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Volumn 50, Issue 50, 2009, Pages 6968-6972

One-pot N-alkylation/Heck approach to substituted indoles

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE DERIVATIVE; INDOLE DERIVATIVE; PALLADIUM; PALLADIUM COMPLEX;

EID: 70350515120     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.09.144     Document Type: Article
Times cited : (19)

References (31)
  • 1
    • 33947259131 scopus 로고    scopus 로고
    • For some recent reviews see:
    • For some recent reviews see:. Ackermann L. Synlett (2007) 507-526
    • (2007) Synlett , pp. 507-526
    • Ackermann, L.1
  • 6
    • 22944454156 scopus 로고    scopus 로고
    • For review see:
    • For review see:. Cacchi S., and Fabrizi G. Chem. Rev. 105 (2005) 2873-2920
    • (2005) Chem. Rev. , vol.105 , pp. 2873-2920
    • Cacchi, S.1    Fabrizi, G.2
  • 12
    • 26844532131 scopus 로고    scopus 로고
    • Jia Y., and Zhu J. Synlett 16 (2005) 2469-2472
    • (2005) Synlett , vol.16 , pp. 2469-2472
    • Jia, Y.1    Zhu, J.2
  • 28
    • 70350437003 scopus 로고    scopus 로고
    • note
    • All reagents were purchased from commercial sources and were used without purification. Reagents were weighed out on the bench top and the reactions were carried out under normal atmosphere conditions. No special precautions to remove oxygen were taken.
  • 29
    • 70350446276 scopus 로고    scopus 로고
    • note
    • 3, δ ppm 8.56-8.60 (1H, m), 8.10-8.15 (1H, m), 7.35-7.40 (1H, m), 7.11-7.16 (1H, m), 2.39 (3H, d, J = 1.2 Hz).
  • 31
    • 70350444110 scopus 로고    scopus 로고
    • note
    • 1H NMR). Both 3-chloro and 4-chloro pyridines analogs also failed to produce the corresponding pyrrolopyridines. On the other hand, 2-chloropyridin-3-amine afforded 13% conversion to the desired 3-methylpyrrolopyridine, but the corresponding N-allyl derivative was the major product. Prolonged heating for 48 h under the reaction conditions resulted in dechlorination of the substrate.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.