No Recovery of Cold Complex Regional Pain Syndrome After Transdermal Isosorbide Dinitrate: A Small Controlled Trial

Journal of Pain and Symptom Management

Volumn 38, Issue 3, 2009, Pages 401-408

  Groeneweg, J George ^a   Huygen, Frank J P M ^a   Niehof, Sjoerd P ^a   Wesseldijk, Feikje ^a   Bussmann, Johannes B J ^a   Schasfoort, Fabienne C ^a   Stronks, Dirk L ^a   Zijlstra, Freek J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

CRPS; endothelial dysfunction; isosorbide dinitrate; Nitric oxide; vasodilation; videothermography

Indexed keywords

ENDOTHELIN 1; ISOSORBIDE DINITRATE; NITRIC OXIDE; PLACEBO;

ADULT; ARM MOVEMENT; ARTICLE; BLISTER; CHRONIC PAIN; CLINICAL ARTICLE; CLINICAL TRIAL; COLD COMPLEX REGIONAL PAIN SYNDROME; COLD COMPLEX REGIONAL PAIN SYNDROME TYPE I; COMPLEX REGIONAL PAIN SYNDROME; COMPLEX REGIONAL PAIN SYNDROME TYPE I; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; MICROCIRCULATION; PAIN ASSESSMENT; PERIPHERAL CIRCULATION; PHYSIOTHERAPY; RANDOMIZED CONTROLLED TRIAL; SKIN TEMPERATURE; TREATMENT OUTCOME;

ADMINISTRATION, CUTANEOUS; ADULT; COLD TEMPERATURE; COMPLEX REGIONAL PAIN SYNDROMES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; ISOSORBIDE DINITRATE; MALE; MIDDLE AGED; PAIN MEASUREMENT; PHYSICAL THERAPY MODALITIES; REGIONAL BLOOD FLOW; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 69549122371     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2008.10.006     Document Type: Article

References (53)

1. Stanton-Hicks M., Janig W., Hassenbusch S., et al. Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain 63 (1995) 127-133
2. Baron R., Schattschneider J., Binder A., Siebrecht D., and Wasner G. Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study. Lancet 359 (2002) 1655-1660
3. Bruehl S., Harden R.N., Galer B.S., et al. External validation of IASP diagnostic criteria for Complex Regional Pain Syndrome and proposed research diagnostic criteria. International Association for the Study of Pain. Pain 81 (1999) 147-154
4. Harden R.N., and Bruehl S.P. Diagnosis of complex regional pain syndrome: signs, symptoms, and new empirically derived diagnostic criteria. Clin J Pain 22 (2006) 415-419
5. Janig W., and Baron R. Complex regional pain syndrome: mystery explained?. Lancet Neurol 2 (2003) 687-697
6. Baron R., and Janig W. Complex regional pain syndromes-how do we escape the diagnostic trap?. Lancet 364 (2004) 1739-1741
7. Schasfoort F.C., Bussmann J.B., Krijnen H.J., and Stam H.J. Upper limb activity over time in complex regional pain syndrome type 1 as objectively measured with an upper limb-activity monitor: an explorative multiple case study. Eur J Pain 10 (2006) 31-39
8. Huygen F.J., De Bruijn A.G., De Bruin M.T., et al. Evidence for local inflammation in complex regional pain syndrome type 1. Mediators Inflamm 11 (2002) 47-51
9. Goris R.J., Dongen L.M., and Winters H.A. Are toxic oxygen radicals involved in the pathogenesis of reflex sympathetic dystrophy?. Free Radic Res Commun 3 (1987) 13-18
10. Schinkel C., Gaertner A., Zaspel J., et al. Inflammatory mediators are altered in the acute phase of posttraumatic complex regional pain syndrome. Clin J Pain 22 (2006) 235-239
11. van der Laan L., and Goris R.J. Reflex sympathetic dystrophy. An exaggerated regional inflammatory response?. Hand Clin 13 (1997) 373-385
12. Birklein F., Schmelz M., Schifter S., and Weber M. The important role of neuropeptides in complex regional pain syndrome. Neurology 57 (2001) 2179-2184
13. Leis S., Weber M., Isselmann A., Schmelz M., and Birklein F. Substance-P-induced protein extravasation is bilaterally increased in complex regional pain syndrome. Exp Neurol 183 (2003) 197-204
14. Sharma A., Williams K., and Raja S.N. Advances in treatment of complex regional pain syndrome: recent insights on a perplexing disease. Curr Opin Anaesthesiol 19 (2006) 566-572
15. Bruehl S., Harden R.N., Galer B.S., et al. Complex regional pain syndrome: are there distinct subtypes and sequential stages of the syndrome?. Pain 95 (2002) 119-124
16. Huygen F.J., de Bruijn A.G., Klein J., and Zijlstra F.J. Neuroimmune alterations in the complex regional pain syndrome. Eur J Pharmacol 429 (2001) 101-113
17. Schwartzman R.J., and Popescu A. Reflex sympathetic dystrophy. Curr Rheumatol Rep 4 (2002) 165-169
18. Birklein F., Weber M., Ernst M., et al. Experimental tissue acidosis leads to increased pain in complex regional pain syndrome (CRPS). Pain 87 (2000) 227-234
19. Koban M., Leis S., Schultze-Mosgau S., and Birklein F. Tissue hypoxia in complex regional pain syndrome. Pain 104 (2003) 149-157
20. Schattschneider J., Binder A., Siebrecht D., Wasner G., and Baron R. Complex regional pain syndromes: the influence of cutaneous and deep somatic sympathetic innervation on pain. Clin J Pain 22 (2006) 240-244
21. Kilo S., Berghoff M., Hilz M., and Freeman R. Neural and endothelial control of the microcirculation in diabetic peripheral neuropathy. Neurology 54 (2000) 1246-1252
22. Birklein F., Weber M., and Neundorfer B. Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?. Neurology 55 (2000) 1213-1215
23. Schattschneider J., Hartung K., Stengel M., et al. Endothelial dysfunction in cold type complex regional pain syndrome. Neurology 67 (2006) 673-675
24. Wasner G., Schattschneider J., Heckmann K., Maier C., and Baron R. Vascular abnormalities in reflex sympathetic dystrophy (CRPS I): mechanisms and diagnostic value. Brain 124 (2001) 587-599
25. Groeneweg J.G., Huygen F.J., Heijmans-Antonissen C., Niehof S., and Zijlstra F.J. Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1. BMC Musculoskelet Disord 7 (2006) 91
26. Groeneweg G., Niehof S., Wesseldijk F., Huygen F.J., and Zijlstra F.J. Vasodilative effect of isosorbide dinitrate ointment in complex regional pain syndrome type 1. Clin J Pain 24 (2008) 89-92
27. Kemler M.A., Rijks C.P., and de Vet H.C. Which patients with chronic reflex sympathetic dystrophy are most likely to benefit from physical therapy?. J Manipulative Physiol Ther 24 (2001) 272-278
28. Wasner G., Heckmann K., Maier C., and Baron R. Vascular abnormalities in acute reflex sympathetic dystrophy (CRPS I): complete inhibition of sympathetic nerve activity with recovery. Arch Neurol 56 (1999) 613-620
29. Huygen F.J.P.M., Niehof S., Klein J., and Zijlstra F.J. Computer-assisted skin videothermography is a highly sensitive quality tool in the diagnosis and monitoring of complex regional pain syndrome type 1. Eur J Appl Physiol 91 (2004) 516-524
30. Pochaczevsky R. Thermography in posttraumatic pain. Am J Sports Med 15 (1987) 243-250
31. Niehof S.P., Huygen F.J., van der Weerd R.W., Westra M., and Zijlstra F.J. Thermography imaging during static and controlled thermoregulation in complex regional pain syndrome type 1: diagnostic value and involvement of the central sympathetic system. Biomed Eng Online 5 (2006) 30
32. Uematsu S. Thermographic imaging of cutaneous sensory segment in patients with peripheral nerve injury. Skin-temperature stability between sides of the body. J Neurosurg 62 (1985) 716-720
33. Uematsu S., Edwin D.H., Jankel W.R., Kozikowski J., and Trattner M. Quantification of thermal asymmetry. Part 1: Normal values and reproducibility. J Neurosurg 69 (1988) 552-555
34. Prens E.P., Benne K., van Damme J., et al. Interleukin-1 and interleukin-6 in psoriasis. J Invest Dermatol 95 (1990) 121S-124S
35. Macdonald N., Cumberbatch M., Singh M., et al. Proteomic analysis of suction blister fluid isolated from human skin. Clin Exp Dermatol 31 (2006) 445-448
36. Michiels J., and Zijlstra F.J. Prostaglandin cyclooxygenase products but not thromboxane A2 are involved in the pathogenesis of erythromelalgia in thrombocythemia. Mediators Inflamm 2 (1993) 385-389
37. Munnikes R.J., Muis C., Boersma M., et al. Intermediate stage complex regional pain syndrome type 1 is unrelated to proinflammatory cytokines. Mediators Inflamm 2005 (2005) 366-372
38. Heijmans-Antonissen C., Wesseldijk F., Munnikes R.J., et al. Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1. Mediators Inflamm 2006 (2006) 28398
39. Schasfoort F.C., Bussmann J.B., and Stam H.J. Outcome measures for complex regional pain syndrome type I: an overview in the context of the international classification of impairments, disabilities and handicaps. Disabil rehabil 22 (2000) 387-398
40. Bussmann J.B., Tulen J.H., van Herel E.C., and Stam H.J. Quantification of physical activities by means of ambulatory accelerometry: a validation study. Psychophysiology 35 (1998) 488-496
41. Bussmann J.B., Martens W.L., Tulen J.H., et al. Measuring daily behavior using ambulatory accelerometry: the Activity Monitor. Behav Res Methods Instrum Comput 33 (2001) 349-356
42. Schasfoort F.C., Bussmann J.B., Zandbergen A.M., and Stam H.J. Impact of upper limb complex regional pain syndrome type 1 on everyday life measured with a novel upper limb-activity monitor. Pain 101 (2003) 79-88
43. Schasfoort F.C., Bussmann J.B., and Stam H.J. Correlation between a novel upper limb activity monitor and four other instruments to determine functioning in upper limb complex regional pain syndrome type I. J Rehabil Med 37 (2005) 108-114
44. Schasfoort F.C., Bussmann J.B., and Stam H.J. Impairments and activity limitations in subjects with chronic upper-limb complex regional pain syndrome type I. Arch Phys Med Rehabil 85 (2004) 557-566
45. Schasfoort F.C., Bussmann J.B., and Stam H.J. Ambulatory measurement of upper limb usage and mobility-related activities during normal daily life with an upper limb-activity monitor: a feasibility study. Med Biol Eng Comput 40 (2002) 173-182
46. Schasfoort F.C., Bussmann J.B., Martens W.L., and Stam H.J. Objective measurement of upper limb activity and mobility during everyday behavior using ambulatory accelerometry: the upper limb activity monitor. Behav Res Methods 38 (2006) 439-446
47. Hudak P.L., Amadio P.C., and Bombardier C. Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) The Upper Extremity Collaborative Group (UECG). Am J Ind Med 29 (1996) 602-608
48. Davidson J. A comparison of upper limb amputees and patients with upper limb injuries using the Disability of the Arm, Shoulder and Hand (DASH). Disabil Rehabil 26 (2004) 917-923
49. Palmen C.M., van der Meijden E., Nelissen Y., and Koke A.J. De betrouwbaarheid en validiteit van de Nederlandse vertaling van de "Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH)" [Reliability and validity of the Dutch translation of the Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH)]. Nederlands Tijdschrift voor Fysiotherapie (Dutch J Phys Ther) 2 (2004) 50-54
50. Keppel G. Design and analysis. A researcher's handbook (1973), Prentice Hall Inc., Englewood Cliffs, NJ
51. El Melegy N.T., Ali M.E., and Awad E.M. Plasma levels of endothelin-1, angiotensin II, nitric oxide and prostaglandin E in the venous and cavernosal blood of patients with erectile dysfunction. BJU Int 96 (2005) 1079-1086
52. Pache M., Schwarz H.A., Kaiser H.J., et al. Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis. Med Sci Monit 8 (2002) 616-619
53. de Jong J.R., Vlaeyen J.W., Onghena P., et al. Reduction of pain-related fear in complex regional pain syndrome type I: the application of graded exposure in vivo. Pain 116 (2005) 264-275