DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4α and negatively regulates gluconeogenic enzyme gene expression

Journal of Biological Chemistry

Volumn 284, Issue 40, 2009, Pages 27511-27523

  Nedumaran, Balachandar ^a   Hong, Sungpyo ^b   Xie, Yuan Bin ^a   Kim, Yong Hoon ^c   Seo, Woo Young ^b   Lee, Min Woo ^b   Lee, Chul Ho ^c   Koo, Seung Hoi ^b   Choi, Hueng Sik ^a  

^a Chonnam National University   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD GLUCOSE LEVEL; CO-IMMUNOPRECIPITATION ASSAYS; COACTIVATORS; COREPRESSORS; CRITICAL REGION; DIABETIC MICE; FORSKOLIN; GENE PROMOTER; GLUCONEOGENIC GENES; GLUCOSE METABOLISM; GLUCOSE-6-PHOSPHATASE; HEPATIC GLUCONEOGENESIS; HEPATOCYTE NUCLEAR FACTORS; HIGH-FAT DIET; IN-VIVO; MOUSE LIVER; NUCLEAR RECEPTORS; PHOSPHOENOLPYRUVATE CARBOXYKINASE; PRIMARY HEPATOCYTES; REFEEDING; TRANSCRIPTIONAL ACTIVITY; X CHROMOSOMES;

BIOACTIVITY; CHROMOSOMES; EMPLOYMENT; FATTY ACIDS; GLUCOSE; INSULIN; LIVER; METABOLISM; NUTRITION; SUGAR (SUCROSE); TRANSCRIPTION FACTORS;

TRANSCRIPTION;

HEPATOCYTE NUCLEAR FACTOR 4ALPHA; NUCLEAR RECEPTOR DAX 1; PHOSPHOENOLPYRUVATE CARBOXYKINASE (PYROPHOSPHATE); DAX 1 ORPHAN NUCLEAR RECEPTOR; DAX-1 ORPHAN NUCLEAR RECEPTOR; DNA BINDING PROTEIN; GLUCOSE 6 PHOSPHATASE; HEPATOCYTE NUCLEAR FACTOR 4; INSULIN; PHOSPHOTRANSFERASE; PPARGC1A PROTEIN, MOUSE; REPRESSOR PROTEIN; RETINOIC ACID RECEPTOR; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENE MAPPING; GENE OVEREXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIVER CELL; MALE; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; ANIMAL; CELL LINE; CHEMISTRY; DOWN REGULATION; FAT INTAKE; GENETIC TRANSCRIPTION; GENETICS; INSULIN RESISTANCE; LIVER; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; RAT; TRANSCRIPTION INITIATION;

ADENOVIRIDAE; MUS;

ANIMALS; BASE SEQUENCE; BLOOD GLUCOSE; CELL LINE; DIETARY FATS; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCONEOGENESIS; GLUCOSE-6-PHOSPHATASE; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; PHOSPHOTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; RECEPTORS, RETINOIC ACID; REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 70350463602     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.034660     Document Type: Article

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