The anti-leukaemic activity of novel synthetic naphthoquinones against acute myeloid leukaemia: Induction of cell death via the triggering of multiple signalling pathways

British Journal of Haematology

Volumn 147, Issue 4, 2009, Pages 459-470

  Hallak, Maher ^a,b   Win, Thida ^d   Shpilberg, Ofer ^c   Bittner, Shmuel ^b   Granot, Yosef ^b   Levy, Itai ^a   Nathan, Ilana ^a,b  

^a Soroka University Medical Centre   (Azerbaijan)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

^d Kyaukse University   (Myanmar)

Author keywords

Apoptosis; Mitochondria; Mitogen activated protein kinases; Reactive oxygen species; TW 92

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 CHLORO 3 (3 AMINO 4 METHYLPHENYLAMINO) 1,4 NAPHTHOQUINONE; ANTILEUKEMIC AGENT; CASPASE; CYTOCHROME C; DIPHENYLIODONIUM SALT; GLUTATHIONE; HYDROGEN PEROXIDE; MENADIONE; METHYL GROUP; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; TW 53; TW 69; TW 92; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CASE REPORT; CELL DEATH; CELL STRAIN U937; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DEATH; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LEUKEMIA, MYELOID, ACUTE; MOLECULAR STRUCTURE; NAPHTHOQUINONES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

EID: 70350455102     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07867.x     Document Type: Article

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