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Volumn 349, Issue 17-18, 2007, Pages 2595-2602

Microwave-assisted asymmetric intermolecular heck reaction using phosphine-thiazole ligands

Author keywords

Asymmetric catalysis; Heck reaction; Microwave heating; Phosphine thiazole ligands

Indexed keywords


EID: 37349095609     PISSN: 16154150     EISSN: 15213897     Source Type: Journal    
DOI: 10.1002/adsc.200700390     Document Type: Article
Times cited : (45)

References (39)
  • 29
    • 0036738330 scopus 로고    scopus 로고
    • For a review on microwave-accelerated homogeneous catalysis see
    • For a review on microwave-accelerated homogeneous catalysis see: C. Moberg, A. Hallberg, M. Larhed, Acc. Chem. Res. 2002, 35, 717
    • (2002) Acc. Chem. Res , vol.35 , pp. 717
    • Moberg, C.1    Hallberg, A.2    Larhed, M.3
  • 34
    • 37349008623 scopus 로고    scopus 로고
    • S)-10 (3.5 mg, 6 mol, and Pd2(dba)3 (1.7 mg, 3 mol% Pd) were weighed into an MW-vial and dry solvent (0.5 mL) was added. The vial was sealed and the mixture was gently heated with a heat gun until the colour remained the same in the mixture (usually the colour changed from purple to yellow-green, The reaction mixture was then allowed to cool down to room temperature before adding triflate 23 (23 μL, 0.13 mmol, 1 equiv, 2,3-dihydrofuran (48 μL, 0.63 mmol, 5 equivs, and DIPEA 66 μL, 0.38 mol, 3 equivs, The mixture was heated to reflux and stirred for 16 h. After cooling, the mixture was diluted in diethyl ether and filtered through a short column of silica. The filtrate was analyzed by chiral GC/MS and 1H NMR. Conversion: 50, regioselectivity: 98:2, ee: 97, S
    • 1H NMR. Conversion: 50%, regioselectivity: 98:2, ee: 97% (S).
  • 37
    • 37349033301 scopus 로고    scopus 로고
    • The reaction has not yet succeeded with substrates other than 2,3-dihydrofuran, such as cyclopentene
    • The reaction has not yet succeeded with substrates other than 2,3-dihydrofuran, such as cyclopentene.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.