A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells

Journal of the Royal Society Interface

Volumn 6, Issue 41, 2009, Pages 1167-1177

  Clyde, Robert G ^a   Craig, Ashley L ^b   De Breed, Lucas ^b   Bown, James L ^a   Forrester, Leslie ^b   Vojtesek, Borivoj ^c   Smith, Graeme ^d   Hupp, Ted ^b   Crawford, John ^e  

^a UNIVERSITY OF ABERTAY DUNDEE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

^d KuDOS Pharmaceuticals Limited   (United Kingdom)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Ataxia telangiectasia mutated inhibition; Cancer; DNA damage; Drug discovery; Mathematics; Model

Indexed keywords

ASYNCHRONOUS TRANSFER MODE; AUTOMATIC TELLER MACHINES; CELL MEMBRANES; DNA; ENZYME INHIBITION; GENES; INTERNET PROTOCOLS; MATHEMATICAL MODELS; NUCLEIC ACIDS; TRANSCRIPTION;

ATAXIA-TELANGIECTASIA MUTATED INHIBITION; CANCER; DNA DAMAGE; DRUG DISCOVERY; MATHEMATICS;

SIGNAL TRANSDUCTION;

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; ATR PROTEIN; DOXORUBICIN; NU 7441; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; AUTOREGULATION; CELL AGING; CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; EMBRYONIC STEM CELL; ENZYME INHIBITION; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO CULTURE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOMATIC CELL; UPREGULATION;

ATAXIA TELANGIECTASIA; MURINAE; MUS;

EID: 70350509827     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2008.0538     Document Type: Article

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