Journal 17 (2007) 1321-1331
7. EFSA, European Food Safety Authority (2009). Review of the potential health impact of β-casomorphins and related peptides. Scientific Report n. 231, 1-107.
8. Elliott R.B., Harris D.P., Hill J.P., Bibby N.J., and Wasmuth H.E. Type I (insulin-dependent) diabetes mellitus and cow milk: Casein variant consumption. Diabetologia 42 (1999) 292-296
9. Gaucher I., Mollé D., Gagnaire V., and Gaucheron F. Effects of storage temperature on physico-chemical characteristics of semi-skimmed UHT milk. Food Hydrocolloids 22 (2008) 130-143
10. Hartmann R., and Meisel H. Food-derived peptides with biological activity: From research to food applications. Current Opinion in Biotechnology 18 (2007) 163-169
11. Hartwig A., Teschemacher H., Lehmann W., Gauly M., and Erhardt G. Influence of genetic polymorphisms in bovine milk on the occurrence of bioactive peptides. Seminar on milk protein polymorphism, IDF Special Issue no. 9702. International Dairy Federation, Brussels (1997) 459-460
12. Hernandez-Ledesma B., Amigo L., Ramos M., and Recio I. Release of angiotensin converting enzyme-inhibitory peptides by simulated gastrointestinal digestion of infant formulas. International Dairy Journal 14 (2004) 889-898
13. IDF-International Dairy Federation (1993). Milk. Determination of nitrogen content. Standard 20B.
14. Jarmolowska B., Kostyra E., Krawczuk S., and Kostyra H. β -casomorphin-7 isolated from Brie cheese. Journal of the Science of Food and Agriculture 79 (1999) 1788-1792
15. Jarmolowska B., Szlapka-Sienkiewicz E., Kostyra E., Kostyra H., Mierzejewska D., and Marcinkiewicz-Darmochwal K. Opioid activity of Humana formula for newborns. Journal of the Science of Food and Agriculture 87 (2007) 2247-2250
16. Jinsmaa Y., and Yoshikawa M. Enzymatic release of neocasomorphin and β-casomorphin from bovine β-casein. Peptides 20 (1999) 957-962
17. Juillard V., Laan H., Kunji E.R., Jeronimus-Stratingh C.M., Bruins A.P., and Konings W.N. The extracellular PI-type proteinase of Lactococcus lactis hydrolyzes beta-casein into more than one hundred different oligopeptides. Journal of Bacteriology 177 (1995) 3472-3478
18. Kahala M., Pahkala E., and Pihlanto A. Peptides in fermented Finnish milk products. Agricultural and Food Science in Finland 2 (1993) 379-386
19. Korhonen H., and Pihlanto A. Bioactive peptides: Production and functionality. International Dairy Journal 16 (2006) 945-960
20. Korhonen H., and Pihlanto A. Bioactive peptides from food proteins. Handbook of food products manufacturing: Health meat, milk, poultry, seafood, and vegetables (2007), John Wiley & Sons pp. 5-38
21. 1 β-casein. Journal of the New Zealand Medical Association 116 (2003) 1168
22. 1 β-casein on heart disease and Type 1 diabetes - the authors reply. Journal of the New Zealand Medical Association 116 (2003) 1170
23. Macaud C., Zhao Q., Ricart G., and Piot J.M. Rapid new casomorphin-like peptide from a peptic casein hydrolysate second order derivative spectroscopy during HPLC. Chromatography and Related Technologies 22 (1999) 401-418
24. 1, ischaemic heart disease mortality, and other illnesses. Medical Hypotheses 56 (2001) 262-272
25. Mierau I., Kunji E.R.S., Venema G., and Kok J. Casein and peptide degradation in lactic acid bacteria. Biotechnology and Genetic Engineering Reviews 14 (1997) 279-301
26. Morris, P.E., & FitzGerald, R.J. (2008). Whey proteins and peptides in human health. In: Onwulata, C. (Ed.), Whey Processing, Functionality and Health Benefits (pp. 287-345). UK: Woodhead Publishing.
27. Muehlenkamp M.R., and Warthesen J.J. Beta-casomorphins: Analysis in cheese and susceptibility to proteolytic enzymes from Lactococcus lactis ssp. cremoris. Journal of Dairy Science 79 (1996) 20-26
28. Murray B.A., and FitzGerald R.J. Angiotensin converting enzyme inhibitory peptides derived from food proteins: Biochemistry, bioactivity and production. Current Pharmaceutical Design 13 (2007) 773-791
29. Napoli A., Aiello D., Di Donna L., Prendushi H., and Sindona G. Exploitation of endogenous protease activity in raw mastitic milk by MALDI-TOF/TOF. Analytical Chemistry 79 (2007) 5941-5948
30. Parrot, S., Degraeve, P., Curia, C., & Martial-Gros, A. (2003). In vitro study on digestion of peptides in Emmental cheese: Analytical evaluation and influence on angiotensin I converting enzyme inhibitory peptides. Nahrung/Food, 47, 87-94.
31. Pellegrino L., Hogenboom J.A., Pazzaglia C., and Todesco R. La caratterizzazione analitica del formaggio Fontina sulla base della sua composizione in amminoacidi liberi. Il Latte 10 (1995) 1086-1093
32. Resmini P., Pellegrino L., Pazzaglia C., and Hogenboom J.A. Free amino acids for the quality control of Parmigiano-Reggiano cheese and particularly for the grated product. Scienza e Tecnica Lattiero-Casearia 36 (1985) 557-592
33. Robinson, R.K. (1995). A colour guide to cheese and fermented milks (pp. 49-51). London, UK: Chapman & Hall.
34. Rokka T., Syväoja E.L., Tuominen J., and Korhonen H. Release of bioactive peptides by enzymatic proteolysis of Lactobacillus GG fermented UHT-milk. Milchwissenschaft 52 (1997) 675-678
35. Saito T., Nakamura T., Kitazawa H., Kawai Y., and Itoh T. Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. Journal of Dairy Science 83 (2000) 1434-1440
36. Schieber A., and Brückner H. Characterization of oligo-and polypeptides isolated from yoghurt. European Food Research and Technology 210 (2000) 310-313
37. Singh T.K., Fox P.F., and Healy A. Water-soluble peptides in Cheddar cheese: Isolation and identification of peptides in the diafiltration retentate of the water-soluble fraction. Journal of Dairy Research 62 (1995) 629-640
38. Singh T.K., Fox P.F., and Healy A. Isolation and identification of further peptides in the diafiltration retentate of the water-soluble fraction of Cheddar cheese. Journal of Dairy Research 64 (1997) 433-443
39. Stepaniak L., Fox P.F., Sorhaug T., and Grabska J. Effect of peptides from the sequence 58-72 of β-casein on the activity of endopeptidase, aminopeptidase, and X-prolyl-dipeptidyl aminopeptidase from Lactococcus lactis ssp. lactis MG1363. Journal of Agricultural and Food Chemistry 43 (1995) 849-853
40. Tamime A.Y., and Robinson R.K. Yoghurt: Science and Technology (1999), CRC Press, Boca Raton, USA
41. Toelstede S., and Hofmann T. Sensomics mapping and identification of the key bitter metabolites in Gouda cheese. Journal of Agricultural and Food Chemistry 56 (2008) 2795-2804
42. Tzvetkova I., Dalgalarrondo M., Danova S., Iliev I., Ivanova I., Chobert J.M., and Haertle T. Hydrolysis of major dairy proteins by lactic acid bacteria from Bulgarian yogurts. Journal of Food Biochemistry 31 (2007) 680-702
43. Wedholm A., Moller H.S., Lindmark-Mansson H., Rasmussen M.D., Andren A., and Larsen L.B. Identification of peptides in milk as a result of proteolysis at different levels of somatic cell counts using LC MALDI MS/MS detection. Journal of Dairy Research 75 (2008) 76-83
44. Yvon M., Chabanet C., and Pélissier J.P. Solubility of peptides in trichloroacetic acid (TCA) solutions. Hypothesis on the precipitation mechanism. International Journal of Peptide and Protein Research 34 (1989) 166-176