Regulation of peripheral blood flow in complex regional pain syndrome: Clinical implication for symptomatic relief and pain management

BMC Musculoskeletal Disorders

Volumn 10, Issue 1, 2009, Pages

  Groeneweg, George ^a   Huygen, Frank Jpm ^a   Coderre, Terence J ^b,c,d   Zijlstra, Freek J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIA; CLINICAL ASSESSMENT; COMPLEX REGIONAL PAIN SYNDROME; ENDOTHELIAL DYSFUNCTION; FUNCTIONAL PAIN; HUMAN; ISCHEMIC PAIN; NEUROPATHIC PAIN; NOCICEPTIVE PAIN; PAIN; PAIN ASSESSMENT; PERIPHERAL CIRCULATION; REVIEW; TEMPERATURE SENSITIVITY; ANIMAL; BLOOD FLOW; DISEASE MANAGEMENT; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VASOCONSTRICTION;

ANIMALS; COMPLEX REGIONAL PAIN SYNDROMES; DISEASE MANAGEMENT; HUMANS; PAIN; PAIN MEASUREMENT; REGIONAL BLOOD FLOW; VASOCONSTRICTION;

EID: 70350460067     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-10-116     Document Type: Review

References (148)

1. Complex regional pain syndrome: mystery explained? W Janig R Baron, Lancet Neurol 2003 2 11 687 697 14572737 10.1016/S1474-4422(03)00557-X (Pubitemid 37311322)
2. Differential expression patterns of cytokines in complex regional pain syndrome. N Uceyler T Eberle R Rolke F Birklein C Sommer, Pain 2007 132 1-2 195 205 17890011 10.1016/j.pain.2007.07.031 (Pubitemid 47494574)
3. The reflex sympathetic dystrophy syndrome. I. Clinical and histologic studies: evidence for bilaterality, response to corticosteroids and articular involvement. F Kozin DJ McCarty J Sims H Genant, The American journal of medicine 1976 60 3 321 331 56891 10.1016/0002-9343(76)90747-6
4. Bone tissue in reflex sympathetic dystrophy syndrome - Sudeck's atrophy: structural and ultrastructural studies. MF Basle A Rebel JC Renier, Metabolic bone disease & related research 1983 4 5 305 311 10.1016/S0221-8747(83) 80004-6 6194403
5. Partial algodystrophy of the knee. An anatomico-radiological study of one case. R Lagier, J Rheumatol 1983 10 2 255 260 6864679
6. [The Sudeck-Leriche syndrome as a disturbance in distant regions of the body, clinical picture, and histology (author's transl)] Das Sudeck-Syndrom als Fernstorung. (Klinik und Histologie). K Kirsch, Z Orthop Ihre Grenzgeb 1978 116 2 199 203 77594
7. Complex regional pain syndrome type I (RSD): pathology of skeletal muscle and peripheral nerve. L van der Laan HJ ter Laak A Gabreels-Festen F Gabreels RJ Goris, Neurology 1998 51 1 20 25 9674773
8. Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome. PJ Albrecht S Hines E Eisenberg D Pud DR Finlay MK Connolly M Pare G Davar FL Rice, Pain 2006 120 3 244 266 10.1016/j.pain.2005.10.035 16427199
9. Expression of endothelial nitric oxide synthase and endothelin-1 in skin tissue from amputated limbs of patients with complex regional pain syndrome. JG Groeneweg CH Heijmans Antonissen FJ Huygen FJ Zijlstra, Mediators Inflamm 2008 2008 680981 18663383 10.1155/2008/680981
10. Proposed new diagnostic criteria for complex regional pain syndrome. RN Harden S Bruehl M Stanton-Hicks PR Wilson, Pain medicine (Malden, Mass) 2007 8 4 326 331 10.1111/j.1526-4637.2006.00169.x 17610454
11. Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). AL Oaklander JG Rissmiller LB Gelman L Zheng Y Chang R Gott, Pain 2006 120 3 235 243 10.1016/j.pain.2005.09. 036 16427737
12. Evidence for local inflammation in complex regional pain syndrome type 1. FJ Huygen AG De Bruijn MT De Bruin JG Groeneweg J Klein FJ Zijlstra, Mediators Inflamm 2002 11 1 47 51 11930962 10.1080/09629350210307 (Pubitemid 34252547)
13. Complex regional pain syndrome. F Birklein, J Neurol 2005 252 2 131 138 10.1007/s00415-005-0737-8 15729516
14. Serum and salivary oxidative analysis in Complex Regional Pain Syndrome. E Eisenberg S Shtahl R Geller AZ Reznick O Sharf M Ravbinovich A Erenreich RM Nagler, Pain 2008 138 1 226 232 10.1016/j.pain.2008.04.019 18539395
15. Objectifying CRPS-I. TJ Coderre GJ Bennett, Pain 2008 138 1 3 4 10.1016/j.pain.2008.06.006 18584964
16. Warm and cold complex regional pain syndromes: differences beyond skin temperature? T Eberle B Doganci HH Kramer C Geber M Fechir W Magerl F Birklein, Neurology 2009 72 6 505 512 10.1212/01.wnl.0000341930.35494.66 19204260
17. Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results. B Okudan C Celik, Rheumatology international 2006 26 5 404 408 10.1007/s00296-005-0009-z 16025330
18. De la causalgie envisagée comme une névrite du sympathique et de son traitement par la dénudation et l'excision des plexus nerveux péri-artériels. R Leriche, Presse Med 1916 24 178 180
19. Reflex sympathetic dystrophy: skin blood flow, sympathetic vasoconstrictor reflexes and pain before and after surgical sympathectomy. R Baron C Maier, Pain 1996 67 2-3 317 326 10.1016/0304-3959(96)03136-3 8951925
20. Reflex sympathetic dystrophy: result of autonomic denervation? HA Kurvers MJ Jacobs RJ Beuk FA van den Wildenberg PJ Kitslaar DW Slaaf RS Reneman, Clin Sci (Lond) 1994 87 6 663 669 7874857
21. Vascular abnormalities in reflex sympathetic dystrophy (CRPS I): mechanisms and diagnostic value. G Wasner J Schattschneider K Heckmann C Maier R Baron, Brain 2001 124 3 587 599 10.1093/brain/124.3.587 11222458
22. Thermoregulatory and rhythm-generating mechanisms governing the sudomotor and vasoconstrictor outflow in human cutaneous nerves. G Bini KE Hagbarth P Hynninen BG Wallin, The Journal of physiology 1980 306 537 552 7463376
23. Thermography imaging during static and controlled thermoregulation in complex regional pain syndrome type 1: diagnostic value and involvement of the central sympathetic system. SP Niehof FJ Huygen RW van der Weerd M Westra FJ Zijlstra, Biomed Eng Online 2006 5 30 16689997 10.1186/1475-925X-5-30 (Pubitemid 43885289)
24. Imaging in early posttraumatic complex regional pain syndrome: a comparison of diagnostic methods. M Schurmann J Zaspel P Lohr I Wizgall M Tutic N Manthey M Steinborn G Gradl, Clin J Pain 2007 23 5 449 457 10.1097/AJP.0b013e31805c9e66 17515744
25. Vascular abnormalities in acute reflex sympathetic dystrophy (CRPS I): complete inhibition of sympathetic nerve activity with recovery. G Wasner K Heckmann C Maier R Baron, Arch Neurol 1999 56 5 613 620 10.1001/archneur.56.5. 613 10328258
26. Reflex sympathetic dystrophy: evolution of microcirculatory disturbances in time. HA Kurvers MJ Jacobs RJ Beuk FA Van den Wildenberg PJ Kitslaar DW Slaaf RS Reneman, Pain 1995 60 3 333 340 10.1016/0304-3959(94)00133-Y 7596630
27. Microvascular reactivity differences between the two legs of patients with unilateral lower limb ischaemia. DT Ubbink MJ Jacobs DW Slaaf GJ Tangelder RS Reneman, European journal of vascular surgery 1992 6 3 269 275 10.1016/S0950-821X(05)80317-2 1592131
28. The role of the sympathetic nervous system in autonomic disturbances and 'sympathetically maintained pain' before and after surgical sympathectomy. G Wasner PD Drummond F Birklein R Baron, Progress in Pain Research and Management Seattle: IASP Press, Harden R, Baron R, Jänig, 2001 22
29. Mechanism of complex regional pain syndrome: no longer excessive sympathetic outflow? PD Drummond, Lancet 2001 358 9277 168 170 10.1016/S0140-6736(01)05400-9 11476829
30. Complex regional pain syndrome - diagnostic, mechanisms, CNS involvement and therapy. G Wasner J Schattschneider A Binder R Baron, Spinal Cord 2003 41 2 61 75 10.1038/sj.sc.3101404 12595868
31. Increased venous alpha-adrenoceptor responsiveness in patients with reflex sympathetic dystrophy. JM Arnold RW Teasell AP MacLeod JE Brown SG Carruthers, Annals of internal medicine 1993 118 8 619 621 8383935
32. Basal blood flow in complex regional pain syndrome does not necessarily indicate vasoconstrictor nerve activity. K Toda H Muneshige T Asou T Harada M Okazaki N Tachiki N Horie W Cheng S Nakamura, Clin J Pain 2006 22 1 109 110 10.1097/01.ajp.0000161527.32998.f8 16340600
33. Experimental tissue acidosis leads to increased pain in complex regional pain syndrome (CRPS). F Birklein M Weber M Ernst B Riedl B Neundorfer HO Handwerker, Pain 2000 87 2 227 234 10.1016/S0304-3959(00)00286-4 10924816 (Pubitemid 30621455)
34. Tissue hypoxia in complex regional pain syndrome. M Koban S Leis S Schultze-Mosgau F Birklein, Pain 2003 104 1-2 149 157 10.1016/S0304-3959(02) 00484-0 12855324
35. Reflex sympathetic dystrophy of the hand: an excessive inflammatory response? WJ Oyen IE Arntz RM Claessens JW Van der Meer FH Corstens RJ Goris, Pain 1993 55 2 151 157 10.1016/0304-3959(93)90144-E 8309706
36. Central processing of tactile and nociceptive stimuli in complex regional pain syndrome. NV Vartiainen E Kirveskari N Forss, Clin Neurophysiol 2008 119 10 2380 2388 10.1016/j.clinph.2008.06.008 18723393
37. Cortical reorganization during recovery from complex regional pain syndrome. C Maihofner HO Handwerker B Neundorfer F Birklein, Neurology 2004 63 4 693 701 15326245
38. Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial. GL Moseley, Pain 2004 108 1-2 192 198 10.1016/j.pain.2004.01.006 15109523
39. The threat of predictable and unpredictable pain. GL Moseley L Brhyn M Ilowiecki K Solstad PW Hodges, Aust J Physiother 2003 49 4 263 267 14632625
40. Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I). V Huge M Lauchart S Forderreuther W Kaufhold M Valet SC Azad A Beyer W Magerl, PLoS ONE 2008 3 7 2742 18648647 10.1371/journal.pone. 0002742
41. Complex regional pain syndrome is a disease of the central nervous system. W Janig R Baron, Clin Auton Res 2002 12 3 150 164 10.1007/s10286-002- 0022-1 12269546 (Pubitemid 34994574)
42. Endothelial dysfunction. DH Endemann EL Schiffrin, J Am Soc Nephrol 2004 15 8 1983 1992 10.1097/01.ASN.0000132474.50966.DA 15284284
43. Nitric oxide, platelet function, myocardial infarction and reperfusion therapies. D Alonso MW Radomski, Heart Fail Rev 2003 8 1 47 54 10.1023/A:1022194921040 12652159
44. The nitric oxide-endothelin-1 connection. D Alonso MW Radomski, Heart Fail Rev 2003 8 1 107 115 10.1023/A:1022155206928 12652164
45. Biological mechanisms for the clinical success of lipid-lowering in coronary artery disease and the use of surrogate end-points. S Kinlay AP Selwyn D Delagrange MA Creager P Libby P Ganz, Current opinion in lipidology 1996 7 6 389 397 10.1097/00041433-199612000-00009 9117144
46. Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. S Moncada EA Higgs JR Vane, Lancet 1977 1 8001 18 20 10.1016/S0140-6736(77)91655-5 63657
47. Endothelial functions and dysfunctions. R De Caterina M Massaro P Libby, Endothelial dysfunctions and vascular disease Malden Oxford Victoria: Blackwell Futura, De Caterina R, Libby P, 2007 3 25
48. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa H Kurihara S Kimura Y Tomobe M Kobayashi Y Mitsui Y Yazaki K Goto T Masaki, Nature 1988 332 6163 411 415 10.1038/332411a0 2451132 (Pubitemid 18090241)
49. Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. MC Verhaar FE Strachan DE Newby NL Cruden HA Koomans TJ Rabelink DJ Webb, Circulation 1998 97 8 752 756 9498538
50. Pathophysiology of endothelin in the cardiovascular system. T Miyauchi T Masaki, Annual review of physiology 1999 61 391 415 10.1146/annurev.physiol.61. 1.391 10099694
51. Endothelial vasodilatory dysfunction. S Kinlay P Ganz, Endothelial dysfunctions and vascular disease Malden Oxford Victoria: Blackwell Futura, De Caterina R, Libby P, 2007 179 188
52. Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo. C Cardillo CM Kilcoyne RO Cannon 3rd JA Panza, Hypertension 2000 35 6 1237 1241 10856270
53. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. JA Panza AA Quyyumi JE Brush Jr SE Epstein, The New England journal of medicine 1990 323 1 22 27 2355955
54. Endothelial function and coronary artery disease. S Kinlay P Libby P Ganz, Current opinion in lipidology 2001 12 4 383 389 10.1097/00041433- 200108000-00003 11507322
55. Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E). AC Carr BZ Zhu B Frei, Circ Res 2000 87 5 349 354 10969031
56. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. R Joannides WE Haefeli L Linder V Richard EH Bakkali C Thuillez TF Luscher, Circulation 1995 91 5 1314 1319 7867167
57. Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans. M Kooijman DH Thijssen PC de Groot MW Bleeker HJ van Kuppevelt DJ Green GA Rongen P Smits MT Hopman, The Journal of physiology 2008 586 4 1137 1145 18096601 10.1113/jphysiol.2007.145722 (Pubitemid 351267351)
58. Prognostic significance of endothelial dysfunction in hypertensive patients. F Perticone R Ceravolo A Pujia G Ventura S Iacopino A Scozzafava A Ferraro M Chello P Mastroroberto P Verdecchia, et al. Circulation 2001 104 2 191 196 11447085
59. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. RF Furchgott JV Zawadzki, Nature 1980 288 5789 373 376 10.1038/288373a0 6253831
60. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. PL Ludmer AP Selwyn TL Shook RR Wayne GH Mudge RW Alexander P Ganz, The New England journal of medicine 1986 315 17 1046 1051 3093861
61. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. DS Celermajer KE Sorensen VM Gooch DJ Spiegelhalter OI Miller ID Sullivan JK Lloyd JE Deanfield, Lancet 1992 340 8828 1111 1115 10.1016/0140-6736(92)93147-F 1359209
62. Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. JT Kuvin AR Patel KA Sliney NG Pandian J Sheffy RP Schnall RH Karas JE Udelson, American heart journal 2003 146 1 168 174 10.1016/S0002-8703(03)00094-2 12851627
63. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. P Ganz JA Vita, Circulation 2003 108 17 2049 2053 10.1161/01.CIR. 0000089507.19675.F9 14581383
64. Assessment of endothelial function in complex regional pain syndrome type I. I Duman HT Sanal K Dincer TA Kalyon, Rheumatology international 2008 28 4 329 333 10.1007/s00296-007-0451-1 17763850
65. Correlation of endothelial function in large and small arteries in human essential hypertension. JB Park F Charbonneau EL Schiffrin, Journal of hypertension 2001 19 3 415 420 10.1097/00004872-200103000-00009 11288811
66. Assessment of endothelial function in complex regional pain syndrome type I using iontophoresis and laser Doppler imaging. R Gorodkin T Moore A Herrick, Rheumatology (Oxford, England) 2004 43 6 727 730 10.1093/rheumatology/keh158 15026582
67. Endothelial dysfunction in cold type complex regional pain syndrome. J Schattschneider K Hartung M Stengel J Ludwig A Binder G Wasner R Baron, Neurology 2006 67 4 673 675 10.1212/01.wnl.0000229931.40631.31 16924021
68. Exaggerated vasoconstriction in complex regional pain syndrome-1 is associated with impaired resistance artery endothelial function and local vascular reflexes. L Dayan S Salman D Norman JJ Vatine E Calif G Jacob, J Rheumatol 2008 35 7 1339 1345 18464300
69. Complex regional pain syndrome-a multifaceted disorder requiring multidimensional care: case study. M Mogilevsky W Janig R Baron RN Harden, J Pain 2007 8 9 677 681 10.1016/j.jpain.2007.05.009 17652030
70. Pain: moving from symptom control toward mechanism-specific pharmacologic management. CJ Woolf, Annals of internal medicine 2004 140 6 441 451 15023710
71. Is CRPS I a neuropathic pain syndrome? W Janig R Baron, Pain 2006 120 3 227 229 10.1016/j.pain.2005.11.015 16426757
72. Unravelling the Pathophysiology of Complex Regional Pain Syndrome: Focus on Sympathetically Maintained Pain. GF Gibbs PD Drummond PM Finch JK Phillips, Clin Exp Pharmacol Physiol 2008 35 7 717 724 10.1111/j.1440-1681.2007.04862.x 18215185
73. Sympathetic Vasoconstrictor Antagonism and Vasodilatation Relieve Mechanical Allodynia in Rats With Chronic Postischemia Pain. DN Xanthos TJ Coderre, J Pain 2008 9 5 423 433 10.1016/j.jpain.2007.12.005 18262849
74. Sensory testing of pathophysiological mechanisms of pain in patients with reflex sympathetic dystrophy. DD Price S Long C Huitt, Pain 1992 49 2 163 173 10.1016/0304-3959(92)90139-3 1608643
75. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Z Ali SN Raja U Wesselmann PN Fuchs RA Meyer JN Campbell, Pain 2000 88 2 161 168 10.1016/S0304-3959(00)00327-4 11050371
76. Noradrenaline-evoked pain in neuralgia. E Torebjork L Wahren G Wallin R Hallin M Koltzenburg, Pain 1995 63 1 11 20 10.1016/0304-3959(95)00140-N 8577481
77. Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study. R Baron J Schattschneider A Binder D Siebrecht G Wasner, Lancet 2002 359 9318 1655 1660 10.1016/S0140-6736(02)08589-6 12020526
78. Pain increases during sympathetic arousal in patients with complex regional pain syndrome. PD Drummond PM Finch S Skipworth P Blockey, Neurology 2001 57 7 1296 1303 11591852
79. Intravenous guanethidine in patients with reflex sympathetic dystrophy. R Kaplan M Claudio E Kepes XF Gu, Acta Anaesthesiol Scand 1996 40 10 1216 1222 8986185
80. Involvement of the sympathetic nervous system in complex regional pain syndrome. PD Drummond, The international journal of lower extremity wounds 2004 3 1 35 42 10.1177/1534734604263365 15866786
81. Persistence of pain induced by startle and forehead cooling after sympathetic blockade in patients with complex regional pain syndrome. PD Drummond PM Finch, J Neurol Neurosurg Psychiatry 2004 75 1 98 102 14707316
82. Local anaesthetic sympathic blockade for complex regional pain syndrome. MS Cepeda DB Carr J Lau, Cochrane Database ofSystematic Reviews 2005 4
83. ber die acute entzündliche Knochenatrophie. P Sudeck, Archiv für klinische Chirurgie 1900 62 147 156
84. ber die akute (reflektorische) Knochenatrophie nach Entzündungen und Verletzungen an den Extremitäten und ihre klinischen Erscheinungen. P Sudeck, Fortschritte auf dem Gebiete der Röntgenstrahlen 1901 5 277 293
85. The reflex sympathetic dystrophy syndrome. II. Roentgenographic and scintigraphic evidence of bilaterality and of periarticular accentuation. F Kozin HK Genant C Bekerman DJ McCarty, The American journal of medicine 1976 60 3 332 338 10.1016/0002-9343(76)90748-8 56892
86. The important role of neuropeptides in complex regional pain syndrome. F Birklein M Schmelz S Schifter M Weber, Neurology 2001 57 12 2179 2184 11756594 (Pubitemid 34016448)
87. Innate cytokine profile in patients with complex regional pain syndrome is normal. WJ van de Beek EJ Remarque RG Westendorp JJ van Hilten, Pain 2001 91 3 259 261 10.1016/S0304-3959(00)00443-7 11275382
88. Tumor necrosis factor-alpha and interleukin-6 are not correlated with the characteristics of Complex Regional Pain Syndrome type 1 in 66 patients. F Wesseldijk FJ Huygen C Heijmans-Antonissen SP Niehof FJ Zijlstra, Eur J Pain 2007 12 6 716 721 10.1016/j.ejpain.2007.10.010 18055234
89. Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1. JG Groeneweg FJ Huygen C Heijmans-Antonissen S Niehof FJ Zijlstra, BMC musculoskeletal disorders 2006 7 91 17137491 10.1186/1471-2474-7-91 (Pubitemid 44912703)
90. Intermediate stage complex regional pain syndrome type 1 is unrelated to proinflammatory cytokines. RJ Munnikes C Muis M Boersma C Heijmans-Antonissen FJ Zijlstra FJ Huygen, Mediators Inflamm 2005 2005 6 366 372 16489257 10.1155/MI.2005.366 (Pubitemid 41803405)
91. Six years follow-up of the levels of TNF-alpha and IL-6 in patients with complex regional pain syndrome type 1. F Wesseldijk FJ Huygen C Heijmans-Antonissen SP Niehof FJ Zijlstra, Mediators Inflamm 2008 2008 469439 18596918 10.1155/2008/469439 (Pubitemid 352000406)
92. The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review. FW Blaisdell, Cardiovascular surgery (London, England) 2002 10 6 620 630 10.1016/S0967-2109(02)00070-4 12453699
93. Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. TJ Coderre DN Xanthos L Francis GJ Bennett, Pain 2004 112 1-2 94 105 10.1016/j.pain.2004.08.001 15494189
94. Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome - type I. M Millecamps TJ Coderre, European journal of pharmacology 2008 583 1 97 102 10.1016/j.ejphar.2008.01.006 18272148
95. Cutaneous tactile allodynia associated with microvascular dysfunction in muscle. A Laferriere M Millecamps DN Xanthos WH Xiao C Siau M de Mos C Sachot JV Ragavendran FJ Huygen GJ Bennett, et al. Mol Pain 2008 4 49 18957097
96. Norepinephrine-induced nociception and vasoconstrictor hypersensitivity in rats with chronic post-ischemia pain. DN Xanthos GJ Bennett TJ Coderre, Pain 2008 137 3 640 651 10.1016/j.pain.2007.10.031 18079061
97. Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. PE Zollinger WE Tuinebreijer RS Breederveld RW Kreis, J Bone Joint Surg Am 2007 89 7 1424 1431 10.2106/JBJS.F.01147 17606778
98. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. PE Zollinger WE Tuinebreijer RW Kreis RS Breederveld, Lancet 1999 354 9195 2025 2028 10.1016/S0140-6736(99)03059-7 10636366
99. Reflex sympathetic dystrophy: model of a severe regional inflammatory response syndrome. RJ Goris, World J Surg 1998 22 2 197 202 10.1007/ s002689900369 9451936
100. Are toxic oxygen radicals involved in the pathogenesis of reflex sympathetic dystrophy? RJ Goris LM Dongen HA Winters, Free Radic Res Commun 1987 3 1-5 13 18 10.3109/10715768709069764 3508426
101. Treatment of acute reflex sympathetic dystrophy with DMSO 50% in a fatty cream. WW Zuurmond PN Langendijk PD Bezemer HE Brink JJ de Lange AC van loenen, Acta Anaesthesiol Scand 1996 40 3 364 367 10.1111/j.1399-6576.1996.tb04446.x 8721469
102. Treatment of Patients With Complex Regional Pain Syndrome Type I With Mannitol: A Prospective, Randomized, Placebo-Controlled, Double-Blinded Study. RS Perez E Pragt J Geurts WW Zuurmond J Patijn M van Kleef, J Pain 2008 9 8 678 686 10.1016/j.jpain.2008.02.005 18403271
103. The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study. RS Perez WW Zuurmond PD Bezemer DJ Kuik AC van Loenen JJ de Lange AJ Zuidhof, Pain 2003 102 3 297 307 10.1016/S0304-3959(02)00414-1 12670672
104. Complex regional pain syndromes: the influence of cutaneous and deep somatic sympathetic innervation on pain. J Schattschneider A Binder D Siebrecht G Wasner R Baron, Clin J Pain 2006 22 3 240 244 10.1097/01.ajp.0000169672.49438. 67 16514323
105. Reflex sympathetic dystrophy of the upper extremity - a 5.5-year follow-up. Part II. Social life events, general health and changes in occupation. JH Geertzen PU Dijkstra JW Groothoff HJ ten Duis WH Eisma, Acta Orthop Scand Suppl 1998 279 19 23 9614811
106. Relationship between impairments, disability and handicap in reflex sympathetic dystrophy patients: a long-term follow-up study. JH Geertzen PU Dijkstra EL van Sonderen JW Groothoff HJ ten Duis WH Eisma, Clin Rehabil 1998 12 5 402 412 10.1191/026921598676761735 9796931
107. Neglect-like symptoms in complex regional pain syndrome: results of a self-administered survey. BS Galer M Jensen, J Pain Symptom Manage 1999 18 3 213 217 10.1016/S0885-3924(99)00076-7 10517043
108. Impaired self-perception of the hand in complex regional pain syndrome (CRPS) [S. Forderreuther, U. Sailer, A. Straube, Pain 2004; 110:756-761]. CS McCabe N Shenker J Lewis DR Blake, Pain 2005 114 3 518 10.1016/j.pain.2005.01. 003 15777877
109. Impaired self-perception of the hand in complex regional pain syndrome (CRPS). S Forderreuther U Sailer A Straube, Pain 2004 110 3 756 761 10.1016/j.pain.2004.05.019 15288417
110. Body perception disturbance: a contribution to pain in complex regional pain syndrome (CRPS). JS Lewis P Kersten CS McCabe KM McPherson DR Blake, Pain 2007 133 1-3 111 119 10.1016/j.pain.2007.03.013 17509761
111. Changes in dorsal horn neuronal responses in an experimental wrist contracture model. T Ushida WD Willis, J Orthop Sci 2001 6 1 46 52 10.1007/s007760170024 11289586
112. Disuse and CRPS. SH Butler, Complex Regional Pain Syndrome, Progress in Pain Research and Management Seattle: IASP Press, Norman R, Harden RBaWJ, 2001 22 141 150
113. Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I. TZ Guo SC Offley EA Boyd CR Jacobs WS Kingery, Pain 2004 108 1-2 95 107 10.1016/j.pain.2003.12.010 15109512
114. Quantitative sensory studies in complex regional pain syndrome type 1/RSD. AJ Tahmoush RJ Schwartzman JL Hopp JR Grothusen, Clin J Pain 2000 16 4 340 344 10.1097/00002508-200012000-00011 11153791
115. Treating patients with complex regional pain syndrome. DV Nelson, Psychological approaches to pain management A practitioner's handbook New York: Guildford, Turk DC, Gatchel R, 2002
116. Reduction of pain-related fear in complex regional pain syndrome type I: the application of graded exposure in vivo. JR de Jong JW Vlaeyen P Onghena C Cuypers M den Hollander J Ruijgrok, Pain 2005 116 3 264 275 10.1016/j.pain.2005. 04.019 15964686
117. [Psychological abnormalities in patients with complex regional pain syndrome (CRPS)] Psychische Veranderungen bei Patienten mit komplexem regionalem Schmerzsyndrom (CRPS). O Rommel A Willweber-Strumpf P Wagner D Surall JP Malin M Zenz, Schmerz 2005 19 4 272 284 10.1007/s00482-004-0337-z 15243794
118. The Symptom Checklist-90 Revised questionnaire: no psychological profiles in complex regional pain syndrome-dystonia. L van der Laan K van Spaendonck MW Horstink RJ Goris, J Pain Symptom Manage 1999 17 5 357 362 10.1016/S0885- 3924(99)00009-3 10355214
119. Medical history and the onset of complex regional pain syndrome (CRPS). M de Mos FJ Huygen JP Dieleman JS Koopman BH Stricker MC Sturkenboom, Pain 2008 139 2 458 466 10.1016/j.pain.2008.07.002 18760877
120. Asymmetric dimethylarginine is associated with macrovascular disease and total homocysteine in patients with type 2 diabetes. K Krzyzanowska F Mittermayer W Krugluger C Schnack M Hofer M Wolzt G Schernthaner, Atherosclerosis 2006 189 1 236 240 10.1016/j.atherosclerosis.2005.12.007 16414052
121. Treatment of chronic painful diabetic neuropathy with isosorbide dinitrate spray: a double-blind placebo-controlled cross-over study. KC Yuen NR Baker G Rayman, Diabetes Care 2002 25 10 1699 1703 10.2337/diacare.25.10.1699 12351464
122. Topical nifedipine vs. topical glyceryl trinitrate for treatment of chronic anal fissure. T Ezri S Susmallian, Dis Colon Rectum 2003 46 6 805 808 10.1007/s10350-004-6660-8 12794583
123. A randomized trial of glyceryl trinitrate ointment and nitroglycerin patch in healing of anal fissures. BF Zuberi MR Rajput H Abro SA Shaikh, International journal of colorectal disease 2000 15 4 243 245 10.1007/s003840000230 11008725
124. Topical nitric oxide application in the treatment of chronic extensor tendinosis at the elbow: a randomized, double-blinded, placebo-controlled clinical trial. JA Paoloni RC Appleyard J Nelson GA Murrell, Am J Sports Med 2003 31 6 915 920 14623657
125. Tratamiento de la Distrofia Simpatico Refleja (DSR). Con nitroglicerina transdermica. H Badala S Toledo, Archivos de Medicina Interna Volumen 2002 XXIV 52 23 27
126. Vasodilative effect of isosorbide dinitrate ointment in complex regional pain syndrome type 1. G Groeneweg S Niehof F Wesseldijk FJ Huygen FJ Zijlstra, Clin J Pain 2008 24 1 89 92 10.1097/AJP.0b013e318156db3b 18180642
127. No Recovery of Cold Complex Regional Pain Syndrome after Transdermal Isosorbide Dinitrate. A Small Controlled Trial. JG Groeneweg FJ Huygen S Niehof F Wesseldijk JB Bussmann FC Schasfoort DL Stronks FJ Zijlstra, Journal of Pain and Symptom Management 2009 38 3 401 408 10.1016/j.jpainsymman.2008.10.006
128. Erectile dysfunction. TF Lue, The New England journal of medicine 2000 342 24 1802 1813 10.1056/NEJM200006153422407 10853004
129. Effect of tadalafil on blood flow, pain, and function in chronic cold Complex Regional Pain Syndrome: a randomized controlled trial. G Groeneweg FJ Huygen SP Niehof F Wesseldijk JB Bussmann FC Schasfoort DL Stronks FJ Zijlstra, BMC musculoskeletal disorders 2008 9 143 18937830 10.1186/1471-2474-9-143
130. Reliability of observer assessment of thermographic images in complex regional pain syndrome type 1. SP Niehof FJ Huygen DL Stronks J Klein FJ Zijlstra, Acta orthopaedica Belgica 2007 73 1 31 37 17441655
131. Using skin surface temperature to differentiate between complex regional pain syndrome type 1 patients after a fracture and control patients with various complaints after a fracture. SP Niehof A Beerthuizen FJ Huygen FJ Zijlstra, Anesth Analg 2008 106 1 270 277 10.1213/01.ane.0000289635.95869.70 18165590
132. Long-term skin temperature measurements - a practical diagnostic tool in complex regional pain syndrome. EK Krumova J Frettloh S Klauenberg H Richter G Wasner C Maier, Pain 2008 140 1 8 22 10.1016/j.pain.2008.07.003 18723287
133. The spinal component to skin blood flow abnormalities in reflex sympathetic dystrophy. HA Kurvers MJ Jacobs RJ Beuk FA van den Wildenberg PJ Kitslaar DW Slaaf RS Reneman, Arch Neurol 1996 53 1 58 65 8599560
134. Efficacy of oral nifedipine in the treatment of reflex sympathetic dystrophy. DS Prough CH McLeskey GG Poehling LA Koman DB Weeks T Whitworth EL Semble, Anesthesiology 1985 62 6 796 799 10.1097/00000542-198506000-00017 4003801
135. Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. JP Muizelaar M Kleyer IA Hertogs DC DeLange, Clin Neurol Neurosurg 1997 99 1 26 30 10.1016/S0303-8467(96)00594-X 9107464
136. Clinical applications of slow channel blocking compounds. AG Ellrodt BN Singh, Pharmacol Ther 1983 23 1 1 43 10.1016/0163-7258(83)90025-6 6140691
137. Comparative pharmacological properties among calcium channel blockers: T-channel versus L-channel blockade. G Noll TF Luscher, Cardiology 1998 89 Suppl 1 10 15 10.1159/000047274 9570424
138. Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis. M Pache HA Schwarz HJ Kaiser P Wuest M Kloti B Dubler J Flammer, Med Sci Monit 2002 8 9 616 619
139. Plasma levels of endothelin-1, angiotensin II, nitric oxide and prostaglandin E in the venous and cavernosal blood of patients with erectile dysfunction. NT El Melegy ME Ali EM Awad, BJU Int 2005 96 7 1079 1086 10.1111/j.1464-410X.2005.05780.x 16225532
140. Microvascular ischemia-reperfusion injury in striated muscle: significance of "reflow paradox". MD Menger S Pelikan D Steiner K Messmer, Am J Physiol 1992 263 6 Pt 2 1901 1906 1282785
141. Abnormalities of cutaneous blood flow regulation in patients with reflex sympathetic dystrophy as measured by laser Doppler fluxmetry. MD Bej RJ Schwartzman, Arch Neurol 1991 48 9 912 915 1953414
142. A standardized bedside test for assessment of peripheral sympathetic nervous function using laser Doppler flowmetry. M Schurmann G Gradl H Furst, Microvascular research 1996 52 2 157 170 10.1006/mvre.1996.0051 8901444
143. Assessment of peripheral sympathetic nervous function for diagnosing early post-traumatic complex regional pain syndrome type I. M Schurmann G Gradl HJ Andress H Furst FW Schildberg, Pain 1999 80 1-2 149 159 10.1016/S0304- 3959(98)00198-5 10204727
144. Sympathectomy for complex regional pain syndrome. B Singh J Moodley AS Shaik JV Robbs, J Vasc Surg 2003 37 3 508 511 10.1067/mva.2003.78 12618683
145. [Evaluation of sympathicolysis after continuous brachial plexus analgesia using laser Doppler flowmetry in patients suffering from CRPS I]. G Gradl A Beyer S Azad M Schurmann, Anasthesiol Intensivmed Notfallmed Schmerzther 2005 40 6 345 349 10.1055/s-2005-861244 15942853
146. Involvement of the Sympathetic Nervous System in Complex Regional Pain Syndrome. PD Drummond, Lower Extremity Wounds 2004 3 1 35 42 10.1177/1534734604263365
147. Correlation of pain with temperature and blood-flow changes in the lower limb following chemical lumbar sympathectomy in reflex sympathetic dystrophy. A case report. ED Cooke J Harris CE Fleming MD Steinberg JM Foster, Int Angiol 1995 14 3 226 228 8919238
148. Sympathetic skin responses in reflex sympathetic dystrophy. K Bolel S Hizmetli A Akyuz, Rheumatology international 2006 26 9 788 791 10.1007/s00296-005-0081-4 16328419