Synthesis of 3,5,7-substituted indoles via heck cyclisation

Synlett

Volumn , Issue 20, 2005, Pages 3071-3074

  Charrier, Nicolas ^a   Demont, Emmanuel ^a   Dunsdon, Rachel ^a   Maile, Graham ^a   Naylor, Alan ^a   O'Brien, Alistair ^a   Redshaw, Sally ^a   Theobald, Pam ^a   Vesey, David ^a   Walter, Daryl ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Anilines; Heck reaction; Hydroxybenzimidazole; Indoles; Palladium

Indexed keywords

ANILINE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; PALLADIUM;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; HECK REACTION; ISOMERIZATION; SYNTHESIS;

EID: 29744454349     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-921917     Document Type: Article

References (36)

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35. Removal of the TFA proved more difficult than in the case of amide 11 and was not complete after 2 d using similar conditions (deprotection of 11 takes 15 min at r.t). We therefore did not attempt the Heck cyclisation on the unprotected aniline.
36. 3: 310.14377; found: 310.14372.