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S)-10 (3.5 mg, 6 mol, and Pd2(dba)3 (1.7 mg, 3 mol% Pd) were weighed into an MW-vial and dry solvent (0.5 mL) was added. The vial was sealed and the mixture was gently heated with a heat gun until the colour remained the same in the mixture (usually the colour changed from purple to yellow-green, The reaction mixture was then allowed to cool down to room temperature before adding triflate 23 (23 μL, 0.13 mmol, 1 equiv, 2,3-dihydrofuran (48 μL, 0.63 mmol, 5 equivs, and DIPEA 66 μL, 0.38 mol, 3 equivs, The mixture was heated to reflux and stirred for 16 h. After cooling, the mixture was diluted in diethyl ether and filtered through a short column of silica. The filtrate was analyzed by chiral GC/MS and 1H NMR. Conversion: 50, regioselectivity: 98:2, ee: 97, S
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1H NMR. Conversion: 50%, regioselectivity: 98:2, ee: 97% (S).
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The reaction has not yet succeeded with substrates other than 2,3-dihydrofuran, such as cyclopentene
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The reaction has not yet succeeded with substrates other than 2,3-dihydrofuran, such as cyclopentene.
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