A molecular mechanism for mimosine-induced apoptosis involving oxidative stress and mitochondrial activation

Apoptosis

Volumn 13, Issue 1, 2008, Pages 147-155

  Hallak, Maher ^a,b   Vazana, Liat ^a,b   Shpilberg, Ofer ^c   Levy, Itai ^a   Mazar, Julia ^d   Nathan, Ilana ^a,b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Apoptosis; Mimosine; Mitochondria; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; CASPASE 3; CYCLOSPORIN A; CYTOCHROME C; GLUTATHIONE; HYDROGEN PEROXIDE; MIMOSINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL STRAIN U937; CONTROLLED STUDY; DNA REPLICATION; DOWN REGULATION; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; TOXIN ANALYSIS;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CYCLOSPORINE; CYTOCHROMES C; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIMOSINE; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 38049177594     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0156-7     Document Type: Article

References (36)

1. Kristen NSK, Vulliet P (1996) Mimosine blocks cell cycle progression by chelating iron in asynchronous human breast cancer cells. Toxic App Pharm 139:356-364
2. Dewreede S, Wayman O (1970) Effect of mimosine on the rat fetus. Teratology 3:21-27
3. Kalejta RF, Hamlin JL (1997) The dual effect of mimosine on DNA replication. Exp Cell Res 231:173-183
4. Soedarjo M, Borthakur D (1998) Mimosine, a toxin produced by the tree-legume Leucaena provides a nodulation competition advantage to mimosine-degrading Rhiobuim strains. Appl Environ Microbiol 30:1605-1613
5. Krude T (1999) Mimosine arrests proliferating human cells before onset of DNA replication in a dose-dependent manner. Exp Cell Res 247:148-159
6. Dai Y, Gold B, Vishwantha JK, Rhode S (1994) Mimosine inhibits viral DNA synthesis through ribonucleotide reductase. Virology 205:210-216
7. Wang Y, Zhao J, Clapper J, Martin LD, Du C, Devore ER et al (1995) Mimosine differentially inhibits DNA replication and cell cycle progression in somatic cells compared to embryonic cells of Xenopus laevis. Exp Cell Res 217:84-91
8. Gilbert DM, Neilson A, Miyazawa H, dePamphelis ML, Burhans WC (1995) Mimosine arrests DNA synthesis at replication forks by inhibiting deoxynucleotide metabolism. J Biol Chem 270:9597-9606
9. Kip1. Exp Cell Res 254:64-71
10. Mosca PJ, Lin HB, Hamlin JL (1995) Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. Nuc Acids Res 23:261-268
11. Lin H, Falchetto R, Mosca PJ, Shabanowit J, Hunt DF, Hamlin J (1996) Mimosine targets serine hydroxymethyl transferase. J Biol Chem 271:2548-2556
12. Park MH,Wolff EC, Folk JE (1993) Hypusine. Its post-translational formation in eucaryotic initiation factor 5A and its potential role in cellular regulation. Biofactors 4:95-104
13. Hanauske-Abel HM, Park MH, Hanauske AR, Popowitz AM, Lalande M, Folk JE (1994) Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation. Biochem Biophys Acta 122:115-124
14. 2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor α-induced but not interleukin-1β induced IκB kinase complex/nuclear factor-κB activation. J Biol Chem 280:2912-2923
15. Mikhailov I, Russev G, Anachkova B (2000) Treatment of mammalian cells with mimosine generates DNA breaks. Mut Res 459:299-306
16. Crompton M (1999) The mitochondrial permeability transition pore and its role in cell death. Biochem J 341:233-249
17. Halestrap AP, McStay GP, Clarke SJ (2002) The permeability transition pore complex: another view. Biochimie 84:153-166
18. Kroemer G, Reed JC (2000) Mitochondrial control of cell death. Nat Med 6:513-519
19. Gogvadze V, Orrenius S, Zhivotovsky B (2006) Multiple pathways of cytochrome c relese from mitochondria in apoptosis. Biochim Biophys Acta 1757:639-647
20. Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552:335-344
21. Shen HM, Liu ZG (2006) JNK siganling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 40:928-939
22. Kowaltowski AJ, Castilho RF, Vercesi AE (2001) Mitochondrial permeability transition and oxidative stress. FEBS Lett 495:12-15
23. Hayon T, Dvilansky A, Oriev L, Nathan I (1999) Non-steroidal antiestrogens induce apoptosis in HL-60 and MOLT3 leukemic cells; involvement of reactive oxygen radicals and protein kinase C. Anticancer Res 19:2089-2093
24. Hayon T, Atlas L, Levy E, Dvilansky A, Shpilberg O, Nathan I (2003) Multifactorial activities of nonsteroidal antiestrogens against leukemia. Cancer Detect Prev 27:389-396
25. Zalk R, Israelson A, Garty ES, Azoulay-Zohar H, Shoshan-Barmatz V (2005) Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria. Biochem 386:73-83
26. Baker MA, Cerniglia GJ, Zaman A (1990) Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Analy Biochem 190:360-365
27. Enari M, Talanian RV, Wong WW, Nagata S (1996) Sequential activation of ICE-like and CPP32-like protease during Fas-mediated apoptosis. Nature 380:723-726
28. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf/Caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489
29. Lalande M (1990) A reversible arrest point in the late G1 phase of the mammalian cell cycle. Exp Cell Res 186:332-339
30. Reno F, Tontini A, Burattini S, Papa E, Falcieri E, Trazai G (1999) Mimosine induces apoptosis in the HL-60 human tumor cell line. Apoptosis 4:469-477
31. Marchetti P, Castedo M, Susin SA, Zamzami N, Hirsch T, Macho A, Haeffner A, Hirrsch F, Geuskens M, Kroemer G (1996) Mitochondrial permeability is a central coordinating event of apoptosis. J Exp Med 184:1155-1160
32. Hileti D, Panayiotidis P, Hoffbrand AV (1995) Iron chelators induce apoptosis in proliferating cells. Br J Haematol 89:181-187
33. ++: effect of coenzyme Q redox state. Free Radic Biol Med 18:55-59
34. Link G, Saada A, Pinson A, Konijn AM, Hershko C (1998) Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells. J Lab Clin Med 131:466-474
35. Tudor G, Aguilara A, Halverson DO, Laing ND, Sausville EA (2000) Susceptibiltiy to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ 6:574-586
36. Szuts D, Krude T (2004) Cell cycle arrest at the initiation step of human chromosomal DNA replication causes DNA damage. J Cell Sci 117:4897-4908